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This Powerful, Ancient Herb Offers Impressive Benefits
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/07/22/jiaogulan-immortality-herb.aspx
Analysis by Dr. Joseph Mercola July 22, 2025
Story at-a-glance
- Used since 1406 CE in Chinese medicine, jiaogulan enhances stamina, lowers cholesterol, and supports metabolism, earning it the nickname “immortality herb” for its powerful benefits
- With an Oxygen Radical Absorbance Capacity (ORAC) value eight times higher than green tea, jiaogulan protects against cellular damage by neutralizing free radicals and reducing oxidative stress, which are key factors in aging and chronic disease
- Jiaogulan activates 5′ adenosine monophosphate-activated protein kinase (AMPK), your body’s energy switch, to enhance insulin sensitivity, block fat storage, and support cholesterol clearance — making it an effective ally in weight and blood sugar control
- This herb detoxifies the liver, improves circulation, and lowers inflammation through different flavor compounds, offering relief for conditions like fatty liver, high blood pressure, and chronic inflammation
- Studies show jiaogulan can shrink tumors, block cancer cell growth, and boost immunity — while sparing healthy tissue. Its natural compounds work across more than 30 cancer types, making it a promising adjunct therapy
When it comes to popular herbs in traditional Chinese medicine (TCM), you probably think of ginseng, goji berries, and astragalus. But have you heard of jiaogulan? This herb has a long history in TCM and is revered for promoting longevity, stamina, cardiovascular health, and more. Now, modern science is beginning to confirm these ancient claims with hard data.
One of the reasons jiaogulan is becoming widely appreciated is its high antioxidant content. According to studies, this humble plant has eight times the antioxidant power of green tea, earning it the name “the immortality herb.”
The Herb That Promotes Longevity — Basic Facts About Jiaogulan
Jiaogulan (Gynostemma pentaphyllum) is a creeping perennial herb that belongs to the Cucurbitaceae family. It’s also known by other names, such as southern ginseng or fairy herb, and is widely used in Northeast and Southeast Asia.1,2 In a New York Post article, Dr. Michael Aziz, a board-certified internal medicine physician, provides insight as to why jiaogulan is rising in popularity in recent years.3
• Jiaogulan has been used in folk medicine for centuries — One study notes that its use dates back to 1406 CE, when it was identified as a valuable survival food. However, in the U.S., very few people know about it, Aziz said. Some of jiaogulan’s benefits include helping boost metabolism, lower cholesterol, and promote longevity.
• This herb surpasses green tea’s antioxidant levels — Oxygen Radical Absorbance Capacity (ORAC) is a laboratory test that measures how well a food or substance neutralizes harmful free radicals. According to Aziz, jiaogulan’s ORAC value is eight times higher than green tea. To put it simply, the higher the ORAC score, the better the food protects your cells.
• Jiaogulan is available as an herbal tea or a supplement — Aziz says he consumes 900 milligrams of jiaogulan daily, brewing 1 to 2 teaspoons of jiaogulan tea leaves in 250 milliliters of water. He describes its flavor as bitter, earthy, and slightly sweet.
• The herb’s bitterness comes from saponins — In particular, jiaogulan contains gypenosides, a type of saponin that’s similar to the ginsenosides in ginseng. Aziz explains:
“Gypenosides stimulate AMP-activated protein kinase, an enzyme that plays a central role in maintaining cellular energy balance. They have antioxidant effects. They also improve insulin signaling and improve the function of mitochondria, which are the batteries of our cells. Those are some of the hallmarks of aging that affect longevity.”4
How This Ancient Herb Restores Balance and Curbs Inflammation
A recently published study featured in the Journal of Functional Foods offered a fresh look at how jiaogulan offers multiple benefits in body. After conducting an in-depth review of existing pharmacological literature on gypenosides and jiaogulan extracts.5
The study outlines how this herb influences multiple systems, particularly through its detoxifying, anti-inflammatory, and circulation-supporting effects.
• Jiaogulan can be categorized into three flavors — These are sweet, bitter, and slightly bitter. Each flavor exhibits distinct efficacy and effects. For example, in TCM, the bitter gypenosides are believed to clear “heat” and reduce inflammation, toxic buildup, and oxidative stress, while sweet compounds promote healthy organs, blood, and “qi” (your life force or energy). According to the researchers:
“The bitter taste and cold nature of GP [Gynostemma pentaphyllum] are particularly effective in clearing heat and detoxifying the body, making it beneficial for conditions such as viral hepatitis, chronic gastroenteritis, and chronic bronchitis [sic].
In addition, the sweet taste of GP nourishes the heart and protects the liver, benefits the qi and blood better, and is more effective against hyperlipidemia, hypertension, fatty liver, insomnia, and headaches.”
• The study highlights jiaogulan’s antioxidant effects — According to their research, this herb helps scavenge harmful molecules like DPPH and hydroxyl radicals before they inflict long-term damage. An overload of reactive oxygen species (ROS) in the body causes oxidative stress, which leads to numerous chronic diseases, including cancer, hypertension, diabetes, and atherosclerosis.
• Jiaogulan also has beneficial effects for diabetics — This herb is a valuable dietary ally for those managing diabetes, offering metabolic support while reducing reliance on pharmaceutical drugs.
Jiaogulan protects and repairs pancreatic beta cells, which are responsible for producing insulin, and enhances the production of key antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GSH-px), activating the Nrf2 signaling pathway to shield these cells from oxidative damage. It also inhibits alpha-glucosidase and alpha-amylase — enzymes that break down carbohydrates into glucose — thereby slowing the rise in blood sugar after meals.
• The herb also supports liver health — Jiaogulan has hepatoprotective effects, meaning it supports liver detoxification, protects against liver injury, and even shows promise in treating nonalcoholic fatty liver disease (NAFLD). According to the researchers:
“Through an experimental liver disease model induced by carbon tetrachloride (CCl4), GP has been shown to significantly alleviate hepatocyte necrosis and liver injury, which involves downregulation of Bax and cleaved PARP expression and upregulation of Bcl-2 expression.
In summary, GP has demonstrated extensive activity and application prospects in liver protection through various mechanisms, providing valuable natural resources for the development of new liver disease treatment drugs.”6
Overall, this research paper shows how jiaogulan works across systems to restore overall balance — something modern approaches often miss. Rather than just being another “anti-inflammatory” herb, it supports deep, systemic regulation that aligns both ancient and modern views of how healing should work.
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Jiaogulan Actively Reprograms Fat and Cholesterol Metabolism
Recent research published in The Journal of Ethnopharmacology explored the specific compounds in jiaogulan responsible for its ability to regulate blood fats, including triglycerides and cholesterol. The study aimed to isolate which active substances are doing the work and map out the exact biological processes involved in their lipid-lowering effects.7
• The researchers looked at 101 individual compounds to identify their effect on lipid levels — They found that jiaogulan doesn’t just block fat absorption or reduce calorie intake. Instead, it goes deeper — modifying how fat is created, stored, and burned inside your body. In one major pathway, it suppresses enzymes that are responsible for turning excess calories into triglycerides (stored fat), while boosting those that help the body break down and use existing fat for energy.
By activating this switch, jiaogulan addresses one of the core drivers of weight gain and high triglycerides — excess lipogenesis, or the internal manufacture of fat from sugars and carbs.
• For cholesterol, the herb uses a different set of tools — It regulates genes that control cholesterol synthesis in the liver. At the same time, it improves how the liver clears out excess cholesterol by enhancing LDL receptor activity. These receptors pull LDL (“bad” cholesterol) from the blood and break it down.
• Jiaogulan also encourages bile acid production — Bile acids are made from cholesterol, so when your body makes more bile, it uses up cholesterol in the process.
The study also highlighted 5′ adenosine monophosphate-activated protein kinase (AMPK) activation as a central player in how jiaogulan supports metabolic health. AMPK is like a cellular thermostat for energy. When it senses low energy in the cell, it triggers pathways to increase fuel usage and reduce storage. Jiaogulan’s gypenosides flip that switch, which leads to increased fat burning, improved insulin sensitivity, and better blood sugar control.
For those struggling with stubborn weight, high triglycerides, or borderline cholesterol, this herb offers multiple levers of support. It doesn’t require a complete lifestyle overhaul to begin making a difference — it meets the body where it is and helps it respond more efficiently to the energy it already has.
Earlier Research Points to Jiaogulan’s Anticancer Benefits
Studies have highlighted this herb’s anticancer effects, and a comprehensive review published in the Chinese Medicine journal demonstrates this. After examining 108 peer-reviewed studies, the researchers confirmed that jiaogulan has broad-spectrum anticancer activity across 30 different cancer cell lines, while leaving normal cells largely unharmed.8
• The study included a wide range of tumor types from leukemia to liver, breast, and colon cancers — In one clinical report, patients receiving Gynostemma pentaphyllum (GpM) therapy had far lower relapse and metastasis rates compared to untreated controls (11.9% vs. 72.4% for relapse, and 8.5% vs. 55.2% for metastasis). Patients also showed improved immune responses, a key measure of resilience during cancer treatment.
• In terms of how fast and how powerfully GpM worked, the numbers were impressive — A compound called GP-B1 showed 65.4 µg/mL inhibitory concentration (IC50) against B16 melanoma cells, meaning it effectively blocked tumor cell growth at a relatively low dose.
Another component — a carotenoid fraction — had one of the lowest IC50 values recorded, at just 1.6 µg/mL against Hep3B liver cancer cells. Gypenosides also reduced tumor sizes by up to 75% in live animal models of colorectal cancer over 19 days.
• So what exactly improved? The researchers noted that GpM extracts stopped cancer cells from multiplying, triggered them to self-destruct, and prevented them from spreading. Polysaccharides from GpM also enhanced the body’s immune response, increasing levels of cancer-fighting cells and chemicals like tumor necrosis factor-a (TNF-a), interleukin-10 (IL-10), and interferon-γ.
These compounds didn’t just work in lab dishes — they shrank tumors in mice and boosted survival rates without harming healthy tissues.
Time-wise, the effects of GpM compounds were impressive, appearing just within days in lab tests. In animal models, tumors shrank significantly after just four weeks of treatment. And importantly, the longer the treatment continued, the more pronounced the anticancer effects became. For example, tumor size in SAS oral cancer models dropped by 65.76% after 28 days of daily gypenoside injections.
• Some extracts showed particularly strong benefits in certain types of cancers — For example, the carotenoid and chlorophyll fractions were particularly effective against liver cancer cell lines. Meanwhile, polysaccharides were more potent in melanoma and colorectal models, while gypenosides were broadly effective across leukemia, lung, prostate, and gastrointestinal cancers.
• Saponins (especially gypenosides) and polysaccharides were the most potent cancer-fighting agents — Saponins halted the cancer cell cycle, while polysaccharides acted more like immune boosters, giving the body extra firepower to fight tumors naturally. Other compounds like flavonoids and chlorophyll had moderate effects, with antioxidant benefits that complemented the main therapeutic effects.
Lastly, jiaogulan slowed down energy production in cancer cells by blocking glycolysis — a trick cancer cells use to fuel their aggressive growth — while enhancing immune response markers.
“In summary, GpM has been investigated extensively as a potent anti-cancer agent against many types of cancers both in vitro and in vivo. The general consensus from the literature is that GpM exerts its anti-cancer activities through multiple mechanisms, including cell cycle arrest, the induction of apoptosis, inhibition of invasion and metastasis, glycolysis inhibition and immunomodulation,” the researchers concluded.9
How to Safely Use Jiaogulan
Jiaogulan is popularly taken as an herbal tea and dietary supplement, but in China, it is also used in meals, like a vegetable. The immature stems are commonly eaten as a cold dish, similar to a salad, while the leaves are added to congee for flavor.10
• What’s the ideal dose? In studies, daily doses of up to 450 ml for 16 weeks (divided into two doses, one in the morning and another at night) have been found to be safe. However, it’s best to consult with your doctor to confirm the appropriate dosage for your needs.11
• Possible side effects — While jiaogulan has been found to be generally safe, there are instances when it causes minor side effects, like nausea and diarrhea. In rare cases, vomiting, dizziness, tinnitus, constipation, and blurred vision may occur.12
• Always consult with your healthcare provider before using jiaogulan — Jiaogulan’s safety in pregnant women and breastfeeding mothers has not been studied, so if you fall under these groups, it may be better to avoid using this herb.
According to VeryWell Health, the gypenosides in jiaogulan inhibit a liver enzyme called cytochrome P450 2D6 (CYP2D6), which is responsible for breaking down certain medications. Insufficient amounts of this enzyme may cause the drugs to build up in your body, leading to toxicity.13 Hence, if you’re taking any medications, check with your physician if jiaogulan is safe for you to take.
“Diabetics should be careful and adjust their medications down with the help of their doctors if they drink massive amounts,” Aziz said. This is due to jiaogulan’s ability to lower blood sugar.
Frequently Asked Questions (FAQs) About Jiaogulan
Q: What is jiaogulan and why is it called the “immortality herb”?
A: Jiaogulan (Gynostemma pentaphyllum) is a climbing herb used for centuries in Traditional Chinese Medicine. It’s called the “immortality herb” due to its reputation for promoting longevity, vitality, and disease resistance — now supported by research showing its potent antioxidant and metabolic effects.
Q: How does jiaogulan compare to green tea in antioxidant strength?
A: Jiaogulan has an ORAC (Oxygen Radical Absorbance Capacity) score eight times higher than green tea. This makes it extremely effective at neutralizing harmful free radicals, reducing oxidative stress, and supporting healthy aging and disease prevention.
Q: What are the metabolic and cardiovascular benefits of jiaogulan?
A: Jiaogulan activates AMPK, a key enzyme that regulates energy use and fat metabolism. It improves insulin sensitivity, lowers blood sugar, reduces triglycerides and LDL cholesterol, and boosts fat burning — making it beneficial for managing weight, diabetes, and heart health.
Q: Can jiaogulan help protect against cancer and support the immune system?
A: Yes. Research shows that jiaogulan extracts inhibit cancer cell growth, induce apoptosis (cell death), and prevent metastasis across various cancers, including liver, colon, and breast. Its polysaccharides and gypenosides also enhance immune responses without damaging healthy cells.
