Supplements

now browsing by category

Posted by: admin | Posted on: October 2, 2024

Polycystic Ovarian Syndrome — A Health Issue Affecting Women Worldwide

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/09/24/polycystic-ovarian-syndrome.aspx

Analysis by Dr. Joseph Mercola September 24, 2024

STORY AT-A-GLANCE

Polycystic ovarian syndrome (PCOS) affects 5 to 6 million women in the U.S. and 8% to 13% of women worldwide. It’s characterized by elevated testosterone, ovulation problems and large ovaries with small follicles, impacting fertility and mental health
Women with PCOS are at higher risk for depression, anxiety, eating disorders and suicide attempts. PCOS also affects self-esteem, gender identity, relationships and sexuality
PCOS has no specific cause or cure, but risk factors include family history, diabetes, and insulin resistance. Symptoms are manageable and pregnancy still occurs with proper treatment
Inositol and carnitine supplements show promise in managing PCOS symptoms, improving menstrual regularity, fertility and other metabolic markers. Other helpful supplements include CoQ10, turmeric, licorice and vitamin K2
Environmental factors like exposure to “forever chemicals” (PFAS) and microplastics increase PCOS risk and disrupt hormones. Reducing exposure and considering progesterone therapy may help balance hormones

According to the Endocrine Society, an estimated 5 to 6 million women in America are affected with polycystic ovary syndrome (PCOS), a condition marked by elevated testosterone, ovulation problems and large ovaries with small follicles.¹ Around the world, 8% to 13% of women have PCOS, and many more remain undiagnosed.²

I believe PCOS is an issue that warrants discussion, as research indicates it’s a leading cause of infertility worldwide.³ Sharing stories of women going through it will help others become aware of symptoms they have, allowing them to get appropriate help. It just so happens that September is also PCOS Awareness Month, so this is an opportune moment for everyone to learn.

The Impact of PCOS on Women’s Mental Health

Aside from the ovulation problems that PCOS brings, it largely affects mental health. Writing for The Guardian, freelance journalist Ali Francis, shares how PCOS is linked to a rise in various mental health issues:⁴

“Though estimates vary, between 8% and 13% of reproductive-age women have PCOS, and many experience adverse mental health outcomes. Recent studies have revealed that people with PCOS are four to seven times more likely to have depression and anxiety, three to six times more likely to have an eating disorder, and 8.47 times more likely to attempt suicide.

In a survey conducted by the nonprofit PCOS Challenge: The National Polycystic Ovary Syndrome Association, 62.15% of the 900 respondents reported high to severe mental health impacts caused by the condition.”

Francis also noted that PCOS affects other aspects of your mental well-being. These include “self-esteem, gender identity, relationships and sexuality.” Visiting a doctor can be mentally jarring, too. Conflicting medical advice, delayed diagnoses and unsuccessful treatments contribute to the mental health burden experienced by women with PCOS.⁵

Francis experienced the very same struggle herself. To understand what was going through her mind, she consulted a psychiatrist. During her consultation, she explained that she had mood swings that “seemed to occur at the same time every month.”⁶

However, the psychiatrist dismissed her claims, suggesting that she could have bipolar disorder. While the consultation didn’t arrive at a final diagnosis, Francis was already offered a prescription to take medication for bipolar disorder. Thankfully, she didn’t take it, determined to look for other solutions.⁷

While there are studies^8,⁹ indicating a link between PCOS and bipolar disorder due to overlapping symptoms, Francis didn’t experience excessive energy and other sudden behavioral changes — hallmark symptoms of bipolar disorder. The fact that the symptoms happen at regular intervals reinforced her intuition. “This suggests a sensitivity to hormonal fluctuations during the menstrual cycle,” says Phoutdavone Phimphasone-Brady, Ph.D., a PCOS specialist.¹⁰

What Causes PCOS?

It’s important to understand that PCOS is not a disease. In an interview for The Independent,¹¹ hormone specialist Hannah Alderson says that it is a collection of symptoms that vary from one woman to another. She also adds that it’s marked by an overproduction of testosterone, cortisol and insulin. Contributing to the problem further is that there’s no accurate way to diagnose PCOS with a single test. Instead, women need to meet two of three criteria:¹²

• Elevated androgens — Diagnosed via blood tests as well as visual examination, including excess facial hair and acne. One example of an androgen doctors look for is testosterone

• Ovulatory dysfunction — Common markers include irregular or absent periods

• Presence of polycystic ovaries — Viewed during an ultrasound session

One reason why PCOS is difficult to diagnose is because the cause is unknown. However, factors such as prior family history of PCOS, diabetes and insulin resistance increase accuracy of the diagnosis. Chronic inflammation has been associated with PCOS, too.¹³

Is there a cure for PCOS, at the very least? Unfortunately, there is no known treatment,¹⁴ and it is a lifelong disorder.¹⁵ However, that doesn’t mean all hope is lost. In fact, the symptoms of PCOS are manageable through natural strategies. Alderson even noted that women can still become pregnant:¹⁶

“PCOS can impact fertility because if you’re not ovulating, you won’t naturally fall pregnant, making PCOS a leading cause of infertility,” explains Alderson. “However, it is not a definitive sentence of infertility. By addressing the root causes of PCOS, a woman’s chances of falling pregnant can be positively impacted.”

Save This Article for Later – Get the PDF Now

Download PDF

Inositol Is Effective for PCOS

In a 2023 study published in the journal Reproductive Biology and Endocrinology,¹⁷ researchers from Budapest, Hungary demonstrated that inositol is effective for managing PCOS. For context, inositol (typically called vitamin B8) is a sugar synthesized by the human body that belongs to the vitamin B complex group.

It’s considered an insulin sensitizer since it modulates the insulin signaling pathway, and the researchers hypothesize it to be a better alternative to metformin, a drug that causes digestive distress.¹⁸

The team conducted a meta-analysis of previously published literature to assess the safety and effectiveness of inositol. From their initial search, they identified 26 high-quality trials with a total of 1,691 participants. The primary measurement of success was the normalization of the menstrual cycle. Other outcomes considered to be a success were clinical and laboratory hyperandrogenism, body mass index and carbohydrate metabolism.

Based on the team’s analysis, inositol produced a regular menstrual cycle in women with PCOS 1.79 times higher than placebos and showed noninferiority compared to metformin. Inositol also induced greater decreases across various biomarkers, including free and total testosterone, glucose levels — important aspects implicated in PCOS.¹⁹

Inositol also produced fewer side effects reported with inositol than with metformin. Meanwhile, side effects in those who took metformin include bloating, generalized weakness and nausea.²⁰ The researchers concluded by saying, “Inositol is an effective and safe treatment in PCOS. Moreover, inositol showed noninferiority in most outcomes compared to the gold standard treatment, metformin.”²¹

Consider Taking a Carnitine Supplement

Carnitine is a popular supplement used in exercise to support energy production and muscle repair,²² but research shows that it has other uses as well. In the context of PCOS, carnitine supplementation helps improve fertility.

In a systematic review and meta-analysis published in 2023,²³ a total of 839 women diagnosed with PCOS were given a dosage ranging anywhere from 250 milligrams to 3,000 milligrams daily for 84 to 90 days, respectively. After calculating the results, those who took carnitine supplements had 3.42 times better ovulation rates and 11.05 times better pregnancy rates compared to placebo groups.

Interestingly, carnitine also helps facilitate weight loss, which is a boon for women struggling to maintain a healthy weight due to PCOS. In a systematic review and meta-analysis of 37 trials published in Clinical Nutrition ESPEN,²⁴ L-carnitine (a type of carnitine) supplementation significantly decreased body weight, body mass index and fat mass in overweight and/or obese adults:

“A nonlinear dose-response association was seen between L-carnitine supplementation and body weight reduction … suggesting that ingestion of 2000 mg L-carnitine per day provides the maximum effect in adults,” the team, from Shahid Sadoughi University of Medical Sciences in Iran, noted.

Other Supplements to Help Manage PCOS Better

In addition to taking a carnitine supplement, there are other alternatives available. Here are some recommendations, based on published research:

• CoQ10 — A 2023 meta-analysis²⁵ found that CoQ10 supplementation improved insulin resistance and blood lipid levels, as well as increased sex hormone levels (while reducing testosterone) in 1,021 participants across nine randomized controlled trials.

• Turmeric — Research²⁶ has shown this culinary spice has therapeutic applications thanks to its curcuminoids. In particular, they “are useful in managing PCOS and preventing ovarian cell dysfunction, thereby improving ovulation and fertility.”

• Licorice — In the same study,²⁷ licorice was noted to have potent anti-androgen properties and helps maintain healthy estrogen levels. Furthermore, the flavonoids in licorice help secrete insulin better, which contributes to better management of insulin-related PCOS symptoms.

• Vitamin K2 — Depression is another notable symptom of women experiencing PCOS, and one study²⁸ noted that increasing vitamin K2 helps relieve this condition.

Reduce Your Exposure to ‘Forever Chemicals’

The very environment you live in and the things you touch influence your risk of developing PCOS. According to one study²⁹ conducted by Mount Sinai Health System researchers, exposure to PFAS (per- and polyfluoroalkyl substances), also known as “forever chemicals,” reduces a woman’s fertility by 40% and increases the risk of PCOS. In a news release, senior study author Dr. Damaskini Valvi explains:³⁰

“PFAS can disrupt our reproductive hormones and have been linked with delayed puberty onset and increased risks for endometriosis and polycystic ovary syndrome in few previous studies. What our study adds is that PFAS may also decrease fertility in women who are generally healthy and are naturally trying to conceive.”

Valvi’s findings are supported by other research. In a study³¹ published in Singapore, researchers gathered plasma from 382 women of childbearing age hoping to conceive. Using various analytical models, they noted that “higher exposure to PFAS, individually and as a mixture, is associated with reduced probability for clinical pregnancy and live birth.”³²

The researchers also noted that forever chemicals not only disrupt reproductive hormones, but also increase the risk of endometriosis and polycystic ovary syndrome (PCOS).³³ Thus, reducing your exposure to forever chemicals is paramount. To start, I recommend avoiding the products listed below:

Pretreated or stain-repellent treatments — Do your due diligence to find out if these chemicals are on your clothing, furniture and carpeting, as well as any you’re about to buy. Clothing advertised as “breathable” is typically treated with polytetrafluoroethylene, a synthetic fluoropolymer commonly known as Teflon.

Products treated with flame-retardant chemicals — This includes furniture, carpet, mattresses and baby items. Instead, choose naturally less flammable materials such as leather, wool and cotton.

Fast food and carry-out foods — The containers are typically treated with PFAS.

Microwave popcorn — PFAS may be present in the inner coating of the bag and may migrate to the oil from the packaging during heating. If you still want to eat popcorn, use “old-fashioned” stovetop non-GMO popcorn cooked in healthy cooking oil.

Nonstick cookware and other treated kitchen utensils — Healthier options include ceramic and enameled cast iron cookware, both of which are durable, easy to clean and completely inert, which means they won’t release any harmful chemicals into your home.

Personal care products containing PTFE, “fluoro” or “perfluoro” ingredients such as Oral B Glide floss — The Environmental Working Group Skin Deep database is an excellent source to search for healthier personal care options.³⁴

Plastics Cause Hormonal Imbalances

As noted earlier, PCOS causes androgens such as testosterone to rise, causing hormonal imbalance. However, that’s just one example. According to Nicole Galan, a registered nurse who has worked with many patients with PCOS, high levels of estrogen are also a factor.³⁵ And what is a major contributor for elevated estrogen levels? Microplastics.

As noted in my article “Microscopic Menage — Scientists Discover Plastic Nanoparticles in Men’s Testicles,” plastics are xenoestrogens that mimic the effects of estrogen in the body, and the danger occurs due to them stimulating your estrogen receptors. Phthalates, for instance, have estrogenic properties, and some endocrine-disrupting chemicals are also considered estrogenic carcinogens.

To help restore hormonal balance, consider taking progesterone. As noted in a 2020 study,³⁶ “cyclic progesterone for PCOS lowers androgens and restores estradiol-progesterone balance.” In another study,³⁷ progesterone helped a woman develop regular menstrual cycles, cervical mucus and breast tenderness. While these findings shine a ray of hope for PCOS, progesterone must be taken properly. Below, I’ll discuss how to take it properly for maximum effect.

How to Use Progesterone

Before you consider using progesterone, it is important to understand that it is not a magic bullet, and that you get the most benefit by implementing a Bioenergetic diet approach that allows you to effectively burn glucose as your primary fuel without backing up electrons in your mitochondria that reduces your energy production. My new book, “Your Guide to Cellular Health: Unlocking the Science of Longevity and Joy” comes out very soon and covers this process in great detail.

Once you have dialed in your diet, an effective strategy that can help counteract estrogen excess is to take transmucosal progesterone (i.e., applied to your gums, not oral or transdermal), which is a natural estrogen antagonist. Progesterone is one of only four hormones I believe many adults can benefit from. (The other three are thyroid hormone T3, DHEA and pregnenolone.)

I do not recommend transdermal progesterone, as your skin expresses high levels of 5-alpha reductase enzyme, which causes a significant portion of the progesterone you’re taking to be irreversibly converted primarily into allopregnanolone and cannot be converted back into progesterone.

Ideal Way to Administer Progesterone

Please note that when progesterone is used transmucosally on your gums as I advise, the FDA believes that somehow converts it into a drug and prohibits any company from advising that on its label. This is why companies like Health Natura promotes their progesterone products as “topical.”

However, please understand that it is perfectly legal for any physician to recommend an off-label indication for a drug to their patient. In this case, progesterone is a natural hormone and not a drug and is very safe even in high doses. This is unlike synthetic progesterone called progestins that are used by drug companies, but frequently, and incorrectly, referred.

