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DMSO — The Forgotten Remedy Revolutionizing Eye Healing


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2026/03/30/dmso-for-eye-health.aspx


Analysis by A Midwestern Doctor     
March 30, 2026

dmso for eye health

Story at-a-glance

  • DMSO is an “umbrella remedy” capable of treating a wide range of challenging ailments due to its combination of therapeutic properties (e.g., reducing inflammation, improving circulation, and reviving dying cells)
  • DMSO has a unique affinity for the eyes, resulting in it (often spontaneously) treating a wide range of visual disorders that frequently cannot be treated with conventional therapeutic options — including blindness
  • DMSO’s ability to heal the skin, moisten tissue, and relax muscles makes it excellent for reducing eye strain. It helps heal a variety of challenging conditions around the eyes, such as blepharitis, styes, psoriasis, burns, bags under the eyes, and eye twitches
  • DMSO’s anti-inflammatory and antimicrobial properties allow it to treat a variety of infections and inflammatory conditions damaging the surface of the eyes (e.g., shingles or keratitis), in many cases facilitating a complete recovery of the eye
  • DMSO’s ability to heal tissue from injury also allows it to heal damaged eyes, which in many cases would otherwise require the eye to be removed. This article will review how DMSO is able to treat these conditions and how those healing properties allow it to treat many other challenging eye conditions, such as vision loss, macular degeneration, cataracts, and floaters

Dimethyl sulfoxide (DMSO) is a simple compound with a remarkable blend of therapeutic properties that allows it to treat a wide range of conditions including:

Numerous neurological disorders (e.g., strokes, dementia, paralysis, neuropathies, Down syndrome, and circulatory disorders (e.g., Raynaud’s, varicose veins, hemorrhoids)) — are discussed here.

Tissue injuries, such as sprains, concussions, burns, surgical incisions, and spinal cord injuries — are discussed here.

Chronic pain (e.g., from a bad disc, bursitis, arthritis, or complex regional pain syndrome) — are discussed here.

Autoimmune, protein, and contractile disorders, such as scleroderma, amyloidosis, and interstitial cystitis — are discussed here.

Head conditions, such as tinnitus, dental problems, and sinusitis — are discussed here.

Internal organ diseases (e.g., prostate enlargement, pancreatitis, and cirrhosis) — are discussed here.

Respiratory disorders, including asthma, COPD, and pulmonary fibrosis — are discussed here.

Many different gastrointestinal disorders, such as bowel inflammation, cirrhosis, and pancreatitis — are discussed here.

Skin conditions (e.g., hair loss, varicose veins, acne, ulcers, skin cancer, or psoriasis) — are discussed here.

Infections, such as onychomycosis, herpes, and shingles, are remarkably treatable when combined with an antimicrobial agent — are discussed here.

Many aspects of cancer (e.g., eliminating cancers, enhancing chemotherapy, and reducing the toxicity of mainstream cancer treatments) — are discussed here.

Because of how effective DMSO was for a wide range of “incurable” conditions, when it was discovered in the 1960s, it rapidly took America by storm and became the most demanded drug in the country — at which point the FDA did everything they could to suppress it (e.g., see this 1980 segment 60 minutes did on DMSO). Regretfully, this was successful, and decades later, DMSO’s remarkable properties, which could have reshaped medicine, were largely forgotten.

However, due to the new political climate we entered — widespread loss of trust in medical authorities and the mass media for their handling of COVID-19 (which allowed the alternative media to rise to prominence) — an unprecedented window was created for unorthodox therapies to gain prominence. As such, over the last year, my attempts to promote the vast body of evidence behind DMSO went viral, and there is now a similar interest in DMSO to what was seen in the 1960s.

Because of this, I have now received over 5,000 reports from readers1 who’ve benefitted from DMSO (which I compiled here), most of which match the effects typically attributed to DMSO (rapid healing from an injury and/or elimination of debilitating pain). However, I also come across some that are quite extraordinary, such as this 75 year old man who regained sight in his eye after being blind since birth after using DMSO to eliminate a chronic sinus infection.

Note: The journalist who filmed this interview previously filmed her neighbor with terminal COPD recovering with nebulized DMSO.

Murray’s story (and hundreds more I’ve received from readers) illustrates one of the least appreciated facets of DMSO — it is exceptionally well suited to treating a wide range of eye conditions — many of which are considered incurable within conventional medicine.

Note: The German DMSO community (including DMSO utilizing ophthalmologists) has reported very similar results to those shared with me by readers when using DMSO to treat the eyes.

DMSO and the Eyes

“Ophthalmologist Norbert J. Becquet, M.D. reported in May 1980 that he had great success using DMSO in treating cataracts and other eye problems. ‘I’ve treated two hundred patients in the last year for macular degeneration, macular edema, and traumatic uveitis.’”

Note: DMSO has been repeatedly shown to enhance the penetration of drugs into the eyes,2,3,4,5 potentiate certain ocular medications (e.g., anesthetic eye drops6 or 5-IDU to treat shingles)7 and authors have proposed using these combinations to enhance the efficacy of ophthalmologic medications and bypass the need to inject them into the eyes.8 Likewise, doctors like Norbert Becquet used topical DMSO nutraceutical combinations to treat otherwise “incurable” eye conditions.9

DMSO’s uses for the eyes originally emerged after participants in early clinical trials noted that their vision frequently improved when an unrelated issue was being treated (due to DMSO’s tendency to concentrate within the eyes). Likewise, readers here have frequently reported that vision significantly improves after DMSO is applied to another part of the body — particularly the neck (which is likely due to its blood supply being closer to the eyes).

Note: Due to the intense scrutiny DMSO was subjected to, its safety within the eyes was extensively studied — after which no one detected eye toxicity. For example, a JAMA publication attested to DMSO’s eye safety,10 and in a study where DMSO was applied to the eyes of 108 patients11 — including those with numerous pre-existing eye diseases — no side effects occurred besides a concentration dependent temporary irritation of the eyes.

I will now review how DMSO makes it suited to treat a wide range of disorders on the surface of the eyes.

Peripheral Eye Issues

“My mother (100 yrs old) fell three weeks ago.12 When she fell, she broke her nose and fractured a couple of orbital bones — one around each eye — which resulted in terrible black bruising due to her blood thinner medication. She spent 6 days in the hospital and my sister and I visited her everyday. After applying daily DMSO, the bruises rapidly changed color, and in three days they began to fade and then completely disappeared.”

Due to DMSO’s ability to rapidly heal injuriesrelax muscles, and reduce skin inflammation, it is well-suited for treating a wide range of issues around the eyes. Studies in turn have shown:

DMSO combined with iodine safely treated inflammatory eye conditions13,14,15,16 (e.g., in 17 patients with blepharitis and blepharoconjunctivitis all had a partial or complete response to it17).

In children with eyelid styes, DMSO reduced swelling and pain.18

DMSO treated inflammatory diseases of the eyelids.19

“I have a really complicated eye history [including] having blepharitis many times that left my eyelids inflamed for a very long time.20 I’ve now had inflammation on my eyelids for over a year. It’s almost gone in [after] about a week of DMSO.”

Likewise, many readers have reported DMSO treats issues around the eyes (e.g., for bags and wrinkles,21 blepharitis,22,23,24 psoriasis,25,26 styes,27,28,29 burns,30,31 milia,32 cellulitis,33 skin tags, and pedicules,34,35).

“After reading your articles I tried DMSO on a huge eye stye my husband has, a recurring issue that no doctor had been able to fix.36 In less than 24 hours it went from the size of a large pea to near gone.”

“I have used DMSO even on the lower lids of my eyes, at 25%, with astonishing success in treating a chemical/heat burn [hot tar while fighting a fire] that troubled me for about ten years, AND IT RESOLVED ABRUPTLY.”37

Finally, DMSO’s ability to relax muscles likely accounts for many of its therapeutic properties (e.g., chronically tight muscles distort focusing and many readers have reported they no longer needed to wear eye glasses after using DMSO). Likewise:

 • One reader reported being able to treat superior oblique myokymia, a rare “untreatable” eye condition where that muscle will spontaneously twitch, distorting vision, fatigue the eyes, and making it impossible to drive.38

James Miller M.D. has reported successfully curing chronic eye twitches with DMSO.39

Using DMSO in conjunction with eye exercises has been reported to dramatically improve their efficacy.

Corneal and Conjunctival Disorders

DMSO’s therapeutic properties and its tendency to concentrate within the cornea make it well-suited to healing issues at the surface of the eyes, particularly since DMSO, being an acetylcholine esterase inhibitor, also stimulates parasympathetic activity (which increases tear secretion) and reduces duct inflammation or obstruction (also increasing tear secretion).

Because of this, many readers have reported remarkable results for eye dryness40,41,42,43,44,45,46,47,48,49,50,51 (including severe cases from Parkinson’s,52 severe mast cell activation disorder which had eroded the surface of the cornea,53 or previous chemotherapy54).These include:

“I have suffered from severe dry eye for years.55 (I’ve had to have Meibomian Gland Probing done twice for my condition, in addition to numerous other treatments). I am having a [very] positive experience using daily DMSO eye drops, I find I need much less commercial eye drops and I am very hopeful about the continued benefit of the DMSO drops.”

“It takes care of my chronic dry eyes for 6 to 8 hrs.”56

“I no longer have dry eye syndrome in that eye.”57

“I’ve been using DMSO in my eyes for more than a year now. Slowly increasing the strength.58 Even at [low doses] it’s life changing! No more dry eyes or eye infections. Better vision. For anyone who is hesitant, start slowly and ‘see’ 🤣 the amazing results.”

Likewise, many readers have also reported less blurriness,59,60,61 reduced eye strain62,63,64 (particularly from screens), and the eyes feeling refreshed.65,66 I have also seen numerous reports of DMSO healing debilitating corneal injuries like this readers:

“For decades, I experienced mysterious, intermittent left eye pain [which] contributed to regular severe sleep disruption.67 After seeing 12 doctors, they finally discovered I had corneal injury from a piece of glass getting stuck in there for a few days in 1974, but had nothing to offer me. After starting DMSO because of your article, the pain finally went away and I could sleep. Tests this week also showed the eye’s tear production recovered. Thank you AMD!”

Note: I have also received reports of DMSO rapidly treating conjunctivitis,68 a conjunctival cyst,69 and a pterygium70 (which incidentally resulted from applying DMSO to the neck).

DMSO’s unique properties (e.g., its ability to remove edema and pathologic protein deposits) can also address a few challenging corneal issues for which there are currently no viable therapeutic options. For example:

Gelatinous drop-like corneal dystrophy is a rare genetic eye disorder where amyloids build up just beneath the corneal epithelium (progressively clouding it, and impairing vision) that is difficult to treat (requiring corneal transplantation once it progresses — which can then be followed by recurrences). Extensive research shows DMSO eliminates amyloids, and in one case report,71 DMSO was found to eliminate the amyloid which had accumulated after a corneal transplant.

One of the early DMSO studies repeatedly found DMSO treated corneal edema.72

Likewise, three readers shared they used it for Fuchs’ dystrophy (an incurable eye disorder where the cornea swells with fluid, causing gradual vision loss). Of them, one reported it significantly reduced corneal edema and improved their vision, one reported the same (but did not have a formal diagnosis), while a third reported they’d begun trying it, but weren’t yet sure if it was helping.73,74

One reader reported DMSO rapidly cleared a corneal deposit in her 15-year-old Boston terrier.

boston terrier cleared corneal deposit

Finally, in both the reports I received and those I’ve seen throughout the DMSO community, users frequently report that DMSO “cleans their eyes out” and makes vision much sharper and clearer. This likely comes from DMSO removing insoluble protein aggregates (from the cornea, lens, or vitreous) or its reviving retinal function — something DMSO is uniquely suited to do in a noninvasive manner.

Note: DMSO has a unique ability to refold and eliminate misfolded proteins (e.g., amyloids), including opaque ones that accumulate within the eyes. In turn, one of the most common things readers report is DMSO treating floaters (and in almost all cases, the treatment being successful), followed by cataracts — which likely accounts for many of the instances where DMSO appears to clean the eyes out.

Additionally, one reader noted this clearing of the eyes could be externally observed with (as the sickly look hadn’t returned), suggesting DMSO can increase the eye’s ability to absorb the critical spectrums in natural light (particularly since other studies have shown DMSO increases the skin’s ability to transmit light).

Inflammatory and Infectious Conditions

DMSO’s potent anti-inflammatory and antimicrobial properties make it well suited for treating a variety of conditions throughout the eye and often to do so in a safer and more potent manner than existing treatments (e.g., in one clinical trial, 30% DMSO was found to have therapeutic anti-inflammatory effects on the eye similar to 0.01% dexamethasone75).

In turn, numerous studies show DMSO eliminates challenging inflammation and infection on the surface of the eye. For example, DMSO has repeatedly been shown to be an effective treatment for chronic superficial keratitis (CSK), which over time, can reduce eye inflammation without any adverse effects to the corneal epithelium76,77 and in many cases, to be a superior CSK treatment to steroids.78,79 For example:

In dogs with CSK, 50% DMSO combined with dexamethasone or prednisolone was found to be a much more effective treatment than either alone (e.g., it effectively reduced corneal inflammation and improved corneal transparency).80,81,82,83,84

chronic superficial keratitis with dexamethasone or prednisolone

In dogs, DMSO has also been shown to safely treat CSK in combination with cyclosporine.85 Significant benefit has also been seen from combining DMSO with both dexamethasone and cyclophosphamide (e.g., a 77.9% to 90.7% reduction in neovascularization, a 45% to 51% reduction in corneal surface inflammation, 72.9% of corneas had a reduction in pigmentation, 74.3% had an increase of transparency, and 95.4% had a repigmentation of the nictitating membrane).86

chronic superficial keratitis with cyclosporine

Note: Another dog CSK study found DMSO and tacrolimus halved inflammatory infiltration and neovascularization of the cornea,87 while another found similar results with picrolimus and DMSO.88

Likewise, DMSO and penicillin treated calves infectious keratoconjunctivitis.89

calves infectious keratoconjunctivitis

Topical DMSO and itraconazole was able to resolve chronic (fungal) keratomycosis in 80% of treated horses.90

chronic fungal keratomycosis

Likewise, a horse with fungal ulcerative keratitis fully recovered with DMSO and fluconazole.91,92

Note: DMSO has been extensively shown to treat ocular inflammation (e.g., uveitis, iritis, and episcleritis) and associated complications (e.g., synechia).

Eye Injuries and Trauma

DMSO has been repeatedly shown to protect tissue throughout the body from a variety of injuries, and does the same for the eyes:

In rabbits, 3 days, 20% DMSO was found to significantly reduce the corneal opacification and ulcerations that followed alkali burns.93

In multiple studies, DMSO was found to be an effective treatment for corneal acid burns from hydrofluoric acid94,95 (and also for hydrofluoric acid burns on other parts of the body).96

In another study,97 DMSO was combined with monomycin to treat corneal burns.98

Likewise, many readers have reported that DMSO has healed a variety of eye injuries:

“I was kicked in my eye by our puppy, 50 lbs and strong, did serious damage and was legally blind seeing double, no progress healing for a month.99 So I found a DMSO recipe and my vision was restored. I’m no expert, it worked for me and quick. I had 80% healing in days, a good part of that in 24 hours. Month previous, as stated, I was not improving at all.”

“Many years ago my mother-in-law burst a blood vessel in her eye.100 After trying allopathic approaches with the MD, we made her [eye] drops containing DMSO. In mere days, the eye returned to normal.”