Q: Is jiaogulan safe to use, and how should it be taken?
A: Jiaogulan is generally safe when consumed as tea or supplements (up to 450 ml daily in studies), but may cause mild side effects like nausea or dizziness in some people. It may interact with medications, especially those processed by liver enzymes or used for diabetes. Always consult a healthcare provider before starting.
Curcumin stops cancer cell growth, new research confirms
Reproduced from original article:
https://www.naturalhealth365.com/curcumin-stops-cancer-cell-growth-new-research-confirms.html
by: January 11, 2025
(NaturalHealth365) Turmeric, a kitchen spice from India and Southeast Asia, has long been treasured by natural healers for its ability to fight inflammation, regulate blood sugar, and combat infections. But turmeric benefits extend even beyond these traditional uses. Ongoing research suggests that its active ingredient – a plant pigment known as curcumin – could be a valuable weapon in the fight against cancer.Many studies have supported turmeric’s anticancer effects, including its ability to reduce the number and size of tumors. However, studies also revealed a dramatic and encouraging “twist:” turmeric can potentially target several particularly aggressive and lethal forms of cancer while leaving noncancerous cells unharmed. For instance, recent research has shown that curcumin may help fight colorectal cancer by influencing how cancer cells clean out damaged parts (autophagy) and self-destruct when unhealthy (apoptosis), offering new hope in combating this common and deadly disease.
An international team of scientists concludes that curcumin inhibits an enzyme involved in carcinogenesis
Researchers at the University of California, San Diego School of Medicine, Peking University, and Zhejiang University collaborated on a study published in the Proceedings of the National Academy of Sciences. The researchers used multiple models to show that turmeric can powerfully inhibit a specific enzyme called DYRK2 (or dual-specificity tyrosine-regulated kinase 2).
The team used cutting-edge X-ray crystallography to obtain 3D images – in which curcumin could be seen binding to the enzyme at the atomic level. This is significant because binding to and inhibiting DYRK2 impairs the activity of proteasomes – protein complexes involved in cancer development.
The team noted that inhibiting proteasome activity in cancer cells interfered with proliferation, reducing tumors, slower cancer growth, and an overall lessening of the cancer burden.
Curcumin targets the “Achilles heel” of lethal cancers
Some cancers – including triple-negative breast cancer and multiple myeloma – are classified by scientists as “proteasome-addicted,” meaning they are dependent on proteasome complexes. Impairing the activity of the proteasome inhibits tumor development, leading scientists to theorize that this dependency may well be the “Achilles’ heel” of these aggressive, hard-to-treat cancers.
Pharmaceutical proteasome inhibitors have already been developed and approved, but there is a catch: these medications damage noncancerous cells. In response, resourceful researchers have been focusing on inhibiting proteasome activity by identifying and manipulating proteasome regulators.
This is where the power of turmeric comes into play. By depleting DYRK2, curcumin suppresses proteasome activity – with very little damage to healthy cells in the area. Curcumin strengthens the cancer-fighting effects of pharmaceutical proteasome inhibitors – meaning that smaller dosages – and fewer side effects – may be possible.
When used with carfilzomib – an FDA-approved proteasome inhibitor used to treat multiple myeloma – curcumin increased apoptosis (cancer cell death) – while causing minimal harm to healthy cells.
Curcumin uses multiple pathways to target cancer
If curcumin’s only cancer-fighting abilities were impairing the DYRK2 enzyme and inhibiting proteasome activity, it would still be a promising area for study in cancer prevention and treatment. However, curcumin has an impressive variety of cancer-fighting pathways.
Curcumin helps inhibit angiogenesis, the growth and development of new blood vessels to nourish and support tumors. It also “switches off” genes that promote tumor development while helping the immune system identify and destroy malignant cells.
In addition, curcumin can help to protect your DNA from potentially cancer-causing mutations caused by radiation and environmental toxins. It also suppresses the production of MMPs or matrix metalloproteinases. These enzymes attack the extracellular matrix and facilitate the invasion of cancer cells.
Finally, by reducing the production of adhesion molecules that cling to cell walls, curcumin stops cancer cells from settling in place – effectively “throwing a monkey wrench” into the ability of cancer cells to metastasize. Additional research supports curcumin’s effectiveness.
In one study, curcumin supplementation caused a 36 percent reduction in the size of lung tumors. In another, it caused a 40 percent decrease in the development of colon tumors. And – in one particularly promising clinical study – curcumin cut the growth rate of prostate-specific androgen (a marker of tumor progression) in half.
How can I take curcumin?
Study co-author Sourav Banerjee, Ph.D., a postdoctoral scholar at UCSD School of Medicine, remarked on curcumin’s “chemical drawbacks,” noting that orally administered curcumin is broken down and eliminated by the human body very quickly. Dr. Banerjee says, “It (curcumin) needs to be modified to enter the bloodstream and stay in the body long enough to target the cancer.”
This is why experts say that adding turmeric to food may not provide enough bioavailable curcumin to obtain therapeutic results.
The best option currently is to seek a high-quality, high-potency organic curcumin extract standardized to contain at least 95 percent curcuminoids.
Note: Do not attempt to treat cancer or any other serious medical condition with turmeric or curcumin without the guidance of a qualified doctor. Before supplementing with curcumin, get the go-ahead from your trusted holistic healthcare provider.
Simply put, as scientists continue to discover curcumin’s multiple effects against cancer, this amazing flavonoid seems destined to play a major role in natural cancer therapies and cancer prevention.
Sources for this article include:
The Cancer-Fighting and Chemoprotective Properties of Ginger
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/10/10/ginger-cancer.aspx
Analysis by Dr. Joseph Mercola October 10, 2024
STORY AT-A-GLANCE
- Studies have highlighted ginger’s benefits for treating various cancers due to its anti-inflammatory, antioxidant and immunoregulatory effects
- Active compounds in ginger, including gingerol, shogaol, zingerone and paradol, exhibit antitumor properties by inhibiting cancer cell growth and promoting apoptosis in multiple cancer types
- Studies indicate ginger’s effectiveness against breast and cervical cancers, with extracts demonstrating cytotoxic benefits against cancer cells while sparing healthy cells
- Ginger helps alleviate chemotherapy side effects, reducing nausea and vomiting in cancer patients, and enhancing the effectiveness of chemotherapy drugs
- Beyond cancer protection, ginger promotes healthy aging and guards against neurological diseases, cardiovascular issues and obesity, while offering anti-inflammatory and pain-reducing benefits
Medicinal plants are becoming more widely appreciated for their ability to protect and even help treat diseases, and one of the most popular ones is ginger (Zingiber officinale). Traditionally used to help reduce inflammation and relieve pain, ginger is now recognized for its protective effects against cancer.
With more than 2 million cancer cases expected to arise in the U.S. this year,1 it is important to find alternative therapies that are helpful against this disease. In recent years, multiple studies have provided evidence of ginger’s cancer-fighting benefits.
Ginger’s Pharmacodynamic Effects Against Colorectal Cancer
There were more than 1.9 million new diagnoses and 935,000 deaths associated with colorectal cancer worldwide in 2020, making it the cancer with the highest incidence rate and second-highest mortality rate.2 Many recent studies have found that ginger has therapeutic actions against this type of cancer, mainly due to its anti-inflammatory, antioxidant and immunoregulatory effects. One study notes:
“Indisputable evidence show that among all natural products, ginger (Zingiber officinale), which is extensively used in foods and beverages as a spice worldwide, is a unique source of bioactive compounds that can show both chemo-preventive and chemotherapeutic effect against different types of cancers and has attracted the interest of medical scientists recently.”3
A 2024 review published in the Journal of Ethnopharmacology4 highlighted ginger’s ability to help inhibit and treat colorectal cancer by inhibiting cancer cell proliferation, inducing cell cycle blockage, promoting apoptosis (programmed cell death) and suppressing cancer cell invasion and migration. The review, which looked at clinical studies and animal and in vitro experiments, also noted that ginger helps enhance the anticancer effects of chemotherapy drugs.
An animal study that explored ginger’s effects on colorectal cancer was also published in 2022 in the journal Anti-Cancer Agents in Medicinal Chemistry.5 The researchers induced colorectal cancer in rats using dimethylhydrazine, a cancer-causing chemical. They then divided the test subjects into those given the cancer drug cisplatin and those treated with ethanolic ginger extract.
Remarkably, after 21 weeks of treatment, they found not only did ginger extract work better than cisplatin, but it also didn’t damage the kidneys or liver, indicating its safety.
“This study proved that the antitumor activity of GE against the DMH induced-CRC is superior to cisplatin. GE was also safer than cisplatin and did not elicit hepatotoxicity or nephrotoxicity. GE induced apoptosis and has carcinostatic activity,” the study authors concluded.6
Studies Investigate the Cancer-Protective Compounds in Ginger
Ginger’s unique and multifaceted composition is responsible for its benefits against cancer. This root crop contains more than 60 active compounds with strong biological activity and pharmacological properties, such as antioxidant, antibacterial and anti-inflammatory, which all contribute to its ability to help suppress tumor formation.7,8
A 2023 study published in the World Journal of Gastrointestinal Oncology9 investigated the components of ginger that give it its antitumor effects against cancers of the digestive tract, including gastric, liver, laryngeal, colorectal and pancreatic cancers. These beneficial components include:
• Gingerol — A specific type of gingerol called 6-gingerol was found to slow down the growth of colon cancer cells by counteracting the effects of a substance called phorbol 12-myristate 13-acetate (PMA).10
PMA activates proteins that allow cancer cells to survive and thrive. When scientists added 6-gingerol to PMA-induced colon cancer cells, it interfered with the cellular pathways activated by PMA. 6-gingerol also activates caspases, which are protease enzymes essential in apoptosis.
• Shogaol — 6-shogaol also activates caspases, helping eliminate tumor cells. In addition, it was found to kill tough Mahlavu cells — a type of liver cancer cell that’s very resistant to treatment — by causing oxidative stress.11
• Zingerone — According to the researchers, this compound has significant pharmacological effects. Higher amounts of zingerone are found in dried or cooked ginger, as opposed to raw ginger.12
Zingerone creates an unpleasant, stressful environment for colon cancer cells. When scientists treated HCT116 colon cancer cells with this compound, it produced more reactive oxygen species (ROS) that damage their mitochondria and decrease the cells’ natural defenses, causing them to die.13
• Paradol — Found in dried ginger, paradol has antitumor and anti-proliferative effects. It fights pancreatic cancer by reducing the amount of epidermal growth factor receptor (EGFR), which triggers cancer cell growth. Paradol also slows down PI3K/AKT signaling, which are cellular communication pathways in cancer cells that instruct them to grow and resist death.14
In addition, major terpene components like β-bisabolene, curcumene, α-farnesene and β-sesquiculene are found in ginger. According to the study authors, extracting these active components will help develop more efficient modern treatments for gastrointestinal tumors.
“Ginger’s active ingredients have the ability to regulate several signaling pathways such as PI3K/Akt/mTOR, Wnt/β-catenin, EGFR and NF-κB. This regulation is achieved through components such as 6-gingerol, 6-shogaol, zingerone and others that can directly or indirectly act on signal targets, leading to an antitumor effect,” they concluded.15
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Ginger Extract Has Cytotoxic Benefits Against Breast and Cervical Cancer Cells
The active compounds mentioned above are also found to be beneficial against other types of cancer, including breast and cervical cancer, which are predominant among women. According to the World Health Organization, 2.3 million women were diagnosed with breast cancer in 2022.16 In the same year, 660,000 women received a cervical cancer diagnosis.17
A 2021 review published in the International Journal of Molecular Science18 focused on ginger’s ability to protect against these two types of cancers, as well as other types. They featured one experiment from 201519 that found breast cancer cells treated with 6-shogaol underwent cell death by targeting cancer stem cells.
According to the researchers, “The efficacy of 6-shogaol in monolayer and cancer stem cell-like spheroids raise hope for its therapeutic benefit in breast cancer treatment.”
A methanolic ginger extract was tested on cervical and breast cancer cells in a separate study.20 The researchers observed changes in the cells, such as shrinking, indicating apoptosis. They also found that ginger extract has a dose-dependent effect; the more extract they used, the more cancer cells died.
In a 2020 study,21 researchers studied the effects of ginger in two types of breast and pancreatic cancer cells. They found that ginger extract eliminated cancer cells without harming healthy cells. And even though breast cancer cells were more easily eradicated and required less extract to be efficient compared to pancreatic cancer cells, the effects were seen in both types.
“Since that selectivity for cancerous cells, high tolerance by humans and low toxicity for normal cells are ideal features of potential cancer chemopreventive and therapeutic agents, after more animal studies and human trials on ginger extract (especially using the purified active compounds), it can be considered as a novel chemopreventive and therapeutic agents.”22
Ginger Protects Against the Side Effects of Chemotherapy
Available conventional treatments for cancer are often aggressive and toxic, not to mention expensive. Chemotherapy, one of the most common treatments that cancer patients undergo, works by destroying cancer cells and preventing them from spreading.
However, chemotherapy drugs are very strong and come with unpleasant and debilitating side effects. According to one study,23 88% of patients who underwent chemotherapy experienced one or more side effects. Fatigue was the most common symptom (80%), followed by nausea and vomiting (48%) and then pain (48%).
Since cancer patients need to stay well-nourished and energized when undergoing aggressive chemo sessions, easing these side effects is a necessity — and using ginger is one way to help with this. Studies have found that ginger provides protection against chemotherapy’s side effects.
A 2022 study24 conducted by researchers from Daejeon University in Korea looked at four randomized controlled trials involving a total of 337 patients; some were given ginger after finishing chemotherapy, while others didn’t.
The study authors found that breast cancer patients that were given ginger had delayed and reduced severity of acute chemotherapy-induced nausea and vomiting (CINV) compared to those who didn’t ingest it. There were no serious adverse effects associated with it as well.
While the above study showed ginger’s positive effects when given after chemotherapy, an earlier review25 highlights that taking ginger before or during chemotherapy treatments provided immense effects as well.