Dr. Ray Peat has done the seminal work in progesterone and probably was the world’s greatest expert on progesterone. He wrote his Ph.D. on estrogen in 1982 and spent most of his professional career documenting the need to counteract the dangers of excess estrogen with low LA diets and transmucosal progesterone supplementation.

He determined that most solvents do not dissolve progesterone well and discovered that vitamin E is the best solvent to optimally provide progesterone in your tissue. Vitamin E also protects you against damage from LA. You just need to be very careful about which vitamin E you use as most supplemental vitamin E on the market is worse than worthless and will cause you harm not benefit.

There are also other vitamin E isomers, and you want the complete spectrum of tocopherols and tocotrienols, specifically the beta, gamma, and delta types, in the effective D isomer. As an example of an ideal vitamin E, you can look at the label on our vitamin E in our store. You can use any brand that has a similar label.

You can purchase pharmaceutical grade bioidentical progesterone as Progesterone Powder, Bioidentical Micronized Powder, 10 grams for about $40 on many online stores like Amazon. That is nearly a year’s supply, depending on the dose you choose.

However, you will need to purchase some small stainless steel measuring spoons as you will need a 1/64 tsp, which is 25 mg and a 1/32 tsp, which is 50 mg. A normal dose is typically 25-50 mg and is taken 30 minutes before bed, as it has an anti-cortisol function and will increase GABA levels for a good night’s sleep.

Unfortunately, this vendor frequently runs out of product, and if that’s the case, then you can use Simply Progesterone by Health Natura. It’s premixed with vitamin E and MCT oil. Again, while Health Natura states that its product is for “topical use only,” I recommend applying it transmucosally, by rubbing it on your gums.

If you are a menstruating woman, you should take the progesterone during the luteal phase or the last half of your cycle, which can be determined by starting 10 days after the first day of your period and stopping the progesterone when your period starts.

If you are a male or non-menstruating woman, you can take the progesterone every day for four to six months and then cycle off for one week. The best time of day to take progesterone is 30 minutes before bed as it has an anti-cortisol function and will increase GABA levels for a good night’s sleep.

This is what I have been personally doing for over a year with very good results. I am a physician so do not have any problems doing this. If you aren’t a physician, you should consult one before using this therapy, as transmucosal progesterone therapy requires a doctor’s prescription.

– Sources and References

Posted in Linoleic Acid, PCOS, Supplements, Vitamins, Women | No Comments »

Posted by: admin | Posted on: October 2, 2024

Natural strategies to prevent NAFLD and support liver health

Reproduced from original article:
https://www.naturalhealth365.com/natural-strategies-to-prevent-nafld-and-support-liver-health.html

by: Lori Alton, staff writer | September 23, 2024

(NaturalHealth365) With rates of obesity and type 2 diabetes continuing to soar, liver disease has been largely ignored by the mainstream media.

And the problem is widespread. In fact, experts say that nonalcoholic fatty liver disease (NAFLD) currently affects around 30 percent of the global population. It’s shocking, to say the least.

Unfortunately, because symptoms of liver disease – in the early stages – can be so mild or unnoticeable, many people don’t even realize they have it. But this ‘silent’ disease can have deadly consequences.

Keep in mind, about 25 percent of the time, NAFLD progresses to a more serious condition known as nonalcoholic steatohepatitis, or NASH – which can cause liver scarring, liver failure, and even liver cancer.

How to prevent HUGE health problems: Avoid liver disease naturally

As you continue to read here, we’ll reveal how proper nutrition can help you to avoid liver disease. But first, we must understand the scope of the issue.

The liver neutralizes and eliminates toxins and waste products – such as ammonia – that would otherwise accumulate in the blood. In addition, it produces the bile needed to digest fat, stores essential vitamins and minerals, and breaks down and detoxifies alcohol, medications, and environmental toxins.

However, liver function can be compromised by NAFLD, which is defined as a condition in which fat constitutes more than 5 percent of the liver. As the name suggests, NAFLD can occur in people who consume few or no alcoholic beverages.

Excessive consumption of processed sugars and conventionally raised fatty foods will increase your risk of liver disease – along with being overweight and living a sedentary lifestyle.

In addition, the use of prescription and over-the-counter medications can contribute to NAFLD.

Warning: NAFLD can progress to steatohepatitis

NAFLD can be considered a warning light on a car’s dashboard – or, even more accurately – a yellow traffic light that signals the need for caution. If not arrested, NAFLD can progress to nonalcoholic steatohepatitis, or NASH – defined as fat comprising 10 percent of the liver.

Symptoms of NASH can include fatigue, dark urine, weight loss, lack of appetite, jaundice (yellowing of skin or eyes), and pain in the center or right upper part of the belly.

Although NAFLD is becoming increasingly common, the good news is that liver cells have an amazing ability to regenerate. NAFLD can be prevented, treated – and even reversed – with simple lifestyle changes and nutritional protocols.

Let’s take a closer look at some of the most effective supplements and nutrients to support liver health. As always, check first with your holistic doctor before trying them.

Silymarin in milk thistle helps restore liver cells

When it comes to herbal interventions for liver disease, milk thistle just might be the all-time MVP.

Its active principle, silymarin, has been shown to detoxify the liver, reduce oxidative damage caused by free radicals, decrease liver inflammation, regulate the metabolism of fats, and help clear the blood of toxins.

Silymarin has even been shown to be effective in reducing the growth of liver cancer cells and has helped prolong survival rates in clinical studies of patients with liver cancer.

In addition, silymarin improves insulin resistance – thereby combating diabetes, another threat to liver health. Because it can rebuild liver cells, silymarin can reverse the damage from alcohol consumption, pesticides, and heavy metals.

Look for non-GMO milk thistle products standardized to contain 70 to 80 percent silymarin. Holistic healthcare providers usually recommend between 280 mg and 450 mg a day for liver support.

Curcumin in turmeric combats NAFLD

Turmeric, a liver support mainstay in the Ayurvedic healing system and traditional Chinese medicine, is a common kitchen spice that lends a tangy flavor and distinctive yellow coloration to curry dishes and mustards. It owes its therapeutic value to the presence of curcumin, an antioxidant flavonoid.

Randomized clinical trials have supported the ability of curcumin to reduce liver fat, cut inflammation, support healthy bile production, and promote detoxification.

Although it’s almost impossible to consume enough turmeric for therapeutic effects, no worries – curcumin is available as a supplement. The ‘standard’ recommended amount is around 450 mg to 1,000 mg daily for liver support.

Glutathione: The body’s ‘master’ antioxidant is crucial for liver health

Glutathione is found in every cell, but is particularly concentrated in the liver – where it is essential to detoxification. But – as is the case with so many precious, life-sustaining compounds – levels drop with normal aging (and with chronic disease).

However, most experts say the best way to boost glutathione levels is not through supplements but through eating optimal amounts of foods rich in glutathione’s three “building blocks” – the amino acids cysteine, glycine, and glutamic acid.

Organic, cage-free eggs, garlic, and non-denatured whey protein are particularly valuable for boosting glutathione levels, as are cruciferous vegetables such as broccoli and Brussels sprouts. Other good sources are asparagus, spinach, avocado, squash, and green tea.

N-acetyl cysteine renews glutathione

N-acetyl cysteine, or NAC, is a supplementary form of cysteine. It is so essential to liver function that medical professionals rely on it in hospital settings to treat life-threatening acetaminophen overdoses.

NAC’s high success rate is because this amino acid restores and replenishes levels of glutathione that toxins have depleted. Clinical studies have also shown that NAC can substantially improve liver function in patients with NAFLD.

The usual amount for treating NAFLD is 500 mg to 1,000 mg daily.

Vitamin C can help you to avoid fat buildup around the liver

Vitamin C, also known as ascorbic acid, is a powerful antioxidant and immune system booster.

This essential vitamin protects against oxidative damage to the liver – and can help reduce accumulated fat. According to one study, amounts as low as 500 mg of vitamin C a day can help prevent fatty buildup – while amounts of 5,000 mg per day help to actively flush out fats.

A holistic physician might suggest an amount of 1,500 mg a day for liver support. As a side note, vitamin C pioneer Dr. Linus Pauling typically advised somewhat higher dosages, in the area of 2,500 mg to 10,000 mg daily.

Alpha-lipoic acid (ALA) enhances the effects of glutathione

This vitamin-like compound is water-soluble, meaning that it can easily penetrate cell membranes for therapeutic effect. A potent antioxidant, ALA works hand-in-glove with glutathione to neutralize and eliminate toxic heavy metals and scavenge harmful free radicals.

Studies have shown that ALA can decrease the scarring associated with liver injury. A typical amount for liver support is 100 to 300 mg a day.

Show your liver some love with an organic diet

Eating foods high in beta-carotene, such as sweet potatoes, squash, and carrots, is a wise move to avoid liver disease. The body converts beta-carotene to vitamin A, indispensable for flushing out toxins and reducing fat in the liver.

Potassium-rich foods, such as bananas and beet greens, are also beneficial to the liver.

Don’t forget: Opt for certified organic foods as much as possible for best results. These can help to greatly lower your toxic burden – thereby reducing stress and strain on the liver.

And, finally, sharply reducing or eliminating alcohol, refined sugars, fried or fatty foods, processed foods or fast (junk) foods is an excellent way to ‘love your liver.’

Editor’s note: Discover the best ways to avoid fatty liver disease from top experts, own the Fatty Liver Docu-Class created by NaturalHealth365 Programs.

Sources for this article include:

NIH.gov

Posted in Fat, Glutathione, Liver, Organic, Sugar, Supplements, Vitamins | No Comments »

Posted by: admin | Posted on: September 19, 2024

Breast cancer surgery might trigger metastasis, researchers discover why

Reproduced from original article:
https://www.naturalhealth365.com/breast-cancer-surgery-might-trigger-metastasis-researchers-discover-why.html

by: Dena Schmidt, staff writer | August 14, 2024

(NaturalHealth365) It is an unfortunate medical fact that people with breast cancer are highly likely to experience a recurrence after surgical tumor removal or a mastectomy. The cancer relapse usually takes place within 18 months of a surgical intervention. However, until now, medical professionals were at a loss as to why. A recent case report published in SAGE Open Medical Case Reports highlights this issue, documenting a case of breast cancer recurrence in both superficial and deep tissues following mastectomy with immediate reconstruction. This study emphasizes the complexity of post-surgical recurrence and the need for vigilant follow-up imaging, even years after the initial surgery.

A study by the Massachusetts Institute of Technology (MIT) and the Whitehead Institute shed light on the underlying mechanisms, adding to our understanding of this phenomenon. Surprisingly, the healing process of the surgical scar is at the root of this high incidence of cancer recurrence following surgery.

Breast cancer surgery taxes the immune system and leads to the spread of cancer cells

The immune system’s default functioning is to prevent the spread of cancer. This action continues even as the body is battling cancer. However, with the added stress of healing from surgery, the body’s healing forces are sidetracked away from their full focus on resolving a cancerous condition.

Cancer cells are then prone to spreading throughout the body, allowing the cancer to progress. The post-surgical wound response provokes already disseminated cells to grow and proliferate, forming tumors called metastases in other parts of the body.

During the wound healing and scarring process, the immune system goes into overdrive, sending cells to the area to promote healing and closure of the wound. This reaction of the immune system can actually fuel the formation of secondary tumors in critical areas such as the brain, liver, and lungs, where they can become even more life-threatening than the original appearance of cancer in the breasts.

Anti-inflammatory agents show promise in supporting the immune system, fighting the formation of cancer cells

In the past, researchers chalked up increased incidents of breast cancer following surgery to handling and disrupting the area. However, since healthy breast tissue is also removed, it could not be the surgery alone spreading cancer.

Get access to health coaching from Jonathan Landsman and many other top health experts. Plus, our social community is full of great health information. Start chatting with our incredible health moderators + much more. Click here to learn more.

The researchers believe anti-inflammatory drugs could help control the immune system so that cancer does not spread to other parts of the body. Foods high in antioxidants are known to be effective in fighting and protecting against cancer.

Favor anti-inflammatory foods and supplements to support your immune system

Antioxidant-rich foods have anti-inflammatory effects and suppress the formation of free radicals in the body. Free radicals are highly damaging to cells and set the stage for the rogue cell division that characterizes the formation of cancer cells.

Organic dark leafy green vegetables (i.e. kale and collard greens), berries, artichokes, pecans, and dark chocolate are among the foods highest in healing antioxidants. Whether you are facing a cancer diagnosis or want to decrease your odds of getting it, these foods can help support a healthy immune system.

In addition, as an added ‘anticancer effect,’ you might want to consider taking anti-inflammatory supplements such as vitamin C, D and curcumin.

