Osteoporosis

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Posted by: admin | Posted on: January 16, 2025

High Iron Levels Threaten Bone Health and Increase Fracture Risk

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/01/16/high-iron-levels-bone-health.aspx

Analysis by Dr. Joseph Mercola January 16, 2025

Story at-a-glance

High iron levels, particularly serum ferritin above 1,000 µg/L, significantly increase the risk of fractures, with vertebral fractures being most common. Managing iron levels is key to reducing this risk
Both iron overload and deficiency weaken bones. Excess iron promotes osteoclast activity, leading to bone resorption, while insufficient iron impairs osteoblast function, disrupting bone formation
Elevated iron levels adversely affect bone microarchitecture, compromising bone strength and increasing fracture susceptibility
Excess iron leads to the production of reactive oxygen species, causing oxidative stress that damages bone cells and disrupts their function, further weakening bones
If your ferritin levels are high, establish a regular blood donation schedule of two to four times per year to effectively remove excess iron from your body

Iron overload, often abbreviated as IO, presents a significant risk factor for fractures. Conventional treatments for IO, such as phlebotomy and iron chelation therapy, aim to reduce iron levels but come with their own set of challenges. Phlebotomy, for instance, involves regular blood removal, which is inconvenient and uncomfortable for patients. Iron chelation therapy, while effective, leads to side effects like gastrointestinal disturbances and kidney issues.

The underlying causes of IO are diverse and complex. Hereditary hemochromatosis (HH) is a genetic disorder that leads to excessive iron absorption from the diet. Other conditions, such as thalassemia and sickle cell disease, also result in iron overload due to frequent blood transfusions.

Chronic liver diseases, including hepatitis C and nonalcoholic fatty liver disease, contribute to elevated iron levels as well. Additionally, postmenopausal women may experience increased iron stores due to hormonal changes. These underlying causes disrupt your body’s iron regulation, leading to IO.

In HH, mutations in the HFE gene cause the body to absorb more iron than needed, resulting in accumulation in organs like the liver and heart. In thalassemia and sickle cell disease, repeated blood transfusions introduce excess iron, which the body cannot excrete efficiently. Chronic liver diseases impair the liver’s ability to produce hepcidin, a hormone that regulates iron balance, further exacerbating iron accumulation.

Diagnosing IO is challenging due to the variability in symptoms and the overlap with other conditions. Many individuals with IO remain undiagnosed until significant organ damage occurs.

Iron Overload Significantly Increases Fracture Risk

A population-based matched cohort study investigated the relationship between iron overload disorders and the risk of bone fractures, aiming to determine whether elevated iron levels significantly increase the likelihood of fractures among affected individuals.¹

The study included 20,264 patients diagnosed with iron overload and 192,956 matched control participants. The population consisted of adults over 18 years old, with an average age of 57, and approximately 40% were female. The findings revealed a 55% increased risk of fractures among patients with iron overload, with the highest risk observed for vertebral fractures.²

Specifically, patients with serum ferritin levels exceeding 1,000 µg/L, a marker indicating high iron in the blood, had a 91% increased risk of any fracture and a 2.5-fold increased risk of vertebral fractures.³ Notably, the study found no elevated fracture risk among patients without high serum ferritin levels. Additionally, the risk was consistent across both males and females, indicating that iron overload affects fracture risk similarly regardless of sex.⁴

One of the key biological mechanisms identified is that iron overload adversely affects both bone quantity and the microarchitecture — the tiny structures that make up bone. This deterioration compromises bone strength, making fractures more likely.⁵ The study underscores the importance of monitoring serum ferritin levels as an indicator of fracture risk, especially in individuals with laboratory-confirmed iron overload.⁶

Moreover, the research highlighted that hereditary hemochromatosis, thalassemia major and sickle cell anemia are significant contributors to iron accumulation in the body. These inherited blood disorders disrupt iron regulation, leading to excessive iron storage and subsequent bone health issues.⁷

In fact, decreased bone mineral density was observed in over 70% of adults with sickle cell disease and over 60% of adult thalassemia patients.⁸ Addressing iron overload effectively therefore helps preserve bone integrity and reduce the incidence of fractures in this vulnerable population.

Iron’s Dual Impact on Bone Health

A review published in the journal Pharmaceuticals further explored how different levels of iron in the body influence bone health, particularly focusing on the roles of osteoclasts and osteoblasts — the cells responsible for breaking down and building up bone, respectively.

The researchers aimed to understand whether having too much or too little iron could disrupt the balance between these two types of cells, ultimately affecting bone strength and increasing the risk of fractures.⁹ The review examined individuals with various iron-related conditions, including hereditary hemochromatosis, thalassemias and sickle cell disease.

A significant percentage of patients with these iron overload disorders exhibited decreased bone mass and an increased likelihood of bone fractures.¹⁰ However, the findings revealed that both high and low iron levels negatively impact bone mineral density, leading to conditions like osteoporosis and osteopenia.

Delving deeper, the research highlighted that excess iron promotes the activity of osteoclasts, the cells that resorb or break down bone tissue. This heightened osteoclast activity accelerates bone loss, weakening the skeletal structure and making bones more susceptible to fractures.

On the flip side, insufficient iron levels also disrupt bone health by impairing the function of osteoblasts, the cells responsible for bone formation. This dual disruption further exacerbates the risk of developing osteoporosis and other bone-related issues.¹¹ The study also uncovered that elevated iron levels lead to the production of reactive oxygen species (ROS), which are chemically reactive molecules containing oxygen.

ROS contribute to oxidative stress, damaging bone cells and impairing their ability to function correctly. This oxidative stress not only hampers the formation of new bone by osteoblasts but also encourages the breakdown of existing bone by osteoclasts, creating a vicious cycle of bone deterioration.¹²

Biologically, the mechanisms by which iron affects bone health are intricate. Excess iron interferes with the differentiation and activity of osteoblasts by downregulating key genes like Runx2, which are essential for bone formation. Additionally, high iron levels enhance osteoclastogenesis — the formation of more osteoclasts — through pathways involving ROS and NF-κB signaling.

These processes collectively lead to increased bone resorption and decreased bone formation, undermining bone integrity and strength.¹³

In summary, maintaining balanced iron levels is necessary for bone health. Both iron overload and deficiency disrupt the delicate equilibrium between bone resorption and formation, leading to weakened bones and a higher risk of fractures. Understanding these mechanisms underscores the importance of monitoring and managing iron levels to preserve bone strength and prevent osteoporosis.¹⁴

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Simple Steps to Reduce Iron Overload and Protect Your Bones

Iron overload wreaks havoc on your bone health by disrupting the delicate balance between bone formation and breakdown. The good news? You have the power to address this issue through straightforward lifestyle changes that make a real difference in protecting your skeletal system. Here are four powerful ways to get your iron levels under control:

1. Get your iron levels tested regularly — You can have your iron levels checked using a simple blood test called a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen.

You want your ferritin level below 100 ng/mL, however the ideal range is 20 to 40 ng/mL. Below 20 ng/mL is an indicator that you are iron deficient. Aside from a serum ferritin test, a gamma-glutamyl transpeptidase (GGT) test is another screening marker for excess free iron and is a great indicator of your risk for sudden cardiac death, insulin resistance and cardiometabolic disease.

2. Donate blood to lower excess iron — Your body has a limited capacity to excrete iron, so it can easily build up in organs like your liver, heart and pancreas. This is dangerous because iron is a potent oxidizer that damages your tissues and contributes to a variety of health problems, including cancer.

If your ferritin levels are high, establish a regular blood donation schedule of two to four times per year. This natural approach effectively removes excess iron from your body since blood loss remains the only way your body eliminates iron. Your contributions help others while protecting your bone health.

You can also remove blood in smaller amounts once a month according to the schedule below. If you have congestive heart failure or severe COPD, you should discuss this with your doctor, but otherwise this is a fairly appropriate recommendation for most. If, for some reason, a blood donor center is unable to accept your blood for donation, you can obtain a prescription for therapeutic phlebotomy.

Men	Postmenopausal Women	Premenopausal Women
150 ml	100 ml	50 ml

3. Monitor your diet — Avoid cooking in iron pots and pans, limit alcohol consumption, which increases iron absorption, and be cautious with iron-fortified processed foods. If you drink well water, install an iron precipitator or reverse osmosis filter to reduce iron exposure.

4. Optimize your calcium and copper intake — Adequate calcium intake reduces iron overload naturally. Focus on getting calcium from whole food sources rather than supplements. When calcium levels are low, your body releases more parathyroid hormone (PTH), which not only dissolves bone but also increases iron storage. Breaking this cycle through proper calcium nutrition helps protect both your bones and overall health.

Iron and copper are also highly interdependent and need to be considered together. Iron overload along with copper deficiency is a dangerous combination. Most people are deficient in copper and need more in order for their iron metabolism to function properly.

Depending on your copper levels, you may need to take up to 3 milligrams (mg) to 4 mg of copper bisglycinate per day, or eat copper-rich foods, such as bee pollen, grass fed beef liver and acerola cherry.

Acerola cherry is very high in vitamin C, which contains copper-rich tyrosinase enzyme. Retinol, which makes copper bioavailable, is also important. It’s found in beef liver and beef organs.

– Sources and References

^1, ^2, ^3, ^4, ^5, ^6, ^7, ⁸ The Journal of Clinical Endocrinology & Metabolism November 18, 2024, dgae807
^9, ^10, ^11, ^12, ^13, ¹⁴ Pharmaceuticals 2018, 11(4), 107

Posted in Bones, Ferritin, Iron, Osteoporosis, Women | No Comments »

Posted by: admin | Posted on: December 19, 2024

CoQ10 Triumphs Over Ubiquinol in Heart Health Battle

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/12/12/coq10-ubiquinol-heart-health.aspx

Analysis by Dr. Joseph Mercola December 12, 2024

STORY AT-A-GLANCE

CoQ10 supplementation shows significant benefits in heart failure patients, leading to lower cardiovascular death rates and improved cardiac function, making it more effective than the reduced form, ubiquinol
CoQ10 aids in the early recovery of cardiac function post-myocardial infarction by reducing inflammation through the inhibition of CCR2+ macrophage recruitment and suppression of the NLRP3/IL1β inflammatory pathway
Intravenous administration of CoQ10 demonstrates promise in emergency ischemic conditions by rapidly increasing tissue penetration, reducing infarct size, and enhancing antioxidant capacity, offering protection during acute ischemia and reperfusion
CoQ10 reduces inflammation via the NLRP3/IL1β pathway, which is crucial for heart health, and its anti-inflammatory properties help improve cardiac function and reduce fibrosis and hypertrophy
CoQ10’s antioxidant properties protect against oxidative stress, providing a promising alternative to conventional heart failure treatments with fewer side effects and long-term benefits

Heart failure is a significant health concern, especially among older adults. The average one-year case fatality rate for heart failure patients is 33%, highlighting the serious nature of this condition.¹ Prevalence rates vary widely however, from as low as 0.2% in a Hong Kong hospital study to as high as 17.7% in a U.S. Medicare population aged 65 and older between 2002 and 2013.²

Coenzyme Q10 (CoQ10) has been extensively researched for its role in heart health, and numerous studies suggest CoQ10 supplementation can significantly reduce cardiovascular mortality and improve cardiac function. These benefits are crucial, given the high prevalence and mortality rates associated with heart failure.