According to their findings, giving ginger extract as a daily supplement three days before chemotherapy “significantly elevated antioxidant activity and reduced oxidative marker levels in patients who receive moderate-to-high emetogenic potential chemotherapy compared to a placebo.”26 In addition, the compounds 6-gingerol and 6-shogaol were able to help overcome multidrug resistance in cancer cells; this helps make chemotherapy more effective.
“Ginger derivatives possess high potential chemopreventive properties such as cell cycle arrest, increased cellular death (apoptosis, autophagy and autosis), as well as redox homeostasis unbalance. Furthermore, they inhibit angiogenesis, CSCs formation and the EMT process.
Therefore, this natural compound directly and indirectly influences tumor cell survival and inhibits invasion and metastasis processes, without significant toxic effects on normal cells,” the researchers concluded.27
Ginger Promotes Healthy Aging and Longevity
While these studies highlight ginger’s benefits against different types of cancer, the therapeutic uses of this versatile root crop have long been appreciated, especially in Asian civilizations. In traditional Chinese, Indian and Ayurvedic medicine, ginger is used to help loosen and expel phlegm with its expectorant action. Its ability to alleviate pain, treat digestive issues and ease nausea are also well-known.28
A review published in Oxidative Medicine and Cellular Longevity journal29 says that ginger contributes to healthy aging and protects against age-related conditions, including Alzheimer’s, Parkinson’s and dementia, cardiovascular issues, respiratory disorders and gastrointestinal diseases.
“Aging is a complex process that is determined by multiple and interdependent genetic, cellular, and environmental factors. Ginger, one of the most commonly used natural products both for gastronomic and medicinal purposes, has documented antioxidant, anti-inflammatory, anti-infection, and chemopreventive properties,” the researchers noted.30
In an earlier animal study,31 test subjects that were given ginger extract had reduced buildup of β-amyloid proteins that contribute to Alzheimer’s disease. Meanwhile, another study found that 6-shogaol protected brain cells with its anti-neuroinflammatory effects.
Another animal study highlighted the importance of optimal intestinal function to neurodegenerative disorders. In mice that demonstrated gut damage associated with Parkinson’s disease, ginger was able to reduce inflammation, protect nerve cells and keep the integrity of the gut lining.32 In addition, ginger’s ability to help reduce the risk of obesity are praised as well. The researchers said:
“Recent studies suggest that gut microbiota may represent an important target in the treatment of obesity. In a recent study, ginger supplementation has been reported to reduce body weight, fatty liver, and insulin resistance by restoring gut microbiota in rats fed a high-fat diet.”33
What Else Is Ginger Good For?
You’ll be pleased to know that beyond its uses to help protect against cancer and support healthy aging, ginger offers a host of other whole-body benefits, which include:34
| Reducing inflammation and pain associated with conditions like dysmenorrhea and osteoarthritis | Promoting vasodilation to help manage blood pressure levels |
| Stimulating fat breakdown to aid in weight management | Alleviating motion sickness, nausea and headaches |
| Supporting cardiovascular health | Reducing blood sugar levels to protect against diabetes |
Ginger is a culinary treasure; when cooked and added to your favorite dishes, it provides a delicious yet mild spiciness and fragrance. There’s no reason not to add more of it to your daily meals, and if you need a few tips, here are some ideas to help you out:35
- Put a few pieces of fresh ginger in a mug and add hot water to make fragrant ginger tea
- Add fresh ginger, grated or finely chopped, or powdered ginger to your curry or stir-fry
- Add a small amount of fresh ginger to your morning smoothie
- 1 NIH, Cancer Statistics
- 2, 4 Journal of Ethnopharmacology, April 24, 2024, Volume 324, 117733, Introduction
- 3, 21 Archives of Pharmacy Practice, 2020, Volume 11, Issue 3, Introduction
- 5 Anti-Cancer Agents in Medicinal Chemistry, 2022, Volume 22, Number 8, pp. 1601-1610(10)
- 6 Anti-Cancer Agents in Medicinal Chemistry, 2022, Volume 22, Number 8, pp. 1601-1610(10), Conclusion
- 7, 18 Int. J. Mol. Sci. 2021, 22(12), 6599, Introduction
- 8, 9 World J Gastrointest Oncol. November 15, 2023; 15(11): 1835–1851
- 10, 11, 13, 14 World J Gastrointest Oncol. November 15, 2023; 15(11): 1835–1851, Anti-Tumor Mechanisms of the Active Components of Ginger
- 12 World J Gastrointest Oncol. November 15, 2023; 15(11): 1835–1851, The Main Active Ingredient of Ginger for Anti-Tumor Effect
- 15 World J Gastrointest Oncol. November 15, 2023; 15(11): 1835–1851, Conclusion
- 16 WHO, March 13, 2024
- 17 WHO, March 5, 2024
- 19 PLOS One, September 10, 2015
- 20 Indian J Exp Biol. 2016 Nov;54(11):767-773
- 22 Archives of Pharmacy Practice, 2020, Volume 11, Issue 3, Conclusion
- 23 Nutrients. 2022 Dec; 14(23): 4982, Introduction
- 24 Int. J. Mol. Sci. 2022, 23(19), 11267
- 25 Int. J. Mol. Sci. 2021, 22(12), 6599
- 26 Int. J. Mol. Sci. 2021, 22(12), 6599, Ginger, Its Constituents, and ROS Balance
- 27 Int. J. Mol. Sci. 2021, 22(12), 6599, Conclusions and Future Perspectives
- 28 Oxidative Medicine and Cellular Longevity, May 9, 2022, Ginger
- 29, 32 Oxidative Medicine and Cellular Longevity, May 9, 2022
- 30 Oxidative Medicine and Cellular Longevity, May 9, 2022, Conclusion and Future Directions
- 31 Food Chem Toxicol. 2012 May;50(5):1454-9
- 33 Oxidative Medicine and Cellular Longevity, May 9, 2022, Endocrine Diseases
- 34 Nutrition Reviews, 2023, 81(9), pp. 1213-1224
- 35 Business Insider, October 15, 2020
Guard against bacteria and fungi with THIS natural defender
Reproduced from original article:
https://www.naturalhealth365.com/guard-against-bacteria-and-fungi-with-this-natural-defender.html
by: June 12, 2024
(NaturalHealth365) As you know, Western medicine relies heavily on antibiotics to treat infections – and sometimes, these drugs are truly needed. But the rise of antibiotic-resistant “superbugs” – along with the unwanted side effects that can accompany antibiotic use – has triggered an urgent search for naturally sourced substances, oregano oil, to kill pathogens safely and effectively.
In fact, recently published research reveals the potential of a familiar Mediterranean cooking herb to do just that, and the results are stunning.
Oregano oil has potent effects against Candida albicans
A member of the mint family, oregano is scientifically known as origanum vulgare L. The name “oregano” derives from the Greek words for “mountain” and “joy” – and oregano certainly seems to be bringing joy to researchers when it comes to its surprising antimicrobial properties.
In a study conducted at Georgetown University Medical Center and published in Molecular and Cellular Biology, the research team investigated the ability of oregano essential oil to kill Candida albicans. This fungal yeast overgrowth can cause joint pain, exhaustion, and digestive problems.
They found amazing results: at concentrations of .25 mg/ml, wild oregano oil – a blend known as P73 – completely inhibited both the germination and the mycelial growth of C. albicans in cultures.
The team credited the oil with “potent’ antifungal effects against C. albicans.
Defend against dangerous bacteria and viruses
In a 2012 study, researchers found that oregano essential oil inhibited the growth of 20 different clinical bacterial strains of E. coli – which can cause severe gastrointestinal problems, anemia, and even kidney failure – and 20 strains of P. aeruginosa, which can cause ear infections, skin rashes, and pneumonia.
The encouraging results led researchers to call for further study on oregano oil as an alternative antibacterial remedy – and to explore its use as an “effective means for the prevention of antibiotic-resistant bacteria.”
And there’s more.
Additional studies have shown that oregano oil kills at least 30 different strains of disease-causing bacteria, including staphylococcus aureus, the leading cause of skin and soft tissue infections, and coronavirus, a primary cause of the common cold, pneumonia, and other respiratory infections.
In addition, oil of oregano kills the H. pylori bacterium – a contributory factor in 90 percent of all duodenal ulcers and 80 percent of all gastric ulcers.
What makes this all-natural oil so potent?
Oregano’s two most formidable weapons are a pair of volatile oils, thymol and carvacrol. Carvacrol has also been studied for its therapeutic effects, and a 2016 study published in the European Review for Medical and Pharmacological Sciences showed that carvacrol from oregano oil protected against methotrexate toxicity.
Other constituents of oregano include various flavonoids, essential vitamins, and minerals, including iron, manganese, vitamin E, tryptophan, and omega-3 fatty acids. Oregano also contains ursolic acid, a powerful antioxidant and antibacterial agent.
Even MRSA is no match for this potent essential oil
Did you know that the World Health Organization (WHO) has classified the advent of “superbugs” as a global public health crisis? Currently, methicillin-resistant staphylococcus aureus – or MRSA – strikes 80,000 people and claims over 11,000 lives worldwide every year. Just don’t expect any organization – like WHO – to tell you the health benefits of a substance like, oregano oil.
By the way, the news about oregano oil just keeps getting better. A team of British and Indian researchers reports that the essential oil of Himalayan oregano – simply, origanum vulgare, which happens to grow in the Himalayas – is effective against the MRSA pathogen.
According to researcher Professor Vyv Salisbury, the essential oil kills MRSA at a dilution of 1 to 1,000. The oil kills MRSA both as a liquid and a vapor, and its antimicrobial ability is undiminished by heating in boiling water.
Plans are underway to develop an oregano-based soap for use in hospitals, both for washing hands and disinfecting surfaces.
How should I take this powerful essential oil?
P73 oil of oregano is available in capsule form.
Natural healthcare providers will often advise the use of oregano essential oil for colds, flu, sinusitis, and other respiratory illnesses, as well as for candida and yeast infections.
It can also be used for duodenal and gastric ulcers – in conjunction with other medications that target H. pylori – and, when mixed with coconut oil, can be used topically for athletes’ foot and ringworm.
Because oregano oil is so potent, you should only use it under the guidance of your trusted holistic physician, who can advise you on the correct amount. Some experts say oil of oregano should be diluted with water or mixed with coconut oil and not taken internally for more than two weeks.
Because oregano oil is such an effective antibacterial agent, long-term use can deplete levels of friendly gut bacteria. So it’s wise to make sure you consume sufficient amounts of probiotic foods – such as live-cultured yogurt, miso soup, or raw sauerkraut – along with prebiotic foods such as organic garlic, onion, and asparagus.
Sources for this article include:
NIH.gov
NIH.gov
NIH.gov
Medicalnewstoday.com
Medicalnewstoday.com
5 Potent Nootropic Herbs to Supercharge Memory and Concentration
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/05/20/nootropic-herbs-memory-concentration.aspx
Analysis by Dr. Joseph Mercola May 20, 2024
STORY AT-A-GLANCE
- Focus and concentration issues can significantly impact quality of life, affecting everything from daily routines to overall mental health
- Nootropic herbs are known for their ability to enhance cognitive function, including memory and concentration. Five notable nootropic herbs for enhancing cognitive function include Bacopa monnieri, Ginkgo biloba, Rhodiola rosea, Panax ginseng, and ashwagandha
- Elevated levels of serotonin have been linked to an increased risk of dementia in numerous studies. Another hazard is linoleic acid, which when consumed in excess can result in inefficient cellular energy production within the brain
- GABA’s role in the brain as a neurotransmitter helps in calming neural activity and can mitigate the harmful effects of too much linoleic acid and serotonin
- Nootropic herbs, GABA, and tailored lifestyle interventions can be incorporated as a comprehensive strategy to check cognitive decline and address both memory and concentration issues
Nootropics are sometimes called “smart drugs” since they enhance cognitive performance and especially executive functions like memory, focus and creativity. Naturally occurring nootropics support focus and concentration by improving neural mechanisms related to learning and memory.
Nootropic herbs have long been a staple of Ayurveda, Siddha, Unani and other traditional medicine practices. They have gained wide recognition in alternative and complementary medicine for their ability to boost mental processes. Rooted in centuries of traditional use, nootropic herbs form a bridge between ancient wisdom and contemporary natural health.
Among the most widely used and extensively researched nootropic herbs are Bacopa monnieri, Ginkgo biloba, Panax ginseng, and Rhodiola rosea. Each herb has a unique profile of benefits, from improving memory retention and speeding up reaction times to reducing mental fatigue and enhancing overall brain function.
In combination with lion’s mane mushrooms and GABA, which are not nootropic herbs, nootropic herbs can help promote mental clarity without the harsh side effects often associated with pharmaceutical cognitive enhancers. Each possesses unique properties and components worth further examination.
Consider These Five Nootropic Powerhouses
The rich tradition of herbal remedies is an effective solution for individuals seeking natural ways to support their focus and concentration. These powerhouse nootropics can serve as a cornerstone to a natural approach to cognitive enhancement and neuroprotection.
• Bacopa monnieri — Also referred to as brahmi or water hyssop, this perennial and non-aromatic herb is hailed in Ayurvedic medicine for its memory-enhancing properties. Studies suggest it can improve cognitive function and facilitate better communication between brain cells.1
The bioactive phytochemical constituents of Bacopa monnieri are alkaloids, saponins, flavonoids, triterpenes, and cucurbitacin. Bacopa monnieri contains a compound called bacosides, which are the principal active ingredient and play a pivotal role in neuroprotection. They contribute to the herb’s ability to enhance brain function and protect neural structures.2
Enhanced memory acquisition, verbal learning, reduced anxiety and general cognitive improvement were found in clinical trials of Bacopa monnieri.3 Both Bacopa monnieri and its extracts are famous for their antioxidant powers, working along several pathways to shield your brain from oxidative damage and help prevent cognitive decline in older adults.
The brain-boosting benefits of this potent herb likely come from the antioxidant properties found in both extracts and bacosides.4 Based on animal studies, the B. monnieri extract and bacosides were shown to enhance antioxidant status in the brain region of the hippocampus, frontal cortex, and striatum.5
• Ginkgo biloba — Often celebrated as one of the oldest living tree species, Ginkgo biloba is renowned for its powerful antioxidant properties and its ability to enhance cerebral blood flow, improve oxygen delivery and protect against damage from free radicals. Ginkgo biloba is one of the best-known nootropic herbs.