Sources for this article include:

NIH.gov
News-Medical.net
ScienceMag.org

Posted in Cancer, Food, Immunity, Inflammation, Supplements, Surgery, Vitamins | No Comments »

Posted by: admin | Posted on: September 19, 2024

Magnesium’s Role in the 12 Hallmarks of Aging

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/09/17/magnesiums-role-12-hallmarks-of-aging.aspx

Analysis by Dr. Joseph Mercola September 17, 2024

STORY AT-A-GLANCE

Magnesium deficiency is common, affecting over 50% of the population. It plays crucial roles in over 300 enzymatic reactions and is linked to an increased risk of chronic diseases
A 2024 study explored magnesium’s effects on the 12 hallmarks of aging, including genomic instability, telomere attrition and mitochondrial dysfunction. Magnesium deficiency negatively impacts these aging processes
Magnesium deficiency, which is often caused by chronic diseases or malabsorption conditions, can lead to various symptoms like muscle cramps, lethargy, depression and heart arrhythmia
Adequate magnesium intake may help improve sleep quality, which is crucial for overall health and reducing cortisol levels. Poor sleep accelerates aging and increases health risks
To increase your magnesium intake, consume magnesium-rich foods like leafy greens. Supplements and Epsom salt baths are also recommended methods to boost magnesium levels

Magnesium may be one of the most undervalued minerals when it comes to optimizing your health. According to the Linus Pauling Institute in Oregon State University, surveys indicate that 52.2% of the population do not get enough magnesium.¹ This information is concerning since magnesium is the fourth most abundant mineral in the body, playing a role in more than 300 enzymatic reactions.²

According to Harvard T.H. Chan School of Public Health, magnesium is essential to numerous body processes, such as building proteins and strong bones. It also plays a role in regulating your blood sugar and blood pressure levels, as well as muscle and nerve functions.³

Being deficient in magnesium has also been linked to an increased risk of chronic degenerative diseases, including diabetes and cancer.⁴ Now, research suggests that magnesium deficiency influences at least a dozen aging processes as well.

Are You Getting Enough Magnesium?

In a 2024 study published in Nutrients,⁵ researchers dove deep into the effects of magnesium on the aging process, as well as its impact on age-related diseases. This is an important undertaking, as they noted that magnesium deficiency becomes more common as you age. According to the study, here are the most common signs of magnesium deficiency:⁶

Muscle cramps/spasms	Lethargy	Vertigo
Depression	Convulsions	Hypertension
Osteoporosis	Migraine	Asthma
Chronic fatigue	Heart arrhythmia

Magnesium deficiency can occur due to a variety of factors. Prominent examples include chronic diseases such as diabetes, hypertension and chronic diarrhea. Malabsorption diseases like celiac disease, cystic fibrosis and pancreatitis can also contribute to deficiency.⁷

The Effects of Magnesium on the 12 Hallmarks of Aging

The featured Nutrients study builds upon the nine hallmarks of aging proposed back in 2013 by Lopez-Otin et al.⁸ Since its publication, new research has come out, and this study adds three new aging hallmarks linked to magnesium. The list below presents a summary of the current research:⁹

1. Genomic instability — This refers to an increased risk of genetic problems, such as mutations and DNA damage. As your genes become unstable, the aging process accelerates, and essential functions, such as cell-to-cell communication, fall by the wayside.

In the context of magnesium, your DNA has both minor and major binding sites for it. Magnesium also contributes to chromatin (mixture of DNA and proteins¹⁰) stability and is involved in the secondary and tertiary structure of DNA.

“Thus, maintaining intracellular magnesium at a physiological level is an important determinant of DNA stability,” the researchers say.

2. Telomere attrition — Telomeres are protein structures located at both ends of a chromosome, which provide structural integrity to a cell during replication.¹¹ As cells continue to replicate, they become shorter and will shut down after reaching a limit, helping prevent cancer.

Magnesium plays a role in telomerase regulation, as well as telomeric chromatin structure and integrity. In fact, over 50% of telomere are reliant on magnesium, according to the researchers.

3. Epigenetic alterations — Epigenetics is the process of modifying genome expression without changing your DNA sequence that modulates cellular and tissue functions. As you age, inhibitory molecules from injured and stressed cells can cause epigenetic alterations, leading to possible changes in cellular function.

According to the researchers, magnesium can avert this by helping regulate genes related to inflammatory pathways. Furthermore, magnesium deficiency can upregulate the p53 gene and sphingomyelinase in your cardiomyocytes, which is linked to “genomic changes during aging and is associated with the genesis of cardiovascular disease.”

4. Mitochondrial dysfunction — As noted in my article “What You Need to Know About Your Mitochondria,” your mitochondria are responsible for producing the energy your body needs. However, as the featured study points out, they also produce waste in the form of free radicals.

When the free radicals exceed your body’s cellular antioxidant capacity, aging accelerates. Excess free radicals damage your mitochondria, causing DNA to mutate, thereby reducing your body’s ability to produce energy.

According to the researchers, over a third of all cellular magnesium is found in mitochondria, and various cellular processes rely on this mineral to function. When magnesium mitochondrial homeostasis is disrupted, ATP (adenosine triphosphate) production becomes compromised and oxidative stress is intensified.

5. Loss of proteostasis — Proteostasis, a combination of the words “protein” and “homeostasis,” refers to your body’s delicate balancing act of managing proteins¹² through proper production, folding, transportation and degradation in cells.¹³

According to the researchers, proteostasis dysregulation has been linked to several age-related chronic diseases, such as Alzheimer’s and Parkinson’s disease, as well as cardiovascular disease.

Considering this, the researchers noted that low magnesium levels in the brain have been linked to Alzheimer’s, Parkinson’s and epilepsy. Furthermore, they noted that magnesium downregulates the primary mechanisms of these conditions.

6. Deregulated nutrient sensing — The researchers noted that patients diagnosed with insulin sensitivity, Type 2 diabetes and glucose tolerance impairment were also deficient in magnesium. Conversely, higher magnesium intake was associated with better insulin sensitivity and a lower risk of Type 2 diabetes.

In addition, the researchers pointed out that low intracellular magnesium levels disrupt insulin signaling, which can lead to insulin resistance that can ultimately result in metabolic syndrome and/or Type 2 diabetes.

7. Cellular senescence — Senescence, or the process of deterioration while aging, causes cellular alterations, especially in the context of magnesium deficiency. The researchers noted that it can lead to reduced protection against oxidative stress, culture growth and cell cycle progression.

The researchers also noted that cell replication capacity was reduced. On the other hand, higher magnesium intake was correlated to better mitochondrial function and enhanced lifespan.

8. Stem cell exhaustion — Stem cells are special cells that develop into different types, such as muscle or brain cells.¹⁴ However, their function is reduced when certain factors exacerbate the aging process, possibly reducing immune system function.

However, magnesium may be able to turn things around. The researchers noted that magnesium is a cofactor for immunoglobulins synthesis and immune cell adherence, as well as reducing the expression of proinflammatory molecules.

9. Altered intercellular communication — Proper intercellular communication is important for optimal cell functioning throughout the whole body. In this case, magnesium is a key modulator of various intracellular signaling pathways, such as the NMDA (N-methyl-D-aspartate) receptor, which is linked to memory, neuroplasticity and circadian clock rhythm.

When the NMDA becomes excitable, neurodegeneration occurs.¹⁵ However, increasing magnesium blocks its excessive activation.

10. Compromised autophagy — Autophagy is your body’s way of eliminating damaged cells by consuming them. When activated properly, it can even promote neuronal survival by removing unnecessary proteins, as noted by a 2021 study.¹⁶

According to the Nutrients researchers, magnesium is crucial for important cellular processes, which includes apoptosis. For context, apoptosis, which is programmed cell death, is regulated by the autophagy signaling pathway.¹⁷

11. Gut dysbiosis — According to the researchers, the gut microbiome tends to change around mid- to late adulthood. Notably, they observed that healthy participants over the age of 80 had a unique, diverse gut probiotic profile, which was associated with better survival compared to participants with low gut microbiome uniqueness.

Where does magnesium fit in this picture? Based on their findings, they surmise that the gut acts as an intermediary for the mineral.

In one cited animal study,¹⁸ increased levels of the Bacteroides strain and other probiotics were linked to increased production of short-chain fatty acids. Other research cited in the featured study noted that magnesium deficiency had a negative impact on gut microbiota, which resulted in poorer mental function.^19,^20,²¹

12. Inflammation — Aging is typically correlated with higher inflammatory markers, such as C-reactive protein (CRP). In the featured study, low magnesium levels caused altered calcium homeostasis and increased reactive oxygen species production, which raised inflammatory markers.

They also cited a meta-analysis²² that reviewed 17 studies, noting that “magnesium supplementation significantly reduced different human inflammatory markers, specifically nitric oxide and CRP concentrations.”

Save This Article for Later – Get the PDF Now

Download PDF

How Magnesium Can Boost Sleep Quality to Fight Aging

Are you feeling tired most of the time? If that’s the case, you may want to review your sleeping habits and check if you’re getting enough sleep. According to the National Council on Aging, around 35.5% of Americans adults get fewer than seven hours of sleep, which is below the recommended amount by the American Academy of Sleep Medicine and the Sleep Research Society.²³

Poor sleep habits can have numerous health ramifications that impact aging in one way or another. For example, a study²⁴ noted that sleep deprivation raises cortisol, a known stress hormone. Having elevated cortisol levels can accelerate aging, as noted in my previous article “Key Strategies to Reduce Your Cortisol Levels.” Conversely, getting sufficient, high-quality sleep can help inhibit cortisol secretion to normal levels.²⁵

It’s clear that getting enough high-quality sleep is paramount to keeping cortisol levels down. Moreover, it’s just a good practice to adopt, as sleep plays a role in promoting overall health. As noted in a 2021 study published in the Journal of Clinical Sleep Medicine:²⁶

“Sleep is vital for health and well-being in children, adolescents, and adults. Healthy sleep is important for cognitive functioning, mood, mental health, and cardiovascular, cerebrovascular, and metabolic health. Adequate quantity and quality of sleep also play a role in reducing the risk of accidents and injuries caused by sleepiness and fatigue, including workplace accidents and motor vehicle crashes.”

Here’s where magnesium comes in. According to the Sleep Foundation, magnesium may help improve sleep quality by increasing sleep times while simultaneously lessening waketime tiredness.²⁷ While experts haven’t pinpointed the exact reason how magnesium influences sleep, a study published in BMC Complementary Medicine and Therapies supports this hypothesis, noting that magnesium supplementation may help increase total sleep time.²⁸

Dietary Recommendations for Increasing Your Magnesium Intake

Now that you’re aware of the importance of magnesium for overall health, how do you boost your intake? The most logical answer is modifying your diet. According to the researchers, you can boost your magnesium levels by getting enough green leafy veggies. This is a sensible approach, as these veggies also provide other important nutrients that can contribute to better health.

The RDA (recommended dietary allowances) for magnesium is around 320 to 420 milligrams (mg) per day for women and men, respectively.²⁹ According to James DiNicolantonio, Pharm.D., you may need 600 mg per day, which is more in line with the intake of our ancient ancestors during the Paleolithic period.³⁰

However, even that amount may still be insufficient. I believe most people may benefit from amounts as high as 1,000 to 2,000 mg of elemental magnesium per day, as most of us are exposed to electromagnetic fields (EMFs), and the extra magnesium may help lower the damage from this invisible toxin.

In my interview with Martin Pall, Ph.D., he explains that EMFs activate the voltage-gated calcium channels (VGCCs) located inside your cells. When these gates open, calcium ions flow inward to the cell, causing the hallmark damages related to EMFs.

To protect yourself, one natural solution is to increase your magnesium intake. “It is clear that when we’re deficient in magnesium, you get excessive activity of the VGCCs. It’s important to allay that deficiency,” he says. That said, here are some magnesium-rich foods you can add more of to your diet:

Spinach	Collard greens	Swiss chard
Turnip greens	Beet greens	Broccoli
Brussels sprouts	Kale	Bok choy
Romaine lettuce	Raw cacao	Organic, raw grass fed yogurt
Squash	Fruits and berries	Natto

Herbs and spices also contain high amounts of magnesium and other nutrients. Some of the best options include chives, coriander, cumin, parsley, fennel, basil and cloves.

Other Strategies to Boost Your Magnesium Intake

In addition to a healthy diet, consider taking a magnesium supplement to meet my recommended intake. I recommend magnesium threonate, as I believe it’s the most efficient at penetrating your cell membranes, including your mitochondria and blood-brain barrier.

I am also fond of magnesium malate, as malic acid is a Krebs cycle intermediate useful for ATP production. The interesting thing about magnesium is that it can also be absorbed through your skin, so taking an Epsom salt (magnesium sulfate) bath is another effective method.

You can also make a supersaturated solution of Epsom salts by dissolving 7 tablespoons of Epsom salt into 6 ounces of water. Heat it until all the salt dissolves. This is the strategy I use. I pour the solution onto my skin using a dropper bottle, then apply fresh aloe leaves to melt it. This is an easy way to increase your magnesium in higher doses without having to deal with its laxative effects, since it doesn’t pass through your digestive system.

When taking magnesium as a supplement, space out the doses throughout the day, with or without food. Taking it in one big dose can cause loose stools. If you’re taking a calcium supplement, take them together, too. According to published research,³¹ magnesium ions are a physiological antagonist of calcium ions, and even small changes in your magnesium levels can disturb calcium ion signaling.

While the ideal ratio of magnesium to calcium is thought to be 1-to-1, most people get far more calcium than magnesium from their diet; hence, your need for supplemental magnesium may be two to three times greater than calcium.

– Sources and References

Posted in Age, Minerals, Supplements | No Comments »

Posted by: admin | Posted on: September 16, 2024

6 powerful health benefits of drinking turmeric tea

Reproduced from original article:
https://www.naturalhealth365.com/6-powerful-benefits-of-drinking-turmeric-tea.html

by: Lori Alton, staff writer | September 14, 2024

(NaturalHealth365) Natural healers have long been aware of the healing powers of turmeric, the ingredient that gives curry its piquant taste and bright yellow color. This South Asian spice has long been valued in the Ayurvedic and traditional Chinese medicine systems for its therapeutic and anti-inflammatory effects.

With extensive medical studies supporting turmeric’s ability to combat many serious health concerns – including cancer and heart disease – this ancient remedy impresses modern-day scientists regularly. Let’s take a closer look at why this is happening.