Likewise, a month ago, a friend injured their eye by cliff jumping from quite a height and not shielding their eye when they hit the water (resulting in the eye being filled with blood). Once my friend decided to use DMSO, we saw the eye rapidly heal and the blood within it leave … after which they repeated the same jump, again did not correctly shield their eye, and then healed the eye again with DMSO.

I have also received numerous remarkable reports of pets with injured eyes that would normally be removed instead have a complete recovery like these:

This cat had its eye scratched, after which the vet said the necrotic eye needed to be urgently removed.101 While they raised money for the operation, they tried flushing the eye with DMSO and colloidal silver roughly every hour (which Gerald the cat loved), the eye rapidly improved, and a few days after the initial visit, the vet cancelled the operation and after six weeks the eye was healed.

cat eye scratched

This dog had got an eye ulcer from a scratch, and the vet wanted to remove the (blind) eye.102 After a month it fully healed and sight returned.

dog eye ulcer

Note: I have received additional reports of injured pet eyes recovering and reports of human eyes that top doctors said would need to be removed instead of recovering with DMSO.

Conclusion

DMSO’s ability to heal the surface of the eye also allows it to heal conditions deeper within the eyes. In turn, it has been truly extraordinary for me to see how much data there is supporting it treating nearsightedness, floaters, cataracts, glaucoma, uveitis, macular degeneration, and other causes of blindness like retinitis pigmentosa — as for many of these conditions, I was trained to believe there was nothing you could ever do to cure them.

Fortunately, due to our extraordinary political climate, more and more are awakening to the Forgotten Sides of Medicine and realizing they can take direct charge of their health rather than depend on a costly, often counterproductive medical system. It has been an incredible privilege to see just how many readers have been able to restore their eyes with DMSO, and we are deeply grateful that we at last can change the unhealthy medical paradigm we’ve been trapped within.

Author’s Note: This is an abridged version of a longer article that discusses the evidence presented here in more detail along with how DMSO can be used with natural therapies to treat a variety of other complex eye disorders (e.g., macular degeneration, floaters, cataracts, or needing to wear glasses). That article, along with additional links and references, can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

– Sources and References

The Great Alzheimer’s Scam and the Proven Cures They’ve Buried for Billions


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2026/03/26/alzheimers-amyloid-hypothesis-fraud.aspx

Analysis by A Midwestern Doctor     March 26, 2026

alzheimers amyloid hypothesis fraud

Story at-a-glance

  • Alzheimer’s disease is commonly thought to result from abnormal plaque buildup in the brain that gradually destroys brain tissue. Almost all Alzheimer’s research for decades has been directed toward eliminating amyloid, even after the basis for much of this work was shown to stem from fraudulent research
  • The billions spent on amyloid Alzheimer’s research have only produced three drugs, all of which offer minuscule benefits and severe side effects
  • In contrast, affordable and straightforward treatments that reduce dementia or the preceding cognitive impairment have been maligned and buried by the medical industry
  • DMSO for example, has incredible neuroprotective qualities that have spared many stroke and spinal cord injury victims from a life of “incurable” disability. Decades of forgotten research also show it treats cognitive impairment and dementia
  • This article will review the great amyloid scam and the simple therapies for cognitive decline we’re never told about

Medicine is strongly biased towards adopting biochemical models of disease as this facilitates costly therapeutics being developed for each disease and hence sustains the medical industry. Unfortunately, in many cases, the biochemical approach to disease, at best, can manage symptoms, and as a result, many conditions remain “incurable” while non-patentable natural therapies that can cure them languish in obscurity.

That’s why, despite spending an ever increasing amount of money on Alzheimer’s research (e.g., the NIH spent 2.9 billion in 2020 and 3.9 billion in 20241), we’ve still failed to make any real progress on the disease. This is particularly remarkable given the vast costs to the country (e.g., last year Alzheimer’s was estimated to cost the United States 360 billion dollars2) and the even greater social costs that accompany it.

The Amyloid Juggernaut

In 1906, plaques (of amyloid) in the brain were identified as the cause of Alzheimer’s disease. As the years have gone by, the majority of research for treating Alzheimer’s disease has been targeted at eliminating these plaques. Unfortunately, to quote a 2022 article:3

“Hundreds of clinical trials of amyloid-targeted therapies have yielded few glimmers of promise, however; only the underwhelming Aduhelm has gained FDA approval. Yet Aβ still dominates research and drug development. NIH spent about $1.6 billion on projects that mention amyloids in this fiscal year, about half its overall Alzheimer’s funding.

Scientists who advance other potential Alzheimer’s causes, such as immune dysfunction or inflammation, complain they have been sidelined by the ‘amyloid mafia.’ Forsayeth says the amyloid hypothesis became ‘the scientific equivalent of the Ptolemaic model of the Solar System,’ in which the Sun and planets rotate around Earth.”

Note: Frequently, when a faulty paradigm fails to explain the disease it claims to address, rather than admit the paradigm is flawed, its adherents will label each conflicting piece of evidence as a paradox (e.g., the French “paradox” disproves the notion cholesterol causes heart disease4) and dig deeper and deeper until they can find something to continue propping up their ideology (e.g., cholesterol reducing statins provide almost no benefit for heart disease while having significant side effects yet continue being pushed on patients).

The consistent failure of the amyloid model to cure Alzheimer’s gradually invited increasing skepticism towards it, which resulted in more and more scientists studying alternative models of the disease. Before long, they found other factors played a far more significant role in causing the disease (e.g., chronic inflammation), and by 2006, this perspective appeared poised to change the direction of Alzheimer’s research.

In response, the amyloid proponents pivoted to defending their failed hypothesis was due not to amyloid clumps, but rather toxic parts of it (oligomers) and a Nature 2006 paper appeared which identified a previously unknown toxic oligomer, Aβ*56, and provided proof that it caused dementia in rats.5

This paper cemented both the amyloid beta and toxic oligomer hypotheses (as it provided the proof many adherents to the theory had been waiting for) and rapidly became one of the most cited works in the field of Alzheimer’s research. Its authors rose to academic stardom, produced further papers validating their initial hypothesis, and billions more were invested by both the NIH and the pharmaceutical industry in research of the amyloid and toxic oligomer hypothesis.

It should be noted that some were skeptical of their findings and likewise were unable to replicate this data, but rarely had a voice in the debate:

“The spotty evidence that Aβ*56 plays a role in Alzheimer’s had [long] raised eyebrows.6 Wilcock has long doubted studies that claim to use ‘purified’ Aβ*56. Such oligomers are notoriously unstable, converting to other oligomer types spontaneously. Multiple types can be present in a sample even after purification efforts, making it hard to say any cognitive effects are due to Aβ*56 alone, she notes — assuming it exists.

In fact, Wilcock and others say, several labs have tried and failed to find Aβ*56, although few have published those findings. Journals are often uninterested in negative results, and researchers can be reluctant to contradict a famous investigator.”

The Amyloid Scandal

At the end of 2021, a neuroscientist physician was hired by investors to evaluate an experimental Alzheimer’s drug and discovered signs that its data consisted of doctored Western Blots (and therefore erroneous assessments of what oligomers were present within research subjects’ brains).7 As he explored the topic further, he discovered other papers within the Alzheimer’s literature had been flagged for containing doctored Western Blots.

Note: Western blots, used to test for proteins, are one of the few easily detectable forms of research fraud (e.g., we discovered Pfizer submitted fake Western blots to regulators to “prove” their vaccine worked). Regrettably, far more undetectable fraud exists throughout the scientific literature (e.g., independent researchers comparing regulatory submissions discovered Pfizer also submitted doctored data on where the COVID vaccine is distributed in the body8).

Before long, the neuroscientist noticed three of those suspect papers had been published by the same author and decided to investigate the author’s other publications. This led him to the seminal 2006 Alzheimer’s publication, which contained clear signs of fraud.9

As investigation then uncovered 20 doctored papers written by the author, 10 of which pertained to Aβ*56 (along with a co-researcher attesting to earlier scientific misconduct by the author).

The Amyloid Industry

One of the remarkable things about this monumental fraud was how little was done about it. For example, the NIH was notified in January 2022, yet in May 2022, beyond nothing being done, the NIH gave the suspect researcher a coveted $764,792 research grant (signed off by another one of the authors of the 2006 paper10).

In July 2022, Science published an article exposing the incident and the clear fraud that had occurred.11 Despite this, the researcher was allowed to remain in his position as a tenured medical school professor.12 It was not until June 2024 that the 2006 article was retracted at the request of the authors13 — all of whom denied being at fault and insisted the doctored images had not affected the article’s conclusions.

Eventually, on January 29, 2025, during his confirmation hearing, RFK cited the paper as an example of the institutional fraud and wasted tax dollars within the NIH, and a few days later, the suspect researcher announced his resignation from the medical school professorship (while still maintaining his innocence).14

This odd behavior (e.g., the medical field continues to insist the proven fraud has not disproven the Amyloid hypothesis) likely results from how much money is at stake — beyond the research dollars, roughly 7 million adults have Alzheimer’s — equating to hundreds of billions in potential (Medicare funded) sales each year.15

The Failed Amyloid Drugs

Recently, a monoclonal antibody that made immune cells target amyloid demonstrated limited success in treating Alzheimer’s — which was embraced as revolutionary by the medical community, the pharmaceutical industry, and drug regulators. In turn, the first new drug received accelerated approval (which the FDA proudly announced).16 The second then received a quiet backdoor approval (due to the immense controversy surrounding the first),17 and the third was partially approved a year and a half later.18

alzheimers new treatment options

Each year, JP Morgan (Chase Bank) hosts a private conference for pharmaceutical investors that sets the tone for the entire industry. In 2023, its focus (covered in detail here) was on the incredible profitability of the new Alzheimer’s drugs and the GLP-1s like Ozempic (which the FDA has also relentlessly promoted). Most remarkably, the (widely viewed as corrupt) FDA commissioner was a keynote speaker, and a few days before the conference, had enacted the second backdoor approval.

However, despite the rosy pictures painted around the drugs (which each attacked different aspects of amyloids), they were highly controversial as:

The FDA’s independent advisory panel, in a very unusual move, voted 10-0 (with one abstaining) against approving Aduhelm, the first amyloid drug (which targeted amyloid plaques), but the FDA approved it anyways. In a highly unprecedented move, three of the advisors then resigned, calling it “probably the worst drug approval decision in recent U.S. history.”19

That drug was priced at $56,000 a year — making it sufficient to bankrupt Medicare, (which attracted a Congressional investigation).20

Brain swelling or brain bleeding was found in 41% of patients enrolled in its studies.21 Additionally, headaches (including migraines and occipital neuralgia), falls, diarrhea, confusion, and delirium were also notably elevated compared to placebo.

No improvement in Alzheimer’s was noted; rather one analysis found it slowed the progression of Alzheimer’s by 20% (although this could have been a protocol artifact rather than a real effect).

The second monoclonal antibody (which targeted amyloid precursors) had a somewhat better risk benefit profile22 (only 21% experienced brain bleeding and swelling due to reduced targeting of stable amyloid plaques), and 26.4% reduction in the progression of Alzheimer’s was detected in the trial (which for context, translated to a 0.45 reduction on a scale where a reduction of at least 1 to 2 points is needed to create an impact which is in any way meaningful for a patient).

The third monoclonal (which targeted amyloid plaques thought to be more pathologic)23 was also contested as it caused 36.8% of recipients to develop brain bleeding or swelling, like the other amyloid medications, frequently caused headaches and infusion reactions (e.g., nausea, vomiting, changes in blood pressure, hypersensitive reactions, or anaphylaxis) and there were reasons to suspect the trial had greatly overstated its minimal benefits.

Remarkably, despite widespread protest against the third drug, the FDA’s new advisory panel voted unanimously in favor of it, even though it had a very similar mechanism, efficacy, and toxicity to the previously unanimously rejected amyloid drug.

It should therefore come as no surprise that, when the British Medical Journal conducted an independent investigation, it found that, within publicly available databases, 9 out of 9 (assessable) members of the advisory committee had significant financial conflicts of interest.24

Fortunately, despite the aggressive promotion of amyloid drugs and the industry’s best attempts to promote the sector, the market somewhat recognized how bad they were. The first drug had its price halved (then was withdrawn as no one wanted it — making around 5 million dollars total),25 while the other two have had very modest sales (e.g., 290 million for the most popular one26).

What Amyloids Drugs Show Us

From this, four things stand out:

These drugs consistently damage brain tissue, indicating that their mechanism of action was inherently dangerous (e.g., it creates brain swelling by causing immune cells attacking amyloid also to attack brain tissue, or it creates brain bleeding by removing amyloid plaque that patches vessel walls and stabilizes brain tissue). Remarkably, despite this issue being recognized, it has not deterred the usage of these class drugs.

Removing amyloid offers minimal benefit and may be counterproductive. In fact, one of the only protocols that has had proven success in treating Alzheimer’s instead views amyloid as a protective mechanism the brain uses to prevent further damage.

An absolutely absurd amount of money and time has been wasted on this endeavor due to the medical field’s need to find a patentable drug.

The focus on these lucrative drugs has diverted attention from other (off-patent) treatments that are more likely to help Alzheimer’s patients.

For example, a randomized controlled trial which gave MCTs derived from coconut found that over 6 months,27 80% remained stable or improved — which for context, is better than what any of the amyloid drug trials showed, and more importantly, does not cause brain bleeds (and costs a lot less than the annual rough $30,000 cost for those drugs).

Note: Numerous readers have shared that coconut oil improved their relative’s dementia.

Likewise, very few are aware of a 2022 study that should have revolutionized the entire Alzheimer’s field:28

change in cognitive performance

Note: The RECODE protocol was based around identifying the underlying cause of a patient’s cognitive impairment (as five different things can cause dementia), and then providing appropriate natural therapies to address the applicable cause. Since then, many others have replicated its success in their patients.

DMSO and Dementia

Dimethyl Sulfoxide (DMSO) is a naturally occurring compound that has a variety of unique healing properties that allow it to rescue tissues from dying and revive those damaged from previous injuries — best demonstrated by decades of evidence showing DMSO can heal strokes, brain bleeds, severe concussions, and spinal cord injuries and save patients from a lifetime of paralysis.

lance grindle dmso

As many of DMSO’s mechanisms directly counteract the processes that trigger dementia, I have received many accounts like these from readers:

“My uncle’s wife has dementia and has been unable to speak for over a year. My mom recently visited them and told them about DMSO. He began to give his wife DMSO orally. After two weeks she began to talk again.29

I read the article and began giving it to my 93 year old mother in her juice every morning at the end of November. She has had some form of dementia for over 15 years. Since taking the DMSO, she no longer suffers with severe sundowners. She is more ‘with it’ and can communicate and laugh with us. Her personality is back. She is crossing her legs again and lifting her pinky finger when drinking her coffee. It’s a lot of little things that make a difference.

She is able to understand when I am asking her to use the bathroom. She is more cognitive and has started coloring in her coloring books again.30

I deeply appreciate your posts on DMSO. You helped bring spontaneous interaction back into the life of my father with Alzheimer’s.”31

Numerous studies support these experiences:

When rats had their carotid arteries surgically modified to reduce the blood going to the brain, DMSO prevented both the neuronal damage and the significant loss of spatial memory and learning that otherwise occurred.32

In a similar study, rats who developed persistent and severe memory impairment from reduced brain blood flow received DMSO and FDP for 7 days, which improved their memory by 54%, nearly reaching the cognitive function rats whose blood flow was never cut off.33,34

In rats, daily DMSO counteracted memory impairment induced by intracerebroventricular STZ infusions,35 while in a similar study,36 DMSO and Ginkgo biloba improved learning and memory in rats given Alzheimer’s disease.