It has been used for thousands of years in Traditional Chinese Medicine (TCM) to treat a variety of ailments. Today, it is best known for its capacity to improve cognitive functions, particularly in the elderly. Compounds found in Ginkgo biloba, such as flavonoids and terpenoids, contribute to its neuroprotective effects, helping to combat cognitive decline and increase attention span and memory processing.6
Flavanol glycosides are primarily responsible for the antioxidant activity of Ginkgo biloba. Oxidative stress contributes to neurodevelopmental disorders, causing changes to the protein structure, lipid denaturation, and DNA damage. Since Ginkgo biloba has such strong antioxidant activity it is being studied and applied as a treatment modality for ADHD.
Ginkgo biloba also significantly improves attention and memory, making it a staple in natural cognitive enhancement.7
In a comprehensive review, Ginkgo biloba extracts were shown to have a positive impact on cognitive function, memory, and the overall quality of life in patients with cognitive impairment, highlighting its significance in supporting brain health and combating age-related cognitive decline. While ideal for improving memory and concentration, we have only scratched the surface of its potential.8
• Rhodiola rosea — This adaptogenic herb has been used for centuries to enhance memory and concentration. Rhodiola rosea also goes by the names golden root and arctic root. By reducing fatigue and improving resilience to stress, it addresses factors that significantly affect cognitive functions.9
Packed with active ingredients like rosavins and salidroside, it’s a powerhouse for boosting your brain’s dopamine levels. Not only does it enhance neurotransmitter function, but it also fights back against stress-induced cognitive fog, helping to promote a clear and focused mind. Rosavins have been specifically tied to reducing oxidative stress.
Depression is a prevalent mental disorder that manifests through a low mood, sluggish thinking, and notably slower speech and movement. Clinical studies reveal that Rhodiola rosea extract shows remarkable potential for its antidepressant properties in individuals experiencing mild to moderate depression.
Studies have demonstrated rhodiola’s capability to increase attention to detail, cognitive processing speed, and overall ability to multitask efficiently.10 This herb’s adaptogenic qualities make it particularly effective for those under stress, ultimately contributing to improved cognitive outcomes and productivity.
• Panax ginseng — This herb is often referred to as Asian or Korean ginseng. It stands out as a potent adaptogenic herb with significant cognitive enhancement potential. Revered for centuries in TCM, this root possesses strong anti-inflammatory and antioxidant properties.
This makes it an excellent nootropic for improving memory, concentration, and mental clarity. Ginsenosides are the active components in Panax ginseng and have been extensively studied for their ability to modulate neurotransmitter activity, while increasing brain-derived neurotrophic factor (BDNF) levels.
The role of BDNF in diseases of the central nervous system provides a window into the mechanism through which Panax ginseng mitigates stress on the brain and thereby enhances cognitive function and mental performance.11
Panax ginseng is a popular choice among students and professionals looking to boost their mental clarity and focus in a natural, sustained manner. Its benefits extend beyond temporary cognitive improvement, suggesting potential long-term effects in brain health and function.12
• Ashwagandha — Known scientifically as Withania somnifera, ashwagandha is another highly regarded herb within traditional medicine, celebrated for its adaptogenic properties. It is often referred to as Indian ginseng and has been used for centuries in Ayurvedic medicine to bolster memory and improve concentration.
Its potent effects on mental acuity are attributed to a reduction in excessive cortisol levels, a stress hormone, which can adversely impact cognitive functions.13
Ashwagandha supports the regeneration of brain cells and stabilizes the chemicals responsible for learning and memory. By mitigating stress and anxiety, it creates an optimal environment for enhancing cognitive functions.
Clinical studies suggest that consistent supplementation with ashwagandha may lead to significant improvements in task performance, attention, and memory, validating its use to naturally enhance cognition.
Its antioxidants also protect against neural oxidative stress, further supporting brain health and cognitive longevity. This makes ashwagandha a pivotal addition to an herbal arsenal for those aiming to support their mental performance and cognitive capacities.14
Lion’s Mane Stimulates Production of Nerve Growth Factor
While not technically an herb, Lion’s mane mushrooms are also associated with improved mental acuity, concentration, and memory. The core of this power packed mushroom are hericenones and erinacines.15
Lion’s mane mushroom stands at the forefront of natural cognitive enhancers due to its unique ability to stimulate the production of nerve growth factor (NGF). NGF is a protein that plays a crucial role in the maintenance, survival, and regeneration of neurons.16
By promoting the production of NGF, lion’s mane directly contributes to the enhancement of neuroplasticity — your brain’s ability to reorganize itself by forming new neural connections. This capacity is fundamental to improving cognitive functions such as memory and concentration.17
Furthermore, animal studies have demonstrated that the bioactive compounds within lion’s mane, hericenones and erinacines, can cross the blood-brain barrier, directly facilitating the growth and development of brain cells. This direct action not only helps in sharpening focus and recall but also in potentially slowing the cognitive decline associated with aging.18
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Serotonin — The Unhappy Hormone
Understanding the role of serotonin is another crucial component in a comprehensive strategy to optimize your memory and concentration. Often dubbed the “happy hormone,” the role of serotonin in dementia has been completely misconstrued in media coverage.
Serotonin is an antimetabolite, putting the brakes on your body’s energy production within the mitochondria’s electron transport chain. High levels of serotonin might leave you feeling fatigued, slow your metabolism, and even lead to weight gain.
The pharmaceutical industry, however, has a vested interest in keeping the darker side of serotonin under wraps. After all, the narrative that low serotonin levels in your brain lead to depression fuels the sale of most antidepressants on the market today.
Risk of Elevated Serotonin Levels
In the quest to balance and potentially mitigate elevated serotonin levels, GABA emerges as a natural ally. This neurotransmitter functions as a counterbalance to excitatory neurotransmitters in the brain like serotonin. Elevated levels of serotonin can lead to a range of undesirable effects such as fatigue and slowed metabolism, as previously mentioned.
The calming effect of GABA on the brain supports relaxation, reduces stress, and can help improve sleep quality — all of which are beneficial for cognitive function and overall mental health.
By promoting a more balanced neurological environment, GABA supplementation can indirectly support improved memory, concentration, and mental clarity, making it a critical component in the holistic approach to enhancing cognitive performance and mitigating the adverse effects of excessive serotonin.19
Linoleic Acid Increases Inflammation and Lowers Cognitive Performance
Diet is a crucial aspect of maintaining and improving cognitive function. Slashing or eliminating your intake of linoleic acid (LA), a common polyunsaturated fatty acid (PUFA) found in seed oils such as soybean, corn, and sunflower oils is crucial.
The overconsumption of LA can lead to a cascade of health problems that impact brain health. Excessive intake of LA has been associated with increased inflammation and oxidative stress, conditions that are detrimental to brain cells and can impair cognitive functions such as memory and concentration.
Moderating your intake of LA by reducing the consumption of seed oils rich in PUFAs and instead focusing on a diet that includes healthy fats from sources like avocados and fatty fish, and “clean carbs” like ripe fruit and white rice can support brain health. These healthy fats contribute to the maintenance of cell membrane integrity and fluidity, facilitating optimal neuronal communication and cognitive function, while healthy carbs provide the needed fuel for optimal brain function.
Boost Your Cognitive Function and Brain Health With Nootropics
The pursuit of naturally enhanced memory and concentration encompasses a diverse array of powerful nootropics. The combination of these powerful natural compounds can help you optimize your mental performance and support long-term brain health.
A multi-pronged approach can also utilize GABA to mitigate high-serotonin levels, and include replacing PUFAs with healthy fats and clean carbs to optimize mitochondrial energy production, without which cognition will be compromised.
- 1 Frontiers in Nutrition, 2022; 9: 97237, Paragraph 2
- 2 Frontiers in Nutrition, 2022; 9: 97237, Paragraph 1
- 3 STATPEARLS, 2023; 3, Table 1
- 4 Annals of Neuroscience, 2017 May; 24(2): 111–122, Brahmi on Cerebral Blood Flow
- 5 Phytotherapy Research, 2000, May; 14, 174-9, Abstract
- 6 Neurotherapeutics, 2019, Jul; 16 (3), 666-674, Pharmacological Importance
- 7 Human Psychopharmacology, 2002 Aug;17(6):267-77, Abstract
- 8 Ginkgo Biloba, Mount Sinai Health, Memory and thinking
- 9 Molecules, 2022 Jun 17;27(12):3902, Abstract
- 10 Molecules, 2022 Jun; 27(12): 3902, Neuroprotective Effects
- 11 Neural Plasticity, Vol. 2017, Introduction
- 12 Journal of Ginseng Research, 2013 Apr; 37(2): 144–166, Table 3
- 13 Journal of Ayurvedic Integrated Medicine, 2022 Apr-Jun 13(2), Introduction, Discussion
- 14 Indian Journal of Psychological Medicine, 2012 Jul-Sep; 34(3): 255–262., Discussion
- 15 Journal of Neurochemistry, 2023 January 20, Figure 6, 7
- 16, 17 International Journal of Medicinal Mushrooms, 2013;15(6):539-54, Abstract
- 18 Behavioral Neurology, 2018 May 21, Protection against Alzheimer’s Disease, Table 2, Conclusion
- 19 Frontiers in Neuroscience, 2020 Sept 17, Introduction
Study links popular blood thinner to heightened risk of bleeding issues
Reproduced from original article:
https://www.naturalhealth365.com/study-links-popular-blood-thinner-to-heightened-risk-of-bleeding-issues.html
by: December 28, 2023
(NaturalHealth365) Over 50 million individuals in the U.S. are on blood thinners. Precisely 55% of these users express concerns about experiencing life-threatening bleeding due to their medication. While the potential for increased bleeding is a known side effect of blood thinners, it’s essential to weigh the pros and cons of these anticoagulant medications.
A recent research article from the University of Michigan, featured in the American Society of Hematology’s publication, underscores the critical role of patient education regarding the use and implications of blood thinners.
Recent research shapes our understanding of anticoagulant risks
Many are unaware that even with their profound medical knowledge, physicians can sometimes be swayed by factors beyond clinical expertise. Elements such as personal judgments, financial motivations, and inherent biases can subtly influence their treatment decisions, potentially shaping their choices in prescription medications, including anticoagulants.
Illustrating this concern is a recent study that sheds light on the heightened risk associated with Xarelto (rivaroxaban) in terms of severe bleeding incidents when compared to its counterparts, warfarin and Eliquis (apixaban). Given the implications of such research, it begs the question: shouldn’t patients be proactive in seeking and understanding the treatments they are prescribed?
Make an educated decision when taking a blood thinner
The University of Michigan researchers found that in a year-long observation of 100 patients, rivaroxaban would lead to approximately 40 bleeding incidents, whereas warfarin would result in about 25. While apixaban and warfarin had comparable numbers of bleeding episodes, warfarin was linked to more severe bleeding. It is worth noting the study was limited to patients suffering from atrial fibrillation and/or blood clots.
The study is considered a trailblazer as it is the first to analyze the amount of bleeding through a comparative analysis of Xarelto and Eliquis. The results of the study will likely be confirmed or refuted by follow-up randomized clinical trials.
Nature’s solutions to maintaining a healthy blood flow
Rather than blindly following medical advice, patients are urged to approach their health decisions with thoughtful consideration. While we are not suggesting that you simply disregard a doctor’s recommendations, it’s empowering to recognize that nature offers complementary avenues for well-being. Various spices and herbs have been celebrated for their innate ability to support and optimize blood circulation.
A notable example is cayenne pepper, a favorite among athletes and wellness aficionados seeking to boost circulation. The potency of cayenne pepper can be attributed to its active ingredient, capsaicin. Additionally, the pepper contains capsicum, revered for its positive impact on nerve-related ailments. Although cayenne pepper may evoke a brief warming sensation, this fleeting warmth is frequently perceived as beneficial.
Moving beyond cayenne pepper, staples like cinnamon, garlic, and ginger have also earned accolades for their circulatory-enhancing properties. Cinnamon’s effectiveness is credited to compounds such as cinnamaldehyde, cinnamic acid, and cinnamate, which not only promote circulation but also aid in blood pressure management.
Garlic, packed with beneficial sulfur compounds, facilitates unobstructed blood flow. Concurrently, ginger’s array of bioactive constituents, encompassing terpenes and phenolic compounds, serve as guardians against arterial obstructions. Furthermore, ginger is renowned for its blood-cleansing attributes. And, don’t forget to eat some shitake mushrooms – on a regular basis – to improve the quality of your blood circulation.
Sources for this article include:
An Herbal Guide to Natural Pain Relief
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2023/12/21/herbal-options-for-chronic-pain.aspx
The original Mercola article may not remain on the original site, but I will endeavor to keep it on this site as long as I deem it to be appropriate.
Analysis by Dr. Joseph Mercola December 21, 2023
STORY AT-A-GLANCE
- Chronic pain is debilitating, affects millions of people each year, and is a growing public health problem. In 2010, it was costing the nation up to $635 billion each year. The number of people suffering has grown and the economic cost is likely much higher
- The pharmaceutical industry is pouring money into a growing population of people who need pain relief, despite available natural options without the list of side effects and adverse events associated with pain medication
- Herbal options for pain are typically the most effective for chronic pain after several weeks. Because they can interact with other herbs and drugs, it’s important to consult with a provider familiar with natural options
- Consider investigating the use of willow bark, ginger, turmeric, rosehips, Boswellia and feverfew to name a few. The risk-benefit ratio in some herbs is too high, making them a poor choice, such as thunder god vine
- Other strategies can help support pain management, such as supplementing with choline and orange essential oil, and choosing the right foods
Chronic pain is debilitating and affects the lives of millions of people each year. While the pharmaceutical industry has contributed to the rising opioid epidemic and death rates by encouraging the use of opioids, there are several herbal solutions to help reduce your pain and improve your quality of life.
In 2021, the CDC1 estimated 20.9% of all adults had experienced chronic pain and 6.9% experienced high-impact chronic pain, which the CDC defined as pain that substantially restricts daily activities. In 2023, an NIH report2 showed that new cases of chronic pain occur more often than diabetes, high blood pressure and depression.