Curcumin in turmeric has powerful protective effects

Turmeric, derived from the roots of a plant scientifically known as Curcuma longa, gets its disease-fighting powers from its curcumin content – a bright yellow flavonoid.

With potent antioxidant and anti-inflammatory capabilities, curcumin prevents oxidative damage to tissues and cells by scavenging harmful free radicals in the body. It also regulates cytokines and enzymes that trigger inflammation – which is at the root of many diseases, including cancer, heart disease, arthritis, asthma, COPD, and pulmonary fibrosis.

In addition, curcumin is strongly antifungal, antibacterial, and antiviral.

Curcumin helps alleviate serious pulmonary conditions

In a review in Pharmacological Research, researchers reported that curcumin might help with asthma, cystic fibrosis, chronic obstructive pulmonary disease, and even lung cancer.

In addition, curcumin has anti-fibrotic effects, preventing or blocking tissue scarring – making it a valuable weapon against diseases such as pulmonary fibrosis.

The authors cited a controlled trial in which short-term curcumin supplementation improved the severity and frequency of COPD symptoms – and highlighted some of curcumin’s beneficial effects. These include inhibiting mast cells, blocking histamine release, and decreasing levels of the pro-inflammatory chemicals COX-2 and 5-LOX.

The authors also reported that dietary curcumin was found to be effective in ameliorating pulmonary function in a study involving over 2,400 patients.

Curcumin targets cancer cells at virtually every stage of growth

Here’s the good news: By interfering with cancer cell survival, proliferation, invasion, and angiogenesis (the growth of new blood vessels to nourish tumors), curcumin helps to effectively “slam the door” on cancer at the cellular level.

In a review published in Nutrients, researchers pointed to animal studies showing that curcumin inhibits tumor growth and weight.

They reported that the flavonoid works against pancreatic cancer by decreasing oxidative stress, interfering with angiogenesis, and inducing apoptosis or programmed cancer cell death. Yet another protective effect is curcumin’s ability to down-regulate levels of MMPs, or matrix metalloproteases – chemicals that make it easier for cancer cells to invade surrounding tissue.

In other studies, curcumin increased the effectiveness of gemcitabine, a pharmaceutical drug given to pancreatic cancer patients. Curcumin has shown particularly promising results when it comes to treating cancers of the prostate, pancreas, breast, skin, and colon.

Heart-healthy turmeric tea may help fight cardiovascular disease

As a powerful antioxidant and anti-inflammatory agent, curcumin in turmeric can play a role in fighting heart disease.

In addition to neutralizing harmful free radicals, curcumin helps maintain healthy levels of the antioxidant enzymes superoxide dismutase and glutathione peroxidase – two “heavy hitters” in the body’s natural defenses.

It also reduces blood pressure and increases the production of beneficial nitric oxide. By reducing the “stickiness” of blood platelets, turmeric may work against atherosclerosis and cut the risk of heart attack and stroke.

In a review published in 2012 in The American Journal of Cardiology, the authors reported that 4 grams of curcumin 3 days before and 5 days after coronary artery bypass grafting surgery reduced the risk of heart attack by 17 percent.

Finally, curcumin-rich turmeric tea may help decrease LDL cholesterol while boosting HDL.

In one study, 500 mg of curcumin for 7 days showed a 29 percent increase in HDL cholesterol and a 12 percent decrease in total cholesterol – a significant improvement.

How turmeric offers value for many other chronic (unwanted) conditions

Curcumin’s potent anti-inflammatory effects may help treat painful osteoarthritis. When used in an Ayurvedic formula – along with winter cherry, Boswellia, and zinc – curcumin caused patients to have less pain and disability.

Turmeric tea may also help with digestion – reducing symptoms of bloating and gas while increasing the production of bile by the gallbladder.

And turmeric tea may even help prevent neurodegenerative conditions.

India has one of the lowest rates of Alzheimer’s disease in the world – along with high consumption of curry. Researchers believe that curcumin blocks beta-amyloid formation, the protein commonly associated with Alzheimer’s disease.

How can I take turmeric as a tea?

You can brew turmeric tea from a powder or grate it fresh from turmeric root. Turmeric tea aficionados typically add 1 to 2 teaspoons of grated or ground turmeric to four cups of boiling water.

Let the liquid simmer for 10 minutes, then strain and cool.

For some, turmeric tea is an acquired taste. If you find it unpalatable, you can sweeten the beverage with organic honey to make it more palatable. Lemon, lime, and ginger can also go a long way towards improving the taste while adding antioxidant value.

As curcumin in turmeric requires fats to dissolve, you could mix it in a tablespoon of coconut oil or almond milk for maximum benefit. Sprinkling in some black pepper also promotes the absorption of curcumin.

It’s hard to think of a body system or organ that turmeric doesn’t benefit. Sipping turmeric tea may very well be one of the most important things you can do to prevent serious disease and maintain optimal health. (Enjoy!)

Sources for this article include:

NIH.gov
Huffingtonpost.com
MedicalNewsToday.com
ScienceDirect.com
ScienceDirect.com

Posted in Cancer, Cardiovascular, Inflammation, Lungs, Natural Medicine, Supplements | No Comments »

Posted by: admin | Posted on: September 4, 2024

The Science of Magnesium and Its Role in Aging and Disease

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/08/31/magnesium-aging-and-disease.aspx

Analysis by Dr. Joseph Mercola August 31, 2024

STORY AT-A-GLANCE

Nearly 45% of the U.S. population doesn’t get enough magnesium, primarily because our diets lack sufficient dark leafy greens where magnesium is abundant
Lifestyle factors, including sleep deprivation, stress and alcohol consumption, can lead to a decrease in magnesium levels
Even marginally low magnesium intake may take a toll on your health and lead to accelerated aging and the development of chronic disease
Magnesium has been studied for its potential role in preventing and treating migraines, high blood pressure, osteoporosis and more

Magnesium is a mineral that’s essential for human health, playing a crucial role in more than 300 enzymatic reactions in your body. Magnesium is necessary for muscle and nerve function, blood glucose control and protein synthesis. It also supports a healthy immune system, keeps your heartbeat steady and plays a role in bone health.¹ Unfortunately, magnesium is also one of the most prevalent micronutrient deficiencies.

Why Magnesium Deficiency Puts Your Health at Risk

Nearly 45% of the U.S. population doesn’t get enough magnesium, primarily due to insufficient consumption of dark leafy greens. Magnesium is found in the chlorophyll that gives plants their green color.

Magnesium deficiency can have serious consequences, impacting essential biological functions such as DNA repair, replication, and transcription. When magnesium levels are inadequate, these processes may be hindered, potentially leading to the formation of mutations that could contribute to cancer development.

Furthermore, recent research suggests a possible connection between low magnesium levels and increased brain volume loss, which may contribute to a faster decline in cognitive function and an earlier onset of dementia in aging individuals.

The RDA for magnesium is around 310 to 420 milligrams (mg) per day depending on your age and sex,² although some researchers believe we may need as much as 600 to 900 mg/day for optimal health. I believe many may benefit from amounts as high as 1 to 2 grams (1,000 to 2,000 mg) per day.

The Recommended Dietary Allowance (RDA) for magnesium only represents the minimum amount needed to prevent severe deficiency-related diseases. So, meeting the 300 to 400 mg daily requirement only provides the basic level necessary for bodily functions, rather than optimal health.

Magnesium is crucial for maintaining proper electrolyte balance and preventing dehydration. It regulates electrolytes, which are essential for nerve impulse transmission, muscle contraction, and maintaining a healthy heart rhythm. A magnesium deficiency can disrupt this balance, potentially leading to dehydration and associated complications.

The primary reason why so many people have magnesium insufficiency or deficiency is due to the typical standard American diet, which is low in micronutrients like magnesium. However, certain health conditions and lifestyle factors also play a role by increasing magnesium excretion. Diabetes is one example, as is alcohol consumption.

Alcohol consumption can accelerate magnesium loss from the body, even when gut absorption remains normal. This occurs because alcohol acts as a diuretic, stimulating increased urine production. As a result, more magnesium is filtered out by the kidneys and excreted in urine, rather than being retained and used by the body.

This diuretic effect leads to a higher rate of magnesium excretion, potentially depleting your magnesium stores. Sleep deprivation and your stress levels also affect magnesium, and chronic or even intermittent stress may lead to a decrease in magnesium levels.

Magnesium Boosts Brain Health

Intriguing research suggests higher dietary magnesium intake is linked to better brain health, particularly in women. One study of 6,001 people revealed that higher dietary magnesium consumption of about 550 mg per day was associated with larger gray matter and hippocampal volumes in the brain than the average intake of about 350 mg per day.³

Higher magnesium intake may result in larger brain volumes, potentially slowing brain aging by up to one year compared to those with lower magnesium consumption. Research has associated magnesium with the onset and progression of various age-related brain disorders. Elevated cerebral magnesium levels have been shown to reduce oxidative stress and inflammation while enhancing pro-synaptic plasticity.

Additionally, magnesium also helps counteract other mechanisms that contribute to neurodegeneration. For example, a systematic review and meta-analysis of 21 studies also revealed that individuals with Alzheimer’s disease have significantly lower plasma magnesium levels compared to those without.⁴ These effects collectively suggest that maintaining adequate magnesium levels could play a role in preserving brain health and function as we age.

Magnesium is also involved with creatine, a substance naturally found in muscle cells and the brain. Creatine is commonly used by athletes to improve performance, as it’s immediately used by your body to convert adenosine diphosphate (ADP) to adenosine triphosphate (ATP) — the main energy currency of cells — and supply energy muscles need for contraction. However, creatine also helps provide energy to your brain.

Creatine plays a crucial role in energy production by transferring phosphate groups from phosphocreatine to ADP, thereby generating ATP, your body’s primary energy currency. This process is facilitated by enzymes that require magnesium as a cofactor to function effectively.

This mechanism highlights another significant reason why magnesium is essential for brain function, as it directly supports the energy metabolism necessary for optimal cognitive performance and overall brain health.

Save This Article for Later – Get the PDF Now

Download PDF

The Role of Magnesium in Aging

Even marginally low magnesium intake may take a toll on your health and lead to accelerated aging and the development of chronic disease. According to Bruce Ames, Ph.D., professor emeritus of biochemistry and molecular biology at the University of California Berkeley, and former senior scientist at the Children’s Hospital Oakland Research Institute, proteins and enzymes fall into two general categories:

Survival proteins, which are crucial for our immediate survival and ability to reproduce
Longevity proteins, which help us stay healthy in the long run

According to Ames’ triage theory, if your body is low in certain nutrients or cofactors, it prioritizes survival proteins over longevity proteins. This means that in times of nutrient deficiency, your body chooses to support functions that keep you alive and reproducing rather than those that prevent long-term damage, which can lead to faster aging and age-related diseases.

With regard to magnesium, it plays a crucial role in numerous biological functions, both for immediate survival and long-term health. The triage theory suggests that when magnesium is limited, your body then prioritizes its use for essential short-term survival processes, such as energy production, at the expense of long-term health processes like DNA repair.

So, while we may consume enough magnesium to avoid acute deficiency, this level might not be optimal for long-term health. Your body may even deplete magnesium from bones to maintain levels in muscles and other tissues, potentially leading to issues like osteoporosis later in life.

Impaired DNA repair and replication processes due to chronically inadequate magnesium levels can also result in an accumulation of DNA damage and mutations, potentially leading to cell dysfunction and even cancer development over time.

This scenario illustrates how subtle, long-term effects of micronutrient inadequacy, particularly magnesium, can contribute to the aging process and the development of chronic diseases. The damage is insidious, accumulating gradually over time without immediate noticeable effects, but potentially having significant long-term health consequences.

Magnesium for Migraines, High Blood Pressure, Osteoporosis and More

Magnesium has been studied for its potential role in preventing and treating migraines. Several studies suggest that magnesium deficiency may be linked to the occurrence of migraines, and supplementation might help reduce the frequency and severity of migraine attacks.⁵ Magnesium can also affect neurotransmitter release and blood vessel constriction, both of which are factors in migraine development.

Magnesium has been studied for its potential role in preventing and treating migraines. Research suggests that magnesium deficiency may be linked to the occurrence of migraines, and supplementation might help reduce the frequency and severity of migraine attacks. Magnesium can also affect neurotransmitter release and blood vessel constriction, both of which are factors in migraine development.

During a migraine, a phenomenon called cortical spreading depression occurs, which is a wave of brain activity leading to visual and sensory changes often associated with migraine auras. Magnesium supplementation may help prevent these waves.

Additionally, magnesium may decrease the release of certain pain-signaling chemicals in the brain, such as substance P and glutamate, potentially lessening migraine-associated pain. It might also prevent further narrowing of brain blood vessels caused by serotonin, another neurotransmitter involved in migraines.

Magnesium also plays an important role in other common chronic conditions, including high blood pressure. It helps control blood pressure by boosting the production of substances like prostacyclin and nitric oxide, which relax blood vessels and improve overall cardiovascular health. Magnesium aids in vasodilation, making it easier for the heart to pump blood and reducing blood pressure.

Furthermore, its ability to combat inflammation and protect against blood vessel damage contributes to cardiovascular health support.

Magnesium is also a key player in bone health, with adequate intake necessary to build strong bones starting early in life. Most of the magnesium in your body is stored in your bones. They basically serve as a reservoir that your body can draw from when needed. As you age, magnesium losses from the bones increase, partly due to your body’s efforts to maintain a stable range of magnesium in the plasma.

Over a lifetime, this process can lead to a significant decrease in bone magnesium content. Therefore, ensuring adequate magnesium intake early in life is crucial for long-term bone health and reducing your risk of age-related bone density loss and associated conditions like osteoporosis.