Drinking minute amounts of DMSO prevented the visual degeneration otherwise seen in rats engineered to have early Alzheimer’s disease.37 In another study of those rats, it protected key brain cells from disappearing and enhanced both their spatial memory and smell (while decreasing their anxiety).38 Likewise, in rats bred to develop cerebellar disorders, DMSO prevented age-related deterioration of certain cognitive functions (e.g., memory and spatial learning).

These results have also been replicated in humans:

In 18 patients with probable Alzheimer’s after three months, DMSO greatly improved memory, concentration, and communication, alongside a significant decrease in disorientation in time and space.39

In 104 elderly adults with dementia due to cerebrovascular diseases, concussions, or Parkinson’s, DMSO combined with amino acids significantly improved their cognition and motor function.40

In 100 patients with cerebrovascular diseases (many of whom had dementia),41 DMSO caused almost all to have their cardiovascular parameters improve and:

“Recovery from the general symptoms was positive; there were favorable changes which were reflected in a feeling of well being, the recovery of agility, changes of mood from depressed to gay, improvement of sleeping, and clearer speech. As regards the ‘focal’ results, accelerated recovery from hemiplegia and hemiparesia was registered. A speedier recovery of speech in cases of defined or indicated aphasia took place.”

Conclusion

The Alzheimer’s story illustrates how medical science’s relentless focus on commercializable products has failed the country. This must be replaced with prioritizing understanding the root causes of the chronic illnesses we face.

Fortunately, now that MAHA can set national health policy and independent media has broken the media’s monopoly over the truth due to the lies we saw throughout COVID-19, more and more are stepping outside the medical orthodoxy to pursue therapies that can actually heal them. An opportunity like this has never existed before, and it is critical each of us brings attention to the need for real medicine before the window to fundamentally change the practice of medicine closes.

Author’s Note: This is an abridged version of a longer article which discusses the actual causes and treatments for Alzheimer’s disease and the cognitive decline which precedes it. That article, along with additional links and references, can be read here. Additionally, a companion article on how DMSO treats neurological injuries (e.g., strokes, brain hemorrhages, traumatic brain injuries, spinal paralysis, and developmental delay) can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

– Sources and References

From Sharper Night Vision to Curing Lifelong Blindness — How DMSO Heals Each Level of Vision Loss


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/11/28/dmso-reverses-vision-loss-blindness.aspx


Analysis by A Midwestern Doctor     
November 28, 2025

dmso reverses vision loss blindness

Story at-a-glance

  • DMSO is a proven “umbrella remedy” that treats dozens of “incurable” conditions and protects delicate tissues (especially brain and eyes) from otherwise fatal injuries such as a complete loss of blood flow
  • DMSO has a unique, almost magnetic affinity for the eyes, routinely restoring vision in disorders conventional medicine considers untreatable — including decades-long and lifelong blindness
  • DMSO shields the retina from ischemic strokes, intense light damage (e.g., staring directly at the sun), and progressive degenerative diseases such as retinitis pigmentosa, glaucoma, and many others covered below
  • Clinical studies and dozens of reader reports confirm DMSO halts or reverses macular degeneration — often returning eyesight that patients believed was gone forever. Beyond severe disease, DMSO dramatically improves everyday vision: sharper focus, better contrast and night vision, fewer floaters, and many people reduce or eliminate their need for glasses
  • In extreme but meticulously documented cases — including a man blind from birth for 75 years and others blind for decades after severe trauma — DMSO has rapidly restored functional sight that modern medicine had declared impossible

Dimethyl sulfoxide (DMSO) is a simple compound with a remarkable blend of therapeutic properties. Over the last year, I’ve compiled thousands of studies showing how it treats a wide range of conditions including:

Neurological disorders such as strokes, dementia, paralysis, and neuropathies (discussed here).

Circulatory disorders such as Raynaud’s, varicose veins, and hemorrhoids (discussed here).

Chronic pain (e.g., from disc herniations, bursitis, or complex regional pain syndrome) and tissue injuries, such as sprains, concussions, burns, surgical incisions, and spinal cord injuries (discussed here).

Autoimmune, protein, and contractile disorders, such as arthritis, scleroderma, amyloidosis, and interstitial cystitis (discussed here).

Head conditions, such as tinnitus, ear infections, dental problems, and sinusitis (discussed here).

Internal organ diseases such as prostate enlargement, pancreatitis, and cirrhosis (discussed here).

Respiratory disorders, including asthma, COPD, and pulmonary fibrosis (discussed here).

Many different gastrointestinal disorders, such as bowel inflammation, cirrhosis, and pancreatitis (discussed here).

Skin conditions such as hair loss, acne, ulcers, skin cancer, or psoriasis (discussed here).

Infections, such as onychomycosis, herpes, and shingles, and many antibiotic-resistant infections (discussed here).

Many aspects of cancer, including eliminating cancers, enhancing chemotherapy, reducing the toxicity of mainstream cancer treatments, and reducing cancer pain (discussed here).

Because of how effective DMSO was for a wide range of “incurable” conditions, after being discovered in the 1960s, DMSO quickly became the most demanded drug in the country — at which point the FDA did everything they could to suppress it.

The FDA succeeded, and DMSO’s incredible utility became largely forgotten. However, due to its remarkable efficacy and the extensive evidence corroborating its medical utility, once I brought attention to DMSO (in a post-COVID world where widespread skepticism exists towards the medical establishment), it rapidly went viral, and there is now a similar interest in DMSO to what was seen in the 1960s.

Because of this, I have now received over 5,000 reports from readers who’ve benefitted from DMSO (which I compiled here),1 most of which match the effects typically attributed to DMSO (e.g., rapid healing from an injury or eliminating debilitating chronic pain). However, I also come across some that are quite extraordinary, such as this 75 year old man who regained sight in his eye after being blind since birth after using DMSO to eliminate a chronic sinus infection.

Murray’s story illustrates one of the least appreciated facets of DMSO — it is exceptionally well suited to treating a wide range of eye conditions — many of which are considered incurable within conventional medicine.

Note: The German DMSO community (including DMSO utilizing ophthalmologists) has also reported that DMSO has an extraordinary affinity for treating a wide range of eye conditions.

DMSO and the Eyes

DMSO’s uses for the eyes originally emerged after participants in early clinical trials noted that their vision frequently improved when an unrelated issue was being treated (as DMSO will concentrate within the eyes) — something many readers have also reported to me. As DMSO has a variety of different therapeutic effects, such as healing tissues, reducing inflammation, eliminating infection, removing protein deposits, or increasing blood circulation and fluid drainage, it is well suited to treating a variety of eye conditions.

As such, numerous studies and hundreds of readers have reported remarkable improvements in the following eye conditions:

Floaters, cataracts, and other opacities within the eyes

Myopia, astigmatism, presbyopia, and other focusing problems (allowing many people to reduce or eliminate the need for glasses)

Dry eyes, blurry vision, and eye strain (especially from screens)

Eye spasms and muscle twitching

Glaucoma and elevated intraocular pressure

Healing from eye surgeries and eliminating adhesions within the eyes

Growths on or around the eyes (skin tags, chalazia, pterygia, etc.)

Blepharitis, conjunctivitis, uveitis, and other inflammatory or infectious eye conditions

Note: The extremely high success rate readers have reported for treating floaters is quite noteworthy given the lack of satisfactory conventional treatments for the condition.

In turn, since many of the above conditions can impair vision (along with many more minor ones not mentioned), it is not surprising that many readers have reported visual improvements from DMSO2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 (e.g., many reported improved night vision32,33,34,35,36). Reports include:

“I just dabbed a bit of DMSO on my eyelids and got an immediate improvement. I could see my pool shots so much better.”37

“Vision has improved, and I can read some small text again — The deterioration of vision that I felt at night after a few hours on the screen has lessened.”38

“DMSO immediately helped my eyesight by improving contrast after I just put a little above my ankle.”39

Furthermore, DMSO’s therapeutic properties enable it to reach the retina and optic nerve, thereby directly treating many challenging visual disorders that ophthalmology still struggles to address (e.g., beyond lowering eye pressure, DMSO can directly counteract the degenerative process of glaucoma).

Note: DMSO has also been repeatedly shown to enhance the penetration of drugs into the eyes, allowing lower (safer) doses to be used and to potentially eliminate the need for eye medications to be injected.40,41,42,43,44

Eye Protection

One of DMSO’s most well documented properties is its ability to protect tissues throughout the body from a variety of otherwise lethal stressors, such as heat, cold, radiation, poisons, and a loss of blood flow — which is a key reason why it produces such remarkable results for strokes and other central nervous system injuries.

In turn, many readers have reported remarkable stroke recoveries with DMSO (along with a dog who’d developed a variety of vestibular neurological issues such as uncontrolled eye movements, due to mini strokes which immediately resolved from small amounts of DMSO and magnesium).45

Note: Multiple readers have also reported DMSO rapidly resolving the visual disturbances occurring with migraines.46,47

As the eyes are also nervous tissue, similar effects from DMSO have been repeatedly observed within them:

Injecting 1.5% DMSO into the eyes of rats subjected to 90 minutes of retinal ischemia (via optic nerve ligature) was found to reduce the number of ganglion cells that died.48

Note: One reader reported “I got IV DMSO after an optic nerve stroke and I’m pretty sure it saved my eyesight in that eye.”49 Another shared that six weeks after a retinal bleed,50 that eye had episodes of partial loss of vision (“grey outs”) which cleared a few minutes after applying DMSO gel to the eyelid of the affected eye, and a third shared DMSO treated a branched retinal vein occlusion in the eye that was no longer responding to standard therapies.51

In mice, numerous studies have shown that DMSO treatment protects retinal cells from damage caused by toxic bright light exposure, preserving retinal function and structure (whereas in untreated mice, most retinal cells were damaged or died).52,53,54,55

Note: A reader who damaged their eyes from excessive sunlight exposure (due to pre-existing inflammation weakening the eye) was able to heal their eyes with DMSO.56 Likewise, another reader who damaged their eyes by accidentally staring at the sun for too long (presumably due to sun gazing) also healed their eyes with DMSO.57

Finally, in parallel with DMSO’s ability to heal damaged eye tissue, numerous studies have shown that normal doses of DMSO have no toxicity to the retina or optic nerve.

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Retinal Diseases

DMSO’s restorative properties make it uniquely suited to treat challenging degenerative eye diseases.

“My son has retinitis pigmentosa. He uses DMSO eyedrops. They help his [eye’s] field of vision.”58,59

For example, retinitis pigmentosa (RP),60 is a genetic disorder that causes gradually increasing visual loss, and is incurable (excluding a rare subset that an $850,000 gene therapy treats about half the time).61 As such, it immediately caught a few doctors’ attention that their RP patients had their vision improve while receiving DMSO for something else.62

This prompted a preliminary (successful) investigation that found that DMSO applied to the eyes improves RP,63 and then a larger trial of 50 patients with RP or macular degeneration.64

There, no retinal toxicity was observed, and 22 (44%) had improved visual acuity, 9 (19%) had improved visual fields, 5 (10%) had improved night vision and 48 (96%) had no further worsening of their vision (which would otherwise be expected in these retinal disorders) — results which are quite extraordinary. This, for example, was one patient in that study:

“When his DMSO treatment was started, this patient could see hand motion only with his right eye, and had a visual acuity of 20/200 (Snellen) in his left eye. Five days later, his vision was measured as 20/70 + 1 in the left eye, and he could count fingers at 5 ft with his right eye. Three months later, his visual acuity was 20/50 in the left eye.

This patient has continued his treatments daily, except for a 1-week trial interval without DMSO. He noted that his vision began to get worse during this interval, and when he restarted treatment, his vision returned to the level he had just before discontinuance. His most recent visual acuity measurement (two years after starting DMSO) is still 20/50 in the left eye, and he can count fingers at 6 ft with his right eye.”

Animal studies have also shown that DMSO prevents retinal vision loss:

Low doses of DMSO (0.01% in drinking water) protected retinal cells in mice engineered to model RP.65

In RP model mice, from day 4 to day 23 of life, untreated mice experienced a loss of retinal function not seen in normal mice,66 whereas DMSO treated mice had those parameters improve — scotopic a-wave amplitudes (-42% vs. +107%), photopic a-wave amplitudes (-8% vs. +65%) photopic b-wave amplitudes (-20% vs. +56%).

In Alzheimer’s model mice, very low-dose (0.01%) DMSO in drinking water improved early contrast sensitivity deficits and restored normal outer retinal (ELM–RPE) thickness.67,68

In Alzheimer’s model mice, 0.01% DMSO in drinking water prevented the visual loss seen early in the disease process and restored the thickness of the retinal pigment epithelium.

In rats with diabetic retinopathy, subconjunctival injection of 10% and especially 50% DMSO significantly improved retinal function (higher B-wave and flicker ERG amplitudes) and restored retinal thickness.69

In parallel, readers have reported a variety of significant visual improvements from DMSO in a variety of eye disorders (e.g., vision loss due to RP, glaucoma, or multiple sclerosis), including many instances where “incurable” macular degeneration (AMD) improved70,71,72,73,74,75,76,77,78,79,80,81,82 (or stopped progressing83,84,85):

“I personally have used eye drops for 6-7 years. It has effectively stopped my macular degeneration.”86

“Personally I have used dmso eye drops for three years. My retina doc said my scarring is down 50% with my AMD.”87

“I use DMSO eye drops for my macular degeneration, and it brought my sight from 25/40 to 20/25.”88

“I [have AMD] and have been using 40% DMSO for three weeks. Before, I was having ink-blot-like hallucinations that severely affected my central vision, to the point where I couldn’t drive at night even with my glasses on. Just three weeks later, I can now drive at night in the rain without wearing glasses at all, and the impairment in my central vision is completely gone.”89

“I tested my AMD with an Amsler’s chart earlier this year and my left eye showed distorted lines. After a month of DMSO, I had no more distortions.”90

“My husband has macular degeneration and he is using DMSO. It’s been about four months and his vision has not gotten worse, I think it’s improving. He’s driving better.”91

“I now use the drops for my macular degeneration. Have great results.”92

Note: Most of the reports I’ve seen on macular degeneration were improvements of the more common (dry) form. Some evidence also suggests it can help wet macular degeneration by inhibiting VEGF and the formation of new blood vessels, which underlie many eye diseases.93,94,95,96

Additionally, DMSO has also been reported to heal a variety of other challenging retinal conditions. For example, readers have reported improvement of a macular hole,97 a severe macular pucker that had required urgent surgery,98 and a torn retina that had previously healed badly.99

Reversing Blindness

DMSO’s ability to treat conditions like macular degeneration also allows it sometimes to produce even more remarkable results. For example, when I initially received Murray’s seemingly impossible report that DMSO restored sight in an eye which has been blind for 75 years, I was inclined to believe it as I’d read very similar accounts within the early DMSO literature, such as:100

A man who had been blind for more than 30 years after having dynamite explode in his face, who started seeing flashes of light after applying DMSO to the head.

A man who lost sight in the right eye (along with other functions of the eye like focusing) and gradually lost sight in the other after an almost fatal impact by an automobile while skating down the road.

After trying DMSO for hair loss, he noticed a sensation in the back of his right eye, so Dr. Stanley Jacob (the pioneer of DMSO) decided to apply DMSO to that eye, eventually settling on a high concentration (which stung for several minutes, caused tears, and left the eyes bloodshot for about 20 minutes). After this, sight rapidly returned to the right eye (as demonstrated in a blindfold test), along with him regaining the ability to see color (something his good eye had lost since the accident).