The data from the NIH showed that the rate of chronic pain in U.S. adults increased slightly from 2021 to 21%, but high-impact pain rose over 1% to 8%. The NIH wrote that the links between chronic pain and the opioid epidemic “underscores the urgency to understand and address the issue of pain.”3
The high cost of chronic pain is measured in dollars and emotional distress. The economic cost is measured in unemployment, poverty, self-medication with alcohol and street drugs, and health care dollars. A large study in 20104 showed the cost to the nation at that time was up to $635 billion each year. In 2023 dollars that would be equal to $882 billion.5 This points to pain as a major public health challenge.
The Need for Natural Pain Solutions
A lot of money is poured into treating neck and back pain, two of the more common areas of chronic pain. Yet, as the pharmaceutical industry pours more into “discovering” medications that might help alleviate pain, the options typically come with a long list of side effects and some, like Vioxx,6 Darvon and Darvocet,7 are pulled off the market when the side effects include heart problems, stroke and death.
Common side effects from pain medications include constipation, stomach ulcers, nausea, clouded thinking, drowsiness and in some cases, addiction.8 Data also show that men and women perceive pain differently.
Research into gender differences in pain perception9 found that when men and women are exposed to identical pain stimulation, women rate the pain higher on a pain scale. Factors that may affect pain perception include sex hormones, emotions, age, attitude and a learned response from past experiences.
The rising number of people with chronic pain and subsequent economic and emotional costs, gender differences in pain perception and a high number of disrupting and even dangerous side effects from pharmaceutical options point to the need for finding effective natural pain solutions without high costs and significant side effects.
Herbal Options for Chronic Pain
The following alternative herbal options for chronic pain offer a balanced approach. However, it is important to recognize that they can also interact with any drugs you are taking. Before adding herbal remedies to your regimen, it is important to consult with health care providers who are familiar with natural options, such as naturopathic doctors or herbalists. Note that herbal remedies typically work best after taking them for weeks and are not always effective for acute pain.
There are limited data on using herbs in women who are pregnant or breastfeeding and in children, so herbal remedies in this group should be avoided unless they are recommended by a health care provider. Additionally, while some herbs reduce inflammation and pain, the risk-benefit ratio may be too high in some people. Of course, there are also spices and plant extracts that have shown efficacy in treating pain, but the following are herbs that can help with natural pain relief.
1. Willow bark — Extracts from the willow tree have anti-inflammatory properties and have long been used to treat fever and pain.10 The active ingredient, salicin, is similar to aspirin. Willow bark also contains other flavonoids, polyphenols and salicylates that help reduce inflammation in a way that’s similar to nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen or ibuprofen.
The most commonly reported side effects are gastrointestinal issues and allergic reactions.11 Children may be at higher risk of Reye’s syndrome, and it should be avoided in women who are pregnant since it crosses the placental barrier.
In a 2013 study of 436 patients, those taking willow bark extract with musculoskeletal pain demonstrated a significant reduction in pain. In another study with 128 patients receiving standardized willow bark extract, the researchers found patients experienced relief from mild to fairly severe coxarthrosis or gonarthrosis comparable to that of standard therapies, without the subsequent adverse events.
2. Ginger — Ginger has a high number of compounds called gingerols, which are recognized as anti-inflammatories through metabolizing arachidonic acid.12 The botanical name is Zingiber officinale and it has been used by herbalists for roughly 2,500 years.13
Ginger is found growing natively in tropical countries and has a long list of medicinal properties, including having been used to treat digestive and appetite problems, prevent motion sickness, reduce muscle pain, swelling and arthritis, and relieve hyperemesis gravidarum.
Data describe a delay in therapeutic action, so it is not helpful for acute pain conditions. Side effects can include drowsiness and heart arrhythmias as well as interference with platelet aggregation and increased bleeding time, especially when used with other herbs or drugs that have the same risk of bleeding.
In one double-blind, placebo-controlled, randomized clinical trial with 60 patients suffering from migraine headaches, researchers found those who received ginger and NSAIDs had significantly better clinical responses. Other trials demonstrated ginger could significantly improve pain in knee osteoarthritis and reduce knee swelling.
3. Turmeric — Turmeric comes from the rhizome of the plant and has the active polyphenolic compound called curcumin.14 Traditionally, turmeric has been used as an anti-inflammatory agent that promotes wound healing and has an analgesic effect. Curcumin is known to regulate inflammatory cytokines, and this effect has proved useful in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
Curcumin and turmeric also inhibit platelet aggregation, and so caution must be used when using it with other drugs that have a similar potential. Studies have demonstrated a reduction in pain in patients with osteoarthritis and an improvement in quality-of-life scores in women with breast cancer.
4. Rose hips — In standardized trials,15 rose hip powder has been beneficial in reducing pain in people with osteoarthritis without major side effects. In one review of the literature16 researchers found data showing rose hip powder lowered serum measurements of C-reactive protein and over three months, participants experienced a 13% decline in pain relative to no change measured in those taking a placebo.
A meta-analysis of three trials with 287 patients showed standardized rose hip powder consistently lowered pain scores and people taking the rose hip powder were twice as likely to respond as those who took a placebo. Additionally, rose hip powder does not have ulcerogenic effects, nor does it inhibit platelet aggregation.17
5. Devil’s claw — This is a popular medicinal plant native to South Africa that has a reputation for traditional use for the treatment of pain, malaria and liver and kidney problems.18 According to Mount Sinai, there have been several studies that demonstrate a reduction in pain and an improvement in physical functioning after taking Devil’s claw for eight to 12 weeks.
When compared against a leading European medication, those taking Devil’s claw experienced the same pain relief with fewer side effects. Other data showed it may relieve joint pain and was at least moderately effective in people with arthritis.
6. Boswellia — This herb is also known as frankincense. In a 2020 literature review19 of seven trials and 545 patients, the researchers found that Boswellia helped relieve pain, stiffness and improved joint function leading them to conclude that it could be “an effective and safe treatment option for people” with osteoarthritis.
In a 2018 study,20 patients with osteoarthritis received a combination of curcumin and boswellic acid and experienced a reduction in pain symptoms over 12 weeks.
7. Feverfew — This herb has a long history of use for the treatment of inflammation, headaches and fever.21 In the late 20th century, it was used for migraine headaches. In addition to anti-inflammatory action, it also inhibits serotonin release and platelet aggregation, which increases the risk of bleeding when used with other herbs or medications with the same characteristic.
Clinical studies have demonstrated the administration of feverfew and ginger may be an effective first-line abortive treatment for migraines and feverfew alone may help reduce the frequency of migraine attacks
8. Thunder god vine — This traditional Chinese herb has anti-inflammatory and analgesic effects.22 While it has been useful in patients with rheumatoid arthritis pain, it is also associated with several significant side effects, including renal insufficiency, decreased male infertility, hematotoxicity and immune suppression. Clinical researchers do not recommend use due to the high risk-benefit ratio.
9. Black cohosh — According to The Herbal Academy,23 while black cohosh is more commonly used in women during menopause, it was traditionally used as an antispasmodic for cramping and muscle pain of any type, as well as for nerve-related and spinal cord injury-related pain.
10. Corydalis — This flowering plant is in the poppy family and has been used in traditional herbalism for strong pain.24 However, the herb can have significant side effects, including dizziness and nausea, so it is best used under the careful guidance of an experienced herbalist or physician.
11. Rosemary — Rosemary grows natively along the Mediterranean Sea and in sub-Himalayan areas. It’s been used in traditional medicine for headaches, migraine and depression, and as a mild analgesic and antispasmodic. There is evidence that rosemary has significant anti-inflammatory, antioxidant, antitumorigenic and neuroprotective properties as well as clinical effects on memory, pain, anxiety and sleep.25
12. Ashwagandha — Ashwagandha has been used in Ayurvedic medicine for thousands of years to help improve immune health, cognitive function and sleep. A 2016 randomized, double-blind, placebo-controlled study26 analyzed the effect in 60 patients with knee joint pain.
At the end of 12 weeks, the researchers found a significant reduction in pain, stiffness and disability compared to baseline measurements and placebo. The group taking 250 mg showed the earliest improvement at 4 weeks.
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More Strategies That Can Help Lower Pain Perception
Although the focus of this article is on a guide to herbal remedies that can help lower or eliminate your pain, I’ll briefly mention other strategies with links to past articles that you might consider using alongside herbs to improve pain management.
• Steer clear of steroids — While steroid injections sometimes lessen the immediate pain, data show they can make the joints worse and over time can increase pain. Additionally, there is a lack of evidence to support using steroids and shots in the knee may be no more effective than a placebo.
• Food — Food is powerful medicine as it can significantly impact inflammation and therefore, pain, in a variety of chronic conditions. Arthritis is one of those conditions. There are over 100 different types that include symptoms of pain, stiffness and swelling.
Food compounds such as sulforaphane, anthocyanins and compounds found in a variety of spices can help lower pain. Conversely, a diet high in sugar and ultraprocessed foods can alter your gut microbiome and promote inflammation.
• Choline — This precursor to acetylcholine is likely an important part of pain relief, yet an estimated 90% of the population is deficient. Groups with the highest risk of deficiency include pregnant and breastfeeding women, endurance athletes, people who drink a lot of alcohol, postmenopausal women and vegetarians and vegans.
• Orange essential oil — Orange essential oil used for massage or aromatherapy has helped significantly relieve pain in women in labor and older adults with moderate to severe knee pain. The oil also helps ease stress and anxiety and boosts relaxation and mood.
- 1 Morbidity and Mortality Weekly Report, 2023;72(15)
- 2, 3 NIH, May 16, 2023
- 4 US Pain Foundation, September 29, 2021
- 5 Federal Reserve Bank of Indianapolis. Inflation Calculator
- 6 NPR, Vioxx: The Downfall of a Drug
- 7 CNN, November 19, 2010
- 8 Mayo Clinic, Chronic Pain: Medication Decisions
- 9 British Journal of Anesthesia, 2013; 111(1)
- 10 HealthNews, November 16, 2023, Willow Bark
- 11 Pharmaceutics, 2021;13(2) 3.9 Willow Bark 55% DTP and Table 9 for studies
- 12 HealthNews, November 16, 2023, Ginger
- 13 Pharmaceutics, 2021;13(2) 3.2 Ginger
- 14, 20 Pharmaceutics, 2021;13(2) 3.3 Turmeric
- 15 HealthNews, November 16, 2023, Rosehip
- 16 Examine, Rosehip, 6.2 Osteoarthritis
- 17 Australian Family Physician, 2012; 41(7)
- 18 Mount Sinai, Devil’s Claw
- 19 BMC Complementary Medicine and Therapies, 2020; 20
- 21 Pharmaceutics, 2021;13(2) 3.8 Feverfew
- 22 Pharmaceutics, 2021;13(2) 3.6 Thunder God Vine
- 23, 24 The Herbal Academy, 12 Traditional Herbs That Ease Pain
- 25 Iranian Journal of Basic Medical Sciences, 2020; 23(9)
- 26 Journal of Ayurveda and Integrative Medicine, 2016; 7(3)
Black cumin plus vitamin D equals a top antiviral combination
Reproduced from original OMNS article (OrthoMolecular News Service):
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Orthomolecular Medicine News Service, June 1, 2023
The remarkable clinical versitility of Nigella sativa
by Max Langen
OMNS (June 1, 2023) Nigella sativa, also called black cumin, is one of the most important medicinal plants. Its seeds (sometimes called “black seeds”) have been used for thousands of years as a spice and condiment, and in several traditional medicine systems to treat a wide range of diseases. This plant is described and acknowledged in ancient medical and religious literature. The Bible mentions Nigella sativa as “Curative black seed,” and it is also known as prophetic medicine, since Prophet Muhammad, the founder of Islam, referred to it as “cure for every disease except death.” It was mentioned in Chinese and Indian traditional medicine and was also described in traditional Arab and Islamic medicine. [1-3]
The biochemical content of nigella sativa seeds includes oils (30-40%), essential oils including thymoquinone, nigellidine, and PUFAs, and many other proteins (~25%), minerals, fatty acids, alkaloids, sterols (alpha-hederine), phenolics, flavonoids, and saponins. Recent clinical studies have shown that seeds of nigella sativa and their major compounds including thymoquinone have strong immunomodulatory, anti-inflammatory, anti-oxidant, antiviral, antibacterial, antimalarial, antifungal, antihistaminic, anticancer, antidiabetic, anti-epileptic, anti-asthmatic, anti-allergic, antitussive, anticoagulant, analgesic, cardioprotective, hepatoprotective, gastroprotective and neuroprotective effects, among others. [1-3]
Nigella sativa has shown in several studies to be highly effective for the prevention and treatment of Covid-19, massively reducing severe outcomes and mortality. Many could still be alive had this therapy not been widely ignored. Also, the combination of nigella sativa and vitamin D has shown to be remarkably effective in the clearance of a viral infection.
Before looking more closely at those impressive results from studies on Covid-19, here are short summaries of what recent clinical studies have shown about the healing effects of nigella sativa for other conditions, including other infectious diseases. As of April 2023, there are more than 1900 scientific publications on nigella sativa. More than 90 randomized controlled trials (RCTs) and meta-analyses of RCTs have been published to date that tested the effectiveness of nigella sativa for various diseases and health outcomes, with a large majority of them showing clear benefits. This evidence suggests that nigella sativa could be used as an effective (adjuvant) treatment to improve many conditions. RCTs, often placebo-controlled, or meta-analyses of RCTs have shown that nigella sativa, often administered as capsules with 1000 or 2000 mg of nigella sativa seed oil, or pharmaceutical powder of the seeds (and sometimes given in other forms, for example as pure, non-powdered nigella sativa seeds or as topical ointment/gel application) can effectively:
- reduce hypertension by lowering both systolic and diastolic blood pressure. [4]
- support achieving and maintaining a healthy weight in overweight individuals by helping to moderately reduce weight and body mass index. [5]
- treat metabolic syndrome, by reducing body mass index, waist circumference and body fat percentage, fasting glucose and lipid levels. The combination of nigella sativa + turmeric was even more effective. [6]
- improve glucose status in patients with type 2 diabetes, by decreasing fasting plasma glucose, postprandial glucose and long term glucose (HbA1c) levels. [7] In patients with prediabetes, it reduces glycemic and anthropometric parameters just as effectively as the drug metformin. [8]
- decrease blood lipid levels, including total cholesterol, very low density cholesterol, LDL cholesterol and triglycerides for individuals with excessive levels. [9]
- treat nonalcoholic fatty liver disease by improving the grades of liver steatosis, injury and fatty liver. Various liver and cholesterol parameters improved. [10,11]
- increase total antioxidant capacity and reduce oxidative stress. [12]
- reduce inflammatory processes (especially hs-CRP and TNF-alpha), suggesting that it decreases chronic inflammation. [12] Of note, chronic low-grade inflammatory processes are important causes of most diseases and conditions including cancer.