What Are the Best Sources of Magnesium?

When it comes to oral supplementation, my personal preference is magnesium threonate, as it appears to be the most efficient at penetrating cell membranes, including your mitochondria and blood-brain barrier. However, as a general rule, I recommend starting out with a dose of 200 mg of oral magnesium citrate per day, gradually increasing your dose until you develop slightly loose stools.

I recommend using a food tracking app such as Cronometer to find out your magnesium intake. Dark green leafy vegetables are a good source of magnesium, and juicing your greens is an excellent way to boost your intake, although supplementation is likely necessary for most people, as magnesium-depleted soils have dramatically lowered the magnesium content of our food.

– Sources and References

Posted in Age, Blood Pressure, Bones, Brain, Minerals, Osteoporosis, Supplements | No Comments »

Posted by: admin | Posted on: August 31, 2024

The Many Forgotten Health Benefits of Aspirin

Reproduced from original article:

Analysis by Dr. Joseph Mercola August 29, 2024

STORY AT-A-GLANCE

Aspirin offers benefits beyond heart health, including cancer prevention, improved pregnancy outcomes during influenza infection and treatment for fatty liver disease and pulmonary fibrosis
Long-term low-dose aspirin use (over 10 years) may reduce the risk of dementia, particularly in people with pre-existing coronary heart disease
Aspirin can enhance glucose utilization, reduce fatty acid release, lower cortisol levels and increase metabolic rate, potentially aiding in weight loss and hormone balance
Studies suggest aspirin may improve survival rates in intensive care units, slow the progression of abdominal aortic aneurysms and reduce the risk of developing Type 2 diabetes
When considering aspirin use, opt for immediate-release, uncoated versions. The suggested dosage is dependent on your circumstances 82 mg to 325 mg tablet daily with your largest meal

For years, you’ve probably heard that a daily low-dose aspirin can help prevent heart attacks and strokes. Now, suddenly, health authorities are backpedaling on this advice.¹

Why the change? They claim it’s about bleeding risks, but there’s more to the story. Look at the timing — this shift comes as newer, far more expensive blood thinners flood the market. These drugs can cost up to $550 a month,² while aspirin sets you back just $1.50.³

It’s a pattern we’ve seen before with drugs like ivermectin. Safe, effective and cheap medicines get pushed aside to make way for pricier alternatives. The pharmaceutical industry has a long history of this, dating back to when nonsteroidal anti-inflammatory drugs (NSAIDs) were introduced in the 1970s.

They’re telling you to avoid aspirin, but are they telling you the whole truth? As always, I encourage you to look beyond the headlines and consider who benefits from these changing guidelines. Your health — and your wallet — may depend on it.

For decades, aspirin has been a cornerstone in the prevention of cardiovascular disease (CVD). A comprehensive review of 13 primary prevention trials recently revealed that low-dose aspirin is associated with small but statistically significant reductions in major CVD events, such as heart attack and stroke.⁴

The absolute risk reduction can be up to 2.5%, which means that for every 1,000 people taking aspirin, up to 25 fewer may experience a major CVD event. But the truth is, aspirin offers numerous health advantages beyond heart health that are rarely talked about. Learning about these benefits can help you take control of your health.

Aspirin’s Role in Cancer Prevention

Recent studies have shed light on aspirin’s potential to prevent colorectal cancer (CRC) and other types of cancer. Taking at least 75 milligrams (mg) of aspirin daily for several years has been shown to reduce the long-term incidence and death from CRC,⁵ with the greatest benefit seen for proximal colon cancers, which are malignancies that occur in the first and middle sections of the colon, also known as the right side of the colon.

In fact, in women, aspirin use for over 20 years was associated with a 35% reduction in CRC incidence.⁶ The effect appears to be dose-dependent, with longer duration of use linked to greater benefits. Aspirin may also improve survival rates after a CRC diagnosis, with regular users showing reductions in CRC mortality of 29% and overall mortality of 21%.⁷

Interestingly, the benefits of aspirin use in CRC may extend to other cancer types as well. An analysis of eight trials found that the 20-year risk of any cancer death was reduced by 20%, and gastrointestinal cancer deaths by 35%. These findings suggest that low-dose aspirin use over multiple years could be a valuable tool in your cancer prevention strategy.

Research has also uncovered a role for aspirin in treating certain types of hepatocellular carcinoma (HCC), or liver cancer. A case study revealed that aspirin effectively controlled disease progression in a patient with HCC caused by adenomatous polyposis coli (APC) mutations.⁸ These mutations, which activate the Wnt pathway, were identified as the primary driver of the patient’s cancer.

By administering high-dose aspirin (300 mg daily), doctors achieved disease control for nearly five years. The effectiveness of aspirin in this HCC case is linked to its ability to inhibit the Wnt pathway, which plays a crucial role in cancer development. In patients with APC mutations, the Wnt pathway becomes overactivated, promoting tumor growth.

Aspirin works by activating glycogen synthase kinase 3 beta (GSK3β), which in turn increases the phosphorylation and degradation of β-catenin, a key protein in the Wnt pathway.

This mechanism effectively counteracts the effects of the APC mutation. Additionally, aspirin’s action as a cyclooxygenase 2 (COX2) inhibitor may contribute to its anticancer effects. This case demonstrates how a common, inexpensive drug like aspirin could be repurposed for targeted cancer therapy based on specific genetic profiles.

Aspirin Improves Pregnancy Outcomes During Influenza Infection

Low-dose aspirin may also offer benefits during influenza infection in pregnancy.⁹ A study using a mouse model found that aspirin treatment significantly improved vascular function in pregnant mice infected with influenza A virus.¹⁰ The infected mice showed impaired blood vessel relaxation, but aspirin treatment restored normal vascular function.

This is important because vascular dysfunction during pregnancy can lead to complications like preeclampsia and restricted fetal growth. The study also found that aspirin reduced inflammation in the blood vessels and decreased viral spread from the lungs to other tissues. Most notably, aspirin treatment improved outcomes for the offspring, including better survival rates and higher birth weights.

These findings suggest that the vascular protective effects of aspirin may help support a healthier pregnancy even in the face of influenza infection. The dosage used in the study was comparable to the low doses of aspirin already safely prescribed to some high-risk pregnant women to prevent preeclampsia. This suggests the treatment could be readily translatable to clinical use. However, as Georgi Dinkov notes:¹¹

“The even better news is that these findings do not apply only to flu and/or only to pregnancy. COVID-19, as well as most other viral infections, cause similar systemic state of inflammation, which affects primarily the vascular system. As such, the study … suggests that aspirin may be a viable prophylactic and treatment intervention for all other viral conditions as well.”

Save This Article for Later – Get the PDF Now

Download PDF

Aspirin Therapy Shows Promise for Fatty Liver Disease

A daily aspirin regimen may offer more benefits than you realize. A study presented at the 2023 meeting of the American Association for the Study of Liver Diseases¹² revealed that low-dose aspirin could be an effective treatment for metabolic dysfunction-associated steatotic liver disease (MASLD), a condition previously known as nonalcoholic fatty liver disease.

The terminology shift aims to more accurately reflect the underlying metabolic dysfunction associated with the condition, emphasizing the metabolic risk factors and pathophysiology rather than just the absence of alcohol consumption. In a groundbreaking trial, researchers found that taking 81mg of aspirin daily led to significant improvements in liver health for patients with MASLD.¹³

Over a six-month period, participants who took aspirin experienced a substantial reduction in liver fat content compared to those who received a placebo. This decrease in liver fat was accompanied by improvements in other markers of liver health, including inflammation and fibrosis.

The study’s findings are particularly exciting because they demonstrate aspirin’s ability to address multiple aspects of liver health. Not only did aspirin reduce the amount of fat in the liver, but it also showed promise in tackling inflammation and fibrosis — two key factors in the progression of liver disease.

Participants who took aspirin saw a 17.3% decrease in intrahepatic lipid content — the amount of fat stored within liver cells — while those in the placebo group experienced a 30.3% increase. This striking difference suggests that aspirin could potentially halt or even reverse the accumulation of fat in the liver, a hallmark of MASLD.

Additionally, the aspirin group showed improvements in liver enzyme levels and other markers of liver health, indicating a broader positive impact on liver function.

Aspirin Improves Mortality Rates in the ICU

While the previous study focused on aspirin’s benefits for fatty liver disease, new research suggests its potential extends to critical care settings. A large-scale study involving 146,191 intensive care unit (ICU) patients found that aspirin use during ICU stays was associated with a significant reduction in 28-day mortality rates.¹⁴

This effect was particularly notable in patients with systemic inflammatory response syndrome (SIRS) symptoms but without sepsis. The findings add another layer of understanding of aspirin’s many health benefits. Not only might it help protect your liver from fat accumulation and inflammation, but it could also improve your chances of survival if you ever find yourself in intensive care.

Aspirin’s Role in Preventing Diabetes and Abdominal Aortic Aneurysms

Aspirin also has a protective effect against Type 2 diabetes. An analysis of the ASPREE trial, which involved 16,209 adults aged 65 and older, revealed that those taking low-dose aspirin (100 mg daily) had a 15% lower risk of developing diabetes compared to those on placebo.¹⁵ This finding adds a new dimension to the potential benefits of aspirin therapy, especially for older adults.

The study also found that aspirin use was associated with a slower increase in fasting plasma glucose levels over time, revealing that aspirin might help maintain better blood sugar control, even in individuals who don’t develop full-blown diabetes.

A large cohort study involving 3,435 patients also revealed that aspirin use is associated with slower progression of abdominal aortic aneurysms (AAAs), particularly in men and nonsmokers.¹⁶ This reveals even more about aspirin’s potential benefits, extending beyond heart health and diabetes prevention.

AAAs are a serious vascular condition that can lead to life-threatening ruptures if left unchecked. The study found that patients taking aspirin had a 36% lower odds of rapid aneurysm progression compared to those not taking aspirin. While aspirin didn’t significantly impact long-term mortality or major bleeding risks, its potential to slow AAA growth could be a game-changer in managing this condition.

Aspirin’s Impressive Anti-Fibrotic Effects

Aspirin could also be useful as a treatment for pulmonary fibrosis,¹⁷ a lung disease that occurs when lung tissue becomes damaged and scarred. This thickening and stiffening of the tissue make it difficult for your lungs to work properly, leading to a decline in lung function.

Aspirin may help combat lung scarring. A study found that aspirin significantly inhibited the differentiation and migration of lung fibroblasts, which are key drivers of fibrosis, or scarring.¹⁸ When researchers treated fibrotic lung cells with aspirin, it markedly decreased the expression of proteins associated with fibrosis like collagen, fibronectin, and alpha-smooth muscle actin.

In a mouse model of pulmonary fibrosis, aspirin treatment reduced collagen deposition and lung fibrosis compared to untreated mice. These findings suggest aspirin may help prevent the excessive scarring and tissue remodeling seen in pulmonary fibrosis. Given aspirin’s wide availability, low cost and established safety profile, it presents an intriguing option for pulmonary fibrosis treatment.

The study also sheds light on how aspirin might combat pulmonary fibrosis — by enhancing a cellular process called autophagy. Autophagy is your cells’ way of recycling damaged components and maintaining homeostasis. Interestingly, insufficient autophagy has been observed in lung tissue from patients with idiopathic pulmonary fibrosis.

The research found that aspirin treatment increased markers of autophagy in fibrotic lung cells and tissues. Using electron microscopy, the researchers also observed more autophagosomes (structures involved in autophagy) in aspirin-treated samples. When autophagy was blocked using inhibitors, it reversed aspirin’s anti-fibrotic effects. This suggests that aspirin may work by activating autophagy to clear out damaged proteins and prevent the build-up of scar tissue.

By promoting this natural cellular cleaning process, aspirin could potentially slow down or even reverse the progression of pulmonary fibrosis, adding to aspirin’s diverse health benefits and opening up new possibilities for its therapeutic use.

Long-Term Aspirin Use Offers Cognitive Benefits

While previous research on aspirin’s cognitive benefits has been mixed, research published in Alzheimer’s Research & Therapy highlights the importance of long-term use.¹⁹ The analysis found that taking low-dose aspirin for more than 10 years was critical for detecting a protective effect against dementia.

This suggests that starting aspirin use in middle age and continuing it for at least a decade may offer cognitive benefits. Aspirin’s protective effects for dementia were mainly seen in people with pre-existing coronary heart disease (CHD).

Among CHD patients, low-dose aspirin use was associated with a 31% reduced risk of Alzheimer’s disease, 69% reduced risk of vascular dementia and 54% reduced risk of all-cause dementia. If you have CHD, it’s therefore possible that low-dose aspirin could provide dual benefits for your cardiovascular and cognitive health.

Aspirin’s Metabolic Magic: From Fat Burning to Hormone Balance

Aspirin also enhances your body’s use of glucose for energy while reducing the release of fatty acids from fat cells, particularly linoleic acid (LA), an omega-6 fat that’s a significant contributor to chronic disease.

This is crucial because most Americans have excess LA in their tissues, and it takes seven years of a low-LA diet to reduce it to healthy levels. Therefore, you want to avoid increasing LA release from fat stores into your body. It’s preferable to release LA gradually, allowing your liver to process it. Being water-soluble, you can eliminate it through urine without it being converted into inflammatory prostaglandins.

Notably, aspirin also lowers your baseline cortisol — indirectly by reducing inflammation, and directly by inhibiting an enzyme that converts inactive cortisone to active cortisol. Aspirin decreases stress-induced aldosterone production, potentially helping to lower blood pressure.