Note: One reader has also reported being able to cure their colorblindness with DMSO.101

A man who had been blind for many years in one eye (only able to distinguish light and dark) regained his sight in that eye with DMSO (e.g., he demonstrated this by walking unaided in public areas and describing objects and events while his good eye was covered).

A man who was almost blind (leading to him being entirely dependent on others, like his wife, to take him anywhere, cut his meat, or keep his house clean), after a year on DMSO, regained his sight and no longer needed assistance to do anything (which was of great relief to his family).

Note: These results led Jacob to test DMSO on a series of patients with incurable blindness, many of whom then had their vision improve.

Conclusion

I’ve spent decades seeking out methods to treat macular degeneration, and seen a few approaches (e.g., intensive nutritional regimens, eye circulation improving regimens or energetic inputs that reawaken dormant retinal cells) “do the impossible” and bring lost sight back to the eyes.

It’s hence quite noteworthy that DMSO is both able to create many of these same therapeutic effects (e.g., by increasing microcirculation to the eyes, it greatly increases the vital nutrition retinal cells receive), and like those therapies, restore vision, but do so in a much more broad and economical way (rather than only targeting one component of vision loss).

“I’ve had countless patients who were already doing all the ‘right’ things with nutrition and weren’t getting better with their pain/autoimmune problems, and then they did well after adding DMSO.” — James Miller MD

More importantly, the fact that DMSO can quickly and easily treat “incurable” conditions like vision loss provide a critical lesson into the myriad of other chronic illnesses we are facing, as the eyes are not the only part of the body affected by the ever increasing circulatory impairments (many of which result from vaccination) and nutritional depletion of the food supply seen throughout society.

The significant health challenges our society faces require doing something different. Fortunately, as things like DMSO’s saga show, the solutions we are searching for already exist.

More importantly, we have reached a unique historical crossroad, as the dire need to fix America’s disastrous healthcare has thrust us into a never-before-seen political climate where large parts of the culture, media, and government support rather than oppose the adoption of these real and affordable pathways to health. It is up to each of us to make the best of this moment and rediscover the forgotten umbrella therapies.

Author’s Note: This is an abridged version of a longer article that discusses the evidence presented here in more detail along with how DMSO can be used in conjunction with natural therapies to treat the conditions discussed in this article (e.g., macular degeneration) along with a variety of other eye disorders (e.g., floaters, cataracts, glaucoma, nearsightedness, dry eyes, and chronic eye strain). That article, along with additional links and references, can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

 

– Sources and References

DMSO — The Remarkable Compound That Heals the Eye from the Inside Out


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/11/21/dmso-treats-eye-conditions.aspx


Analysis by A Midwestern Doctor     
November 21, 2025

dmso treats eye conditions

Story at-a-glance

  • DMSO is an “umbrella remedy” capable of treating a wide range of challenging ailments. It has a unique affinity for the eyes, resulting in DMSO frequently treating a wide range of visual disorders that frequently cannot be treated with conventional therapeutic options — including blindness
  • DMSO’s potent anti-inflammatory properties allow it to treat a variety of challenging inflammatory eye conditions throughout the eye, including uveitis, iridocyclitis, and iritis, along with releasing the troublesome adhesions (synechia) associated with them
  • DMSO’s ability to restore fluid circulation and protect compromised nerves allows it to rapidly reduce intraocular pressure and protect the optic nerves of glaucoma patients
  • DMSO’s unique ability to stabilize proteins and solubilize misfolded ones allows it to eliminate a variety of pathologic protein deposits in the eyes, such as floaters and cataracts. Likewise, users often report that their eyes become much sharper and clearer as less obvious deposits are eliminated
  • DMSO’s ability to normalize the shape of the eyes also frequently results in users reporting their eyes regain the ability to focus and glasses no longer being needed (particularly for nearsightedness). This article will review how DMSO can treat these conditions and how those healing properties allow it to treat many other challenging eye conditions, such as eye strain, dry eyes, vision loss, and macular degeneration

Dimethyl sulfoxide (DMSO) is a simple compound with a remarkable blend of therapeutic properties. Over the last year, I’ve compiled thousands of studies showing how it treats a wide range of conditions including:

Neurological disorders such as strokes, dementia, paralysis, and neuropathies (discussed here).

Circulatory disorders such as Raynaud’s, varicose veins, and hemorrhoids (discussed here).

Chronic pain (e.g., from disc herniations, bursitis, or complex regional pain syndrome) and tissue injuries, such as sprains, concussions, burns, surgical incisions, and spinal cord injuries (discussed here).

Autoimmune, protein, and contractile disorders, such as arthritis, scleroderma, amyloidosis, and interstitial cystitis (discussed here).

Head conditions, such as tinnitus, ear infections, dental problems, and sinusitis (discussed here).

Internal organ diseases such as prostate enlargement, pancreatitis, and cirrhosis (discussed here).

Respiratory disorders, including asthma, COPD, and pulmonary fibrosis (discussed here).

Many different gastrointestinal disorders, such as bowel inflammation, cirrhosis, and pancreatitis (discussed here).

Skin conditions such as hair loss, acne, ulcers, skin cancer, or psoriasis (discussed here).

Infections, such as onychomycosis, herpes, and shingles, and many antibiotic-resistant infections (discussed here).

Many aspects of cancer, including eliminating cancers, enhancing chemotherapy, reducing the toxicity of mainstream cancer treatments, and reducing cancer pain (discussed here).

Because of how effective DMSO was for a wide range of “incurable” conditions, after being discovered in the 1960s, DMSO quickly became the most demanded drug in the country — at which point the FDA did everything they could to suppress it.

The FDA succeeded, and DMSO’s incredible utility became largely forgotten. However, due to its remarkable efficacy and the extensive evidence corroborating its medical utility, once I brought attention to DMSO (in a post-COVID world where widespread skepticism exists towards the medical establishment), it rapidly went viral, and there is now a similar interest in DMSO to what was seen in the 1960s.

Because of this, I have now received over 5,000 reports from readers who’ve benefitted from DMSO1 (which I compiled here), most of which match the effects typically attributed to DMSO (e.g., rapid healing from an injury or eliminating debilitating chronic pain). However, I also come across some that are quite extraordinary, such as this 75 year old man who regained sight in his eye after being blind since birth after using DMSO to eliminate a chronic sinus infection.

Murray’s story (and hundreds more I’ve received from readers) illustrates one of the least appreciated facets of DMSO — it is exceptionally well suited to treating a wide range of eye conditions — many of which are considered incurable within conventional medicine.

Note: The German DMSO community (including DMSO utilizing ophthalmologists) has also reported that DMSO has an extraordinary affinity for treating a wide range of eye conditions.

DMSO and the Eyes

Ophthalmologist Norbert J. Becquet, M.D. reported in May 1980 that he had great success using DMSO in treating cataracts and other eye problems. “I’ve treated two hundred patients in the last year for macular degeneration, macular edema, and traumatic uveitis.”2

Note: DMSO has been repeatedly shown to enhance the penetration of drugs into the eyes,3,4,5,6 potentiate certain ocular medications (e.g., anesthetic eye drops7 or 5-IDU to treat shingles8) and authors have proposed using these combinations to enhance the efficacy of ophthalmologic medications and bypass the need to inject them into the eyes.9 Likewise, doctors like Norbert Becquet used topical DMSO nutraceutical combinations to treat otherwise “incurable” eye conditions.

DMSO’s uses for the eyes originally emerged after participants in early clinical trials noted that their vision frequently improved when an unrelated issue was being treated (due to DMSO’s tendency to concentrate within the eyes). Likewise, readers have repeatedly reported to me that vision significantly improves after DMSO is applied to another part of the body (e.g., the ankle).

Note: Due to the intense scrutiny DMSO was subjected to, its safety within the eyes was extensively studied — after which no one detected eye toxicity other than temporary irritation from higher doses applied directly to the eyes.

I will now review how DMSO’s therapeutic properties and its ability to travel through tissues make it suited to treat a wide range of disorders within the eyes.

Eye Inflammation

DMSO’s robust anti-inflammatory properties make it well suited for treating inflammation within the eyes. For example:

In an extensive study, numerous forms of eye inflammation responded to DMSO including four severe cases of episcleritis that had previously failed to respond to the use of corticosteroids.10

A study induced uveitis in dogs and found that subsequently giving DMSO decreased intraocular pressure and fibrin production.11

DMSO (with its delivery augmented by ultrasound) was found to treat endogenic iridocyclitis (inflammation around the iris).12,13

Note: DMSO has been repeatedly shown to treat a wide range of inflammatory and infectious conditions on the surface of the eyes.

Readers likewise have reported excellent results for uveitis, retinitis, and iritis:14,15,16,17,18

“I used to struggle with uveitis and for years had synechia (adhesions) in my eyes related to my (now past rheumatoid arthritis).19 I used DMSO for a couple of months after your initial articles and haven’t had any bouts of uveitis since, despite engaging in the reading style that often triggers synechia induced spasms (and then iritis).

Since all my symptoms have resolved I stopped using steroid drops and haven’t had anyone look again for synechia that I finally don’t feel anymore … doesn’t seem like much of a point. I read for a living so I really enjoy using my eyeballs better.” — James Miller MD

Note: In chronically inflamed eyes, DMSO was found to decrease fibrin production.20

“I had been dealing with recurring iritis in my right eye for about a year and a half.21 My ophthalmologist had prescribed prednisolone (steroid) drops which cleared up the symptom of cloudiness in my vision in that eye but it would always recur in a week or two. [After 2 months of DMSO applied to the eyes] my iritis is permanently gone now.

DMSO works better than dexamethasone for uveitis. It saved my sight and normalised my eye pressure.”22

Note: In many cases, DMSO can also treat the underlying systemic autoimmune disorder that triggers eye inflammation.

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Glaucoma and Intraocular Pressure

“I am 2 months into using 99.9% pharmaceutical grade DMSO for loss of vision due to glaucoma based on your article. I felt like I had nothing to lose since my vision in one eye was reduced to blurs. I haven’t been able to read letters in over two years with that eye. This week, I can now begin to see specific letters and numbers on my computer and the television screen.

I am still amazed that this is real. Sure, it burns like hell for about 15 seconds [as he used a high dose]. But that pales to the orbital bone pain from one of the 4 glaucoma eyedrops I used multiple times daily … not to mention the 2 surgeries.”23

Glaucoma is peripheral vision loss resulting from optic nerve degeneration (the cause of which is unknown) that occurs in association with elevated intraocular pressure (IOP). As such, glaucoma is managed by lowering eye pressure (often with increasingly invasive methods) and hoping that this is enough to keep the vision loss at bay for the remainder of the patient’s life (which doesn’t always work). DMSO hence, is well-suited to addressing glaucoma as it:

Protects and restores the function of compromised nerves, thereby allowing it to counteract the glaucoma disease process directly.

Excels at reducing edema (including within the cornea24 or pressure within the brain — which also contributes to IOP), transporting fluids, and removing obstructions to fluid drainage (including adhesions within the eye) — all of which allow DMSO to normalize eye pressure.25

For example, in rabbits, a DMSO-brinzolamide gel designed to treat glaucoma (as brinzolamide lowers IOP) effectively reduced intraocular pressure and showed no toxicity.26 Likewise, in another rabbit study, DMSO alone was shown to effectively lower IOP:27

solution intraocular pressure

Readers have also reported that DMSO improved or resolved their glaucoma,28,29,30,31,32,33,34,35,36,37,38 including in a cat.39 I’ve found numerous online reports of DMSO rapidly reducing glaucoma pressure pain, or allowing patients to no longer need eye medications to control their IOP.

Floaters and Cataracts

Many complex diseases result from misfolded proteins clumping together and depositing in the body. Fortunately, DMSO’s unique ability to both stabilize normal protein folding and to dissolve pathologic protein deposits makes it able to treat a variety of challenging conditions (e.g., dozens of studies show DMSO treats amyloidosis).

In the case of the eyes, once proteins lose their normal shape, they often turn opaque and scatter light, impairing vision (e.g., this is what causes cataracts and floaters). As these proteins are within the eyes, it is often challenging to remove them (e.g., for cataracts, with surgery, the lens can typically be removed and replaced with an artificial cataract-free one, whereas floaters lack any widely accepted, low-risk treatment).

Since DMSO’s properties seem naturally indicated to treat cataracts, this has been extensively explored, with numerous doctors reporting at conferences40,41 that they had a high rate of success treating cataracts with various DMSO combinations, and many online likewise reporting significant cataract improvement from various DMSO combinations (including DMSO authors working with the German ophthalmology community).

Conversely, I have seen virtually no mentions of floaters in the DMSO literature (with the few that did using the formal terminology, “vitreous opacities”).

Within the reports I’ve received, floaters have had a remarkable response to DMSO (far better than any other therapy I know of), with 27 readers sharing that DMSO improved or eliminated their floaters and only one stating it didn’t help. Additionally, in many cases, this improvement was an incidental occurrence (e.g., after DMSO was applied to the leg).42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68

“I started DMSO maybe 4 months ago topically for muscle spasms and it’s amazing! I have not required a muscle spasm pill since I started.69 I used to take 1 to 2 a day. It happens to have other huge advantages I was unaware of. My eyes no longer burn. I used to use eyedrops everyday. I no longer need them. I had several moderate eye floaters. My ophthalmologist told me it was age. Nothing could be done. Well … The floaters are GONE!”

After I shared this remarkable success rate with a colleague, he decided to test it and recently shared with me that:

“Ok so 1.5 weeks of ocular DMSO each day. My floaters are almost completely transparent and don’t block my vision anymore.70 Visual blurring when fatigued is much less and if I do get it I can close my eyes for 5 mins and the sharpness is back. You’ve convinced me to try this on my patients.”

Likewise, to quote a DMSO using colleague:

“In one of the ladies in my trial for cataracts, while it’s too soon to say for that, her floaters that were present have completely vanished. So far, we are definitely seeing the greatest response to floaters.”

Note: I also received one report of DMSO being used for a vitreous detachment (after which there were less floaters and flashes, and the field of vision became much clearer).71

Likewise, numerous readers have reported success treating cataracts with DMSO,72,73,74,75,76,77,78,79,80,81,82,83 including in dogs,84,85 with reports including:

“[4 months of DMSO] saved my husband from cataract surgery.”86

“I have a diabetic dog that went blind from cataracts and have been giving him DMSO eye drops and it has cleared most of his eyes up and he can see again!”87

“My January eye checkup showed cataracts, early stage glaucoma and peripheral vision loss. Monday’s (July) follow up all in normal ranges! She said keep doing what I’m doing.”88

“I have been using DMSO eye drops for cataracts for several months and have seen a noticeable improvement in my vision.”89

However, unlike floaters, I’ve noticed that about half of the readers report DMSO not improving their cataracts — which is likely due to how it’s applied, what DMSO is combined with, and the type of cataract present.

Note: Many DMSO users also report their eyes being much clearer and sharper — something I suspect results from DMSO removing opacities throughout the eyes which obstruct vision.