Interestingly, in a surprising reversal of long-held beliefs, recent research suggests that CoQ10 (ubiquinone) is more effective for heart health than its reduced form, ubiquinol.³ For years, health experts and supplement manufacturers have advocated for ubiquinol, claiming its superior bioavailability made it the obvious choice for those seeking cardiovascular benefits.

Their recommendation seemed logical: since ubiquinol is the active form of CoQ10 in the body, taking it directly should provide better results. However, emerging evidence challenges this conventional wisdom, indicating that the body may actually use standard CoQ10 more effectively for cardiac function. As noted by the authors:⁴

“A slightly better water solubility and a lack of understanding absorption and transfer of CoQ10 and CoQH2 have led to misleading interpretations pushing CoQH2 as more bioactive form.”

This finding not only questions our understanding of CoQ10 supplementation but also highlights how assumptions about bioavailability don’t always translate to real-world therapeutic benefits.

I was absolutely thrilled to come across this new study, which confirms what I concluded after delving into Ray Peat’s work. It has helped me recognize that reductive stress is a significant factor contributing to reverse electron flow in the electron transport chain (ETC). The solution to reductive stress lies in the use of oxidants. Examples of effective oxidants that can help remove excess electrons include quinones such as vitamin K2, methylene blue, and ubiquinone (CoQ10).

When we were selling ubiquinol, the studies seemed to support its use, so I took the initiative to confront the company about it. After three months, their chief scientists produced a 30-page PowerPoint presentation in an attempt to convince me that ubiquinol was superior. However, the scientific evidence I presented indicated that the oxidized form was actually more effective.

Now, with this new study providing objective confirmation of my conclusions from two years ago, I finally have the proof I needed.

CoQ10 Mechanisms of Action

CoQ10 is a vital supplement for cardiovascular health, known for its role in energy production and antioxidant protection. This compound is essential for the production of ATP, the energy currency of cells, and plays a crucial role in maintaining mitochondrial function.

Mitochondria, often referred to as the powerhouses of the cell, rely on CoQ10 to shuttle electrons during the process of energy generation. This function is particularly important in heart cells, which have high energy demands.

Conventional treatments for heart failure often fall short, leaving patients with limited options and significant side effects. CoQ10 offers a promising alternative, providing cardiovascular benefits with fewer adverse effects. Its ability to reduce heart failure mortality and improve cardiac function makes it a key player in heart health management.

By improving mitochondrial function and energy production, CoQ10 supports the heart’s ability to pump efficiently. Additionally, its antioxidant properties protect against oxidative stress, a major contributor to heart disease. This dual action not only aids in the prevention of heart failure but also supports recovery in those already affected.

CoQ10 has also been shown to aid in the early recovery of cardiac function following a myocardial infarction, commonly known as a heart attack. By reducing inflammation and oxidative stress, CoQ10 helps to preserve heart tissue and improve overall cardiac health. This makes it an important supplement for those at risk of or recovering from heart-related events.

CoQ10 Proven Superior in Lowering Heart-Related Deaths

Importantly, a recent scientific review of 28 studies found that CoQ10 is more effective than its reduced form, ubiquinol, in reducing deaths related to heart diseases.⁵ Participants who took CoQ10 supplements showed significantly lower rates of cardiovascular mortality compared to those who took ubiquinol.

CoQ10 enhances mitochondrial function, which is crucial for energy production in heart cells. By improving how mitochondria operate, CoQ10 ensures that the heart muscle gets the energy it needs to pump blood efficiently. This improvement in energy production directly contributes to better heart health and reduced mortality rates.

Moreover, CoQ10 is more stable and bioavailable than ubiquinol. This means that CoQ10 is easier for the body to absorb and use effectively. Higher bioavailability ensures that more of the supplement reaches the heart cells where it is needed most, providing greater benefits.

Long-term studies have shown that the positive effects of CoQ10 persist over time, offering sustained protection against heart failure. In contrast, ubiquinol does not demonstrate the same level of long-term benefits, making CoQ10 the preferred choice for ongoing heart health management.

CoQ10 supplementation is particularly important if you’re on a statin drug. Statins block HMG coenzyme A reductase in your liver, which is how they reduce cholesterol. But this is also the same enzyme that makes CoQ10, making deficiency highly likely. Statin-induced CoQ10 deficiency is in many cases responsible for the myopathic side effects attributed to these drugs (i.e., side effects involving loss of muscle control).

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CoQ10 Aids in Early Recovery of Cardiac Function Post-Myocardial Infarction

Other recent research found that CoQ10 significantly reduces inflammation by inhibiting the recruitment of CCR2+ macrophages. CCR2+ macrophages are a type of immune cell that contribute to inflammation in the heart after a myocardial infarction, making their reduction crucial for recovery.⁶

Additionally, CoQ10 suppresses the NLRP3/IL1β inflammatory pathway. This pathway plays a key role in the body’s inflammatory response, and its inhibition by CoQ10 helps decrease overall inflammation, promoting better heart function after an infarction.⁷

The research also demonstrated that CoQ10 improves cardiac function and reduces both fibrosis and hypertrophy. Fibrosis refers to the stiffening of heart tissue, while hypertrophy is the enlargement of heart muscle cells. By mitigating these factors, CoQ10 supports a healthier heart structure and more efficient pumping action.⁸

Furthermore, CoQ10 enhances survival rates in models of myocardial infarction. This improvement in survival underscores the compound’s potential to not only aid in recovery but also to increase the likelihood of long-term survival following a heart attack.

CoQ10’s anti-inflammatory properties are therefore crucial for heart health. By targeting specific inflammatory pathways and reducing harmful immune cell activity, CoQ10 helps maintain a balanced inflammatory state, which is essential for the heart’s healing process and overall function after ischemic injury.

Intravenous CoQ10 Administration Shows Promise in Emergency Ischemic Conditions

Yet another 2024 study found that administering CoQ10 directly into the bloodstream can quickly boost its levels in vital organs.⁹ This rapid increase is crucial because it allows CoQ10 to act swiftly during emergencies like heart attacks or strokes.

When CoQ10 is given intravenously, it reaches the affected tissues much faster than when taken orally. This speedy delivery ensures that organs under stress from a lack of blood flow receive the necessary protection immediately. By enhancing the heart’s ability to function during acute ischemia, CoQ10 helps maintain essential energy production and prevents further damage.

In emergency situations, CoQ10 plays a significant role in reducing the size of the damaged area, known as the infarct. Smaller infarct sizes mean that less heart muscle is lost, which directly improves the heart’s overall function and the patient’s chances of recovery.¹⁰ This reduction in damage is a key factor in improving long-term outcomes for patients experiencing severe heart conditions.

Additionally, intravenous CoQ10 boosts the body’s antioxidant defenses, which help neutralize harmful free radicals created during ischemic events. By reducing oxidative stress, CoQ10 protects cells from further injury and supports the healing process.¹¹ This enhanced antioxidant capacity is vital for minimizing the overall impact of the ischemic event on the body.

Given these benefits, intravenous CoQ10 stands out as a valuable treatment option in acute medical settings. Its ability to rapidly increase tissue concentrations, protect against immediate damage, and support long-term heart function makes it an essential tool for managing emergency ischemic conditions.¹²

CoQ10 Counteracts Reductive Stress

As mentioned earlier, reductive stress is a major factor that contributes to reverse electron flow in the electron transport chain, and CoQ10, being a potent oxidant, helps remove excess electrons.

Reductive stress is an important topic because it’s fundamental to optimizing your biology. In a nutshell, reductive stress means you have too many mobile electrons in the cell. Think of your body’s cells as tiny engines that need to process fuel (from the food you eat) efficiently.

Just like a car needs the right mixture of fuel and air to run smoothly, your cells need the right balance of electrons (which come from breaking down food) and carriers (like NAD) to transport these electrons. These carriers work like taxis moving passengers (electrons) around the city (your cell).

Reductive stress happens when there’s too much fuel coming in. When all the electron carriers are full, new electrons have nowhere to go, creating a traffic jam in your cells. This typically occurs when we flood our system with too many calories. Just as a car engine runs poorly with too much fuel and not enough air (called a “rich” mixture), your cells can’t function properly when overwhelmed with too much energy input.

This cellular traffic jam is what scientists call reductive stress, and it’s a key feature of metabolic syndrome and other health issues.

To understand how oxidants like CoQ10 helps in this instance, think of it as a traffic controller for those electrons. When you have reductive stress, oxidants open up new routes to help move the traffic along.

CoQ10 specifically has a unique ability to accept backed-up electrons and safely transport them through the cellular machinery, helping to clear the congestion. By providing these alternative pathways for electron flow, oxidants like CoQ10 help restore balance to the system. They essentially help convert those backed-up electron carriers back into their empty form (NAD+), making them available to transport more electrons again.

Optimizing Your Heart Health with CoQ10

If you’re new to CoQ10 supplementation, an initial dose of 200 to 300 mg per day is recommended. After about three weeks, when plasma levels typically reach their optimal plateau, you can transition to a maintenance dose of 100 mg daily, which is sufficient for most healthy individuals. However, if you maintain an active lifestyle, exercise frequently, or experience high stress levels, you might benefit from continuing with 200 to 300 mg daily.

Special consideration must be given to certain health conditions. Those taking statin medications should supplement with at least 100 to 200 mg of CoQ10 daily, and possibly more. Similarly, individuals managing chronic conditions such as heart disease, diabetes, ALS, chronic fatigue, or autism may require higher doses.