It increases your carbon dioxide and progesterone levels while inhibiting a major inflammatory pathway, NF kappa-B, which can help your body naturally boost the production of two important hormones: testosterone and progesterone.

Aspirin also uncouples mitochondria. This uncoupling of mitochondrial oxidative metabolism from ATP production can help increase your metabolic rate and aid in weight loss. Dinitrophenol (DNP), like aspirin, uncouples mitochondrial metabolism and causes significant weight loss. However, DNP’s effective dose is dangerously close to its toxic dose, making it too risky for clinical use and no longer available in the U.S.

Aspirin Purchasing Guidelines

If you decide to use aspirin, avoid coated extended-release versions due to their additives. Opt for immediate-release aspirin, which can be found on Amazon. Check the inactive ingredients list carefully — corn starch should be the only one listed. After thorough research, I found a product meeting these criteria. The suggested dosage is dependent on your circumstances 82 mg to 325 mg tablet daily with your largest meal.

I’m convinced of aspirin’s preventive value and now take 111 mg daily using Health Natura’s USP grade 60 gram aspirin powder for under $20. However, I use a 99% pure USP aspirin version that’s not in tablet form. I find its prometabolic, antilipolytic, anti-inflammatory, anticortisol, and anti-estrogen effects appealing, and its safety is well-established.

If you’re sensitive to aspirin, consider using a salicylic acid or willow bark supplement instead. When you take aspirin, your body metabolizes the acetylsalicylic acid into salicylic acid, which is responsible for aspirin’s anti-inflammatory, pain-relieving and antithrombotic effects. This compound is naturally found in willow bark.

Overall, aspirin is a versatile and underappreciated medication with a wide array of health benefits beyond its well-known cardiovascular applications. From cancer prevention and improved pregnancy outcomes to potential treatments for liver disease and cognitive decline, aspirin’s diverse effects warrant further research and consideration.

Its metabolic impacts and potential to influence hormone balance add another layer to its therapeutic potential. The breadth of aspirin’s potential benefits suggests that this common, inexpensive medication may have more to offer than health authorities are acknowledging in supporting overall health and preventing various chronic conditions.

– Sources and References

Posted in Brain, Diabetes, Fat, Hormones, Liver, Metabolism, Mortality, Pain, Pregnancy, Supplements | One Comment »

Posted by: admin | Posted on: August 23, 2024

Are Your Eyeglasses Worsening Your Vision?

<span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/08/07/are-your-eyeglasses-worsening-your-vision.aspx

Analysis by Dr. Joseph Mercola August 07, 2024

STORY AT-A-GLANCE

It’s often said that wearing glasses won’t worsen your vision, but there are cases when wearing glasses can cause problems with your eyesight
If your eyeglass prescription is based on your vision at 20 feet, then when you’re working on something up close, like your computer, your prescription is actually 20 times too strong; so, wearing those glasses while working all day will make your vision worse
For presbyopia, commonly known as age-related farsightedness, I recommend avoiding reading glasses, as they may make vision worse
Your eyes are highly susceptible to damage caused by linoleic acid, which should be avoided to protect vision health
Carotenoids, including lutein, zeaxanthin and astaxanthin, are beneficial for your eyes and may protect against age-related macular degeneration, cataracts and other eye conditions

It’s a common concern that if you wear eyeglasses, your eyes may become “dependent” on them. Then, when you take off your glasses, your vision might seem worse than before you started wearing them. While according to the American Academy of Ophthalmology wearing glasses won’t worsen your vision,¹ there are cases when wearing glasses can cause problems with your eyesight, even making vision worse.

This is particularly true if you wear the wrong glasses while doing work up close, such as on a computer. There are, however, a number of reasons why your vision may seem to worsen when you take your glasses off compared to before you started wearing them.

Why Might Your Eyesight Seem to Worsen After Wearing Glasses?

When you start wearing glasses, your brain adapts to the clearer and more focused vision they provide. Once you remove them, the sudden return to blurred vision can feel more pronounced because your brain has become accustomed to the clarity.

Further, glasses correct your vision by improving focus and detail. When you begin wearing them, you become more aware of what clear vision looks like. This increased awareness makes the contrast between corrected and uncorrected vision more noticeable. Glasses also help reduce eye strain by correcting your vision.

When you remove them, the strain from trying to focus without assistance can make your vision seem blurrier than before. The perception of worsening vision when you wear glasses can be more about your brain’s adaptation to corrected vision rather than a real decline in eye health.

Writing in The Conversation, James Andrew Armitage, professor of optometry at Deakin University in Geelong, Australia, and Nick Hockley, director of Deakin Collaborative Eye Care Clinic, said, “Some people sense an increasing reliance on glasses and wonder if their eyes have become ‘lazy’ … Once we are used to seeing clearly, our tolerance for blurry vision will be lower and we will reach for the glasses to see well again.”²

Reading Glasses for Presbyopia May Make Matters Worse

There are cases in which a reliance on glasses may worsen vision. For presbyopia, for instance, I recommend not wearing sunglasses and avoiding reading glasses. As you age, there’s a tendency to want to make font bigger to see text better, but I recommend resisting that temptation, as it’s only going to make matters worse.

People with presbyopia, commonly known as age-related farsightedness, have trouble focusing on objects close up. It commonly affects people beginning in their early- to mid-40s, progressively worsening until about age 65.³

If you have presbyopia, you may find that you need to hold books farther away in order to see them clearly. Other symptoms include blurred vision at a normal reading distance and eyestrain or headaches that occur after you’ve been reading or doing close-up work. The blurry close-up vision may be worse when you’re tired or in a dimly lit area.⁴

The conventional solution is typically reading glasses, which many keep with them throughout the day — in the kitchen, the car, the office and the bedroom — just to go about their daily activities. However, this may encourage your eyes to stay in one place instead of moving around — which is essential for healthy eyes.

Optometrist and eye health coach Taylor DeGroot uses a holistic, bioenergetic approach to eye health. In our interview, she noted, “Healthy eyes like to move a lot and they don’t like to just stay in one place and stare. That’s another bad habit people have. They stare and keep their eyes in one place. That’s also what glasses train the eyes to do.

Glasses have an optical center, so there’s one part in the glasses where you see most clearly. Glasses in a way are kind of visual confinement because they lock your eyes into one place.”

There’s also evidence that training your brain, namely targeting perceptual learning by repeatedly practicing a demanding visual task, may improve visual performance in people with presbyopia. In one study, the brain training enabled subjects to “overcome and/or delay some of the disabilities imposed by the aging eye.”⁵

A number of apps are available that offer this form of brain training for improved vision. In a study published in Scientific Reports, researchers explained that the vision benefits seemed to stem from changes in the brain — not in the eye itself:⁶

“This improvement was achieved without changing the optical characteristics of the eye. The results suggest that the aging brain retains enough plasticity to overcome the natural biological deterioration with age.”

In addition to avoiding reading glasses, also avoid squinting and simply blink instead. Blink multiple times until the text becomes clear, then relax your eyes to refocus. Brighter light may also help you read without increasing the font size on your tablet or computer, or using reading glasses. You can also use nutritional approaches to help stop the progression of many eye diseases, which I’ll discuss below.

Save This Article for Later – Get the PDF Now

Download PDF

Why You May Need Two Pairs of Glasses

In our interview, DeGroot highlighted little-known problems with prescription eyeglasses. If your prescription is based on your vision at 20 feet, then when you’re working on something up close, like your computer, your prescription is actually 20 times too strong. So, wearing those glasses while working all day will make your vision worse. She explains:

“If you’re doing your work and you’re using a prescription that’s set for 20/20, that glasses prescription is 20 times too strong for you. If you’re working on your computer, ideally you would be using a prescription that’s set for that distance.

I would say if you’re spending most of the day on the computer and you can go without the glasses, obviously, do that. But if your prescription is too high and you can’t see anything at near, just get another prescription that’s set for that distance.

I prefer two separate pairs of glasses. The problem with bifocals and progressives is that they lock your eyes. You can only see from a very specific part of the glasses, so that locks your eyes into that one position. That’s locking up your posture, and that’s also locking up the nervous system because eye movements obviously correlate with emotions.

When we think and access emotions, our eyes make certain movements. That’s actually how we access information. We use certain eye movements because the eyes are pattern addicts and so are the brain. When those two have to work together, the eyes are always working with the brain, basically because they’re part of it.

That’s why when you lock the eyes into any certain position, you’re not able to access your brain, your brain isn’t as fluid, your thinking isn’t as fluid, your body isn’t as fluid. That’s the big downside to wearing things like bifocals and progressives — they do lock your eyes into a certain position to see clearly.”

Important Carotenoids for Eye Health

Carotenoids, including lutein, zeaxanthin and astaxanthin, act as antioxidants, protecting your eyes from the damaging effects of oxidative stress and harmful light wavelengths. This protection helps prevent the development of age-related macular degeneration (AMD)⁷ and cataracts, which are common causes of vision impairment and blindness.

Lutein and zeaxanthin are concentrated in the macula,⁸ a small area of the retina responsible for central vision. They help filter out blue light from digital screens, which can damage your eyes over time. According to a team of researchers from Harvard Medical School and The University of Hong Kong, writing in the journal Nutrients:⁹

“As the peak wavelength of lutein’s absorption is around 460 nm which lies within the range of blue light, lutein can effectively reduce light-induced damage by absorbing 40% to 90% of incident blue light depending on its concentration.

The outer plexiform layer of the fovea, where the majority of axons of rod and cone photoreceptor cells are located, is the retinal layer having the highest density of macular carotenoids including lutein. Hence the photoreceptors are protected against photo-oxidative damages from blue light.”

While there are about 850 known carotenoids, most are not found in the human body¹⁰ and only lutein and zeaxanthin cross the blood-retina barrier to form macular pigment.¹¹ Not only are higher blood levels of lutein and other carotenoids associated with a lower risk of AMD, but one study found people with the highest lutein and zeaxanthin intake had a 65% lower incidence of neovascular AMD compared to those who consumed the least.¹²

In another study, those who consumed to most lutein had a 50% lower likelihood of cataracts than those who consumed the least.¹³ Glaucoma, another leading cause of blindness worldwide, is also linked to lutein. A systematic review revealed that lutein enhanced neuroprotection of retinal ganglion cells, helping to preserve synaptic activity.¹⁴

Foods rich in lutein and zeaxanthin include leafy greens such as spinach and kale, as well as eggs and yellow and orange fruits and vegetables. Even eating just 60 grams of spinach — about 1/2 cup — daily for four weeks was found to protect the eyes by increasing macular pigment density.^15,¹⁶ Following are 10 foods that are particularly rich sources of lutein.

Dark leafy greens, such as spinach and kale	Carrots
Broccoli	Egg yolks
Red and yellow peppers	Sweet corn
Avocados	Raspberries
Cherries	Paprika

Astaxanthin Is a Top Nutrient for Vision Health

Astaxanthin is another notable nutrient that has emerged as a top carotenoid for eye health and the prevention of blindness. Research shows it easily crosses into the tissues of your eye and exerts its effects safely and with more potency than any of the other carotenoids, without adverse reactions.

Astaxanthin improves many eye conditions, including retinal dysfunction caused by light, nonadvanced AMD and cataracts, while leading to improvements in visual acuity and vision-related functions.¹⁷

Krill oil is a great source of astaxanthin, but for higher doses a supplement works well. If you decide to give astaxanthin a try, I recommend starting with 4 milligrams (mg) per day and working your way up to about 8 mg per day — or more if you’re suffering from chronic inflammation.

Avoid Linoleic Acid to Protect Your Vision

Your eyes are highly susceptible to damage caused by polyunsaturated fats (PUFAs) such as linoleic acid (LA).^18,¹⁹ This is one reason why it’s important to ignore the mainstream advice to eat vegetable oils, which are more accurately defined as seed oils.

Seed oils, such as soybean, cottonseed, sunflower, rapeseed (canola), corn and safflower, are high in LA and hidden in virtually every processed food, including restaurant foods, and there’s virtually nothing more destructive to your body in producing age-related macular degeneration²⁰ and other chronic health problems.

LA is found in virtually every processed food, including restaurant foods, sauces and salad dressings, so to eliminate it you’ll need to eliminate most processed foods and restaurant foods from your diet. It’s also hidden in “healthy” foods like chicken and pork,²¹ as well as olive oil, which is often cut with cheaper seed oils.

DeGroot agrees, stating she believes it’s important to recognize this health threat and to make sure children aren’t overexposed, as LA builds up in tissues over time. Even at the age of 18, these lipids start building up in the eyes. “You can actually see it,” she says.

“One of the earliest ways that we can see degeneration in the eye is using a visual field test, because we’ll see parts of the visual field that are missing or little spots in the visual field that are missing before we actually see degeneration in the optic nerve.

That’s actually a really good early detection for glaucoma, because we’ll see the visual field defect before we see changes on the optic nerve. That’s one of the most sensitive tests we can do to catch things early.

With macular degeneration specifically, you see these spots that they call drusen, which is a buildup of calcium, lipids, and things like that. They’re very tiny, so you have to look very carefully in younger people. But it’s interesting how early these things actually start.”

Blue Light Is Another Threat to Healthy Eyes

Blue light emitted from digital screens may accelerate AMD, as it affects retinal and results in the death of photoreceptor cells in the macula.²² Retinal is essential in order to trigger photoreceptor cells to produce electrical signals. Kasun Ratnayake, from the University of Toledo, commented:²³

“It’s toxic. If you shine blue light on retinal, the retinal kills photoreceptor cells as the signaling molecule on the membrane dissolves. Photoreceptor cells do not regenerate in the eye. When they’re dead, they’re dead for good.”