Focusing

“I used DMSO cream on my jawline at night and noticed my eyesight was noticeably better the next day. I kept using it daily and completely eliminated my eyeglasses — I’d worn them for 25 years. I no longer need glasses for reading OR driving.”90

Many readers shared that after taking DMSO, their vision initially seemed worse — only to discover their eyes’ focusing ability had sharply improved, making their old prescription too strong, leading to them switching to weaker lenses or ditching glasses entirely. For example:

“I’ve always been near-sighted and was starting to need bifocals. One day I couldn’t see clearly through my reading glasses and thought my eyes were getting worse. Took them off — could suddenly read the smallest print perfectly. I’m 60 and have never needed reading glasses since.”91

“My husband’s eyesight was deteriorating fast — he’s 43 and already in bifocals. I was putting DMSO on his ingrown toenail 3x/day. In two weeks his eyes healed so much he only needs glasses for very close work now.”92

“After reading the EENT article and successfully using DMSO to treat my patients, I noticed ghosting in my right eye. Put 2 DMSO drops in the affected eye before bed. Woke up — completely corrected. Still my go-to if anything feels off.”93

“Near-sighted since teens (L -2.25, R -1.5), stable since early 20s. Used DMSO on my face on/off for 6 to 8 months. Contacts started irritating, went in expecting stronger Rx. New Rx: L -1.5, R -1.25. Optometrist was surprised!”94

“Just had my annual eye exam. For the first time since I was a kid, my astigmatism is gone. Distance is 20/20 one eye, better than 20/20 the other. Happened really fast after starting DMSO — I was shocked.”95

“My friend no longer needs her glasses to read texts on her phone after putting DMSO on her eyelids each night.”96

Note: Many more readers have also reported improvements in focus.97,98,99,100,101,102,103,104,105,106,107,108,109,110,111

Additionally in most cases, I noticed the focusing issue that improved was nearsightedness and then discovered the German DMSO community had made the same observation.

near and far sighted

Since nearsightedness results from the eye becoming longer and narrower, this suggests DMSO (a muscle relaxant) relaxes the muscle responsible for that motion (the ciliary muscle located at the front of the eye), and that our tendency to stare at screens all the time locks the muscle into a chronic state of tension.

Separately, DMSO’s ability to reduce fluid congestion within the eye (which lengthens and narrows the eye) may also play a role in DMSO’s ability to restore normal focusing, as does DMSO’s ability to loosen the fibrosis at the back of the eye, which locks in this near-sighted state (which, like its muscle relaxing properties, may explain why DMSO works so well with eye exercises).

Conclusion

DMSO’s ability to heal every single part of the eye (particularly the retina and optic nerve) is extraordinary. It has made me realize many eye conditions we are trained in medical school to view as largely incurable in reality have simple, gentle, and widely available options which can allow us to adapt to the incredible strain the modern electronic-focused world places upon the eyes.

I never expected to see blind eyes open again, floaters vanish in weeks, or 60-year-olds ditch bifocals they’d worn since childhood. Yet that’s exactly what readers keep reporting to me — hundreds of times now. It is astounding that simple knowledge like this, backed by decades of clinical use and thousands of suppressed studies, could be lost for two generations. But what’s even more incredible is that we are now in the one narrow window where it can suddenly sprout from the ashes.

The decades of dedicated research by the DMSO pioneers aren’t gathering dust anymore. They’re saving sight, one reader at a time. And nothing the authorities did in the 1960s can stop what’s happening right now.

Author’s Note: This is an abridged version of a longer article that discusses the evidence presented here in more detail along with how DMSO can be used with natural therapies to treat the conditions discussed in this article (e.g., floaters, cataracts, and nearsightedness) along with a variety of other eye disorders (e.g., macular degeneration, dry eyes, and chronic eye strain). That article, along with additional links and references, can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

– Sources and References

DMSO — The Forgotten Remedy Revolutionizing Eye Healing


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/11/14/dmso-for-eye-health.aspx


Analysis by A Midwestern Doctor     
November 14, 2025

dmso for eye health

Story at-a-glance

  • DMSO is an “umbrella remedy” capable of treating a wide range of challenging ailments due to its combination of therapeutic properties (e.g., reducing inflammation, improving circulation, and reviving dying cells)
  • DMSO has a unique affinity for the eyes, resulting in it (often spontaneously) treating a wide range of visual disorders that frequently cannot be treated with conventional therapeutic options — including blindness
  • DMSO’s ability to heal the skin, moisten tissue, and relax muscles makes it excellent for reducing eye strain. It helps heal a variety of challenging conditions around the eyes, such as blepharitis, styes, psoriasis, burns, bags under the eyes, and eye twitches
  • DMSO’s anti-inflammatory and antimicrobial properties allow it to treat a variety of infections and inflammatory conditions damaging the surface of the eyes (e.g., shingles or keratitis), in many cases facilitating a complete recovery of the eye
  • DMSO’s ability to heal tissue from injury also allows it to heal damaged eyes, which in many cases would otherwise require the eye to be removed. This article will review how DMSO is able to treat these conditions and how those healing properties allow it to treat many other challenging eye conditions, such as vision loss, macular degeneration, cataracts, and floaters

Dimethyl sulfoxide (DMSO) is a simple compound with a remarkable blend of therapeutic properties that allows it to treat a wide range of conditions including:

Numerous neurological disorders (e.g., strokes, dementia, paralysis, neuropathies, Down syndrome, and circulatory disorders (e.g., Raynaud’s, varicose veins, hemorrhoids)) — are discussed here.

Tissue injuries, such as sprains, concussions, burns, surgical incisions, and spinal cord injuries — are discussed here.

Chronic pain (e.g., from a bad disc, bursitis, arthritis, or complex regional pain syndrome) — are discussed here.

Autoimmune, protein, and contractile disorders, such as scleroderma, amyloidosis, and interstitial cystitis — are discussed here.

Head conditions, such as tinnitus, dental problems, and sinusitis — are discussed here.

Internal organ diseases (e.g., prostate enlargement, pancreatitis, and cirrhosis) — are discussed here.

Respiratory disorders, including asthma, COPD, and pulmonary fibrosis — are discussed here.

Many different gastrointestinal disorders, such as bowel inflammation, cirrhosis, and pancreatitis — are discussed here.

Skin conditions (e.g., hair loss, varicose veins, acne, ulcers, skin cancer, or psoriasis) — are discussed here.

Infections, such as onychomycosis, herpes, and shingles, are remarkably treatable when combined with an antimicrobial agent — are discussed here.

Many aspects of cancer (e.g., eliminating cancers, enhancing chemotherapy, and reducing the toxicity of mainstream cancer treatments) — are discussed here.

Because of how effective DMSO was for a wide range of “incurable” conditions, when it was discovered in the 1960s, it rapidly took America by storm and became the most demanded drug in the country — at which point the FDA did everything they could to suppress it (e.g., see this 1980 segment 60 minutes did on DMSO). Regretfully, this was successful, and decades later, DMSO’s remarkable properties, which could have reshaped medicine, were largely forgotten.

However, due to the new political climate we entered — widespread loss of trust in medical authorities and the mass media for their handling of COVID-19 (which allowed the alternative media to rise to prominence) — an unprecedented window was created for unorthodox therapies to gain prominence. As such, over the last year, my attempts to promote the vast body of evidence behind DMSO went viral, and there is now a similar interest in DMSO to what was seen in the 1960s.

Because of this, I have now received over 5,000 reports from readers1 who’ve benefitted from DMSO (which I compiled here), most of which match the effects typically attributed to DMSO (rapid healing from an injury and/or elimination of debilitating pain). However, I also come across some that are quite extraordinary, such as this 75 year old man who regained sight in his eye after being blind since birth after using DMSO to eliminate a chronic sinus infection.

Note: The journalist who filmed this interview previously filmed her neighbor with terminal COPD recovering with nebulized DMSO.

Murray’s story (and hundreds more I’ve received from readers) illustrates one of the least appreciated facets of DMSO — it is exceptionally well suited to treating a wide range of eye conditions — many of which are considered incurable within conventional medicine.

Note: The German DMSO community (including DMSO utilizing ophthalmologists) has reported very similar results to those shared with me by readers when using DMSO to treat the eyes.

DMSO and the Eyes

“Ophthalmologist Norbert J. Becquet, M.D. reported in May 1980 that he had great success using DMSO in treating cataracts and other eye problems. ‘I’ve treated two hundred patients in the last year for macular degeneration, macular edema, and traumatic uveitis.’”

Note: DMSO has been repeatedly shown to enhance the penetration of drugs into the eyes,2,3,4,5 potentiate certain ocular medications (e.g., anesthetic eye drops6 or 5-IDU to treat shingles)7 and authors have proposed using these combinations to enhance the efficacy of ophthalmologic medications and bypass the need to inject them into the eyes.8 Likewise, doctors like Norbert Becquet used topical DMSO nutraceutical combinations to treat otherwise “incurable” eye conditions.9

DMSO’s uses for the eyes originally emerged after participants in early clinical trials noted that their vision frequently improved when an unrelated issue was being treated (due to DMSO’s tendency to concentrate within the eyes). Likewise, readers here have frequently reported that vision significantly improves after DMSO is applied to another part of the body — particularly the neck (which is likely due to its blood supply being closer to the eyes).

Note: Due to the intense scrutiny DMSO was subjected to, its safety within the eyes was extensively studied — after which no one detected eye toxicity. For example, a JAMA publication attested to DMSO’s eye safety,10 and in a study where DMSO was applied to the eyes of 108 patients11 — including those with numerous pre-existing eye diseases — no side effects occurred besides a concentration dependent temporary irritation of the eyes.

I will now review how DMSO makes it suited to treat a wide range of disorders on the surface of the eyes.

Peripheral Eye Issues

“My mother (100 yrs old) fell three weeks ago.12 When she fell, she broke her nose and fractured a couple of orbital bones — one around each eye — which resulted in terrible black bruising due to her blood thinner medication. She spent 6 days in the hospital and my sister and I visited her everyday. After applying daily DMSO, the bruises rapidly changed color, and in three days they began to fade and then completely disappeared.”

Due to DMSO’s ability to rapidly heal injuriesrelax muscles, and reduce skin inflammation, it is well-suited for treating a wide range of issues around the eyes. Studies in turn have shown:

DMSO combined with iodine safely treated inflammatory eye conditions13,14,15,16 (e.g., in 17 patients with blepharitis and blepharoconjunctivitis all had a partial or complete response to it17).

In children with eyelid styes, DMSO reduced swelling and pain.18

DMSO treated inflammatory diseases of the eyelids.19

“I have a really complicated eye history [including] having blepharitis many times that left my eyelids inflamed for a very long time.20 I’ve now had inflammation on my eyelids for over a year. It’s almost gone in [after] about a week of DMSO.”

Likewise, many readers have reported DMSO treats issues around the eyes (e.g., for bags and wrinkles,21 blepharitis22,23,24 psoriasis25,26 styes,27,28,29 burns,30,31 milia,32 cellulitis,33 skin tags and pedicules,34,35).

“After reading your articles I tried DMSO on a huge eye stye my husband has, a recurring issue that no doctor had been able to fix.36 In less than 24 hours it went from the size of a large pea to near gone.”

“I have used DMSO even on the lower lids of my eyes, at 25%, with astonishing success in treating a chemical/heat burn [hot tar while fighting a fire] that troubled me for about ten years, AND IT RESOLVED ABRUPTLY.”37

Finally, DMSO’s ability to relax muscles likely accounts for many of its therapeutic properties (e.g., chronically tight muscles distort focusing and many readers have reported they no longer needed to wear eye glasses after using DMSO). Likewise:

One reader reported being able to treat superior oblique myokymia, a rare “untreatable” eye condition where that muscle will spontaneously twitch, distorting vision, fatigue the eyes, and making it impossible to drive.38

James Miller M.D. has reported successfully curing chronic eye twitches with DMSO.39

Using DMSO in conjunction with eye exercises has been reported to dramatically improve their efficacy.

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Corneal and Conjunctival Disorders

DMSO’s therapeutic properties and its tendency to concentrate within the cornea make it well-suited to healing issues at the surface of the eyes, particularly since DMSO, being an acetylcholine esterase inhibitor, also stimulates parasympathetic activity (which increases tear secretion) and reduces duct inflammation or obstruction (also increasing tear secretion).

Because of this, many readers have reported remarkable results for eye dryness40,41,42,43,44,45,46,47,48,49,50,51 (including severe cases from Parkinson’s,52 severe mast cell activation disorder which had eroded the surface of the cornea,53 or previous chemotherapy54).These include:

“I have suffered from severe dry eye for years.55 (I’ve had to have Meibomian Gland Probing done twice for my condition, in addition to numerous other treatments). I am having a [very] positive experience using daily DMSO eye drops, I find I need much less commercial eye drops and I am very hopeful about the continued benefit of the DMSO drops.”

“It takes care of my chronic dry eyes for 6 to 8 hrs.”56

“I no longer have dry eye syndrome in that eye.”57

“I’ve been using DMSO in my eyes for more than a year now. Slowly increasing the strength.58 Even at [low doses] it’s life changing! No more dry eyes or eye infections. Better vision. For anyone who is hesitant, start slowly and ‘see’ 🤣 the amazing results.”

Likewise, many readers have also reported less blurriness,59,60,61 reduced eye strain62,63,64 (particularly from screens), and the eyes feeling refreshed.65,66 I have also seen numerous reports of DMSO healing debilitating corneal injuries like this readers:

“For decades, I experienced mysterious, intermittent left eye pain [which] contributed to regular severe sleep disruption.67 After seeing 12 doctors, they finally discovered I had corneal injury from a piece of glass getting stuck in there for a few days in 1974, but had nothing to offer me. After starting DMSO because of your article, the pain finally went away and I could sleep. Tests this week also showed the eye’s tear production recovered. Thank you AMD!”

Note: I have also received reports of DMSO rapidly treating conjunctivitis,68 a conjunctival cyst,69 and a pterygium70 (which incidentally resulted from applying DMSO to the neck).

DMSO’s unique properties (e.g., its ability to remove edema and pathologic protein deposits) can also address a few challenging corneal issues for which there are currently no viable therapeutic options. For example:

Gelatinous drop-like corneal dystrophy is a rare genetic eye disorder where amyloids build up just beneath the corneal epithelium (progressively clouding it, and impairing vision) that is difficult to treat (requiring corneal transplantation once it progresses — which can then be followed by recurrences). Extensive research shows DMSO eliminates amyloids, and in one case report,71 DMSO was found to eliminate the amyloid which had accumulated after a corneal transplant.

One of the early DMSO studies repeatedly found DMSO treated corneal edema.72

Likewise, three readers shared they used it for Fuch’s dystrophy (an incurable eye disorder where the cornea swells with fluid, causing gradual vision loss). Of them, one reported it significantly reduced corneal edema and improved their vision, one reported the same (but did not have a formal diagnosis), while a third reported they’d begun trying it, but weren’t yet sure if it was helping.73,74

One reader reported DMSO rapidly cleared a corneal deposit in her 15-year-old Boston terrier.

boston terrier cleared corneal deposit

Finally, in both the reports I received and those I’ve seen throughout the DMSO community, users frequently report that DMSO “cleans their eyes out” and makes vision much sharper and clearer. This likely comes from DMSO removing insoluble protein aggregates (from the cornea, lens, or vitreous) or its reviving retinal function — something DMSO is uniquely suited to do in a noninvasive manner.

Note: DMSO has a unique ability to refold and eliminate misfolded proteins (e.g., amyloids), including opaque ones that accumulate within the eyes. In turn, one of the most common things readers report is DMSO treating floaters (and in almost all cases, the treatment being successful), followed by cataracts — which likely accounts for many of the instances where DMSO appears to clean the eyes out.

Additionally, one reader noted this clearing of the eyes could be externally observed with (as the sickly look hadn’t returned), suggesting DMSO can increase the eye’s ability to absorb the critical spectrums in natural light (particularly since other studies have shown DMSO increases the skin’s ability to transmit light).