For optimal absorption, split your daily dose into two or three portions rather than taking it all at once, and take it with a healthy source of fat since CoQ10 is fat-soluble. While these guidelines provide a general framework, working with an integrative physician can help determine the most appropriate dosage for your specific needs.

Additionally, given the varying quality of supplements available in the market, it’s crucial to select a CoQ10 product specifically formulated for maximum absorption and bioavailability.

CoQ10 Outshines Ubiquinol in Enhancing Heart Health

CoQ10 significantly reduces heart-related deaths more effectively than Ubiquinol. Studies demonstrate that individuals taking CoQ10 supplements experience lower rates of cardiovascular mortality due to improved mitochondrial function and efficient energy production in heart cells.

The stability and bioavailability of CoQ10 ensure it is easily absorbed and utilized by the body. This higher bioavailability allows more of the supplement to reach heart cells, providing consistent and long-lasting benefits that surpass those of Ubiquinol.

CoQ10 plays a crucial role in the early recovery of cardiac function after a myocardial infarction. It reduces inflammation by inhibiting specific immune cells and inflammatory pathways, which helps preserve heart tissue and improves overall heart health following a heart attack.

Intravenous administration of CoQ10 offers rapid elevation of its levels in vital organs during emergency ischemic conditions. This swift delivery protects the heart muscle, reduces the size of damaged areas, and supports better long-term recovery, making CoQ10 an essential treatment option in acute medical settings.

Incorporating CoQ10 into your daily routine can optimize heart health. By selecting a high-quality supplement, determining the appropriate dosage based on age, and maintaining consistent supplementation, you can enhance energy production, boost immune responses, and protect your heart from damage.

– Sources and References

^1, ² Heart 2022;108:1351-1360
^3, ^4, ⁵ Current Cardiology Reports (2023) 25:1759–1767
^6, ^7, ⁸ BMC Cardiovascular Disorders (2024) 24:76
^9, ^10, ^11, ¹² Life 2024, 14(1); 134

Posted in Blood Thinners, Cardiovascular, COPD, Eggs, Faint, Fermentation, Heart, Osteoporosis, Pneumonia, Polyphenols, Spice, Supplements, Thymus | No Comments »

Posted by: admin | Posted on: December 2, 2024

Osteoporosis warning: How bone loss signals inflammation and a risk of disease

Reproduced from original article:
https://www.naturalhealth365.com/osteoporosis-warning-how-bone-loss-signals-inflammation-and-a-risk-of-disease.html

by: Lori Alton, staff writer | November 23, 2024

(NaturalHealth365) Osteoporosis, a disease in which bones become brittle and prone to breakage, is so widespread that 50 percent of all women over age 50 (and 25 percent of all over-50 men) will eventually suffer an osteoporosis-related bone fracture. A new study published in the Journal of Cachexia, Sarcopenia and Muscle reveals systemic inflammation and frailty as key contributors to osteoporosis and fracture risks.

Unfortunately, the consequences of osteoporosis extend even beyond the pain and disabling effect of broken bones. In fact, recent research highlights a shocking connection between osteoporosis and life-threatening conditions such as heart disease, Alzheimer’s disease, and cancer.

Fortunately, a combination of natural nutrients may help prevent osteoporosis – and offer protection against the devastating diseases that can accompany it.

Pro-inflammatory molecules released by bone loss are linked to increased risk of deadly diseases

The creation of bone is regulated by the actions of the body’s osteoblasts (bone cells that create new bone) and osteoclasts (cells that break down bone).

At about age 35, the “balancing act” begins to shift – and the rate of bone breakdown starts to overtake the rate of bone development, leading to bone loss. Researchers are now learning that aging bones contain more “senescent” cells – meaning they have stopped reproducing themselves and now exclusively promote the breakdown of bone tissue.

These senescent cells release pro-inflammatory molecules into the bloodstream, laying the groundwork for disease. Senescent bone cells have been found in plaque deposits in heavily calcified arteries.

And, having large numbers of senescent cells in the bones is linked in studies with accelerated aging – particularly affecting the brain. Finally, people with osteoporosis have an increased risk of cancer.

Keep in mind, when over-activated, the bone proteins that normally regulate bone maintenance and healing can lead to uncontrollable cell growth and replication.

Discover a natural way to strengthen your bones

The antioxidant vitamin C plays a critical role in preventing bone loss – which it does by preventing the oxidative stress that destroys bone structure. Vitamin C also plays a pivotal role in the formation and structure of bones by forming collagen and developing other bone proteins.

If the body’s need for vitamin C is unmet, insufficient collagen production can result – leading to easily fractured bones. Many natural health experts believe osteoporosis is a vitamin C deficiency or “scurvy of the bones.”

Bone-building vitamin C is found in citrus fruits, kiwi, strawberries, and bell peppers. However, supplementation may be necessary – especially if you have osteoporosis. By the way, for superior bioavailability (absorption), natural health experts advise using a liposomal form of vitamin C.

Boron reduces the loss of indispensable calcium from the bones

This little-known trace mineral packs a powerful punch when it comes to supporting bone health.

Simply put, boron helps the body produce and use vitamin D – a mainstay of bone health. The mineral also helps regulate calcium, magnesium, and phosphorus levels – all “MVPs” of bone maintenance and support.

A study published in the Federation of American Societies for Experimental Biology Journal showed that 3 mg of boron daily helped prevent calcium loss and bone demineralization in postmenopausal women.

Natural health experts may advise 3 to 6 mg of boron daily. You can increase your dietary boron intake by eating organic nuts, beans, avocados, and whole grains.

Calcium: The primary structural component of bones

Bones contain 99 percent of the body’s calcium stores – integral to bone building.

But, for your body to use calcium to build bone, you must have sufficient levels and adequate amounts of vitamin D. Deficiency in both minerals can cause bone loss and symptoms of muscle pain, muscle cramps, and weakness.

Calcium exists in sardines, including the bones, dark leafy greens, and cruciferous vegetables, such as Brussels sprouts. Most adults require between 1,000 and 1,200 mg of calcium a day.

Magnesium deficiency is a cause of “incalculable” suffering

Magnesium works in concert with calcium to suppress hormones that break down bones – while activating enzymes needed to produce new bone. Unfortunately, experts estimate that about half of all Americans fail to consume enough of this important mineral.

More than 40 percent of post-menopausal women have low magnesium blood levels, which can trigger excessive bone breakdown.

In one landmark study on magnesium benefits, the researchers lamented that the deficiency of such an “inexpensive, low-toxicity nutrient” is currently causing diseases that are a source of untold “suffering and expense” worldwide.

Eating organic dark leafy greens, potatoes, raisins, chocolate, pumpkin seeds, nuts, and avocados can help ramp up your dietary intake of magnesium. Of course, your holistic healthcare provider may recommend supplementing with magnesium to avoid shortfalls.

Most natural healers recommend 250 to 750 mg a day. Magnesium citrate, magnesium glycinate, and magnesium taurate are considered the most bioavailable forms.

Vitamin D helps improve calcium absorption

Vitamin D reduces the activity of the pro-inflammatory signaling molecules that are released from senescent bone cells during bone breakdown. Unsurprisingly, vitamin D shortfalls are bad news for your bones and the rest of your body.

Vitamin D deficiency has been identified as a major contributor to osteoporosis – as well as to cancer, heart disease, type 2 diabetes, and lowered cognitive functioning. This fat-soluble vitamin is found in cold-water fatty fish (like wild-caught salmon), as well as in mushrooms and egg yolks.

Because the body manufactures vitamin D in response to sunlight, many natural health experts advise getting 20 minutes of direct sunlight three or four times a week. However, supplementation may be necessary to maintain healthy vitamin D levels, especially in northern climates.

Just remember to opt for vitamin D3 (cholecalciferol) over vitamin D2.

Vitamin K2 directs calcium in the body

Vitamin K2’s job is to route calcium where it belongs – in the bones and teeth – while keeping it out of blood vessel walls (thereby helping to prevent heart disease).

Vitamin K2 improves bone mineral density and is particularly beneficial for improving bone mineral content of the femoral bone – which is particularly susceptible to fracture during falls. Researchers have found that vitamin K2 is synergistic with vitamin D3 – meaning that each nutrient enhances the beneficial effect of the other.

In an influential study published in Maturitas, supplementation with a combination of vitamins K2 and D3 protected and increased vertebral bone mass in postmenopausal women.

Food sources of vitamin K2 include liver, egg yolks, and natto, a food made from fermented soybeans.

Your doctor may recommend 100 mcg per day of vitamin K2 in the form of menaquinone-7, a highly available form of the nutrient.

Prescription drugs can jeopardize zinc supply

Zinc is needed for bone cells (osteoblasts) to create bone tissue – and is crucial for the entry of vitamin D into cells. And, yes, patients with osteoporosis have been found to have low levels of zinc.

Ironically, pharmaceutical osteoporosis drugs – such as Boniva and Reclast – actually rob the body of this important trace mineral. The RDA for zinc is 8 mg for women and 11 for men.

You can increase your dietary zinc intake by eating organic pumpkin seeds, chickpeas, nuts, yogurt, and cruciferous vegetables, such as broccoli. Grass-fed beef, oysters, and pasture raised poultry are also rich in zinc.

As with the other vitamins and minerals, consult your holistic doctor before supplementing with zinc.

With millions of people either suffering from osteoporosis – or at serious risk – it’s time to fight back. And, your best weapons in the battle to slow and reverse bone loss could be these non-toxic, natural micronutrients.

Sources for this article include:

NIH.gov
LifeExtension.com
SaveOurBones.com
UniversityHealthNews

Posted in Blood Thinners, Bones, COPD, Eggs, Faint, Fermentation, Food, Inflammation, Minerals, Osteoporosis, Pneumonia, Polyphenols, Prescription Medication, Spice, Supplements, Thymus, Vitamins | One Comment »

Posted by: admin | Posted on: November 24, 2024

Why Your Multivitamin May Be Harming Your Health

© GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC.
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Reproduced from original article:
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Posted on: Thursday, November 7th 2024 at 12:15 pm
Written By: Sayer Ji, FounderThis article is copyrighted by GreenMedInfo LLC, 2024

What comes to mind when you think of toxic waste disposal? Biohazard suits, lead-lined vaults, and burial deep underground? You might be shocked to learn that a dumping ground for these chemicals is a product that many people consume daily to ensure good health – and it may be in your medicine cabinet.

When it comes to dietary supplements, all products are not created equal. A label can identify the presence of a specific ingredient without indicating if it’s from a natural, bioavailable and biocompatible source, or from a synthetic, inorganic source. This is despite the fact that our bodies may not recognize these synthetic ingredients as food.