It’s important to note that blue light is likely only able to cause this damage if you have an excess of LA. If your LA levels are normal, blue light is far less likely to cause this damage. That said, it’s important to avoid blue light, as it reduces melatonin in your lens, which is a contributor to cataracts.

Avoiding blue light becomes even more important if you have cataract surgery, as your natural lens has some built-in protection against blue light whereas the artificial lens does not. UV-blocking artificial lenses are available through special order, but it’s not standard. So, if you’ve had cataract surgery, it’s especially important to wear blue-blocking glasses when you’re looking at screens and spending time in artificial lighting indoors.

If you’re interested in optimizing your vision instead of just relying on glasses to cover up the problem, search for a neuro-optometrist or an optometrist that specializes in vision therapy. They assess how your eyes work together and not just “Do you have 20/20 vision?” To find a vision therapist, check out the College of Optometrists in Vision Development’s website.

– Sources and References

Posted in Brain, Cataracts, Eyes, Linoleic Acid, Supplements | No Comments »

Posted by: admin | Posted on: July 30, 2024

Estrogen and Dementia: Challenging Conventional Wisdom

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/07/29/estrogen-and-dementia.aspx

Analysis by Dr. Joseph Mercola July 29, 2024

STORY AT-A-GLANCE

A new study in JAMA Neurology challenges the long-held belief that estrogen protects against dementia in women. The research found that pure estrogen receptor antagonists and aromatase inhibitors were associated with a lower risk of dementia across women’s lifespans
This study contradicts previous research suggesting estrogen’s protective effects on the brain, particularly in post-menopausal women
The findings imply that other substances with anti-estrogenic effects, such as progesterone and certain vitamins, might also protect against dementia
The medical establishment’s response to this study has been mixed, with some attempts to misrepresent or downplay its implications
Natural anti-estrogenic approaches, including diet, exercise, and progesterone supplementation, may offer potential strategies for reducing dementia risk

For decades, mainstream medicine has promoted the idea that estrogen is protective for the brain, particularly in post-menopausal women. The conventional wisdom has been that the increased risk of dementia in older women is due to the “deficiency” of estrogen that occurs during menopause. However, a groundbreaking new study published in JAMA Neurology challenges this long-held belief, providing compelling evidence that blocking estrogen may lower the risk of dementia.¹

Research Causing a Paradigm Shift

This recent study is perhaps the most damaging piece of evidence I’ve encountered in the last five years that contradicts the claim that estrogen protects the brain. The research, published in one of the most prestigious medical journals, found that using pure estrogen receptor antagonists or aromatase inhibitors was associated with a lower risk of developing dementia across the entire expected female lifespan.

What makes this study particularly significant is its use of “pure” anti-estrogen drugs. Previous studies showing protective effects against dementia often used selective estrogen receptor modulators (SERMs) like clomiphene, tamoxifen, or raloxifene. These drugs have anti-estrogenic effects in some tissues but are potent estrogens in others.

This dual nature allowed the medical establishment to explain away the protective effects as actually confirming the “benefit” of estrogen for the brain, since SERMs can be estrogenic in brain tissue.

However, the current study leaves no room for such interpretations. It examined the effects of pure estrogen receptor antagonists like Faslodex (fulvestrant) and its nonsteroidal analog Elacestrant, as well as aromatase inhibitors like letrozole. These drugs are highly selective blockers of estrogen receptors with no other known major effects.

The fact that aromatase inhibitors, which reduce the body’s production of estrogen, also showed protective effects against dementia further solidifies the case against estrogen as a protective factor for brain health.

Rethinking Estrogen’s Role

These findings suggest that other substances with anti-estrogenic effects might also have protective effects against dementia. This includes:

Progesterone
Fat-soluble vitamins (A, D, E, K)
Aspirin
DHT (dihydrotestosterone)
Flavones and flavanones (apigenin, naringenin, chrysin, quercetin, luteolin)

The study’s results were particularly pronounced in patients under 75 years of age, indicating that anti-estrogenic interventions might be most effective when started earlier in life.

Save This Article for Later – Get the PDF Now

Download PDF

The Medical Establishment’s Response

It will be interesting to see how the medical establishment responds to this study. Given its publication in JAMA, a highly respected journal, it will be difficult to dismiss outright. However, we’re already seeing some concerning trends in how the information is being presented and interpreted.

Nefarious Tactics in Reporting

1. Progesterone misrepresentation — Some popular press articles reporting on this study have attempted to implicate progesterone as a co-culprit with estrogen. They mention that the anti-estrogenic drugs in the study are used to treat breast cancers caused by “estrogen and progesterone.”

This misrepresentation could lead the public to believe that progesterone increases the risk of dementia or cancer, when in fact, the opposite is true. The drugs mentioned in the study target exclusively estrogen and estrogen-positive cancers, not progesterone-positive cancers. Moreover, progesterone itself acts as both an estrogen receptor antagonist and an aromatase inhibitor, potentially offering protection against dementia based on the study’s findings.

2. Misleading terminology — The study itself uses the term “hormone modulating therapy” (HMT) to describe the anti-estrogenic treatments. This vague terminology avoids stating that the therapy is purely estrogen-blocking in nature, unlike SERM drugs which have mixed effects. It also fails to clarify that the therapy targets solely estrogen, not progesterone.

These tactics appear to be attempts to twist the science to serve pharmaceutical interests and avoid stating the obvious conclusion based on the study’s findings: that estrogen may be a cause of dementia and Alzheimer’s, while anti-estrogenic therapy (including natural options like progesterone) may be protective and possibly even therapeutic for existing dementias.

A Critical Examination of the Estrogen Hypothesis

For years, the medical community has operated under the assumption that estrogen is beneficial for brain health, particularly in post-menopausal women. This belief has led to widespread use of hormone replacement therapy (HRT) and other estrogen-boosting interventions. However, this new study forces us to critically examine this hypothesis.

The idea that estrogen deficiency causes cognitive decline in older women has been based largely on observational studies and the timing of when women typically experience increased rates of dementia (post-menopause). However, correlation does not imply causation, and there are many other factors that change as women age that could contribute to cognitive decline.

Moreover, previous clinical trials of hormone replacement therapy have yielded mixed results regarding cognitive function and dementia risk. The Women’s Health Initiative Memory Study,² for instance, found that combined estrogen-progestin therapy actually increased the risk of dementia in postmenopausal women.

The current study provides strong evidence that blocking estrogen or reducing its production may be protective against dementia. This suggests that estrogen might actually be harmful to brain health, rather than protective. If this is the case, it would explain why rates of dementia increase after menopause — not because of estrogen deficiency, but because of the cumulative effects of lifelong estrogen exposure.

Natural Anti-Estrogenic Approaches

If blocking estrogen indeed proves protective against dementia, it opens up a range of potential preventive strategies beyond pharmaceutical interventions. Many natural compounds and lifestyle factors can have anti-estrogenic effects:

1. Cruciferous vegetables — Compounds in broccoli, cauliflower, and Brussels sprouts can help metabolize estrogen.

2. Green tea — Contains compounds that may inhibit aromatase, the enzyme that produces estrogen.

3. Exercise — Regular physical activity can help balance hormones and may have anti-estrogenic effects.

4. Sleep — Proper sleep hygiene is crucial for hormonal balance, including estrogen regulation.

5. Stress management — Chronic stress can disrupt hormone balance. Techniques like meditation, yoga, or deep breathing can help.

6. Vitamin D — This fat-soluble vitamin has been shown to have anti-estrogenic effects.

7. Progesterone — As mentioned earlier, natural progesterone can act as an estrogen antagonist.

The Role of Progesterone

It’s worth delving deeper into the role of progesterone, given its potential importance in light of this study’s findings. Progesterone is often overlooked in discussions about hormones and brain health, with most of the focus being on estrogen. However, progesterone has several properties that make it potentially neuroprotective:

1. Estrogen receptor antagonist — Progesterone can block the effects of estrogen in certain tissues.

2. Aromatase inhibitor — It can reduce the production of estrogen in the body.

3. Neuroprotective effects — Independent of its effects on estrogen, progesterone has been shown to have direct neuroprotective properties in animal studies.

4. Anti-inflammatory — Progesterone can reduce inflammation in the brain, which is thought to play a role in the development of dementia.

Given these properties, and the findings of the current study, it’s possible that progesterone supplementation could be a natural way to potentially reduce dementia risk. However, more research is needed to confirm this hypothesis.

How to Use Progesterone

Before you consider using progesterone it is important to understand that it is not a magic bullet, and that you get the most benefit by implementing a Bioenergetic diet approach that allows you to effectively burn glucose as your primary fuel without backing up electrons in your mitochondria that reduces your energy production. My new book, “Cellular Health: The Unified Theory of All Disease for Ultimate Longevity and Joy” comes out very soon and covers this process in great detail.

Ideal Way to Administer Progesterone

However, please understand that it is perfectly legal for any physician to recommend an off-label indication for a drug to their patient. In this case progesterone is a natural hormone and not a drug and is very safe even in high doses. This is unlike synthetic progesterone called progestins that are used by drug companies, but frequently, and incorrectly, referred.

It is imperative to avoid using any synthetic vitamin E (alpha tocopherol acetate — the acetate indicates that it’s synthetic). Natural vitamin E will be labeled “d alpha tocopherol.” This is the pure D isomer, which is what your body can use. There are also other vitamin E isomers, and you want the complete spectrum of tocopherols and tocotrienols, specifically the beta, gamma, and delta types, in the effective D isomer.

There are also other vitamin E isomers, and you want the complete spectrum of tocopherols and tocotrienols, specifically the beta, gamma, and delta types, in the effective D isomer. As an example of an ideal vitamin E you can look at the label on our vitamin E in our store. You can use any brand that has a similar label.

You can purchase pharmaceutical grade bioidentical progesterone as Progesterone Powder, Bioidentical Micronized Powder, 10 Grams for about $40 on many online stores like Amazon. That is nearly a year’s supply, depending on the dose you choose.

However, you will need to purchase some small stainless steel measuring spoons as you will need a 1/64 tsp which is 25 mg and a 1/32 tsp which is 50 mg. A normal dose is typically 25 to 50 mg and is taken 30 minutes before bed, as it has an anti-cortisol function and will increase GABA levels for a good night’s sleep.

If you are a male or non-menstruating woman you can take the progesterone every day for four to six months and then cycle off for one week. The best time of day to take progesterone is 30 minutes before bed as it has an anti-cortisol function and will increase GABA levels for a good night’s sleep.

This is what I have personally doing for over a year with very good results. I am a physician so do not have any problems doing this. If you aren’t a physician you should consult one before using this therapy, as transmucosal progesterone therapy requires a doctor’s prescription.

Implications for Current Medical Practices

If the findings of this study are corroborated by further research, it could have significant implications for current medical practices:

1. Hormone replacement therapy — The use of estrogen-based HRT for menopausal symptoms and osteoporosis prevention may need to be reconsidered, especially in women with a family history of dementia.

2. Breast cancer treatment — The potential cognitive benefits of anti-estrogen therapies used in breast cancer treatment could be an additional factor to consider when weighing treatment options.

3. Preventive strategies — Healthcare providers may need to start considering anti-estrogenic approaches as part of dementia prevention strategies, particularly in high-risk individuals.

4. Research focus — This study may shift the focus of dementia research towards investigating the potential harmful effects of estrogen on the brain, rather than its presumed protective effects.

Challenges and Controversies

Despite the strength of this study’s findings, it’s likely to face significant pushback from certain sectors of the medical community. The estrogen hypothesis has been deeply ingrained in medical thinking for decades, and paradigm shifts often face resistance.

Moreover, there are powerful financial interests at stake. The hormone replacement therapy industry is worth billions of dollars globally. A shift away from estrogen-based therapies could have significant economic implications.

There’s also the challenge of reconciling these findings with other known effects of estrogen. For instance, estrogen is known to have protective effects against osteoporosis. How do we balance the potential cognitive risks with other health considerations? These challenges underscore the need for more research in this area.

So, while this study provides compelling evidence, it’s just one piece of the puzzle. We need large-scale, long-term studies to fully understand the relationship between estrogen, anti-estrogen therapies, and cognitive health.

A Call for Open-Minded Inquiry

The findings of this study challenge long-held beliefs about estrogen and brain health. They suggest that our understanding of hormones and cognitive function may be more complex than previously thought.

As a medical professional and health advocate, I believe it’s crucial that we approach these findings with an open mind. We must be willing to question our assumptions and follow the evidence where it leads, even if it contradicts established beliefs.

For individuals concerned about cognitive health, these findings offer new avenues to explore. While it’s too early to make definitive recommendations based on this single study, it may be worth discussing anti-estrogenic strategies with your healthcare provider, especially if you have a family history of dementia.

Remember, hormonal balance is complex and individualized. What works for one person may not work for another. Always consult with a qualified healthcare professional before making significant changes to your health regimen.

As we move forward, it’s my hope that this study will stimulate further research into the relationship between hormones and brain health. By continuing to ask questions and challenge our assumptions, we can work towards a better understanding of how to prevent and treat devastating conditions like dementia and Alzheimer’s disease.

In the meantime, focusing on overall brain health through a balanced diet, regular exercise, stress management, and cognitive stimulation remains a prudent approach for everyone. As we await further developments in this exciting area of research, these lifestyle factors continue to be our best defense against cognitive decline.