Inflammatory and Infectious Conditions

DMSO’s potent anti-inflammatory and antimicrobial properties make it well suited for treating a variety of conditions throughout the eye and often to do so in a safer and more potent manner than existing treatments (e.g., in one clinical trial, 30% DMSO was found to have therapeutic anti-inflammatory effects on the eye similar to 0.01% dexamethasone75).

In turn, numerous studies show DMSO eliminates challenging inflammation and infection on the surface of the eye. For example, DMSO has repeatedly been shown to be an effective treatment for chronic superficial keratitis (CSK), which over time, can reduce eye inflammation without any adverse effects to the corneal epithelium76,77 and in many cases, to be a superior CSK treatment to steroids.78,79 For example:

In dogs with CSK, 50% DMSO combined with dexamethasone or prednisolone was found to be a much more effective treatment than either alone (e.g., it effectively reduced corneal inflammation and improved corneal transparency).80,81,82,83,84

chronic superficial keratitis with dexamethasone or prednisolone

In dogs, DMSO has also been shown to safely treat CSK in combination with cyclosporine.85 Significant benefit has also been seen from combining DMSO with both dexamethasone and cyclophosphamide (e.g., a 77.9% to 90.7% reduction in neovascularization, a 45% to 51% reduction in corneal surface inflammation, 72.9% of corneas had a reduction in pigmentation, 74.3% had an increase of transparency, and 95.4% had a repigmentation of the nictitating membrane).86

chronic superficial keratitis with cyclosporine

Note: Another dog CSK study found DMSO and tacrolimus halved inflammatory infiltration and neovascularization of the cornea,87 while another found similar results with picrolimus and DMSO.88

Likewise, DMSO and penicillin treated calves infectious keratoconjunctivitis.89

calves infectious keratoconjunctivitis

Topical DMSO and itraconazole was able to resolve chronic (fungal) keratomycosis in 80% of treated horses.90

chronic fungal keratomycosis

Likewise, a horse with fungal ulcerative keratitis fully recovered with DMSO and fluconazole.91,92

Note: DMSO has been extensively shown to treat ocular inflammation (e.g., uveitis, iritis, and episcleritis) and associated complications (e.g., synechia).

Eye Injuries and Trauma

DMSO has been repeatedly shown to protect tissue throughout the body from a variety of injuries, and does the same for the eyes:

In rabbits, 3 days, 20% DMSO was found to significantly reduce the corneal opacification and ulcerations that followed alkali burns.93

In multiple studies, DMSO was found to be an effective treatment for corneal acid burns from hydrofluoric acid94,95 (and also for hydrofluoric acid burns on other parts of the body).96

In another study,97 DMSO was combined with monomycin to treat corneal burns.98

Likewise, many readers have reported that DMSO has healed a variety of eye injuries:

“I was kicked in my eye by our puppy, 50 lbs and strong, did serious damage and was legally blind seeing double, no progress healing for a month.99 So I found a DMSO recipe and my vision was restored. I’m no expert, it worked for me and quick. I had 80% healing in days, a good part of that in 24 hours. Month previous, as stated, I was not improving at all.”

“Many years ago my mother-in-law burst a blood vessel in her eye.100 After trying allopathic approaches with the MD, we made her [eye] drops containing DMSO. In mere days, the eye returned to normal.”

Likewise, a month ago, a friend injured their eye by cliff jumping from quite a height and not shielding their eye when they hit the water (resulting in the eye being filled with blood). Once my friend decided to use DMSO, we saw the eye rapidly heal and the blood within it leave … after which they repeated the same jump, again did not correctly shield their eye, and then healed the eye again with DMSO.

I have also received numerous remarkable reports of pets with injured eyes that would normally be removed instead have a complete recovery like these:

This cat had its eye scratched, after which the vet said the necrotic eye needed to be urgently removed.101 While they raised money for the operation, they tried flushing the eye with DMSO and colloidal silver roughly every hour (which Gerald the cat loved), the eye rapidly improved, and a few days after the initial visit, the vet cancelled the operation and after six weeks the eye was healed.

cat eye scratched

This dog had got an eye ulcer from a scratch, and the vet wanted to remove the (blind) eye.102 After a month it fully healed and sight returned.

dog eye ulcer

Note: I have received additional reports of injured pet eyes recovering and reports of human eyes that top doctors said would need to be removed instead of recovering with DMSO.

Conclusion

DMSO’s ability to heal the surface of the eye also allows it to heal conditions deeper within the eyes. In turn, it has been truly extraordinary for me to see how much data there is supporting it treating nearsightedness, floaters, cataracts, glaucoma, uveitis, macular degeneration, and other causes of blindness like retinitis pigmentosa — as for many of these conditions, I was trained to believe there was nothing you could ever do to cure them.

Fortunately, due to our extraordinary political climate, more and more are awakening to the Forgotten Sides of Medicine and realizing they can take direct charge of their health rather than depend on a costly, often counterproductive medical system. It has been an incredible privilege to see just how many readers have been able to restore their eyes with DMSO, and we are deeply grateful that we at last can change the unhealthy medical paradigm we’ve been trapped within.

Author’s Note: This is an abridged version of a longer article that discusses the evidence presented here in more detail along with how DMSO can be used with natural therapies to treat a variety of other complex eye disorders (e.g., macular degeneration, floaters, cataracts, or needing to wear glasses). That article, along with additional links and references, can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

 

– Sources and References

How DMSO Heals the Gut and Cures Gastrointestinal Diseases


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/09/26/dmso-heals-gut-gastrointestinal-diseases.aspx


Analysis by A Midwestern Doctor     
September 26, 2025

dmso heals gut gastrointestinal diseases

Story at-a-glance

  • Inflammatory bowel diseases remain challenging for medicine, subjecting many to lifelong healthcare expenses and debilitating complications
  • DMSO is an “umbrella remedy” treating diverse ailments through reducing inflammation, improving circulation, and reviving dying cells, making it uniquely suited for treating gastrointestinal disorders
  • Extensive data shows DMSO produces incredible results for inflammatory bowel disorders (Crohn’s disease, ulcerative colitis, IBS, diverticulitis, leaky gut syndrome, SIBO) and effectively protects gastrointestinal tissues from a wide range of otherwise lethal stressors
  • Data also supports using DMSO for severe GI tract issues (gastritis, peptic ulcers, liver cirrhosis, cholecystitis, pancreatitis, peritonitis, amyloidosis) and problems like hemorrhoids and prostate enlargement
  • This article will review how DMSO can be used to treat those conditions

Living with inflammatory bowel disease (IBD) is a daily balancing act marked by unpredictability. Symptoms like abdominal pain, urgent diarrhea, and fatigue can flare without warning, disrupting plans and demanding constant awareness of diet, stress, and bathroom access. During flares, physical toll — cramping, bloating, sometimes blood in stool — proves exhausting, while remission periods offer relief but never erase underlying uncertainty.

overall rate of irritable bowel syndromes

Recently, I discussed the silent epidemic of chronic constipation affecting 15% to 16%1 of adults, with almost all (14% of adults) having constipation with no known cause — resulting in millions placed on lifetime laxatives rather than addressing actual causes. The situation with inflammatory bowel diseases (affecting approximately 1.17% of adults)2 is similar as rates keep increasing, yet no one knows their causes, allowing an increasingly costly status quo to perpetuate.3

us inflammatory bowel disease treatment market size

This greatly disincentivizes research into actual causes (specific pesticides and herbicides — like glyphosate — have been repeatedly linked to IBD — as have junk food diets and food allergies).4

We’ve seen numerous children develop Crohn’s disease after meningococcal vaccines, but have never seen this link discussed — possibly due to Wakefield’s infamous 1998 paper5 (along with three earlier ones linking the measles vaccine virus to IBD6,7,8) showing children with autism after MMR had significant inflammatory bowel diseases, making this topic taboo.

Note: Vaccines are designed to hyperstimulate the immune system, and extensive evidence links them to autoimmunity (e.g., we’ve seen many develop Crohn’s disease after a college-required meningococcal vaccine, which by design hyperstimulates the immune system).

One of the most common COVID vaccine side effects was exacerbating pre-existing autoimmune disorders (an Israeli government study found 24.2% of booster recipients developed exacerbated autoimmune conditions),9 and we saw numerous debilitating IBD onsets or exacerbations following COVID vaccination. Likewise, in England, after the vaccine rollout, there was a 3-fold increase in disabilities due to both gastrointestinal and autoimmune disorders.10

Finally, as severe illnesses are rarer than mild ones (e.g., far more were disabled than killed by the COVID vaccines),11 a much larger portion of adults are affected by chronic gut inflammation (e.g., 6.1% of Americans have irritable bowel syndrome)12 — with many of these disorders (e.g., leaky gut syndrome or moderate gluten sensitivity) being either understudied or outright dismissed by the medical system.

As such, while reviewing the literature on DMSO, I was immediately struck by the rapid and dramatic IBD improvements reported in many cases. These reports included diagnostic testing confirming complete remission of Crohn’s disease or ulcerative colitis, consistent and rapid relief of the colicky pain commonly associated with IBD, and successful treatment of an intermittent, severe colonic paralysis following colon cancer surgery alongside progressing scleroderma.

Several authors specifically noted that IBD responded exceptionally well to DMSO — something a reader shared they had also observed in their own ulcerative colitis patients. Likewise, I periodically have exchanges like this (which was shared with the reader’s permission):

“Hi! I’m desperately hoping you can help me. How would I take DMSO to help a diverticulitis flare up? Thank you so so much! I don’t trust anyone else but you!”

I wrote a quick reply 19 minutes later, and then two hours and 12 minutes later received this reply:

“Thank you from the bottom of my heart!!! You saved me.”

Then, I asked how fast the response was:

“It actually helped a lot very quickly!! I think taking it really helped to decrease the pain and inflammation. I was ready to go to the hospital! Thank you again from the bottom of my heart!”

Umbrella Remedies

Given that DMSO is primarily thought of as a pain treatment (due to the rapid and dramatic improvement it frequently produces), it seems quite surprising that it could also produce the profound bowel benefits described above. However, in medicine, there are a few therapies (e.g., ultraviolet blood irradiation) that have the ability to cure a wide range of diseases, and as such are referred to as “umbrella therapies.”

This is because, rather than targeting a specific molecular receptor, they are able to address the root causes of many illnesses such as poor circulation throughout the bodyinflammation, and cells entering a state of shock where they stop functioning and eventually die.

DMSO does that, and in turn, has repeatedly been shown to be remarkably effective for a wide range of disorders, including:

Strokes, paralysis, a wide range of neurological disorders (e.g., Down syndrome and dementia), and many circulatory disorders (e.g., Raynaud’s, varicose veins, hemorrhoids), which I discussed here.

A wide range of tissue injuries, such as sprains, concussions, burns, surgical incisions, and spinal cord injuries (discussed here).

Chronic pain (e.g., from a bad disc, bursitis, arthritis, or complex regional pain syndrome), which I discussed here.

A wide range of autoimmune, protein, and contractile disorders, such as scleroderma, amyloidosis, and interstitial cystitis (discussed here).

A variety of head conditions, such as tinnitus, vision loss, dental problems, and sinusitis (discussed here).

A wide range of internal organ diseases, such as pancreatitis, infertility, COPD, and endometriosis (discussed here).

A wide range of skin conditions, such as burns, varicose veins, acne, hair loss, ulcers, skin cancer, and many autoimmune dermatologic diseases (discussed here).

Many challenging infectious conditions, including chronic bacterial infections, herpes, and shingles (discussed here).

Many aspects of cancer (e.g., many of cancer’s debilitating symptoms, making cancer treatments more potent, greatly reducing the toxicity of conventional therapies, and turning cancer cells back into normal cells), which I discussed here.

Note: Most of the above have also been shown for ultraviolet blood irradiation. Likewise, similar data exists for ozone, another umbrella remedy that I plan to focus on once the DMSO series is finished.

Additionally, DMSO possesses a unique ability to enhance the absorption and potency of pharmaceutical medications and natural therapies by facilitating their passage into the body. This property has transformed the way conventional and natural medicine is practiced, opening up nearly limitless possibilities for incredible therapeutic combinations (discussed here and here), and most importantly, DMSO is extremely safe (provided it’s used correctly).

As such, a wealth of data (detailed in the above articles) has accumulated, showing DMSO has a high rate of efficacy in a wide range of conditions. Since DMSO was widely available, it quickly spread like wildfire across America in the 1960s (particularly due to how rapidly it alleviated “incurable” pain).

Regrettably, the FDA then stepped in and went to war with DMSO to protect the status quo. In the decades that followed, despite the public, the scientific community, and Congress petitioning the FDA to rescind their prohibition on DMSO, it all fell on deaf ears.

Eventually, the 1994 DSHEA Act (passed in response to the public outrage over the FDA raiding supplement providers at gunpoint) simply took away the FDA’s ability to regulate natural medicines, and DMSO was able to re-enter the marketplace.13 Sadly by this time, despite thousands of studies supporting its use, many American pharmaceutical products using DMSO, and it being widely used outside the United States, DMSO had become yet another forgotten side of medicine.

As what they did to DMSO has always really bothered me (particularly due to its ability to rescue people from a life of debility after strokes or spinal cord injuries), I decided to try publicizing it and do all that I could to give a strong case for its use. Due to the trust this publication has created, many readers here were willing to try it. Much like the 1960s, when it first emerged, it rapidly caught on since that time.

Just as miraculous, I’ve received numerous testimonials from readers around the world about the life-changing effects DMSO has had on them. Recognizing the importance of not letting these stories become forgotten, I’ve devoted a significant amount of time to compiling them all here. While I know I’ve missed a lot (since they appear in so many places), there are now over 3,000 of them.

The majority of those testimonials match the well-recognized functions of DMSO, but at the same time, I’ve received many astonishing ones like the diverticulitis example above. As such, this article will focus on exactly what the data shows DMSO does for the gastrointestinal system, and how many reader reports mirror what is shown within those studies.

Note: One of DMSO’s key anticancer properties is that it causes cancer cells to differentiate (transform) into normal cells. Data also show that it can create this effect in stem cells,14,15,16 and hence produce the cells needed to regenerate a damaged organ (e.g., this has been repeatedly demonstrated for the heart17,18,19,20,21,22 and kidneys23).

Healing the Stomach

“I adore your substance. Your suggestion to try oral DMSO to heal my stomach issues is slowly but surely working. I have been seeing various docs about the issue for over 2 years now — and your suggestion was the first one to actually help!” — from a retired MD

DMSO has been repeatedly shown to heal the stomach and modulate its function, particularly when injuries occur following excessive acidity. A study of 138 patients with chronic gastritis and ulcers found 50% DMSO applications often reduced gastric juice volume and acidity in those with hypersecretion, generally normalizing function.24

“I have been drinking DMSO diluted in water daily for about 3 months … Since starting this pattern my reflux has disappeared and I am feeling great.”

Bleeding stomach and duodenal ulcers remain major medical issues, with roughly 10,000 Americans dying annually and around 10 billion dollars spent yearly.25 DMSO’s ability to treat and prevent them is noteworthy:

In 115 hospitalized patients at risk for stress-induced gastric ulcers, 22% of controls developed ulcers compared to only 4% receiving DMSO.26 None of DMSO-treated patients deteriorated or required emergency surgery, whereas 8 controls did, with 3 deaths.

In 101 patients with blood-coughing due to erosive gastritis, oral DMSO resulted in 8% having further episodes and 9% showing hemorrhagic inflammation, versus 29% controls having further episodes and 44% showing inflammation.27 No treated patients required surgery, while three controls did.