When a supplement contains an ingredient that is not bioavailable, the body either will not absorb or utilize it correctly. The best one can hope for is that the substance will pass, inert, through the body. But with certain ingredients, the material from which they are extracted is highly toxic, rendering a substance that can do more bodily harm than good.

Industrial waste products such as fluoride (a byproduct of aluminum manufacturing and known neurotoxin), and cobalt-60, a radioactive waste material culled from nuclear reactors, have been used for decades in broad-reaching applications to make our water “healthier” and our food “safer.”

With FDA-approval and cherry-picked, manufacturer-sponsored studies as “proof”, the unsuspecting public is lulled into a sense of safety regarding these practices. And these aren’t the only such hoaxes being perpetrated on the American people.

Hidden in Plain Sight

As with most things in our modern world, understanding this logic requires you to follow the money trail. The economics are simple: chemical byproducts and industrial waste are environmentally hazardous and in abundant supply. This makes them both difficult and costly to dispose of properly. Selling these waste products as cheap, raw materials is a BIG win for manufacturers. And repackaging them as health supplements can be extremely profitable.

One of the most popular health supplements by category is the multivitamin. Consumed by adults and children alike, multivitamins are sold as veritable health insurance. If you don’t get enough of the recommended daily allowance of essential vitamins and minerals, taking a quality multivitamin can fill this dietary gap.

But not all vitamins on supermarket shelves are actually good for you. Some manufacturers source “healthy nutrients” that are toxic to the body, even in small quantities. This confounding trend is not limited to off-brand manufacturers looking to produce cheap knock-offs of “the good stuff”. Some of the most trusted name brands use ingredients that show up on global watch lists of hazardous substances we’ve been instructed to avoid for health and safety.

Disguised as healthy nutrients, the following toxic imposters are listed on the labels of popular multivitamins Centrum, One-A-Day, and Flintstones for Kids. As you will see, some of the biggest dangers to consumers are hidden in plain sight!

Sodium selenate/Sodium selenite

Sodium selenate, a byproduct of copper metal refining, is four times more toxic than the known killing drug, cyanide. Yet, it is proudly listed as a “nutrient” in many common health products.

Based on animal studies, we know that a mere 100 milligrams of the stuff are a fatal dose to most humans. The amount found in Centrum is 55 micrograms (mcg); that’s 5 mcg more than the EPA allows in a liter of drinking water before declaring it unsafe for human consumption!

Organically-bound selenium is the vital human nutrient that sodium selenate can not replace. Selenium is found in foods like nuts, seeds, and organic produce grown in selenium-rich soil. This naturally-occurring trace mineral is very different than the unbound, synthetic form being put into some multivitamins.

Organic selenium is known for its ability to boost the immune system, improve thyroid function, protect against heart disease, and even prevent cancer. Sodium selenite/selenate, on the other hand, has been shown to cause DNA damage associated with cancer and birth defects.

This mass market vitamin reveals a litany of toxic chemicals sold as “nutrients’

Cupric oxide

Cupric oxide is one of several derivative forms of “dietary copper”, a micronutrient needed to ensure proper growth and development of bones and connective tissues, as well as for maintaining the health of vital organs such as the brain and heart.

Organically, copper is found in a variety of foods, including dark leafy greens, organ meats, beans, nuts, dried fruits, nutritional yeast, as well as oysters and shellfish. The synthetic derivations found in many multivitamins are an entirely different kettle of fish!

For decades, cupric oxide was the principal source of dietary copper in supplements sold for livestock and companion animals. But an array of studies conducted as far back as the 1980’s on the bioavailability of cupric oxide determined it was not fit for animal consumption. This hasn’t stopped it from being fed to humans!

A summary of these studies published by The American Society for Nutritional Sciences ascertained that cupric oxide is not bioavailable due to it’s inability to permeate the gut wall. The fact that this form of copper is still being used in human health supplements and even baby formula, is particularly troubling since an estimated 61% of people in the U.S., U.K., and Canada have dietary deficits of this essential nutrient. Copper deficits are linked to heart disease, osteoporosis, and poor blood sugar metabolism, among other troubling disorders.

The dangers of this supplement go beyond the nutritional deficits caused by this deceptive masquerade. Cupric oxide is listed on the European Union’s Dangerous Substance Directive as a hazardous substance, for humans and the environment. Not surprising, considering its use as a chemical in industrial applications such as the production of rayon fabric and dry cell batteries.

Ferrous fumarate (aka iron)

With a list of side effects a mile long including nausea, vomiting, gastrointestinal discomfort, constipation, diarrhea, blackened stools, tooth discoloration, and anorexia, it should come as no surprise that this is the one ingredient in Flintstones vitamins to precipitate the warning on the label:

Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

However, it might surprise you to learn that the amount of ferrous fumarate in one Centrum vitamin is six times higher than the maximum EPA allowed limit for 1 liter of drinking water!

Another tip-off that this isn’t the iron Popeye was getting from spinach, is the fact that it is impossible to die from too much iron obtained from food. But ferrous fumarate is so toxic that accidental overdose is “a leading cause of fatal poisoning in children under 6.”

Ferrous fumarate is an industrial mineral that is not found in nature as food. A byproduct of iron mining, ferrous fumarate has drawn even more criticism as a supplement due to its interaction with vitamin C leading to ulceration of the GI tract, chronic inflammatory diseases, and cancer.

Adding to these concerns are the high doses present in many health supplements. Studies found high concentrations of iron to be associated with several pathologies, including cancer, diabetes, liver and heart disease.

Dishonorable Mention

In addition to the offenders already mentioned, the following common multivitamin ingredients have disturbing toxic rap sheets, and are found in dangerously high concentrations in most multivitamins.

Stannous chloride (tin)

In a 1983 study, it was determined that stannous chloride was “readily taken up by white blood cells and can cause damage to DNA.”

In small doses, it’s known to cause side effects such as skin irritation, headache, nausea, vomiting, and fatigue. In larger doses, severe growth retardation and cancer. While the EPA says a mere 4 mcg is the high-end limit for one liter of water to become undrinkable, you will find 10 mcg in one dose of Centrum.

Manganese sulfate

Manganese sulfate is often promoted as a supplement to prevent bone loss and anemia. The organic form of this essential nutrient helps with blood clotting, the formation of bones and connective tissues, as well as hormone regulation. Found in nuts, beans, seeds, and leafy greens, manganese is considered an essential nutrient. Manganese sulfate’s other claim to fame is its pervasive use as a chemical pesticide.

Even low doses of this chemical present significant neurological risk over time, as evidenced by reports of workplace exposure. Affected field workers showed loss of coordination and balance, along with an increase in reporting mild symptoms such as forgetfulness, anxiety, or insomnia.

In high concentrations, this supplement becomes a neurotoxin, presenting with Parkinson’s disease-like symptoms, including tremors and permanent memory loss. So why is the standard dose in a single Centrum more than four times the EPA safe consumption limit?

It should be noted that even if there aren’t extraordinary large amounts of these metals and toxicants in the vitamins you are taking, the age old justification that small amounts of chemicals or heavy metals won’t hurt you, i.e. “the dose makes the poison,” is now an outdated and disproved toxicological risk model. For instance, recent discoveries indicate that exceedingly small amounts of the following metals: “aluminium, antimony, arsenite, barium, cadmium, chromium (Cr(II)), cobalt, copper, lead, mercury, nickel, selenite, tin and vanadate,” exhibit estrogen receptor binding and stimulating properties, which has lead to them being described as ‘metalloestrogens’ with the capability to induce hormone reponse related carcinogenicity. This concept that, in some cases, the lower the dose concentration, or the lower the energy state, the higher the damage, has also been demonstrated with x-ray mammography, toxicants like glyphosate, and nanoparticles, to name but a few examples.

Who is Minding the Store?

It may seem unfathomable that these harmful, toxic chemicals could be allowed into our food and drug supply. The truth is, no one is minding the store. Loopholes abound, allowable limits are questionable, and even our organic food supply is not safe from subterfuge. Even organic infant formula can skirt regulatory oversight thanks to the numbers game.

According to the USDA’s National Organic Program guidelines, any multi-ingredient product that contains 95% or more organic ingredients may be labeled organic. That means even the copper sulfate in Similac’s Advance Organic formula falls within the “contains less than 2%” ingredient list guideline, giving this noxious chemical a free pass.

The public has a right to expect that any substance that is suspected of being harmful will be held to a high-level of scrutiny before it is approved for mass consumption. This basic, precautionary principle would minimize public risk until all known toxicological data has been thoroughly examined. Only when a determination that no serious health risks are present can be made, should a substance be allowed into mass-market products.

However, it is essentially the reverse of this model that is in effect today. Only when a substance has repeatedly demonstrated harm in already exposed populations, is it subject to the level of scrutiny that can precipitate its removal from FDA-approved products on store shelves. This means lobbying and corporate interests often prevail through the off-loading of harmful substances that are considered “innocent until proven guilty.” Guilt, in this instance, means acute or large-scale sickness suffered by the public.

Currently, no law forbids the use of any of these questionable substances in dietary supplements, despite copious laboratory research demonstrating their toxicity in animals, and significant clinical data demonstrating their actual or potential toxicity in humans. Don’t wait for the fallout to affect you before you act. Look for high-quality, organic supplements with food-grade sources, and a proven supply chain. Also consider using whole food concentrates and focusing on improving the quality of your food instead of focusing on taking supplements to try to counterbalance a deficient diet.

Sayer Ji is founder of Greenmedinfo.com, author of international best-seller REGENERATE: Unlocking Your Body’s Radical Resilience through the New Biology, co-founder of Stand for Health Freedom (501c4), and UNITE.live, a global, multi-media platform for conscious creators and their communities.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

Posted in Blood Thinners, COPD, Diet, Eggs, Faint, Fermentation, Osteoporosis, Pneumonia, Polyphenols, Spice, Supplements, Thymus, Toxins | No Comments »

Posted by: admin | Posted on: September 4, 2024

The Science of Magnesium and Its Role in Aging and Disease

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/08/31/magnesium-aging-and-disease.aspx

Analysis by Dr. Joseph Mercola August 31, 2024

STORY AT-A-GLANCE

Nearly 45% of the U.S. population doesn’t get enough magnesium, primarily because our diets lack sufficient dark leafy greens where magnesium is abundant
Lifestyle factors, including sleep deprivation, stress and alcohol consumption, can lead to a decrease in magnesium levels
Even marginally low magnesium intake may take a toll on your health and lead to accelerated aging and the development of chronic disease
Magnesium has been studied for its potential role in preventing and treating migraines, high blood pressure, osteoporosis and more

Magnesium is a mineral that’s essential for human health, playing a crucial role in more than 300 enzymatic reactions in your body. Magnesium is necessary for muscle and nerve function, blood glucose control and protein synthesis. It also supports a healthy immune system, keeps your heartbeat steady and plays a role in bone health.¹ Unfortunately, magnesium is also one of the most prevalent micronutrient deficiencies.