– Sources and References

Posted in Alzheimer's, Dementia, Estrogen, Hormones, Supplements, Vitamins | One Comment »

Posted by: admin | Posted on: July 19, 2024

Relationship Found Between Creatine in the Brain and Recovery From Traumatic Stress

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/07/17/creatine-brain-benefits.aspx

Analysis by Dr. Joseph Mercola July 17, 2024

STORY AT-A-GLANCE

While creatine is well-known for its benefits in physical performance and muscle health, its potential advantages for brain health are becoming increasingly recognized
Creatine, which is naturally found in muscle cells and the brain, may assist in recovery from the stress of traumatic experiences
Creatine is used by your body to convert adenosine diphosphate (ADP) to adenosine triphosphate (ATP) — the main energy currency of cells — and may be a neurobiological marker of stress reactivity and recovery
Veterans with higher levels of creatine in the anterior cingulate cortex — a brain region involved in processing negative emotional states — had greater reductions in stress since their last traumatic experience
Creatine is found only in animal-based food — not plants — as well as in supplement form; grass fed meats are among the best sources of creatine, but avoid pork and chicken, as they typically have high levels of linoleic acid

Creatine is a substance naturally found in muscle cells and the brain. It helps your muscles produce energy during high-intensity exercise or heavy lifting. Most of the body’s creatine is stored in muscles, where it’s used for quick bursts of energy.

As such, creatine is commonly used by athletes to improve performance, as it’s immediately used by your body to convert adenosine diphosphate (ADP) to adenosine triphosphate (ATP) — the main energy currency of cells — and supply energy muscles need for contraction. However, creatine also helps provide energy to your brain and research suggests it may play an important role in recovery from traumatic stress.

Unraveling the Neurobiological Reasons Why Some Develop PTSD — and Others Don’t

While creatine is well-known for its benefits in physical performance and muscle health, its potential advantages for brain health are becoming increasingly recognized. In a study involving U.S. veterans, researchers with the University of Utah School of Medicine revealed the compound may assist in recovery from the stress of traumatic experiences.

“There is emerging preclinical evidence that creatine (Cr), a molecule critical to brain bioenergetics, may be a neurobiological marker of stress reactivity and recovery,” the scientists wrote in the Journal of Affective Disorders.¹ They noted that little is known about why some individuals recover from traumatic events while others develop post-traumatic stress disorder (PTSD) and other psychological conditions.

The symptoms of PTSD can be categorized into four main types: intrusive memories, avoidance, negative changes in thinking and mood, and changes in physical and emotional reactions. These symptoms can vary over time and differ from person to person.

According to the study, about 70% of adults worldwide have experienced at least one traumatic life event. Yet, the lifetime prevalence of PTSD is 6.1%, “implying that most individuals exhibit robust recovery from traumatic life events.” The researchers explain:²

“This line of research suggests that individual differences in the stress recovery process may be involved in the pathogenesis of PTSD. Thus, understanding factors associated with recovery from traumatic life events may provide novel insights into the assessment, prevention and treatment of PTSD and other trauma-related conditions.”

While early childhood experiences, individual personality and the number of traumatic experiences a person has likely play a role, neurobiological factors may also be involved. Toward this end, the anterior cingulate cortex (ACC) is a brain region involved in processing negative emotional states.³ Located in the frontal lobe, the ACC plays a critical role in various cognitive and emotional processes.

The ACC is particularly active during experiences of negative emotions, such as pain, sadness and fear. It’s also involved in the regulation of emotional responses, decision-making and the anticipation of adverse outcomes. The researchers wondered if neurochemical factors were also involved, leading them to creatine:⁴

“Existing research suggests that Cr concentrations in the ACC are indicative of stress-related mental health conditions, which are often precipitated by traumatic life events. Moreover, preclinical models in animals indicate exposure to traumatic stress reduces ACC Cr levels. Nevertheless, it remains unclear to what extent traumatic life events in humans are associated with Cr concentrations in the brain.”

Creatine May Help Recovery From Traumatic Stress

To help reveal the relationship between creatine concentrations in the ACC and stress related to traumatic life events, the researchers conducted brain scans on 25 U.S. veterans and collected data on their mental health status and history of traumatic events.

Veterans with higher levels of creatine in the ACC had greater reductions in stress in the time since their last traumatic experience.⁵ “ACC concentrations of Cr may be an important neurochemical factor related to stress recovery. Future work should investigate Cr as a possible protective factor against the effects of traumatic stress,” the study concluded.⁶

Again, creatine enables ATP regeneration, which plays a crucial role in cellular function. And, as PsyPost noted, “The researchers hypothesized that creatine levels in the brain could influence an individual’s ability to recover from trauma by affecting the energy availability in critical brain regions.”⁷

This is an example of why you need ample cellular energy for optimal brain function. Your brain, being the most energy-dependent organ, makes up only about 2% of your bodyweight yet consumes 20% of the energy used by your entire body.⁸ Therefore, a surplus of cellular energy creation is necessary to have the ability to allow your brain to work optimally.

Without enough cellular energy, not only is your ability to think and make good decisions compromised, but mental health is subsequently compromised as well.

Save This Article for Later – Get the PDF Now

Download PDF

How to Increase Cellular Energy

Avoiding dietary pitfalls like excess linoleic acid (LA), in the form of vegetable and seed oils, is instrumental in optimizing mitochondrial function and increasing cellular energy. Factors like estrogen and endotoxins can also deplete your cellular energy. Meanwhile, improving your mitochondrial energy production can also help bring you joy, which is essential for mental health.

Creatine, however, is also important. By supporting ATP regeneration, creatine helps improve the efficiency of energy utilization in cells. Creatine may also support mitochondrial function by enhancing the availability of ATP, improving overall cellular energy metabolism.

The following are key concepts that need to be integrated to improve all cellular energy, and certainly energy produced for your brain. They all revolve around improving mitochondrial function:

Lower LA as much as possible — This is the single most important mitochondrial poison. Since there’s no downside to limiting your LA, you’ll want to keep it as low as possible, which you do by avoiding high-LA foods, including vegetable and seed oils found in most ultraprocessed foods.
Lower estrogen excess — Estrogen, even bioidentical, is nearly as dangerous as LA in destroying mitochondrial function. Aside from avoiding all estrogen supplements and plastics, as they are potent sources of xenoestrogens, you can take trans mucosal progesterone, not oral or transdermal, as it is a potent estrogen blocker.
Make sure your thyroid is working well — Thyroid function is absolutely essential to make sure you have a high metabolic rate and produce plenty of ATP. If you are going to do a thyroid test, it is important your TSH be well-suppressed and below 0.5. You can also confirm by taking your temperature first thing in the morning and two hours after meals. Low temperatures indicate low thyroid activity.
Optimize your microbiome — This is also key, as not only are 95% of people metabolically inflexible, but because of mitochondrial poisons their microbiome is out of balance with a preponderance of pathogenic endotoxin-producing bacteria, another potent mitochondrial poison.

Creatine’s Many Brain Benefits

Stuart Phillips, Ph.D., is a professor of kinesiology at McMaster University in Canada. He’s an expert in growing and maintaining muscle mass as you age. In an interview with Rhonda Patrick, Ph.D.,⁹ he commented on using creatine regularly, “You know, the stuff now with creatine that they’re uncovering that makes me think, ‘Maybe this should be part of my regular routine.’ Actually [it] has less to do with the muscle and more to do with the brain and cognitive performance.”

In fact, creatine monohydrate is one supplement that Phillips said makes his short list for its benefits for muscle growth and brain health. “Its effects are pretty mild on muscle, but they’re there. They’re potent. They last. Now the brain and the cognitive side of things … the evidence is growing in that area too.”¹⁰

Research has demonstrated that creatine plays a critical role in the function of the brain and other tissues that have high energy demand.¹¹ Children who have genetic errors of creatine synthesis present with severe neurological symptoms and patients with other neurodegenerative diseases benefit from creatine supplements. Other research suggests reduced creatine is associated with depression and anxiety.¹²

Creatine also has demonstrated beneficial effects in mice with Parkinson’s-like disease.¹³ It prevented 90% of the typical drop in dopamine levels that are associated with several of the serious symptoms, including loss of muscle function and speech impairment.

In an experimental model mimicking the effects of a mild traumatic brain injury, one research team even found supplementing with creatine helped cognitive processing during oxygen deprivation.¹⁴ They concluded, “This is the first demonstration of creatine’s utility as a neuroprotective supplement when cellular energy provision is compromised.”

Other research, published in Nutrition Reviews, found creatine supplementation enhanced memory performance in healthy adults, particularly those aged 66 to 76 years.¹⁵ The study concluded:¹⁶

“These beneficial effects from creatine supplementation on memory performance may be related to creatine’s ability to influence brain bioenergetics. For example, creatine elevates phosphocreatine and ATP levels and increases oxidative phosphorylation in synaptosomes and isolated brain mitochondria. In hippocampal neuron cultures, creatine stimulates mitochondrial activity.”

The Best Sources of Creatine

For individuals looking to increase their creatine intake through diet, including a variety of creatine-rich foods can be beneficial. Creatine is found only in animal-based food — not plants. Grass fed meats are among the best sources of creatine. Avoid pork and chicken, as they typically have high levels of LA.

While grass fed meats can contribute to creatine intake, they may not provide the same high doses that can be achieved through creatine supplementation. Of the different formulations of creatine on the market, creatine monohydrate is the one that has been studied most frequently and therefore has the strongest evidence of health benefits.

It’s important to choose creatine from a reputable manufacturer. Clinical trials that have lasted up to five years have reported no adverse effects in healthy individuals.¹⁷ However, it is important to stay within the recommended dose.

Some people are sensitive to using creatine and feel bloated if they don’t drink enough water with the supplement. However, most of the time it goes away in just a few hours. Factors that affect bloating include how much water you drink, the intensity of your workouts and your diet.

If you’re a vegan or a vegetarian, you might consider using creatine to help protect brain health. Research suggests creatine supplements may boost cognitive function in vegetarians.¹⁸

– Sources and References

Posted in ATP, Brain, Diet, Estrogen, Linoleic Acid, Muscle, Stress, Supplements | No Comments »

« Previous Entries

Next Entries »

LeanMachine Health Solutions

Nutrition for Health

Supplements

now browsing by category

STORY AT-A-GLANCE

The Impact of PCOS on Women’s Mental Health

What Causes PCOS?

Save This Article for Later – Get the PDF Now

Inositol Is Effective for PCOS

Consider Taking a Carnitine Supplement

Other Supplements to Help Manage PCOS Better

Reduce Your Exposure to ‘Forever Chemicals’

Plastics Cause Hormonal Imbalances

How to Use Progesterone

Ideal Way to Administer Progesterone

How to prevent HUGE health problems: Avoid liver disease naturally

Warning: NAFLD can progress to steatohepatitis

Silymarin in milk thistle helps restore liver cells

Curcumin in turmeric combats NAFLD

Glutathione: The body’s ‘master’ antioxidant is crucial for liver health

N-acetyl cysteine renews glutathione

Vitamin C can help you to avoid fat buildup around the liver

Alpha-lipoic acid (ALA) enhances the effects of glutathione

Show your liver some love with an organic diet

Breast cancer surgery taxes the immune system and leads to the spread of cancer cells

Anti-inflammatory agents show promise in supporting the immune system, fighting the formation of cancer cells

Favor anti-inflammatory foods and supplements to support your immune system

STORY AT-A-GLANCE

Are You Getting Enough Magnesium?

The Effects of Magnesium on the 12 Hallmarks of Aging

Save This Article for Later – Get the PDF Now

How Magnesium Can Boost Sleep Quality to Fight Aging

Dietary Recommendations for Increasing Your Magnesium Intake

Other Strategies to Boost Your Magnesium Intake

Curcumin in turmeric has powerful protective effects

Curcumin helps alleviate serious pulmonary conditions

Curcumin targets cancer cells at virtually every stage of growth

Heart-healthy turmeric tea may help fight cardiovascular disease

How turmeric offers value for many other chronic (unwanted) conditions

How can I take turmeric as a tea?

STORY AT-A-GLANCE

Why Magnesium Deficiency Puts Your Health at Risk

Magnesium Boosts Brain Health

Save This Article for Later – Get the PDF Now

The Role of Magnesium in Aging

Magnesium for Migraines, High Blood Pressure, Osteoporosis and More

What Are the Best Sources of Magnesium?

STORY AT-A-GLANCE

Aspirin’s Role in Cancer Prevention

Aspirin Improves Pregnancy Outcomes During Influenza Infection

Save This Article for Later – Get the PDF Now

Aspirin Therapy Shows Promise for Fatty Liver Disease

Aspirin Improves Mortality Rates in the ICU

Aspirin’s Role in Preventing Diabetes and Abdominal Aortic Aneurysms

Aspirin’s Impressive Anti-Fibrotic Effects

Long-Term Aspirin Use Offers Cognitive Benefits

Aspirin’s Metabolic Magic: From Fat Burning to Hormone Balance

Aspirin Purchasing Guidelines

STORY AT-A-GLANCE

Why Might Your Eyesight Seem to Worsen After Wearing Glasses?

Reading Glasses for Presbyopia May Make Matters Worse

Save This Article for Later – Get the PDF Now

Why You May Need Two Pairs of Glasses

Important Carotenoids for Eye Health

Astaxanthin Is a Top Nutrient for Vision Health

Avoid Linoleic Acid to Protect Your Vision

Blue Light Is Another Threat to Healthy Eyes

STORY AT-A-GLANCE

Research Causing a Paradigm Shift

Rethinking Estrogen’s Role

Save This Article for Later – Get the PDF Now

The Medical Establishment’s Response

Nefarious Tactics in Reporting

A Critical Examination of the Estrogen Hypothesis

Natural Anti-Estrogenic Approaches

The Role of Progesterone

How to Use Progesterone

Ideal Way to Administer Progesterone

Implications for Current Medical Practices

Challenges and Controversies