- improve cardiovascular health and therefore reduce the risk of cardiovascular diseases via many different mechanisms (incl. reduction of hypertension, cholesterol and body weight, glucose regulation, reduction of silent inflammation and oxidative stress etc.) In patients at increased risk of cardiovascular disease, it also improved flow-mediated dilation, the level of nitric oxide, and lowered mean arterial pressure and heart rate, [13,14] suggesting that it can greatly stabilize the health of the cardiovascular system.
- improve kidney parameters, suggesting that it may help maintain or increase health of the kidneys. [9] In patients with (advanced) chronic kidney disease (stage 3 or 4) due to diabetic nephropathy, it reduced blood glucose and improved kidney parameters incl. serum creatinine and glomerular filtration rate etc. suggesting that it may stop the progression of kidney disease or even help reverse it. [15] An additional study confirmed that patients with advanced kidney disease greatly improve by nigella sativa. The addition of nigella sativa to the treatment protocol caused a “marked improvement” in clinical features and kidney parameters. [16]
- dissolve kidney stones. In the nigella sativa group, 44% of patients excreted their kidney stones completely, and in a further 52% the size of the stones was reduced. In the placebo group, only 15% excreted their stones, 12% had a reduction of stone size, and 15% even had an increase of stone size. [17] This suggests nigella sativa may also prevent kidney stone formation.
- improve Hashimoto thyroiditis, which is one of the most common autoimmune diseases. TSH, antibodies against the thyroid and vascular endothelial growth factor decreased, while the thyroid hormone T3 level increased, suggesting that it helps reverse the disease, strengthens the health of the thyroid and may also be an effective treatment for autoimmune diseases in general. [18] As will be shown below, nigella sativa has already shown to be effective for several autoimmune conditions: rheumatoid arthritis, ulcerative colitis, psoriasis, vitiligo and asthma.
- decrease the severity of rheumatoid arthritis. Swollen joints and morning stiffness were also reduced. [19]
- reduce stool frequency in patients with ulcerative colitis. [20]
- improve psoriasis. Both oral and gel administration of nigella sativa were effective in most patients and led to improvements after several weeks of treatment. However, the combination of both oral and gel administration led to the best outcomes. 55% of psoriasis patients who received this combination achieved a good response. Further, 30% even had an excellent response or achieved a complete cure. Of note, if the treatment was stopped, the condition returned in some patients, indicating that it may be helpful for these patients to continue the treatment. [21]
- treat vitiligo (patchy skin pigmentation). Nigella sativa (as a gel application) was more effective than fish oil in reducing the vitiligo area scoring index. [22]
- treat hand eczema. Nigella sativa (as gel application) was just as effective as the drug betamethasone, reducing the severity of hand eczema and increasing quality of life in the affected patients. [23]
- treat dermatitis. Nigella sativa reduced the symptoms and signs of occupational contact dermatitis like eczematous lesions. In many patients, dermatitis improved or disappeared completely. Of note, oral capsules were more effective than topical administration. [24]
- treat acne vulgaris (as gel application). After 2 months, the acne disability index had declined by 64% in the Nigella sativa group, compared with 5% in the placebo group. [25]
- reduce symptoms of asthma (shortness of breath, night time waking, interference with activity), reduce rescue treatment and inhaler use, rating of asthma control, and improve lung function measured as forced expiratory volume at 1 second (FEV1). [26]
- treat impaired lung function in chemical war victims. Nigella sativa (as boiled extract) improved pulmonary function, chest wheezing and all other respiratory symptoms. The need to use inhalers and drugs decreased, suggesting that it may at least partially substitute for drugs. [27]
- treat allergic conditions, including allergic rhinitis, by reducing runny nose, nasal congestion, sneezing attacks, nasal itching, turbinate hypertrophy etc. in affected patients. [28,29]
- reduce knee osteoarthritis symptoms and pain. [30] Nigella sativa (as gel/oil application) was more effective in relieving pain (51% reduction) than the common pharmaceutical pain reliever diclofenac (14% reduction). [31]
- improve symptoms of menopausal women (in combination with another herbal medication: Vitex agnus-castus). Psychosocial, physical and vasomotor (hot flashes) symptoms decreased. [33]
- treat polycystic ovary syndrome. It was effective in the treatment of menstrual irregularities in women with PCOS. [34]
- stabilize/increase mood, calmness and cognition, and decrease anxiety. [35]
- treat major depressive disorder. In the intervention group that received the antidepressant sertraline + Nigella sativa capsules, the depression scores declined more than in the control group that only received sertraline + placebo. [36]
- increase attention and memory, suggesting that it may help prevent cognitive decline and dementia. [37]
- treat epilepsy in patients resistant to conventional anti-epileptic drugs. Administration of the aqueous extract of Nigella sativa or high dose thymoquinone (one of its main active ingredients) reduced the frequency of epileptic seizures. [38,39]
- improve nasal dryness, obstruction and crusting (as intranasal application) in older people suffering from nasal mucosa symptoms. [40]
- improve oral submucous fibrosis. Burning sensation decreased by 80% after continuous application of nigella sativa. Mouth opening was also reduced. [41]
- treat alveolar osteitis/dry socket (painful inflammation following tooth extraction). Nigella sativa (as oil and powder) was a more effective dressing material than a commonly used commercial dressing. Those who received this treatment had immediate and complete pain relief and required less repeated visits. [42]
- improve recovery of oral cavity ulcers or traumatic ulcers. [43]
- treat gingivitis. Nigella sativa oil reduced the gingival index score, inflammation, and pathogenic (streptococcus) bacteria. By decreasing biofilm formation and disrupting the colonization of such bacteria, it may help reduce the progression of periodontal diseases. It was as effective as chlorhexidine, suggesting that nigella sativa could be an alternative to chemical mouthwashes. [44]
- treat insomnia. Nigella sativa restored restful sleep in patients with sleep issues. [45]
- improve irritable bowel syndrome after some weeks of continuous intake. Severity of the disease symptoms, abdominal distention and the impact of the condition on daily life decreased, and defecation improved. [46]
- reduce urinary incontinence (in older women). [47]
- improve semen quality (sperm count, motility, morphology, volume etc.) in infertile men, suggesting that it may help reverse infertility and increase pregnancy rates. [48]
- treat female infertility by improving reproductive parameters including the number of ovarian follicles and reducing oxidative stress and may therefore help reverse female infertility and increase pregnancy rates. [49]
- increase volume of breastmilk in breastfeeding mothers. [50]
- treat (chronic) rhinosinusitis. Nigella sativa (as nasal drops) reduced the congestion, pain, numbness, pressure, fullness and bad breath in patients with chronic rhinosinusitis. [51]
- treat arsenic poisoning in patients with palmar arsenical keratosis. Nigella sativa reduced the body arsenic load, which led to an improvement of arsenical keratosis. Therefore, it might also support detoxification of other toxic metals. [52]
- improve immune health. Nigella sativa (1 g of seed oil per day) has an immunopotentiating effect, increasing total lymphocyte count, CD3+ and CD4+ cells, suggesting that it reduces the risk of infectious diseases. [53]
- prevent side effects of toxic cancer therapies: Nigella sativa (as a gel application) reduced the incidence and severity of phlebitis (inflammation of veins), a common complication of intravenous chemotherapy. [54] As a mouth rinse it decreased the severity of chemotherapy-induced oral mucositis. Erythema, ulceration and pain were reduced. Therefore, it enabled those patients to consume normal food. [55] Nigella sativa (as a gel application) reduced the risk of developing acute radiation dermatitis in breast cancer patients treated with radiotherapy. [56] Nigella sativa also reduced the risk of developing febrile neutropenia (FN), a dangerous complication of chemotherapy. Chemotherapy harms the immune system and often leads to a reduction of immune cells (neutrophil granulocytes). 5 grams of nigella sativa seeds per day greatly reduced the risk of developing a chemotherapy-induced FN, inhibiting the harm done to the immune system and reducing by almost 90% severe or deadly (viral, bacterial, fungal) infections. [57]
- treat hepatitis C infections by attenuating viral load. 50% of hepatitis C patients treated with (a relatively low dose of) nigella sativa had a decrease in the quantitative viral load and 17% even became seronegative. [58] A higher dose might have been even more effective. Of note, another study also showed that hepatitis can be treated more effectively by adding nigella sativa and vitamin C to conventional therapy. [59]
- treat vaginitis caused by a candida albicans infection. Standard therapy + nigella sativa was more effective in reducing several symptoms and signs of candida-induced vaginitis compared with standard therapy + placebo. [60]
- eradicate helicobacter pylori infections (bacteria), which are among the leading causes of gastric cancer. Resistance of helicobacter towards pharmaceutical drugs has recently increased alarmingly. Eradication of helicobacter occurred in almost 60% of patients who were treated with high dose nigella sativa + honey. [61] Double-blind RCTs confirmed that patients who received standard therapy + nigella sativa achieved a greater eradication. [62,63]
- treat staphylococcal skin infections. In neonates with staphylococcal skin infections, it was similarly effective as the antibacterial drug mupirocin. [64]
- inhibit bacterial wound infections caused by staphylococcus aureus. A lab study with samples obtained from cases of wound infections in a hospital showed that high dose thymoquinone may inhibit s. aureus and therefore prevent/treat such wound infections. [65]
- inhibit MRSA (methicillin resistant staphylococcus aureus), which is one of the deadliest bacterial infections often acquired in a hospital. Nigella sativa (in high concentrations in a preclinical study) was shown to have inhibitory effects against MRSA. [66] It also had inhibitory effects against vancomycin resistant staphylococcus aureus (VRSA). [67]
- accelerate the recovery of acute respiratory infections overall (flu/cold etc.). Patients with an acute respiratory infection who received nigella sativa had a greater chance of becoming symptom-free after only 4 days. [68] A combination of nigella sativa oil + echinacea extract + garlic powder + panax ginseng extract + vitamin C + zinc cut the duration of a common cold in half (4 vs. 8 days of median recovery time). [69]
Treating Covid-19
Nigella sativa not only prevented Covid-19 in many people, but also accelerated the recovery and greatly reduced the development of severe symptoms or death in patients with Covid-19. [3] Several compounds of nigella sativa, including thymoquinone, nigellidine and alpha-hederin have proven antiviral and anti-inflammatory effects. Thymoquinone can inhibit the main protease in SARS-CoV-2, causing a “strong anti-SARS-CoV-2 activity.” [70]
A prospective prophylaxis study with 376 participants has shown that daily consumption of 40 mg/kg of nigella sativa seeds (= 3000 mg per day for a 75 kg person) reduced the risk of developing a symptomatic case of Covid-19 by more than 60%. Of note, the results of this study were available in Jan 2021. [71] A widespread recommendation to use nigella sativa would therefore have been an effective way to limit the pandemic and reduce the incidence of symptomatic infections in the population.
In a recent RCT with hospitalized Covid-19 patients, the treated group received standard therapy and 80 mg/kg/day of encapsulated nigella sativa seeds plus 1 g/kg/day of honey. [72] The results showed that the treated group had significantly faster viral clearance and recovery. In fact, those who received NS + honey recovered almost twice as fast. Overall, the patients in the treated group had a 82% lower risk of death compared with the control group. Importantly, these striking results of this high quality study were available in Nov. 2020, during the first year of the pandemic. [73]
Therefore, by 2020 it was clear that this treatment could reduce the fatality rate of hospitalized Covid-19 patients by 80%. Since then, millions of Covid-19 patients have died, but many of these deaths could have been easily prevented, not only with nigella sativa and honey, but also with other natural and orthomolecular treatment protocols that have shown to be similarly effective in reducing mortality of Covid-patients. [74,75]
Importantly, earlier treatment with nigella sativa can even prevent the progression and development of severe stages of Covid-19. A recent RCT showed that, if treatment with nigella sativa is started early in the disease course, shortly after symptoms begin, serious complications (and therefore hospitalization etc.) can be strongly reduced. Among those patients who only received the standard treatment, 17% developed a severe case. However, among those who received nigella sativa seeds for a duration of 2 weeks, only 1% developed severe symptoms, a 93% reduction. The results of this RCT were published in Jan 2021. [76]
A recent RCT confirmed that daily treatment with 1000 mg of nigella sativa seed oil (in capsules) improves recovery from Covid-19. The patients in the intervention group (standard therapy + nigella sativa) recovered significantly faster from Covid-symptoms than those in the control group (who only received standard therapy). The intervention group had a 75% lower risk of requiring hospitalization. [77]
In another RCT, Covid-19 outpatients were divided into four groups:
Group 1 received standard therapy + nigella sativa capsules, group 2 received standard therapy + vitamin D, group 3 received standard therapy + a combination of both nigella sativa and vitamin D and group 4 received only standard therapy (control group). The results showed that while viral clearance and symptom recovery occurred faster in groups 1 and 2 compared with the control group, the combination group that received both nigella sativa + vitamin D had the most impressive results with regard to recovery of the disease. The authors noted the remarkably fast viral clearance and reduction of many symptoms in this combination group and recommended this treatment for Covid-patients. [78] It is therefore highly likely that nigella sativa + vitamin D may also be a very effective treatment combination for other (infectious) diseases. They may have synergistic effects.