Why Magnesium Deficiency Puts Your Health at Risk

Nearly 45% of the U.S. population doesn’t get enough magnesium, primarily due to insufficient consumption of dark leafy greens. Magnesium is found in the chlorophyll that gives plants their green color.

Magnesium deficiency can have serious consequences, impacting essential biological functions such as DNA repair, replication, and transcription. When magnesium levels are inadequate, these processes may be hindered, potentially leading to the formation of mutations that could contribute to cancer development.

Furthermore, recent research suggests a possible connection between low magnesium levels and increased brain volume loss, which may contribute to a faster decline in cognitive function and an earlier onset of dementia in aging individuals.

The RDA for magnesium is around 310 to 420 milligrams (mg) per day depending on your age and sex,² although some researchers believe we may need as much as 600 to 900 mg/day for optimal health. I believe many may benefit from amounts as high as 1 to 2 grams (1,000 to 2,000 mg) per day.

The Recommended Dietary Allowance (RDA) for magnesium only represents the minimum amount needed to prevent severe deficiency-related diseases. So, meeting the 300 to 400 mg daily requirement only provides the basic level necessary for bodily functions, rather than optimal health.

Magnesium is crucial for maintaining proper electrolyte balance and preventing dehydration. It regulates electrolytes, which are essential for nerve impulse transmission, muscle contraction, and maintaining a healthy heart rhythm. A magnesium deficiency can disrupt this balance, potentially leading to dehydration and associated complications.

The primary reason why so many people have magnesium insufficiency or deficiency is due to the typical standard American diet, which is low in micronutrients like magnesium. However, certain health conditions and lifestyle factors also play a role by increasing magnesium excretion. Diabetes is one example, as is alcohol consumption.

Alcohol consumption can accelerate magnesium loss from the body, even when gut absorption remains normal. This occurs because alcohol acts as a diuretic, stimulating increased urine production. As a result, more magnesium is filtered out by the kidneys and excreted in urine, rather than being retained and used by the body.

This diuretic effect leads to a higher rate of magnesium excretion, potentially depleting your magnesium stores. Sleep deprivation and your stress levels also affect magnesium, and chronic or even intermittent stress may lead to a decrease in magnesium levels.

Magnesium Boosts Brain Health

Intriguing research suggests higher dietary magnesium intake is linked to better brain health, particularly in women. One study of 6,001 people revealed that higher dietary magnesium consumption of about 550 mg per day was associated with larger gray matter and hippocampal volumes in the brain than the average intake of about 350 mg per day.³

Higher magnesium intake may result in larger brain volumes, potentially slowing brain aging by up to one year compared to those with lower magnesium consumption. Research has associated magnesium with the onset and progression of various age-related brain disorders. Elevated cerebral magnesium levels have been shown to reduce oxidative stress and inflammation while enhancing pro-synaptic plasticity.

Additionally, magnesium also helps counteract other mechanisms that contribute to neurodegeneration. For example, a systematic review and meta-analysis of 21 studies also revealed that individuals with Alzheimer’s disease have significantly lower plasma magnesium levels compared to those without.⁴ These effects collectively suggest that maintaining adequate magnesium levels could play a role in preserving brain health and function as we age.

Magnesium is also involved with creatine, a substance naturally found in muscle cells and the brain. Creatine is commonly used by athletes to improve performance, as it’s immediately used by your body to convert adenosine diphosphate (ADP) to adenosine triphosphate (ATP) — the main energy currency of cells — and supply energy muscles need for contraction. However, creatine also helps provide energy to your brain.

Creatine plays a crucial role in energy production by transferring phosphate groups from phosphocreatine to ADP, thereby generating ATP, your body’s primary energy currency. This process is facilitated by enzymes that require magnesium as a cofactor to function effectively.

This mechanism highlights another significant reason why magnesium is essential for brain function, as it directly supports the energy metabolism necessary for optimal cognitive performance and overall brain health.

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The Role of Magnesium in Aging

Even marginally low magnesium intake may take a toll on your health and lead to accelerated aging and the development of chronic disease. According to Bruce Ames, Ph.D., professor emeritus of biochemistry and molecular biology at the University of California Berkeley, and former senior scientist at the Children’s Hospital Oakland Research Institute, proteins and enzymes fall into two general categories:

Survival proteins, which are crucial for our immediate survival and ability to reproduce
Longevity proteins, which help us stay healthy in the long run

According to Ames’ triage theory, if your body is low in certain nutrients or cofactors, it prioritizes survival proteins over longevity proteins. This means that in times of nutrient deficiency, your body chooses to support functions that keep you alive and reproducing rather than those that prevent long-term damage, which can lead to faster aging and age-related diseases.

With regard to magnesium, it plays a crucial role in numerous biological functions, both for immediate survival and long-term health. The triage theory suggests that when magnesium is limited, your body then prioritizes its use for essential short-term survival processes, such as energy production, at the expense of long-term health processes like DNA repair.

So, while we may consume enough magnesium to avoid acute deficiency, this level might not be optimal for long-term health. Your body may even deplete magnesium from bones to maintain levels in muscles and other tissues, potentially leading to issues like osteoporosis later in life.

Impaired DNA repair and replication processes due to chronically inadequate magnesium levels can also result in an accumulation of DNA damage and mutations, potentially leading to cell dysfunction and even cancer development over time.

This scenario illustrates how subtle, long-term effects of micronutrient inadequacy, particularly magnesium, can contribute to the aging process and the development of chronic diseases. The damage is insidious, accumulating gradually over time without immediate noticeable effects, but potentially having significant long-term health consequences.

Magnesium for Migraines, High Blood Pressure, Osteoporosis and More

Magnesium has been studied for its potential role in preventing and treating migraines. Several studies suggest that magnesium deficiency may be linked to the occurrence of migraines, and supplementation might help reduce the frequency and severity of migraine attacks.⁵ Magnesium can also affect neurotransmitter release and blood vessel constriction, both of which are factors in migraine development.

Magnesium has been studied for its potential role in preventing and treating migraines. Research suggests that magnesium deficiency may be linked to the occurrence of migraines, and supplementation might help reduce the frequency and severity of migraine attacks. Magnesium can also affect neurotransmitter release and blood vessel constriction, both of which are factors in migraine development.

During a migraine, a phenomenon called cortical spreading depression occurs, which is a wave of brain activity leading to visual and sensory changes often associated with migraine auras. Magnesium supplementation may help prevent these waves.

Additionally, magnesium may decrease the release of certain pain-signaling chemicals in the brain, such as substance P and glutamate, potentially lessening migraine-associated pain. It might also prevent further narrowing of brain blood vessels caused by serotonin, another neurotransmitter involved in migraines.

Magnesium also plays an important role in other common chronic conditions, including high blood pressure. It helps control blood pressure by boosting the production of substances like prostacyclin and nitric oxide, which relax blood vessels and improve overall cardiovascular health. Magnesium aids in vasodilation, making it easier for the heart to pump blood and reducing blood pressure.

Furthermore, its ability to combat inflammation and protect against blood vessel damage contributes to cardiovascular health support.

Magnesium is also a key player in bone health, with adequate intake necessary to build strong bones starting early in life. Most of the magnesium in your body is stored in your bones. They basically serve as a reservoir that your body can draw from when needed. As you age, magnesium losses from the bones increase, partly due to your body’s efforts to maintain a stable range of magnesium in the plasma.

Over a lifetime, this process can lead to a significant decrease in bone magnesium content. Therefore, ensuring adequate magnesium intake early in life is crucial for long-term bone health and reducing your risk of age-related bone density loss and associated conditions like osteoporosis.

What Are the Best Sources of Magnesium?

When it comes to oral supplementation, my personal preference is magnesium threonate, as it appears to be the most efficient at penetrating cell membranes, including your mitochondria and blood-brain barrier. However, as a general rule, I recommend starting out with a dose of 200 mg of oral magnesium citrate per day, gradually increasing your dose until you develop slightly loose stools.

I recommend using a food tracking app such as Cronometer to find out your magnesium intake. Dark green leafy vegetables are a good source of magnesium, and juicing your greens is an excellent way to boost your intake, although supplementation is likely necessary for most people, as magnesium-depleted soils have dramatically lowered the magnesium content of our food.

– Sources and References

Posted in Age, Blood Pressure, Bones, Brain, Minerals, Osteoporosis, Supplements | No Comments »

Posted by: admin | Posted on: June 7, 2024

How to Diagnose and Treat Osteoarthritis

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/06/07/how-to-diagnose-and-treat-osteoarthritis.aspx

Analysis by Dr. Joseph Mercola June 07, 2024

STORY AT-A-GLANCE

Osteoarthritis (OA) is often described as a “wear and tear” disease because it typically involves the breakdown of joint cartilage due to repetitive use and load over time
However, the understanding of osteoarthritis has evolved, and it is now recognized as a more complex condition influenced by a combination of factors beyond just mechanical wear and tear
Growing recognition among medical professionals suggests osteoarthritis should be considered a systemic disease, not just a localized joint condition
Maintaining a healthy weight is a key part of osteoarthritis prevention; avoiding linoleic acid in seed oils can help you avoid obesity
Homemade bone broth is rich in collagen, making it a natural food to support joint health; collagen is a major component of cartilage, the tissue that’s degraded in OA

Osteoarthritis (OA), the most common form of arthritis, is a degenerative joint disease that affects 32.5 million U.S. adults.¹ Worldwide, about 595 million people are living with the condition, a 132% increase since 1990.²

Osteoarthritis occurs when the protective cartilage that cushions the ends of your bones wears down over time. Although osteoarthritis can damage any joint, the knee joint is most frequently affected, followed by the hip and hand.³ While there’s no known cure for osteoarthritis, it typically progresses slowly.

This means you can take steps to reduce further damage from the disease, like avoiding obesity and making collagen-rich bone broth. Scientists are also working on methods for early detection, which would allow treatment to begin before joint damage occurs.