In 58 patients with NSAID-induced erosive gastritis,28 DMSO reduced re-bleeding, stabilized hemodynamics, and promoted healing (7% had erosions at 48 hours) compared to placebo (50%), with fewer requiring transfusions or surgery.

Numerous rat studies showed DMSO both prevented and significantly accelerated healing of a wide range of gastric injuries (e.g., from alcohol, blood loss, chemical burns, or aspirin).29,30,31,32,33,34,35,36

A 1968 patent application reported oral DMSO effectively treated numerous gastrointestinal conditions (e.g., 28 acute gastritis patients resumed work within 5 to 8 days, free of symptoms, with 21 remaining symptom-free after one year).

In patients with refractory gastric and duodenal ulcers unresponsive to standard treatments, oral DMSO achieved complete healing within four weeks compared to placebo.37

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Healing the Intestines

Many studies show DMSO protects the intestines:

“In animals, giving IV DMSO after 30 to 60 minutes of complete intestinal blood supply cutoff resulted in 28 of 29 not developing gangrene, with no evidence of ischemic damage within 24 hours.38 Many other studies have yielded similar results (along with other benefits such as a reduction in adhesions).”39,40,41,42,43,44,45,46,47,48,49,50

DMSO has also been repeatedly shown to protect against (and heal) gastric and duodenal ulcers.51,52 and to prevent gut damage from burns,53 lethal radiation,54 freezing,55 or sepsis-like conditions56,57,58,59 (e.g., lethal peritonitis60,61,62,63,64,65,66). Likewise, it has been shown to cause a 1.4-3.9 fold improvement in healing from colonic surgery.67 Similar benefits are seen in humans:

In 363 smokers (or drinkers) with duodenal ulcers that had not healed after three months of treatment, 100% of those who received DMSO recovered (with 7% relapsing in the next year), whereas only 60% recovered with standard therapy alone (with 29% subsequently relapsing).68 In another study of 238 patients with symptomatic acute duodenal ulceration, DMSO yielded similar results (e.g., a 100% recovery and a 6% vs 67% relapse rate).69,70

A study of 302 smokers with healed duodenal ulcers found 13% of those who received DMSO were five times less likely to have a recurrence (65% vs. 13%).71 Likewise, in 5 patients who had recurrent duodenal ulcers, DMSO prevented all subsequent recurrences.72

“I’ve used DMSO for Crohn’s since 2012. Pure miracle for Crohn’s.”

DMSO’s anti-inflammatory and tissue healing properties also make it remarkable for gastrointestinal autoimmune disorders.

A double-blind randomized study of 136 patients with recurrent ulcerative colitis (not prevented by prophylactic regimens) found over two weeks, 51% recovered from standard treatment while 84% using DMSO recovered.73 Over the next year, standard treatment had 25% relapse rate versus only 5% with DMSO.

In mice with encapsulating peritoneal sclerosis, DMSO treatment reduced peritoneum thickening by 30%, decreased inflammatory cells and cytokines while increasing anti-inflammatory markers.74

Amyloidosis (a deposition of abnormal protein often in concurrence with autoimmune conditions) is quite difficult to treat but has an excellent response to DMSO, including cases with severe gastrointestinal issues, which fully resolved following DMSO,75,76,77 including cases that would have otherwise been fatal78 (e.g., one report discusses 4 sequential amyloidosis cases likely triggered by Crohn’s which resolved with oral DMSO).79

Hemorrhoids

In clinical studies, DMSO has been repeatedly found to improve or resolve varicose veins. Many DMSO pioneers reported that hemorrhoids (also engorged veins) respond to DMSO, and there are many successful reports online. Likewise, a dozen readers have shared stories like these with me:

“My husband (who was very skeptical) used it topically on his hemorrhoids and reported significant size reduction after first application.”

“Two friends had their hemorrhoids vanish after a single subcutaneous thigh injection .5ml DMSO. They both had them for many years, one for 15 years, and now they’re completely clear.”

Additionally, DMSO can be used to treat rectal fissures (e.g., patented DMSO preparations have been created for this).80

Note: There is also significant data that DMSO, through the same mechanisms it heals organs within the gastrointestinal tract, also greatly benefits a variety of prostate conditions, including prostatitis and benign prostatic hyperplasia (BPH), and as such, the DMSO community frequently uses it for prostate issues (particularly enlarged prostates — all of which is summarized here).

Saving the Liver

Dozens of studies have also shown DMSO protects the liver from a variety of destructive toxins81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100 (including Tylenol,101,102,103,104 carbon monoxide,105 lethal radiation106 and the bacterial endotoxins which cause sepsis107,108,109) and to protect it from its blood supply being cut off.110,111,112,113,114,115,116

Note: One also found DMSO reduced the oxidative stress that followed part of the liver being surgically removed.117

DMSO has also been repeatedly shown to cause mesenchymal stem cells to differentiate into liver cells, explaining how DMSO is able to regenerate the liver.118,119

These results translate to humans. For example, in 12 terminal liver cirrhosis patients who stopped drinking and took daily oral DMSO and aloe vera, of the 8 who followed the 6-month program, all had improved health, reduced vomiting, and improved liver function tests (and most importantly were alive a year later).

Gallbladder Emergencies

In 50 patients post-emergency surgery for appendicitis or cholecystitis, 50% DMSO reduced postoperative wound complications to 4%, compared to 14% with 30% DMSO and 24% with traditional methods.120 In parallel, multiple readers reported remarkable DMSO results for cholecystitis:

“IV DMSO saved my gallbladder and instantaneously reduced my inflammation to almost nothing in 2013.”

“I found out a couple of months ago that I have gallstones and [despite trying many things] was basically told I couldn’t do anything about it. [After a significant pain started] I immediately looked up your articles and ordered some DMSO. Since I started applying it a week or two ago, the pain and symptoms have almost completely gone away.”

Note: Agents are sometimes infused into the gallbladder to dissolve gallstones. In numerous studies, DMSO combined with another agent (e.g., D-limonene from citrus peels) was found to effectively dissolve gallstones (without side effects).121,122,123,124,125,126,127

Pancreas

DMSO shows promise for diabetes and pancreatitis. Some diabetics have reported DMSO reduces insulin needs and helps diabetic peripheral neuropathy pain.128

For example, diabetes frequently results from insulin producing cells of the pancreas being destroyed. DMSO, in turn, has been found to protect them from a toxin which otherwise triggers diabetes,129 to protect transplanted cells from immunologic attack (suggesting DMSO can reduce autoimmune diabetes),130 and to cause bone marrow stem cells (in the presence of excessive glucose) to transform into new insulin producing cells.131,132,133

DMSO also has been shown to increase pancreatic insulin secretion (in response to elevated blood glucose)134 and (at low doses) to increase the body’s response to GLP-1135 a key hormone the body uses to regulate satiety and blood sugar (and which diabetes drugs like Ozempic mimic), and was reported by Merck to potentiate insulin.136

Likewise, DMSO offers immense benefit for pancreatitis, a disease quite challenging within the conventional model (e.g., one study found 22.1% of hospitalized patients with pancreatitis died).137 In animals:

DMSO prevented the onset of pancreatitis typically induced by known triggers (e.g., specific diets and pancreatic toxins138,139).

DMSO improved existing pancreatitis (e.g., by reducing edema,140 reducing ICAM-1 expression and subsequent leukocyte activation — a key part of the disease process,141 and improving compromised microcirculation142).

DMSO treated acute hemorrhagic necrotizing pancreatitis (a condition which typically has a mortality rate between 25% to 40%143).

Significant clinical improvements have been repeatedly observed:

A randomized double-blind trial took 78 chronic recurring pancreatitis patients presenting within 2 hours.144 Of those receiving 10% DMSO rectally, at least 57% were pain-free after 12 hours (versus 17% controls), and all were pain-free after 24 hours (versus 48% controls still in pain). All DMSO subjects were discharged within 3 days, compared to only 22% of the control subjects within 5 days.

In patients with recurrent pancreatitis, DMSO combined with allopurinol enhanced the efficacy of narcotic analgesics, significantly reducing pain, white cell counts, and serum lactate dehydrogenase levels (indicative of reduced pancreatic and peripancreatic inflammation and necrosis) compared to controls.145,146

In three patients with chronic alcohol-induced pancreatitis, rectal DMSO achieved complete pain relief within 12 hours and resolved epigastric tenderness by day four, compared to persistent pain with pharmaceutical treatment.147

Additionally, DMSO in combination with fluorouracil was found to both prevent and treat the pancreatitis which sometimes follows abdominal surgeries.148

Treating Gastrointestinal Disorders

The results consistently demonstrated with DMSO for GI issues are remarkable and merit immediate adoption into standard care, particularly since it safely treats many conditions medicine struggles with that are often fatal. Nonetheless, this never happens — DMSO adoption by hospitals would greatly reduce heart-wrenching, costly disability and deaths following strokes, spinal cord injuries, and head trauma. Yet, despite decades of supporting data, no American hospital does this.

For this reason, it’s essential that each of us knows how to administer it ourselves, so we aren’t left at the mercy of a medical system prioritizing existing protocols over exploring unorthodox approaches benefiting patients who don’t respond to conventional treatments.

Conclusion

As this article shows, there is extensive evidence demonstrating DMSO effectively treats many challenging gastrointestinal issues that the medical system has struggled for decades to provide a good solution for. Yet despite this, DMSO is virtually never used in medical practice — in fact, few physicians are even aware DMSO exists.

This highlights how imperative it is for each of us to discover how we can take health into our own hands with easily available remedies like DMSO rather than rely upon a dogmatic medical system which will never consider unorthodox treatments regardless of how much the patient needs it.

Fortunately, due to the MAHA moment and the widespread loss of trust in the medical system, our culture at last appears to be open to seriously considering the unapproved therapies, and it is my sincere hope that natural therapies like DMSO can at last end the suffering those with debilitating chronic illnesses suffer.

Author’s Note: This is an abridged version of a longer article which goes into greater details about how DMSO can be used to treat gastrointestinal diseases and prostate issues. That article, along with resources and protocols for obtaining and using DMSO can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

– Sources and References

DMSO for Respiratory Diseases — Research and Patient Reports on COPD, Asthma, and Lung Recovery


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/07/25/dmso-respiratory-diseases-treatment.aspx

Analysis by A Midwestern Doctor    July 25, 2025

dmso respiratory diseases treatment

Story at-a-glance

  • Chronic respiratory diseases remain profitable but poorly treated, subjecting patients to expensive healthcare, impaired stamina, and painful decline
  • DMSO is an “umbrella remedy” treating diverse ailments through therapeutic properties including reducing inflammation, improving circulation, and reviving dying cells
  • These properties uniquely address underlying causes of chronic respiratory diseases by reducing fibrosis and inflammation, restoring damaged organs, and improving circulation
  • DMSO addresses respiratory infections through antimicrobial activity, reduced lung inflammation, and potentiation of antimicrobial therapies
  • Extensive published data and user reports demonstrate DMSO’s remarkable results for asthma, COPD, cystic fibrosis, interstitial lung disease, pulmonary fibrosis, and pneumonia, including cases in which transplant was no longer necessary due to significant organ recovery

Since childhood, I’ve known numerous smokers who had slow, agonizing deaths from COPD (chronic obstructive pulmonary disease). These deaths were often quite traumatic for their family and friends, particularly as patients became increasingly disabled from their loss of respiratory function.

Once I entered medicine, I saw the other half of this tragic story. I lost count of how many COPD patients were subjected to the same medical protocols — which they often couldn’t refuse because people will do anything to be able to breathe. They’d eventually get hospitalized for COPD exacerbations or pneumonia (common COPD complications), and before long, they’d enter a cycle of ever more frequent repeat hospitalizations until they died.

Note: Steroids are frequently used to manage COPD and slow lung destruction. However, steroids suppress the immune system, which coupled with the reduced respiratory turnover seen in COPD, makes patients much more vulnerable to pneumonia.

I later learned that the lungs concentrate a coating of glutathione (at levels 100 times that in other parts of the body1) to protect them from damage and that restoring this coating with nebulized glutathione could (without side effects) prevent further progression of COPD. Numerous studies in turn showed this worked2,3 particularly in COPD exacerbations4 and that in chronic lung diseases, the lung’s glutathione tends to be depleted.5

Unfortunately, this idea never caught on. Most of my conventional colleagues weren’t open to it, though I’ve come across many integrative doctors and naturopaths over the years who offer it for both COPD and chronic damage from wildfire inhalation.

To some extent, this resistance is predictable. Like many businesses, medicine revolves around recurring sales, and COPD is one of its core markets — patients are on medications for life and often need more as the disease progresses.

This helps explain why chronic diseases of the respiratory tract are the fourth most common cause of death in the United States, and in the US alone, 24 billion dollars was spent on COPD in 2023.6 This isn’t a market the medical industry will ever willingly give up, regardless of the suffering created.

Note: Asthma is in a similar situation. While not as fatal as COPD, it still makes over 40 billion a year (increasing at 4.4% annually).7 Despite all the money poured into it, asthma rates keep going up (e.g., in 1999, 9.1% of Americans had ever been diagnosed with asthma; by 2022, 44.2 million Americans had it).8

The Power of Umbrella Remedies

In medicine, there are a few therapies (like ultraviolet blood irradiation) that can cure a wide range of diseases. We call these “umbrella therapies” because they address the root causes of many illnesses — things like poor circulation throughout the bodyinflammation, and cells getting stuck in a state of shock where they stop functioning and eventually die.

DMSO safely does each of these and has repeatedly shown remarkable effectiveness for an incredibly diverse range of disorders:

  • Strokes, paralysis, neurological disorders (like Down syndrome and dementia), and circulatory disorders (Raynaud’s, varicose veins, hemorrhoids) — which I discussed here
  • Tissue injuries like sprains, concussions, burns, surgical incisions, and spinal cord injuries (discussed here)
  • Chronic pain from bad discs, bursitis, arthritis, or complex regional pain syndrome — covered here
  • Autoimmune conditions like scleroderma, amyloidosis, and interstitial cystitis (discussed here)
  • Head and neck problems: tinnitus, vision loss, dental issues, sinusitis (discussed here)
  • Internal organ diseases like pancreatitis, infertility, liver cirrhosis, and endometriosis (discussed here)
  • Skin conditions: burns, varicose veins, acne, hair loss, ulcers, skin cancer, autoimmune skin diseases (discussed here)
  • Challenging infections including chronic bacterial infections, herpes, and shingles (discussed here)
  • Many aspects of cancer treatment and symptoms (discussed here)

Additionally, DMSO has a unique ability to enhance the absorption of medications and natural therapies by facilitating their entry into the body, resulting in a myriad of beneficial therapeutic combinations (discussed here).

Because of this, I’ve now received over 3,000 reports9 from readers of life-changing benefits from using DMSO (which can be read here).

Real Stories from Real People

One thing that caught my eye in those testimonials was that numerous people shared how DMSO had either improved or reversed their incurable lung diseases, such as this man who overcame his incapacitating COPD.

 

Daniel’s Story is not unique. For example:

“I am currently treating a 45 year old CF patient with DMSO and glutathione. She was in the beginning stages of getting worked up for lung transplant. We’ll have PFT’s from before treatment and updates every 3 months starting in August. 1 month in, she’s feeling like a teenager again, exercising and has been illness free for 4 weeks now, which is the longest period without antibiotics since she was in her 20’s.10

Okay, decades of smoking and drinking ruined my lungs — I knew it, but I was unable to stop at that point in my life. I’d had an operation to cut off some of the ruined parts of my lungs and that did not go well — Bullous Emphysema. Long story short, I was bedridden and on 4 liters of supplemental oxygen.