The evidence clearly shows: Had nigella sativa been used widely to treat Covid-19, many lives could have been saved. Unfortunately, however, governments around the world chose to recommend (or enforce) an experimental prophylactic drug, which caused massive numbers of serious adverse events and injuries [79] and led to significant excess mortality. [80] Analyses from various countries clearly showed that the higher the uptake of this experimental drug in 2021, the stronger the increase in excess deaths in 2022. Extensive mortality analyses by many scientists indicate that these drugs caused the deaths of 6.5 to 13 million people worldwide. [81]
Even before the roll-out of those experimental drugs, many people died from side effects of typical conventional medicine. Prescription drugs are one of the leading causes of death in Europe and in the United States of America. [82] Orthomolecular or natural medicine has been shown to be highly effective for many conditions and diseases, suggesting that most of these deaths from conventional drugs could easily be prevented by more widespread use of natural treatment approaches. Of course, each individual’s situation is different and may require different treatment approaches. Health issues should always be discussed with an orthomolecular or natural health care provider who can offer medical advice and help finding the best natural (or natural + conventional) treatment for an individual.
Many nigella sativa products are available and not all of them are high quality. When choosing nigella sativa capsules (rather than consuming the raw seeds in sufficient amounts), one should make sure that the seed oil is cold-pressed, to ensure that the capsules contain the seeds’ effective compounds. The color of the oil needs to be golden and a bitter smell/taste should prevail. A lighter yellow color would be a negative sign, which indicates that too many of the compounds have been removed during the processing.
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29. Kalus U, Pruss A, Bystron J, et al. (2003) Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 17:1209-1214. https://pubmed.ncbi.nlm.nih.gov/14669258
30. Huseini HF, Mohtashami R, Sadeghzadeh E, et al. (2022) Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial. Complement Ther Clin Pract. 49:101666. https://pubmed.ncbi.nlm.nih.gov/36150238
31. Azizi F, Ghorat F, Rakhshani MH, Rad M (2019) Comparison of the effect of topical use of Nigella Sativa oil and diclofenac gel on osteoarthritis pain in older people: A randomized, double-blind, clinical trial. J Herb Med. 16:100529. https://www.sciencedirect.com/science/article/abs/pii/S2210803319300053
32. Huseini HF, Kianbakht S, Mirshamsi MH, Zarch AB. (2016) Effectiveness of Topical Nigella sativa Seed Oil in the Treatment of Cyclic Mastalgia: A Randomized, Triple-Blind, Active, and Placebo-Controlled Clinical Trial. Planta Med. 82:285-288. https://pubmed.ncbi.nlm.nih.gov/26584456
33. Molaie M, Darvishi B, Jafari Azar Z, et al. (2019) Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot flashes: results from a subpopulation analysis. Gynecol Endocrinol. 35:58-61. https://pubmed.ncbi.nlm.nih.gov/30129806
34. Naeimi SA, Tansaz M, Hajimehdipoor H, Saber S (2020) Comparing the Effect of Nigella sativa oil Soft Gel and Placebo on Oligomenorrhea, Amenorrhea and Laboratory Characteristics in Patients with Polycystic Ovarian Syndrome, a Randomized Clinical Trial. Res J Pharmacogn. (RJP) 7:49-58. https://www.rjpharmacognosy.ir/article_99289_f5613bb45b6fb6dd8a7a2a9b5f7857a1.pdf
35. Bin Sayeed MS, Shams T, Fahim Hossain S, et al. (2014) Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J Ethnopharmacol. 152:156-162. https://pubmed.ncbi.nlm.nih.gov/24412554
36. Zadeh AR, Eghbal AF, Mirghazanfari SM, et al. (2022) Nigella sativa extract in the treatment of depression and serum Brain-Derived Neurotrophic Factor (BDNF) levels. J Res Med Sci. 27:28. https://pubmed.ncbi.nlm.nih.gov/35548175
37. Bin Sayeed MS, Asaduzzaman M, Morshed H, et al. (2013) The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol. 148:780-786. https://pubmed.ncbi.nlm.nih.gov/23707331
38. Akhondian J, Parsa A, Rakhshande H. (2007) The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 13:CR555-9. 4 https://pubmed.ncbi.nlm.nih.gov/18049435
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41. Pipalia PR, Annigeri RG, Mehta R. (2016) Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol. 122:705-712. https://pubmed.ncbi.nlm.nih.gov/27720650
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44. Rahman I, Mohammed A, AlSheddi MA, et al. (2023) Nigella sativa oil as a treatment for gingivitis: A randomized active-control trial. Asian Pac J Trop Med. 16:129-1138. https://www.apjtm.org/text.asp?2023/16/3/129/372290
45. Mohan ME, Thomas JV, Mohan MC, et al. (2023) A proprietary black cumin oil extract (Nigella sativa) (BlaQmax(r)) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study. Front Nutr. 10:1152680. https://pubmed.ncbi.nlm.nih.gov/37139438
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47. Alizadeh A, Mohammah-Alizadeh-Charandabi S, Khodaie L, Mirghafourvand M. (2023) Effect of Nigella sativa L. seed oil on urinary incontinence and quality of life in menopausal women: A triple-blind randomized controlled trial. Phytother Res. 37:2012-2023. https://pubmed.ncbi.nlm.nih.gov/36640148
48. Kolahdooz M, Nasri S, Modarres SZ, et al. (2014) Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 21:901-905. https://pubmed.ncbi.nlm.nih.gov/24680621
49. Amalia A, Hendarto H, Mustika A, Susanti I (2022) Effects of Nigella Sativa on Female Infertility: A Systematic Review. Proc 6th Int Conf Med Health Inform. May 2022, 234-237. https://dl.acm.org/doi/abs/10.1145/3545729.3545776
50. Zakaria R, Astuti SCD (2022) The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers. J Info Kesehatan 20:29-40. https://jurnal.poltekeskupang.ac.id/index.php/infokes/article/view/627/437
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52. Bashar T, Misbahuddin M, Hossain MA. (2014) A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmar arsenical keratosis patients. Bangladesh J Pharmacol. 9:15-21. http://www.bdpsjournal.org/index.php/bjp/article/view/188/611
53. Salem A, Bamosa A, Alam M, et al. (2021) Effect of Nigella sativa on general health and immune system in young healthy volunteers; a randomized, placebo-controlled, double-blinded clinical trial. F1000Research 10:1199 https://f1000research.com/articles/10-1199
54. Behnamfar N, Parsa Yekta Z, Mojab F, Kazem Naeini SM. (2019) The effect of nigella sativa oil on the prevention of phlebitis induced by chemotherapy: a clinical trial. Biomedicine (Taipei). 9:20. https://pubmed.ncbi.nlm.nih.gov/31453801
55. Hussain SA, Mohammed Ameen HA, Mohammed MO, et al. (2019) Nigella sativa Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia. Biomed Res Int. 2019:3619357. https://pubmed.ncbi.nlm.nih.gov/31781612
56. Rafati M, Ghasemi A, Saeedi M, et al. (2019) Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial. Complement Ther Med. 47:102205. https://pubmed.ncbi.nlm.nih.gov/31780017
57. Mousa HFM, Abd-El-Fatah NK, Darwish OA, et al. (2017) Effect of Nigella sativa seed administration on prevention of febrile neutropenia during chemotherapy among children with brain tumors. Childs Nerv Syst. 33:793-800. https://pubmed.ncbi.nlm.nih.gov/28349493
58. Barakat EM, El Wakeel LM, Hagag RS. (2013) Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 19:2529-2536. https://pubmed.ncbi.nlm.nih.gov/23674855
59. Ahmed S, Zahoor A, Ibrahim M, et al. (2020) Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxid Med Cell Longev. 2020:7087921. https://pubmed.ncbi.nlm.nih.gov/32566096
60. Adiban Fard F, Tork Zahrani S, Akbarzadeh Bagheban A, Mojab F. (2015) Therapeutic Effects of Nigella Sativa Linn (Black Cumin) on Candida albicans Vaginitis. Arch Clin Infect Dis. 10:e22991. https://brieflands.com/articles/archcid-20960.pdf
61. Hashem-Dabaghian F, Agah S, Taghavi-Shirazi M, Ghobadi A. (2016) Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection. Iran Red Crescent Med J. 18:e23771. https://pubmed.ncbi.nlm.nih.gov/28191328
62. Alizadeh-Naini M, Yousefnejad H, Hejazi N. (2020) The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study. Phytother Res. 34:1367-1376. https://pubmed.ncbi.nlm.nih.gov/31916648
63. Mohtashami R, Huseini HF, Heydari M, et al. (2015) Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol. 175:147-52. https://pubmed.ncbi.nlm.nih.gov/26386381
64. Babu B, Rao P, Suman E, Udayalaxmi J (2023) A Study of Antibacterial Effect of Nigella Sativa Seed Extracts on Bacterial Isolates from Cases of Wound Infection. Infect Disord Drug Targets. 2023 Apr 3. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/37016531
65. Rafati S, Niakan M, Naseri M. (2014) Anti-microbial effect of Nigella sativa seed extract against staphylococcal skin Infection. Med J Islam Repub Iran. 28:42. https://pubmed.ncbi.nlm.nih.gov/25405108
66. Hannan A, Saleem S, Chaudhary S, et al. (2008) Anti bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus. J Ayub Med Coll Abbottabad. 20:72-74. https://pubmed.ncbi.nlm.nih.gov/19610522
67. Liaqat F, Sheikh AA, Nazir J, et al. (2015) Report-Isolation identification and control of vancomycin resistant Staphylococcus aureus. Pak J Pharm Sci. 28:997-1004. https://pubmed.ncbi.nlm.nih.gov/26004734
68. Elango A, Rao LN, Sugumar P, Radhakrishnan A. (2022) Evaluation of Clinical Efficacy and Safety of Nigella Sativa Seed Oil added to Standard Treatment in Uncomplicated Respiratory Infection – A Randomised, Open Labelled, and Parallel Arm Study. Special Issue – COVID-19 & Other Communicable Diseases 91-97. https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/815/702
69. Yakoot M, Salem A. (2011) Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold. Int J Gen Med. 4:45-51. https://pubmed.ncbi.nlm.nih.gov/21403792
70. Abdallah HM, El-Halawany AM, Darwish KM, et al. (2022) Bio-Guided Isolation of SARS-CoV-2 Main Protease Inhibitors from Medicinal Plants: In Vitro Assay and Molecular Dynamics. Plants (Basel) 11:1914. https://pubmed.ncbi.nlm.nih.gov/35893619
71. Al-Haidari KAA, Faiq TAN, Ghareeb OA (2021) Preventive value of black seed in people at risk of infection with COVID-19. Pak J Med Health Sci. 15:384-387. https://pjmhsonline.com/2021/jan/384.pdf
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Hope for cancer patients: The promising effects of ashwagandha’s anticancer properties
Reproduced from original article:
https://www.naturalhealth365.com/hope-for-cancer-patients-the-promising-effects-of-ashwagandhas-anticancer-properties.html
by: April 29, 2023
(NaturalHealth365) Breast cancer is a prevalent form of cancer, accounting for over 10% of all new cases of cancer and a quarter of all cancers in women. It’s possible that someone in your social circle or family has been diagnosed with this disease. Genetics, diet, and environmental factors all play significant roles in the development, prevention, and treatment of breast cancer.
For centuries, ashwagandha (Withania somnifera), also known as Indian ginseng and winter cherry, has been used in Ayurvedic medicine. Its roots are used in various forms, such as powders, pills, and tonics, and it’s known to provide numerous benefits, including aiding sleep and anxiety.
In addition, recent studies have highlighted its antioxidant and anticancer properties, making it especially useful in the prevention and treatment of breast cancer.
From winter cherry to cancer warrior: How ashwagandha is changing the game against breast cancer
While ashwagandha has been traditionally used for its benefits in combating stress, physical weakness, inflammation, and pulmonary tuberculosis, it has emerged as a vital herb in the context of fighting cancer, specifically breast cancer. With its antioxidant properties, ashwagandha is believed to help prevent the onset of cancer cell growth.
Ashwagandha’s unique molecular mechanisms function as a chemotherapeutic force that fights various forms of breast cancer. Its anti-inflammatory, anti-invasive, anti-apoptotic, and other beneficial properties indicate its potential to prevent and treat breast cancer. The herb can be particularly effective in treating the ER/PR positive form of breast cancer, as well as triple-negative breast cancer.
Studies have shown that extracts of ashwagandha display cytotoxicity against cancer cells, meaning they can be toxic to cancerous cells. Using ashwagandha as a cytotoxic compound can result in a negative cell fate for cancer, and there is hope that it can be used in combination with other supplements and treatment modalities to thwart the formation and advancement of breast cancer cells.
How to integrate this timeless herb into your daily routine
If you’re seeking a natural way to boost your vitality, prevent and fight cancer, or simply infuse your body with antioxidants, ashwagandha is the perfect solution. This herbal supplement is commonly available in the form of a liquid extract, with most bottles containing a mix of the herb, organic cane alcohol, and distilled water. You can also consume ashwagandha in pill or powder form, with the latter being the most versatile.
Ashwagandha powder from the herb’s root can be mixed with water, honey, or ghee for consumption. Some also apply it topically to inflamed joints or incorporate it into their skincare routine. For those looking to offset its slightly bitter taste, the powder can be added to desserts, smoothies, or hot drinks.
The possibilities are endless, making ashwagandha a highly versatile and accessible natural solution for a wide range of health benefits. However, it’s important to consult with your integrative healthcare provider before incorporating ashwagandha or any other new supplement into your routine.
Sources for this article include:
Mistletoe and the Emerging Future of Integrative Oncology
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2022/06/12/mistletoe.aspx
The original Mercola article may not remain on the original site, but I will endeavor to keep it on this site as long as I deem it to be appropriate, and will not be bullied into removing it.