Osteoarthritis Is Often Diagnosed After the Damage Is Done

Osteoarthritis is typically diagnosed based on a combination of clinical symptoms, physical examinations and diagnostic tests, including X-rays. Key symptoms of osteoarthritis include:

Joint pain and tenderness — Affected joints may hurt during or after movement.
Stiffness — Joint stiffness may be most noticeable upon waking up in the morning or after a period of inactivity.
Loss of flexibility — There may be a loss of flexibility in the affected joint.
Grating sensation — You might feel a grating sensation or hear a popping or crackling sound, when you use the joint.
Bone spurs — These extra bits of bone, which feel like hard lumps, can form around the affected joint.

Your doctor will ask about any such symptoms and how long you’ve had them, as well as whether you’ve had past injuries or engage in activities that could contribute to joint damage. For instance, according to the Osteoarthritis Action Alliance (OAAA):⁴

“Certain occupations (e.g., construction, healthcare, farming, law enforcement, first responders, military) involving prolonged standing, squatting, lifting, kneeling, and repetitive motion with resultant excessive mechanical stress on a joint, raises the risk of OA and can worsen symptoms.

Osteoarthritis and back pain are the most common diagnoses related to disability-caused separation from the military, both during periods of peacetime and war.

High impact professional sports (e.g., hockey, soccer, and football), where there is not only repetitive loading with excessive force, but also increased joint trauma puts players at risk of OA. In addition to elite-level athletes (soccer, long-distance running, weightlifting and wrestling), non-elite soccer athletes are also at risk of developing OA.”

X-rays are commonly used to diagnose osteoarthritis, as they can reveal changes in joint structure. The problem is that by the time osteoarthritis is visible on an X-ray, the joint is already damaged. Research suggests, however, that earlier diagnosis may be possible.

Blood Biomarkers May Reveal Osteoarthritis Eight Years Before X-Rays Can

Researchers from Duke University conducted a study to find blood markers that could predict the development of knee osteoarthritis in women before any joint damage is visible on X-rays.⁵ In a group of 200 women, they found that just six specific blood proteins were able to indicate a 77% chance of developing OA, up to eight years before it could be seen on X-rays.

Predicting OA based on these blood markers was more accurate than using age, body mass index (BMI) or reports of knee pain, all of which showed much lower accuracy (51% for age and BMI, 57% for knee pain). The findings suggest that the joint tissue may already be undergoing changes long before OA is visible on an X-ray, hinting at an ongoing inflammatory process or “OA continuum.”

Moreover, the majority of the blood proteins that indicated the potential onset of OA also suggested the possibility of OA getting worse. So, the early changes leading to OA and the worsening of OA once it’s begun may share similar underlying processes.

“This tells us that there is an osteoarthritis continuum,” lead study author Dr. Virginia Byers Kraus told The New York Times. “You’re already on an escalator that’s leading you up the path to symptoms and X-ray changes way before we thought.”⁶ One day, a blood test may be used to diagnose osteoarthritis in its early stages, when treatment may be able to stop joint damage from occurring.

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Osteoarthritis Is Caused by More Than Wear and Tear

Osteoarthritis is often described as a “wear and tear” disease because it typically involves the breakdown of joint cartilage due to repetitive use and load over time. However, the understanding of osteoarthritis has evolved, and it is now recognized as a more complex condition influenced by a combination of factors beyond just mechanical wear and tear.

While excessive or abnormal forces on your joints can accelerate the breakdown of cartilage, biomechanical imbalances that place uneven stresses on your joints can also contribute. Further, although osteoarthritis is not a traditional inflammatory arthritis like rheumatoid arthritis, inflammation does play a role. Chemicals in the joint can cause inflammation and damage to the cartilage and surrounding structures. According to OAAA:⁷

“Osteoarthritis is not simply caused by ‘wear and tear’ of the joint but is rather a complex disorder characterized by molecular, anatomic and physiologic changes. As such a complex disease, there are a variety of risk factors — both modifiable and non-modifiable — that contribute to its onset and progression, some of which can be mediated with appropriate management strategies.”

There is growing evidence, for instance, linking metabolic syndrome — a cluster of conditions including high blood pressure, high blood sugar excess body fat around the waist and abnormal cholesterol levels — to an increased risk of osteoarthritis.⁸

Extra body weight also increases the stress on weight-bearing joints like the knees and hips, increasing osteoarthritis risk, but adipose (fat) tissue also produces inflammatory substances that may contribute to joint deterioration. In fact, the Osteoarthritis Research Society International (OARSI) defines osteoarthritis as:⁹

“A disorder involving movable joints characterized by cell stress and extracellular matrix degradation initiated by micro- and macro-injury that activates maladaptive repair responses including pro-inflammatory pathways of innate immunity.

The disease manifests first as a molecular derangement (abnormal joint tissue metabolism) followed by anatomic, and/or physiologic derangements (characterized by cartilage degradation, bone remodeling, osteophyte formation, joint inflammation and loss of normal joint function), that can culminate in illness.”

Age is also a primary risk factor, as the cumulative effects of use on your joints are often compounded by an age-related decrease in the body’s ability to heal and maintain tissue. Hormonal changes, particularly during menopause, also play a significant role in the development of osteoarthritis in women. Genetics may also predispose individuals to osteoarthritis, influencing the durability of cartilage and the body’s repair mechanisms.

Is Osteoarthritis a Systemic Disease?

Growing recognition among medical professionals suggests osteoarthritis should be considered a systemic disease, not just a localized joint condition. Writing in Aging Clinical and Experimental Research, one team of scientists proposed renaming the disease “systemic OA” to move away from the perception that it’s focused solely on joints. They explained:¹⁰

“Its pathogenic mechanisms involve a variety of systemic conditions that contribute to joint damage. These include metabolic dysfunction, chronic low-grade inflammation, neuroplastic pain, and the influence of the central nervous system in the development of neuropathic pain.

Besides, OA can negatively affect other aspects of health, such as quality of life, reduced physical activity, social isolation, depression, and anxiety. OA can be considered a complex system in which pathological interactions involve not only obesity and metabolic dysfunction, but also fragility syndrome, sarcopenia, neurological complications, and systemic energy redistribution.”

This has implications for the way osteoarthritis is treated as well, since conventional treatment typically relies on support care, such as medications, physical therapy and heating pads.¹¹ Instead, the researchers noted that medical care for OA should be “more holistic and personalized.”¹²

In addition to considering individual factors like genetics, lifestyle must be addressed, and resolving obesity should be a primary treatment, along with maintaining muscle health to support the joints.

Tips for Osteoarthritis Prevention

Maintaining a healthy weight is a key part of osteoarthritis prevention. Reducing body weight if you’re overweight can decrease the stress on weight-bearing joints like hips and knees and lower inflammation levels associated with obesity. Obesity is also a leading cause of knee replacements. One Australian study of 56,217 patients showed that, of the patients who received a knee replacement due to osteoarthritis, 31.9% were overweight and 57.7% were obese.¹³

Consuming too much linoleic acid (LA) in seed oils is a primary factor driving the overweight and obesity epidemics. At a molecular level, excess LA consumption also damages your metabolism and impedes your body’s ability to generate energy in your mitochondria.

Examples of seed oils high in LA include soybean, cottonseed, sunflower, rapeseed (canola), corn and safflower. To limit LA in your diet, you’ll need to avoid most processed foods.

Injury prevention is also important, as it’s estimated that up to 12% of OA cases result from injuries caused by automobile or military accidents, falls or sports.¹⁴ “Proper precautions such as stretching and strengthening exercises, appropriate footwear and other devices, along with supportive workplace or athletic team policies, can help reduce onset and progression of OA in occupational and sports settings,” OAAA notes.

Consuming specific anti-inflammatory and healing foods is another strategy to support overall health and osteoarthritis prevention. Cruciferous vegetables like broccoli, Brussels sprouts, cauliflower and cabbage, for instance, contain a compound called sulforaphane, which also helps reduce the risk of osteoarthritis,¹⁵ in part by blocking enzymes that are linked to joint destruction.

A team of researchers from the University of East Anglia published a study in the journal Arthritis and Rheumatism that showed substances in cruciferous vegetables could slow the progression of osteoarthritis, or possibly prevent it.¹⁶

Sulforaphane did this by inhibiting metalloproteinases that have been implicated in the development and progression of osteoarthritis. The researchers found it also blocked inflammation to protect against cartilage destruction both in the lab and animal models.

Other natural compounds, like turmeric, are useful for relieving osteoarthritis pain. A 2021 randomized trial compared turmeric against paracetamol, a painkiller also known as acetaminophen.

Bioavailable turmeric extract was as effective as paracetamol against osteoarthritis pain and symptoms in the knee and was safe and more effective in reducing tumor necrosis factor alpha (TNF alpha) and C-reactive protein (CRP).¹⁷ Acupuncture is another natural strategy that’s useful for pain relief and improving function in osteoarthritis.¹⁸

Bone Broth for Joint Health

Considering the underlying pathological processes leading to osteoarthritis start long before its symptoms, taking steps to support your joint health early on makes sense. One way to do this is by making homemade bone broth. Bone broth is made by simmering animal bones and connective tissue, which releases collagen and other nutrients into the broth.

Collagen is a major component of cartilage, the tissue that’s degraded in OA. While there are plenty of collagen supplements on the market, bone broth is by far the least expensive option. Collagen accounts for about 30% of the total protein in your body.

One of its primary functions is to provide structural support and strength to your tissues, such as skin, bones, tendons, ligaments and cartilage,^19,^20,²¹ allowing them to stretch while still maintaining tissue integrity. As such, collagen is crucial for repairing soft tissue, muscle and connective tissue, all of which tend to get weaker and less elastic with age.

Further, bone broth may help reduce joint pain and stiffness,²² including osteoarthritis pain.²³ It helps reduce joint pain and inflammation, in part, courtesy of chondroitin sulfates, glucosamine and other compounds extracted from the boiled down cartilage.

To make homemade bone broth, simply place bones in an Instant Pot, fill the pot with pure, filtered water — just enough to cover the bones — add salt and other spices to taste, then set it to cook on high for two hours if the bones are from a concentrated animal feeding operation (CAFO) or four hours if organic and grass fed.

Using bones from CAFO beef can be problematic due to potential heavy metal contamination. So, when cooking these bones in the Instant Pot, it’s best to limit the time to two hours to avoid introducing heavy metals into your broth.

If you’re using beef bones from grass fed organic sources, you can safely cook them for four hours. Using bones from an organic source is even more important if you’re using chicken, as CAFO chickens tend to produce stock that doesn’t gel,²⁴ which raises questions about the quality of the collagen you’re getting.

You can further customize your bone broth to align with specific health goals and nutritional needs. For instance, if you’re looking to support joint health, consider adding other ingredients that are rich in collagen such as chicken feet to maximize the health benefits.

– Sources and References

¹ Osteoarthritis Action Alliance, OA Prevalence and Burden
² The Lancet Rheumatology September 2023
³ WHO, Osteoarthritis July 14, 2023
^4, ^7, ⁹ Osteoarthritis Action Alliance, OA Pathogenesis and Risk Factors
⁵ Science Advances April 26, 2024, Volume 10, Issue 17
^6, ¹¹ The New York Times May 2, 2024 (Archived)
⁸ J Clin Endocrinol Metab. 2024 Mar 14:dgae169. doi: 10.1210/clinem/dgae169. Online ahead of print
^10, ¹² Aging Clin Exp Res. 2024; 36(1): 45
¹³ ANZ Journal of Surgery, 2022;92(7-8)
¹⁴ Osteoarthritis Action Alliance, OA Prevention
¹⁵ CNN Health August 29, 2013
¹⁶ Arthritis & Rheumatism 2013;65(12)
¹⁷ Trials, 2021;22(105)
¹⁸ Annals of Internal Medicine 2004 Dec 21;141(12):901-10
¹⁹ Bone 2010 Mar;46(3):827-3
²⁰ PLoS One 2014 Jun 13;9(6):e99920
²¹ J Agric Food Chem. 2010 Jan 27;58(2):835-41
²² Curr Med Res Opin. 2008 May;24(5):1485-96
²³ Curr Med Res Opin. 2006 November; 22(11):2221-32
²⁴ Weston A. Price January 1, 2000

Posted in Bones, Collagen, Joints, Linoleic Acid, Obesity, Osteoporosis | No Comments »

Posted by: admin | Posted on: December 20, 2023

Your Osteoporosis Risk Is Highly Modifiable

As of 2020, an estimated 12.3 million Americans over 50 were affected by osteoporosis (“porous bone” or low bone density), and an additional 47 million younger Americans were in the early stages.⁶ Worldwide, the prevalence is 18.3%, according to data cited by Greger.

If your bones are getting compromised in your 40s or even 30s, your life expectancy, not to mention quality of life, will be seriously lowered. As noted by Greger, the good news is, osteoporosis is not an inevitable outcome even in advanced age, as lifestyle has been shown to play the greatest role in its development.

Rates of hip fractures vary from tenfold to a hundredfold between countries,⁷ showing that low bone density is not a consequence of aging per se, but is dependent on things like diet, exercise, alcohol use — and the use of certain drugs, including:⁸

PPIs and H2 blockers
Antidepressants, anti-anxiety and antipsychotic drugs
Antiparkinsonian drugs
Benzodiazepines and other sedatives
Systemic corticosteroids

PPIs Linked to Bone Fractures

The link between PPIs and brittle bone is strong enough that the U.S. Food and Drug Administration issued a safety alert on it in 2010, warning that the use of these drugs increases the risk of wrist, hip and spine fractures. As noted in that safety announcement:⁹

“The new safety information is based on FDA’s review of several epidemiological studies that reported an increased risk of fractures of the hip, wrist, and spine with proton pump inhibitor use.

Some studies found that those at greatest risk for these fractures received high doses of proton pump inhibitors or used them for one year or more. The majority of the studies evaluated individuals 50 years of age or older and the increased risk of fracture primarily was observed in this age group.

While the greatest increased risk for fractures in these studies involved people who had been taking prescription proton pump inhibitors for at least one year or who had been taking high doses of the prescription medications (not available over-the-counter), as a precaution, the ‘Drug Facts’ label on the OTC proton pump inhibitors (indicated for 14 days of continuous use) also is being revised to include information about this risk.

Healthcare professionals and users of proton pump inhibitors should be aware of the possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors, and weigh the known benefits against the potential risks when deciding to use them.”

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FDA Safety Alert Is Out of Date

However, in March 2011, the FDA removed the warning for PPIs sold over the counter, claiming they had “concluded that fracture risk with short-term low dose PPI use is unlikely.” The caveat, of course, is that users of OTC PPIs must then strictly follow usage recommendations to avoid the risk of bone fractures.

OTC PPIs are not to be used for more than 14 days in a row, up to three times in a single year. Chances are, many users do not stick to these parameters, and since there’s no warning label, they might not think anything of it.

According to one survey, 60% of PPI users stayed on the drug for more than one year, and 31% were still on them after three years. More than 60% were also taking them to treat conditions for which these drugs are not indicated, such as indigestion.¹⁰ So, overuse is clearly a problem.

What’s more, as noted by Greger, as of 2023 there are dozens of studies showing rates of hip fractures are elevated among both long- and short-term users, and at all dose levels. So, the FDA’s safety alert is seriously outdated.

PPIs and the Risk of Bone Fractures

Studies showing a clear link between PPI usage and bone fractures include a prospective study¹¹ published in 2009, which found that use of the PPI omeprazole was “a significant and independent predictor of vertebral fractures,” with a 3.50 relative risk compared to nonusers.

Relative risk ratio refers to the probability of an event occurring in the exposed group versus the probability of the same event occurring in a nonexposed group.¹² So, in this case, PPI users were 3.5 times, or 350%, more likely to fracture their spines during the six-year follow-up compared to those who did not use the drug.

A meta-analysis¹³ published in 2016, which looked at 18 studies involving a total of 244,109 fracture cases, concluded PPI use was associated with a “modestly” increased risk of all fractures, including hip and spine fractures.

Here, pooled analysis showed PPI use raised the relative risk of hip fracture by 1.26 times, and this was true both for short-term (less than one year) and long-term (more than one year) use. The relative risk of spine fracture was also 1.58 times higher, and any-site fractures 1.33 times higher among PPI users.

How PPIs Cause Osteoporosis

As for how PPIs cause osteoporosis, studies suggest they can affect bone density by:

Inducing hypochlorhydria (a state where production of hydrochloric acid production is absent or very low), which inhibits calcium absorption¹⁴

Dysregulating bone resorption, which is essential for healthy bone¹⁵

Secondary hyperparathyroidism caused by a negative calcium balance¹⁶

PPI-induced hypergastrinemia resulting in parathyroid hypertrophy or hyperplasia¹⁷

Gut microbiome alterations¹⁸

Hypomagnesemia (low magnesium)¹⁹

Interestingly, more recent research suggests one of the primary ways by which PPIs damage bone may actually be by way of collagen, as these drugs have been shown to:²⁰

Inhibit Type 1 collagen found in bone by increasing the release of calcium and deoxypyridinoline (the latter of which provides structural stiffness to Type 1 collagen)
Inhibit the gene expression of several collagen types
Reduce total collagen levels by inhibiting expression of dimethylarginine dimethylaminohydrolase (DDAH)
Impair vitamin B12 absorption, which can lead to elevated homocysteine. High homocysteine increases the risk of fractures by altering the quality of collagen²¹

As noted in a 2020 paper in the Frontiers in Endocrinology:²²

“PPIs may actually target the ECM [extracellular matrix] in general and members of the collagen family in particular to influence bone pathophysiology including increasing the risk of osteoporosis and osteoporotic fractures …”

Other Risks Associated With PPIs

Dependency is also a real risk. Research cited by Greger found that just two months of PPI therapy in healthy volunteers induced “acid-related symptoms” when the drug was withdrawn.²³ Besides bone fractures, other health risks associated with PPIs include:²⁴

Kidney disease²⁵

Intestinal infections, including Clostridioides difficile infection — In one study, those taking PPIs had a 1.7 to 3.7 times increased risk of developing C. difficile or Campylobacter infection compared to nonusers²⁶

Stomach cancer

Gastrointestinal polyps

Pneumonia

Heart disease²⁷ and heart attacks, even if you have no prior history of cardiovascular disease²⁸

Erectile dysfunction

Premature death

Higher risk of knee replacement²⁹

Dementia³⁰ and Alzheimer’s disease^31,³² — In one study, PPIs were found to cause statistically and clinically significant impairments in the participants’ executive functions, visual memory and planning function after just one week of use³³

Natural Remedies for Treating Occasional Reflux Problems

As explained in “Keys to Optimal Digestion” and “Why You Should Never Take Antacids for Digestive Reflux,” stomach acid serves several important functions, such as breaking down proteins, killing ingested pathogens, ensuring optimal nutrient absorption, and regulating the rest of the digestion process.

If you use acid-blockers, you’re compromising your entire digestive system. You may also be compromising your bone health and significantly raising your risk of osteoporosis and serious bone fractures that take a long time to heal.

So, if you suffer from occasional heartburn, indigestion and other minor reflux symptoms, forgo the PPIs and try one or more of the following nondrug alternatives instead:^34,^35,^36,^37,³⁸

Aloe juice — The juice of the aloe plant naturally helps reduce inflammation, which may ease symptoms of acid reflux. Drink about one-half cup of aloe juice before meals. To avoid its laxative effect, look for a brand in which the laxative component has been removed.

Apple cider vinegar (raw, unfiltered) — Take 1 tablespoon of raw unfiltered apple cider vinegar in a large glass of water before or directly after meals.

Astaxanthin — When compared to a placebo, this potent antioxidant was found to reduce symptoms of acid reflux, especially for individuals with pronounced H. pylori infection.³⁹ The researchers concluded a daily dose of 40 mg of astaxanthin was effective for reflux reduction.

Baking soda — One-half to 1 teaspoon of baking soda (sodium bicarbonate) in an 8-ounce glass of water, or orange juice, will help neutralize your stomach acid and ease the burn of acid reflux. While I do not advise this as an ongoing remedy, it is effective on an “emergency” basis when you are in excruciating pain.

Ginger root — Ginger has a gastroprotective effect by suppressing H. pylori. It also accelerates gastric emptying which, when impaired, contributes to heartburn. Add two or three slices of fresh ginger root to 2 cups of hot water and let it steep for several minutes. Drink it about 20 minutes prior to your meal.

Sauerkraut — Consuming sauerkraut or cabbage juice will stimulate your body to produce stomach acid.

Glutamine — The amino acid glutamine has been shown to address gastrointestinal damage caused by H. pylori. Glutamine is found in many foods, including beef, chicken, dairy products, eggs, fish and selected fruits and vegetables. L-glutamine is widely available as a supplement.