Analysis by Dr. Joseph Mercola Fact Checked June 12, 2022
STORY AT-A-GLANCE
- Mistletoe, a semi-parasitic plant that grows in the branches of trees all over the world, has been used in herbal medicine for thousands of years for conditions such as epilepsy, spleen disorders, pain and rheumatic conditions
- In 1917, Rudolf Steiner, a philosopher with keen observation skills, noticed that mistletoe looks a lot like a tumor, and proposed it might have anticancer properties. Dr. Ita Wegman confirmed Steiner’s suspicion, and the plant has since enjoyed over 100 years of consistent application in oncology, both standalone and as adjuvant support
- Intravenous or subcutaneous mistletoe appears beneficial as an adjunct therapy for all cancers, and there are no drug or health contraindications. Even the most toxic treatments work better and with fewer adverse effects when combined with mistletoe
- Mistletoe is the most studied integrative oncology therapy in the world, and it is utilized in upward of 60% to 80% of all cancer patients in Europe
- Your immune system and metabolic function are both integral parts of addressing cancer, and mistletoe works on both
In this interview, Dr. Nasha Winters, coauthor of “Mistletoe and the Emerging Future of Integrative Oncology,” reviews some of the benefits of this ancient herb in the modern world of oncology. Winters is herself a cancer survivor, so this topic is close to her heart.
“I’m coming on 30 years out of a death sentence, a terminal cancer diagnosis,” she says, “and still to this day get met with so much resistance to what I’ve learned for myself, and for thousands, if not tens of thousands, of other patients directly, as well as way more than that, indirectly, through the training of their physicians …
My crazy controversy is that I focus more on the human organism and the health of that terrain versus the condition, the disease or the label that overlays that person.”
Mistletoe Has a 100-Year Oncological History
Mistletoe, a semi-parasitic plant that grows in the branches of trees all over the world, has been used as a herbal medicine for thousands of years for conditions such as epilepsy, spleen disorders, pain and rheumatic conditions.
Just over 100 years ago, in 1917, Rudolf Steiner, a philosopher with incredibly keen observation skills, noticed the mistletoe looks a lot like a tumor, and proposed it might have anticancer properties. Many vitalistic medical practices, such as Ayurveda, Chinese medicine, naturopathy and homeopathy, for example, use the doctrine of signatures, which is what Steiner was suggesting.
“For instance, you look at a walnut and it kind of looks like a brain and we think, I wonder if that’s any good for the brain? And sure enough, we find some significance in how it impacts the brain. Or things like lungwort. When you look at it, it looks like a lung and we’ve learned that this herbal medicine is very helpful for lung conditions,” Winters says.
A Swiss doctor named Ita Wegman applied Steiner’s observation of mistletoe to see how it would impact a patient with cancer, and the plant has since enjoyed over 100 years of consistent application in oncology, both standalone and as adjuvant support.
“Interestingly enough … Steiner understood that you needed to harvest different components of the plant — berries that bloom in the winter, which is very abnormal, and the leaves that grow in the summer … and grow inward.
It has a very interesting behavior compared to other plants, and that was an observation of how cancer works as well. It goes against the rhythm. It grows out of sync with the organism. That is very much what he recognized.
And as such, he harvested the plant and aspects of the plant at different times, blended it, and then took a particular extract from it. He also noted that it needed to be injected, because you need to remember, 100 years ago we didn’t know about lectins, we didn’t know about viscotoxins, yet somehow, he understood that you needed to inject it to get the anticancer benefit.
You could take the full tincture. You could take it in other ways, and it has a lot of other medicinal impacts, but then it doesn’t have the anticancer impacts, the reason being, we’ve learned — or at least we suspect, because we’re still learning — is that those lectins and things get broken down in our GI tract and they don’t get into the bloodstream; they don’t access the immune system in the way they need to …”
Mistletoe Can Be Used as an Adjunct for All Cancers
According to Winters, mistletoe is likely to be useful as an adjunct therapy for all cancers, and she, along with several other doctors, has been training physicians on how to use mistletoe for several years now.
“One of our physicians has been using mistletoe for 45 years in his practice, and what we’ve seen clinically, and what the research suggests, is that this therapy, it has always been about using it with others. It plays very well with others.
It was never really developed to be a standalone therapy, though believe me, we’ve seen impact with that as well. And it has virtually no contraindications with any of our standard of care therapies. So, we can literally inject this into a patient the morning before they go into a surgery, or they can start on this therapy the very day they’re going to start a round of chemotherapy or radiation.
It bypasses first phase detox pathways of the liver, so it doesn’t interact, intervene, speed up or slow down detox processes that could otherwise cause some adverse events, or change the desired effect of a certain medication, herbal intervention or dietary intervention.”
Mistletoe Is a Key Cancer Treatment Adjunct
In fact, mistletoe has been shown to enhance other interventions. Even the most toxic treatments seemingly work better and with fewer adverse effects when combined with mistletoe.
“This should be utilized, in my personal opinion, with every patient going through a standard of care approach to just enhance their experience with treatment,” she says.
“There are a lot of things that we kind of have to be careful with … but mistletoe, in my experience, and that of my colleagues, is that this is probably the least harmful and least contraindicated substance and therapy I’ve ever had the privilege of working with. It’s pretty extraordinary and rare to find something that is this applicable to the masses …
As I said, it has over 100 years of continuous use, and has over 250 very good randomized studies … It just completed a Phase 1 clinical trial at John’s Hopkins in the United States as an IV application for solid tumors, and is getting ready to be moved into a Phase 2 clinical trial.
It is the most studied integrative oncology therapy in the world, and it is utilized in upwards of 60% to 80% of all cancer patients in Europe. In parts of South and Central America, all over Southeast Asia and India, in different parts of Europe, this is just part of their medical system … It’s just in the United States where we have a little bit of resistance to embracing it into our conventional medical system …
As a naturopathic physician who’s been practicing integrative oncology for some time and who has teachers, mentors, colleagues from all over the world, some of the most powerful anticancer therapies I’ve seen that are beneficial even to the standard of care model of treatment — things like artesunate, curcumin, quercetin, green tea extract, all of those in intravenous forms — have been taken out of our ability to use here in the United States.
Do my colleagues still find workarounds to get access to these very important medicines? Absolutely they do, but they have to tread very carefully and very lightly. But again, you go north of the border or south of the border and you have no problem accessing these therapies. Or go to Europe — and this is what I’ve been doing for the last two years.
These treatments that we’ve had great success with have been plucked out of our ability to access easily, readily, legally, so we’re now having to send our patients abroad for them to actually get good cancer care.
That’s what’s really devastating to me. So, another part of my purpose and mission is to build an in-house residential research institute and integrative cancer hospital right here on our soil so we don’t lose access and patients don’t lose access [to helpful remedies].”
Arizona Research Facility
Winters is currently building that research institute in Arizona, which will be funded entirely by private donations and research grants. Thousands of patients are anxiously waiting for the doors to open. When asked if she isn’t worried our pro-pharma agencies might shut them down, she replies:
“We will be doing all of our due diligence to let people know that these are not FDA approved therapies, that people are coming into a research environment. They’re either paying cash or they’re getting grants based on their financial ability to help them cover this care.
We’re doing it in a pretty open-minded medical state; Arizona has one of the broadest scopes of practice in the country. And we’re also very close to our southern border with Mexico, so that if we do come up against someone shutting down one of our therapies for a bit, we are able to take our patients across the border to a little sister clinic to keep the continuity of care.
We don’t anticipate that happening because people are coming as a buyer beware. They’re coming being well-informed about who we are and what we’re about. And frankly, we get thousands of inquiries a month from all over the world looking for this approach. The patients will drive this home.
It’s a mighty David versus Goliath story, especially now, but I also think the time is now because we have these acts, like the Right to Try Act, and because we do have more and more patients facing this diagnosis with grim outcomes.
And, a study that came out in the last year that looked at 17 years’ worth of conventional cancer treatments found that, overall, of the 96 different drugs they looked at, the average survival rate was 2.4 months. That is the reality and this is what’s driving the clinical oncologists from around the world to sign up and take my course …
So, there is this massive kind of underground movement that’s starting to sprout and come above ground. That’s happening. And frankly, mistletoe is one of the vehicles for that to happen … Instead of trying to fix the model, we’re just creating a new one.”
Another potential “back door” is to convince insurance companies that this is in their best interest. Mistletoe is a natural remedy and therefore cannot be patented, so there’s no incentive for the drug companies to pursue it. But insurance companies may support its use once they realize how much money they can save on hospitalizations, drug coverage and everything else.
Mistletoe Modulates Immune Function
Your immune system and metabolic function are both integral parts of addressing cancer, and mistletoe works on both. It’s important to recognize, however, that it’s not a magic bullet. If you’re eating a standard American diet and are metabolically dysfunctional, mistletoe is not going to be as effective as for someone who is also eating a healthy whole food diet and supporting their health in other ways.
That said, mistletoe is an immunomodulator. Immune therapies are all the rage right now, with a majority of research dollars being funneled into them. Yet the effectiveness rate for these therapies is less than 20%. In other words, they’re hardly a cure.
“A lot of folks have heard of Jimmy Carter’s melanoma story that had metastasized to his brain. He took this immune drug, Keytruda. That’s a checkpoint inhibitor. The most common drugs you’ll hear about are things like Opdivo, Keytruda, PD-1, PDL1 inhibitors, those are checkpoint inhibitors, or CTLA-4 inhibitors, also a type of checkpoint inhibitor.
These are drugs that kind of pull the breaks off your immune system to go hog wild in treating the cancer. Now that seems like a great idea — unless you have underlying metabolic dysfunction, right? Hello! And then, if you have an underlying autoimmune condition, you are also someone who’s likely going to have a not so positive response to these medications.
What I love about mistletoe is it comes in and it modulates that teeter-totter. It doesn’t take the breaks off and make it go hog wild, and it doesn’t suppress. It’s … kind of adaptogenic in some ways. So, it behaves a little bit like a smart drug, in that it can sort of match itself to the individual.
It is not a protocol, it’s a patient-driven process in that we look at the person’s gender, we look at the tumor type, the tumor stage, the general condition of the patient, and then we consider the most appropriate host tree. The most common are the pine, the fir, and the apple tree hosts. Mistletoe [from these trees] tends to have the highest lectin content that have the highest anti-cancer content.
Then we look at the dosing frequency, and if we’re going to do it subcutaneous, intravenous, intratumoral, intraperitoneal, et cetera, depending on where you live in the world and how we’re going to pair it with other therapies, if at all. So, it is based totally on the individual and the individual’s response.
We want the patient to have a little local reaction if they’re injecting it. We want it to get a little redness, irritation and itchiness and maybe tenderness. We want it to raise the body’s temperature a little bit … The point is, we want to create this cytokine release at a very low-grade level. Whereas when we bring on an immune drug like Keytruda, it creates a cytokine release at an explosive level that can sometimes be fatal for patients.”
Other Mechanisms of Action and Synergies
Similar to drugs, mistletoe also has a systemic effect. It doesn’t target a specific receptor site. Instead, it’s a systemic terrain-centric approach. In its mechanisms of action, it’s engaging with B-cells, T-cells, natural killer (NK) cells.
It will basically calm those that are acting overzealous, to prevent an excessive immune reaction, and activate those that are dormant or underperforming. Mistletoe also reduces inflammation, lowering your levels of C-reactive protein, interleukin-6, homocysteine, liver enzymes and more.
It also lowers vascular endothelial growth factor (VEGF), which can be important for certain cancers, and it lowers blood sugar and insulin. Winters also suspects mistletoe may be upregulating both the endorphin and the endocannabinoid system, so you’re getting stress modulation as well.
“So, it’s hitting all of what we call ‘The Terrain 10,’ from my previous book, ‘The Metabolic Approach to Cancer.’ I find that mistletoe tends to hit every one of those … including epigenetic expression … clean up of DNA.
We use it for people who’ve gone through radiation. We’ll use it as a DNA stabilizer. We’ll use it if people have taken a course of Cipro [and other fluoroquinolones] to help clean up the metabolic mayhem, the DNA damage that they cause. We know that it has some impact on insulin and IGF-1.
In our book, we have hundreds of references to all of the different mechanisms of action. My colleague, Dr. Paul Faust, [has written] a beautiful chapter on its direct impact on the immune system and all the nuances of that.
That chapter alone will illuminate for so many people why this therapeutic support and this therapeutic intervention is so helpful for the cancer patient, for prevention of cancer, for cleanup after cancer treatment …
And the synergy, when you pair mistletoe with hyperthermia, like so many of my colleagues in Europe have been doing for the past 50 years, talk about the biggest bang for your buck. We see some pretty extraordinary outcomes.
I’ve had patients go to Europe with Stage 4 [cancer], metastatic disease everywhere, getting IV mistletoe along with local, regional and whole body high-heat hyperthermia that have put their cancer into complete remission in many cases, but at the very least, turning it back into a manageable disease process, and even more interesting, increasing the responsivity to other therapies again.”
More Information
The good news is the number of doctors trained in this therapy is growing, and the treatment itself is only between $200 and $300 a month, so it’s highly affordable while also being highly effective. I think it would be beyond irrational not to integrate this into any cancer therapy you’re considering.
Again, for cancer, oral supplementation is ineffective, as the lectins responsible for the anticancer effects are broken down in your GI tract and therefore can’t enter your bloodstream.
The Physicians’ Association for Anthroposophic Medicine (PAAM) sponsors Winters’ mistletoe trainings. While most are held in person, there’s now also a course available online for licensed physicians. There are plans to take a group of physicians to Europe for immersive in-hospital training in the fall of 2023. Here’s a list of resources where you can find more information:
• AnthrosophicMedicine.org offers articles, research, books, webinars and more. To locate a clinician trained in the proper administration of mistletoe, see PAAM’s health provider directory.
• Clinicians interested in training, visit the education section of PAAM’s website. The next annual training conference will be held in Loveland, Colorado, April 29 through May 6, 2023.
• Metabolic Terrain Institute of Health (MTIH) is the not-for-profit association cofounded by Winters that is building a research hospital in Arizona. MTIH also offers a master course for practitioners, and grants to help patients access these therapies. Certified practitioners can be found on terrain.network.
These practitioners include medical doctors and oncologists who have been taught Winters’ methodology of testing, assessing and treating cancer (which includes but is not limited to mistletoe therapy). MTIH certified practitioners are also listed on DrNasha.com.
• Mistletoe-therapy.org is a European website that offers helpful information for patients and scientific papers directed at clinicians.
• A load of resources are found on the book’s website: www.themistletoebook.com. Proceeds from this book go to fund clinical research and contribute to physician training.
Last but certainly not least, you’ll want to pick up a copy of “Mistletoe and the Emerging Future of Integrative Oncology.” It’s an excellent book.