Ripe papaya or a papain supplement — Papaya contains papain, an enzyme useful for breaking down both protein and carbohydrates.

Fresh pineapple or bromelain supplement — Bromelain is a proteolytic enzyme found in pineapple that helps digest proteins.

Pepsin supplement — Like bromelain, pepsin is a proteolytic enzyme involved in protein digestion.⁴⁰

Betaine HCI supplement — Betaine HCl is the hydrochloride salt of betaine, not to be confused with betaine or trimethylglycine (TMG). As noted in a 2020 review paper:⁴¹ “… the most common recommendation for the use of betaine HCl supplements is usually implemented using an empirical test for low stomach acid whereby increasing doses of betaine HCl are given during sequential meals until such time as an uncomfortable sensation is noticed by the patient.

Along with improvements in symptoms of dyspepsia (or laboratory analysis of improved protein digestion), the lack of side effects acts is an empirical confirmation that low gastric acid production was contributing to poor digestion and/or dyspeptic symptoms.”

Bitters — Bitters have a long history of use in herbal medicinal traditions to promote digestion and/or to relieve digestive complaints.⁴²

Slippery elm — Slippery elm coats and soothes your mouth, throat, stomach and intestines, and contains antioxidants that may help address inflammatory bowel conditions. Because it stimulates nerve endings in your gastrointestinal tract, it is useful for increasing mucus secretion, which has a protective effect against ulcers and excess acidity.

Vitamin D — Vitamin D is important for your gut health. Once your vitamin D levels are optimized, you will benefit from your body’s production of about 200 antimicrobial peptides that will help eradicate gut infections.

Zinc — Your stomach needs zinc to produce stomach acid, so make sure your body has the necessary raw ingredients. The recommended daily amount for adults is 8 to 11 mg. Zinc-rich foods include oysters, lobster, beef, cashew nuts, beans and raw yogurt. A zinc supplement can be used if you rarely eat these foods.⁴³

Talk to Your Doctor About Getting Off PPIs

If you’re currently on a PPI, I strongly recommend working with your doctor to wean off it, as inhibiting stomach acid can raise your risk of other, far more serious health conditions, including:⁴⁴

Osteoporosis	Asthma
Depression	Gallbladder disease
Migraines	Macular degeneration
Autoimmune conditions, including but not limited to Celiac disease, Type 1 juvenile diabetes, Grave’s disease (hyperthyroid), lupus, multiple sclerosis (MS), rheumatoid arthritis and ulcerative colitis

The best and safest way to do that is to work with your doctor to lower the dose you’re taking while simultaneously implementing the following lifestyle modifications:

Avoid reflux triggers and/or any food that irritates your stomach
Avoid processed foods and sugar
Eat a Mediterranean diet, focused on fruits, healthy fats, lean meats, nuts and vegetables. Research published in the Journal of the American Medical Association Otolaryngology — Head & Neck Surgery found a Mediterranean diet was as effective as PPIs in treating acid reflux symptoms⁴⁵
Reseed your gut with beneficial bacteria from traditionally fermented foods or a high-quality probiotic supplement
Thoroughly chew each bite of food

Once you get down to the lowest dose of the PPI, you can start substituting with an over-the-counter H2 blocker like Pepcid (famotidine) which appears to be the safest of all the OTC H2 blocker options out there. Then, gradually wean off the H2 blocker over the next several weeks.

– Sources and References

Posted in Alzheimer's, Auto-Immune, Bones, Cancer, Cardiovascular, Celiac, Depression, Diabetes, Erectile Dysfunction, Eyes, FDA, Gut, Heart, Kidney, Macular, Migraine, Osteoporosis, PPI, Probiotics, Processed Food | One Comment »

Posted by: admin | Posted on: July 24, 2019

Selenium in your cancer prevention program

by: Lori Alton, staff writer | July 20, 2019

Original article: www.naturalhealth365.com/selenium-bladder-3052.html

(NaturalHealth365) What does selenium have to do with your health? The answer may surprise you (and motivate you – in a whole new way!)

Let’s start with a discussion about cancer – the second leading cause of death in the United States, right behind heart disease. Experts predict that cancer will soon surpass heart disease as the leading killer of American adults.

No doubt, we can all agree: the need for a safe (non-toxic) methods of preventing and treating this deadly disease is truly urgent. This brings us to why we – at NaturalHealth365 – are pleased to feature studies like this one – from Nutrition and Cancer highlighting the importance of consuming enough selenium – on a regular basis. (Note: PubMed has over 1,500 studies on “selenium and cancer prevention.”)

An essential trace element found in various foods, soil and water, selenium helps to prevent cancer by enhancing our immune system, increasing protection against stress and disease plus suppressing the growth of cancerous cells.

Selenium enhances the power of a “master antioxidant” to help detoxify the body

One of selenium’s most vital functions is to help create antioxidant enzymes, or selenoproteins, that recycle glutathione, the body’s “master antioxidant” and detoxifier. In this way, selenium strikes a blow against the disease-causing oxidative stress – which contributes to chronic degenerative disease.

But selenium also has many more “tricks up its sleeve” when it comes to fighting cancer.

Do NOT ignore the health dangers linked to toxic indoor air. These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Unlike therapies that address only one specific stage or type of cancer, selenium is pleiotropic. This means that it combats cancer through multiple pathways and mechanisms, allowing it to target the disease in various forms and stages.

So important is selenium that low levels are linked with an eight-fold increased risk of cancers of the bladder, lungs, stomach, esophagus and liver.

And, supplementation has been shown to lower cancer risk, particularly cancers of the bladder, lung and colon.

Selenium’s extensive therapeutic “toolkit” allows it to prevent cancerous cells from developing into tumors

In addition to preserving the selenoproteins that recycle antioxidants, selenium regulates inflammatory molecules that contribute to cancer growth.

This versatile nutrient also helps to boost the immune system, detoxify carcinogens and heavy metals, protect DNA from cancer-causing mutations and inactivate molecules crucial to the development of cancer cells.

In addition, selenium induces apoptosis – the programmed death of cancer cells – meaning it may help check the uncontrolled reproduction that can help cancer spread so swiftly.

Finally, selenium regulates sex hormone receptors used by some cancers, thereby helping to suppress tumor invasion and growth. Peer-reviewed research has documented reductions in cancer risk through selenium supplementation.

One recent meta-analysis involving nine randomized controlled clinical trials and over 152,000 participants showed that selenium supplementation can cut cancer risk by 26 percent.

Participants who had low levels of selenium at the beginning of the study experienced an even larger (36 percent) reduction in risk – and those in high-risk populations experienced a sizeable 34 percent decrease as well.

Great NEWS: Three different forms of selenium join forces to fight cancer “across the board”

Selenium exists in three distinct forms, each with its own unique capabilities against cancer. While their names can be tongue-twisters, it’s worth noting their individual benefits.

Inorganic sodium selenite destroys the mitochondria that exist in tumor cells – while leaving the mitochondria of healthy cells unharmed. It also helps repair damaged DNA while boosting the immune response.

While it is not absorbed as well as organic forms of selenium, sodium selenite seems to do the best job of boosting crucial glutathione activity.

The second form, selenium-methyl L-selenocysteine, is an organic complex of selenium that contains the sulfur-containing amino acid cysteine.

This form suppresses tumor growth by inhibiting angiogenesis – the creation of new blood vessels that carry nutrients to tumors. It also induces the destruction of cancer cells, and has been shown to boost the effectiveness of chemotherapy drugs.

The third form, L-selenomethionine, is an organic compound of selenium that contains the amino acid L-methionine. This is the form most frequently used in clinical trials – and it has yielded extremely promising results.

In a landmark 1996 University of Arizona study, participants were given 200 mcg of L-selenomethionine a day in order to discern whether the complex could prevent skin cancer. The study did not yield any evidence at all that L-selenomethione could prevent basal or squamous cell skin cancer, per se.

But what it did do – slash the incidence of death from all cancers, by 50 percent – caused researchers to do a double take.

The results were so impressive that the team did something that is almost unprecedented in medical research: stopped the “blinded” phase of the study cold – so that all participants could immediately begin to take advantage of maximum protection against cancer.

And that’s not all.

A separate study showed that L-selenomethionine could reduce risk of prostate cancer by 63 percent – when a prior history of cancer existed – and by a whopping 74 percent in those with normal levels of PSA (prostate-specific androgen, which researchers use as a marker of prostate cancer).

How to decrease your risk of bladder cancer by nearly 40 percent

Over 70,000 Americans will be diagnosed with bladder cancer over this year alone – and 14,000 will lose their lives to the disease.

A recent review shows that selenium can substantially decrease the risk of the disease.

In a meta-analysis involving over 17,000 participants and published in Cancer Epidemiology and Prevention Biomarkers, the authors noted that selenium supplementation was associated with a 39 percent decrease in the risk of bladder cancer – when averaged out over both sexes.

When the researchers looked at the effects of selenium supplementation on women alone, they found that it reduced bladder cancer risk by a robust 45 percent. The team called for more study to further explore the benefits of selenium supplementation.

Proper nutrition can help raise selenium levels

The USDA advises that the adult daily allowance for selenium is 55 mcg a day.

You can increase your selenium levels by eating organic cage-free eggs, wild-caught salmon, halibut, poultry and grass-fed beef.

Vegans and vegetarians can obtain selenium through sunflower seeds and Brazil nuts. In fact, with a whopping 607 micrograms of selenium per cup, Brazil nuts are the single best source of this essential mineral.

If you think selenium supplementation might be right for you, check with your integrative healthcare provider before adding it to your health routine – to best advise you on the proper forms and dosages to take.

Sources for this article include:

LifeExtension.com
NaturalHealthResearch.org
NIH.gov
CDC.gov

Posted in Age, Anxiety, Blood Thinners, Cancer, COPD, Eggs, Faint, Fermentation, Fertility, Glutathione, Hair, Methylation, Nails, Osteoporosis, Oxygen, Pneumonia, Polyphenols, Skin, Spice, Supplements, Thymus | No Comments »

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by: Lori Alton, staff writer | July 20, 2019

Selenium enhances the power of a “master antioxidant” to help detoxify the body

Selenium’s extensive therapeutic “toolkit” allows it to prevent cancerous cells from developing into tumors

Great NEWS: Three different forms of selenium join forces to fight cancer “across the board”

How to decrease your risk of bladder cancer by nearly 40 percent

Proper nutrition can help raise selenium levels