Trying to get upstairs in my home to shower was the biggest impediment. I was tremendously depressed and ready, (in my mind) to die. I tried nebulizing DMSO and now I can do household chores and light yardwork and my blood oxygen goes to 100%.11

I was told I have emphysema in the upper part of my lungs. After 2 strokes due to a clogged left carotid, I purchased DMSO to apply on my scar — which diminished pretty quickly. I also rub it on my chest and nebulize it — which cured my COPD. I also apply a drop to my ear to lessen tinnitus — it went from 35 decibels to five.12

My husband is 85 and has pulmonary fibrosis and emphysema. I rubbed his shoulders, back, and sides with DMSO for back pain and it’s amazing. Now he has more energy, is getting stronger, refused his wheelchair to go to church yesterday, and makes coffee for me before going to bed.13

I am using DMSO via a nebulizer (as well as topically) and it seems to be showing significant improvement in my lungs! I was on 4 liters and now use NO supplemental oxygen or any other medicine for my lungs (I was also taking Trelogy). Despite decades of excessive smoking and drinking, I am seeing remarkable results.14

I had a patient with scleroderma and interstitial lung disease (which had put them on the transplant list) but after receiving DMSO, the lung recovered and they no longer need a transplant. I also just saw a patient with sarcoidosis treating himself with DMSO nebulized. He said it made a big difference.” — James Miller MD15

Numerous studies over the decades in turn, corroborate these reports.

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How DMSO Protects Injured Lungs

DMSO’s protective and restorative properties have been shown to rescue and revitalize the functions of many different organs including the lungs. For example:

  • DMSO was found to prevent significant inflammation and tissue injury following traumatic impact on the lungs.16
  • In mice exposed to lethal radiation doses, oral DMSO allowed all to survive and protected many body parts including the lungs.17
  • DMSO prevented injuries from respiratory anoxia (being unable to breathe air in).18
  • Following cold-restraint stress, DMSO reduced lipid peroxidation and stress-induced injuries in the stomach and lungs.19,20
  • In rats with lung injury caused by blood flow loss and restoration, treatment with 5% DMSO reduced lung swelling, lowered harmful inflammation markers, and decreased mitochondrial DNA release, helping protect lung tissue.21 Similar results have been obtained in other studies.22,23,24
  • DMSO was found to prevent lung injury from hemorrhagic shock (significant blood loss) and transfusing lost fluids back.25

COPD and Pulmonary Fibrosis — Where DMSO Really Shines

DMSO has been shown to effectively reduce fibrosis and scar tissue throughout the body (particularly in the skin). As this characterizes the lung damage in many chronic lung disorders, DMSO hence is a promising therapeutic option for them. Data includes:

  • DMSO at 0.5% to 3% in a dose-dependent fashion, roughly halving the proliferation of fibroblast cells, suggesting it could reduce the fibrosis seen in chronic lung diseases.26
  • In rats with experimentally induced silicosis, DMSO (2 ml/kg) reduced pulmonary fibrosis, lowered hydroxyproline levels, and normalized lung white blood cell counts.27
  • DMSO reduced chronic pulmonary fibrosis, particularly when combined with zinc.28

DMSO hence has been shown to help those lung patients regain the ability to breathe. For example, in older patients with chronic respiratory insufficiency (characterized by chronically low blood oxygen levels, elevated carbon dioxide, and abnormal acid-base balance), daily intramuscular DMSO was found to lead to recovery without hospitalization in 35/43 (81%) patients.29

Note: Other studies have also shown that DMSO helps with chronic non-specific lung diseases.30

Protection Against Toxic Exposures

“DMSO has helped me though. I have a weak heart and lungs due to 10 years of exposure to chlorine in a pool. My chest pain instantly retreats when I use it as well as tinnitus when I apply to my forehead.”31

Many chronic lung issues come from respiratory exposure to toxins or numerous small ones, such as the particulate matter from smoking and wildfires (e.g., research from Hawaii shows the majority of those in the Lahaina fire still have symptoms such as headaches, dizziness, weakness, breathing issues, chest pain).32,33

After sheep experienced lung injury from inhaling smoke, nebulized DMSO (with negatively charged heparin) was found to reduce lung damage significantly.34

Note: Positive ions (which disrupt the physiologic zeta potential) disable the movement of cilia, and hence prevent the airway from expelling harmful particulates.35,36

In human lung cells, cooking oil fume condensate caused genetic damage — which DMSO effectively reduced.37

Radioactive uranium dust (either from mining or depleted uranium munitions) is quite toxic and challenging to heal from. Fortunately, numerous studies have shown DMSO effectively neutralizes its toxicity and DNA damage in airway cells in a dose-dependent fashion.38,39,40,41,42,43,44,45,46,47,48

DMSO prevents the inflammation, cellular damage, and edema alloxan causes in the lungs.49

In human lung cells exposed to harmful cigarette smoke, a mixture of tea polyphenols and DMSO provided strong protection by significantly reducing DNA damage, chromosome abnormalities, and gene mutations.50

Note: Nebulized glutathione is also often very helpful for recovering from smoke or wildfire injuries.

Respiratory Infections

My English bulldog had a very stubborn case of pneumonia. She was on three different antibiotics over eight weeks and nothing seemed to help. Then we added DMSO to the treatment protocol! One week later her lungs were clear.51

Many of DMSO’s properties make it uniquely suited for treating infections, particularly in enhancing the penetration of antibiotics and reducing antimicrobial resistance. Since pneumonia is one of the top causes of hospital admissions and deaths, particularly in individuals with chronic lung diseases, this facet of DMSO is also quite helpful. Here’s what the research shows.

Tuberculosis is the world’s most deadly infection, particularly due to increasing resistance. Many lab studies have shown DMSO directly inhibits bacterial growth52 and increases sensitivity to antibiotics by 3 to 200 times.53,54,55,56 As such, in guinea pigs with isoniazid-resistant tuberculosis, all died despite treatment, whereas if DMSO was given prior, they all survived.57

In humans, DMSO significantly improves tuberculosis outcomes, such as in patients with destructive pulmonary and endobronchial tuberculosis who received nebulized antibiotics mixed in DMSO,58 in children,59 including a study where it healed destructive cavities,60 and where children had contracted tuberculosis from contaminated vaccines.61

DMSO also treats other acute or suppurative respiratory diseases such as acute stenosing laryngotracheobronchitis in children.62,63,64 For example, in 2020,65 a Libyan hospital reported administering 16.67% DMSO and 2.78% ceftriaxone to 31 patients with lung abscesses — all experienced complete recovery with no recurrence.66

ARDS — When Lungs Fill with Fluid

Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition where alveoli fill with fluid and collapse (often requiring ventilators). DMSO has also been shown to help here:

In rats with ARDS, intraperitoneal DMSO maintained blood oxygen levels, reduced plasma protein leakage into the lungs, and significantly protected the capillary-alveolar lining.67 When vitamin E was given as well lung injury further decreased.68

In one study where DMSO was used for ARDS (given intravenously at concentrations under 10%),69 it produced a dramatic improvement in all three patients who received it. Prior to DMSO, all three were near death. In one case, when DMSO was nebulized, improvement was observed within one hour.

DMSO Table 1

Asthma — Breathing Easy Again

As DMSO both reduces inflammation, relaxes muscles, and increases blood circulation, it holds significant promise for asthma.70 Many readers with asthma, in turn, have shared how DMSO changed their lives:

“Holy moly, this is crazy. Dosed this weekend, 3 days, taking a short break (just can’t have that odor during office hours), and already my asthma is almost non-existent. Beyond belief.71

I’ve been using DMSO for about a week now for rather persistent asthma … and have felt a marked improvement! I went from using my inhaler more than I have in a while to now using nothing but DMSO and feeling like my chest has opened entirely and I can take entire deep breaths! I went on a walk this morning and cruised up rather steep hills without barely any increase in my respirations! That never happens.72

Within days of starting to take 1 tablespoon of DMSO per day, I was able to use my albuterol inhaler less. Now it’s been months since I last used it. I used to need an inhaler every time I played table tennis, but now never. I feel less sensitive to dust, although certainly not cured.73

I’ve been using DMSO since November 2024 (big improvement in veins and circulation). That is helping my severe asthma amazingly.74 DMSO has greatly improved my asthma.”75

Including for a cat:

“My 20 yr old cat developed a cough which the vet diagnosed as asthma.76 He wanted to put her on an inhaler, but I had my doubts that she would tolerate that. So I tried using DMSO on the back of her neck … No coughing at all. Amazing stuff.”

Research supports these accounts:

In mice with asthma, DMSO significantly reduced the proportion of TCD4 cells (which play a key role in airway inflammation and hyperresponsiveness).77,78

A study gave 153 adults DMSO mixed with a bronchodilator, steroid, and antihistamine via intramuscular injections. After evaluation, 37 (24.5%) had excellent results, 92 (60%) had good responses, while 24 (15.5%) had no change.79,80

Numerous studies found DMSO increases steroid potency, making it possible to use much lower doses.81,82,83,84 Since steroids often have significant toxicity,85 this can be quite useful.

Note: There is also a century of research showing ultraviolet blood irradiation (which shares many therapeutic properties with DMSO) treats asthma, including treatment resistant cases.

Conclusion

DMSO’s broad spectrum of applicability for so many different diseases suggests that many illnesses we have arise from similar causes, and that illnesses rather than being discrete entities are simply different ways the body ends up manifesting that disease process.

Unfortunately, this way of looking at medicine goes against the interests of the medical industry, as it relies upon having different proprietary treatments for each condition that do enough to improve the condition that patients continue to take them, but not enough to cure it (and hence prevent them from becoming lifelong customers).

As such, umbrella remedies like DMSO are heavily marginalized by the medical profession, irrespective of how much data supports their use or how dire the need is for an effective therapy in many of the conditions they treat.

Fifty years ago, the recognition of what DMSO could do for struggling patients motivated many scientists and doctors around the world to devote themselves to studying it, and while the FDA largely succeeded in erasing their work — in reality, they only delayed it because if something is true, it is impossible to suppress it forever.

Due to an extraordinary confluence of events, it now appears we have arrived at the time many of the things the medical industry has spent a century burying can no longer be suppressed, with DMSO being just one of many things now suddenly emerging into the public consciousness. This is an incredibly exciting time to be alive and thank each of you for being a part of it with me.

Author’s Note: This is an abridged version of a longer article which goes into greater details about how DMSO and nebulized glutathione can be used to treat lung diseases. That article, along with resources and protocols for obtaining and using DMSO can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

 

– Sources and References

Varicose Veins Are More Than a Cosmetic Concern


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/07/24/varicose-veins-more-than-cosmetic-concern.aspx


Analysis by Dr. Joseph Mercola     
July 24, 2025

Story at-a-glance

  • Varicose veins affect over 40 million Americans and are often mistaken for a cosmetic issue, even though they signal deeper problems in circulation that worsen silently over time
  • These enlarged, twisted veins usually appear on the legs. They form when blood begins to flow backward and collect in the veins, increasing pressure and causing the vessel walls to stretch and swell
  • Risk increases with age, hormonal shifts, pregnancy, prolonged standing or sitting, obesity, sedentary behavior, connective tissue disorders, and a family history of vein problems or clotting disorders
  • Treatment options for varicose veins include the use of dimethyl sulfoxide (DMSO) to reduce swelling and support healing, and inclined bed therapy to restore circulation overnight
  • Prevention focuses on daily walking, regular leg elevation, proper footwear, weight control, hydration, and avoiding prolonged sitting, standing, or restrictive clothing that places unnecessary pressure on the lower body

About 40 million Americans live with varicose veins,1 yet most don’t think much about them until they start to hurt. These enlarged veins are often dismissed as a cosmetic problem — unwelcome in appearance but not taken seriously. That mindset keeps many people from paying attention early on, even when subtle symptoms start interfering with their daily life.

However, varicose veins are more than a surface issue. They reflect real changes in your circulation that, if overlooked, will lead to more persistent and serious health problems. Knowing what causes varicose veins and what they’re telling you about your overall vascular health allows for timely interventions and makes it easier to take care of your body long-term.

Understanding Varicose Veins — Causes, Risk Factors, and Diagnosis

Any vein close to the skin’s surface can become varicosed, meaning enlarged and twisted, but the veins in the legs are affected most often. These varicose veins tend to appear bluish or purple, raised above the skin, and may feel warm or tender to the touch. They often become more pronounced after long periods of standing or sitting.2

Although they may look similar to spider veins, varicose veins are deeper, larger, and more disruptive to healthy blood flow. Their presence reflects your body’s inability to move blood upward against the force of gravity.

Healthy circulation depends on one-way valves in the veins — Beneath the surface, healthy veins rely on a network of one-way valves to return blood to the heart. These valves work in sync with muscle contractions in the lower body to keep blood moving upward, against gravity.3

With each step, your calf muscles compress nearby veins, helping blood overcome the long vertical distance back to the chest. This mechanism depends on vessel integrity and the coordination of many small components that maintain pressure and direction. When the system functions well, blood flows steadily and without interruption.4

Varicose veins begin to form when these one-way valves no longer close completely — When the valves weaken or fail, blood slips backward and settles in the lower section of the vein. This accumulation increases local pressure, gradually distending the vessel and further impairing valve function.

Over time, the walls of the vein lose their elasticity and begin to bulge outward, creating a visible enlargement. Gravity amplifies this effect, especially in your legs, where the vertical distance from the heart is longest and the circulatory demand is greatest.5

Several factors influence the likelihood of this process — Your risk of developing varicose veins increases with age, as the wear and tear on vein walls and valves builds gradually over time. If you’re a woman, hormonal shifts, especially during pregnancy or menopause, further relax the vein walls and make you more susceptible.

During pregnancy, circulating blood volume increases, hormone levels shift, and the expanding uterus compresses the pelvic veins, all of which elevate the pressure in leg veins. Genetics also play a strong role, along with obesity and sedentary behavior, which increase venous burden and reduce the efficiency of the muscle pump.

If your work keeps you on your feet for long stretches or seated for hours without movement, your veins face added stress. You’re also more vulnerable if you’ve had deep vein thrombosis (DVT), a leg injury, or a condition that affects connective tissue strength and flexibility.6,7,8

How are varicose veins diagnosed? — A clinician will evaluate your legs while you’re standing, looking for visible swelling, bulging, or color changes. If venous reflux is suspected, a duplex ultrasound will be ordered to assess the direction and speed of blood flow, valve function, and signs of obstruction.

This test also helps differentiate between superficial veins and the deeper veins embedded within the muscles. Identifying where dysfunction originates allows for more precise treatment and helps rule out other vascular or lymphatic conditions.9,10

Complications emerge as the condition advances — While many people live with varicose veins for years with minimal discomfort, it could turn into more serious problems if left unaddressed. One of its complications is superficial vein thrombosis, where a section of the vein becomes hardened, red, and painful due to clotting.

In some cases, these clots may extend into deeper veins, raising the risk of DVT, which carries the risk for a life-threatening embolism if a clot dislodges and travels to the lungs. As venous pressure continues to build, the skin around the ankles might become discolored, fragile, or inflamed, setting the stage for ulcers.

Chronic swelling, known as edema, places additional stress on the surrounding tissues, and fragile veins rupture with minimal trauma, causing spontaneous bleeding.11

Symptoms of Varicose Veins You Need to Watch Out For

The progression of varicose veins tends to be slow and subtle, so their early signs are often missed or dismissed, especially when the skin remains intact and the surrounding tissue appears normal. Paying attention to the following symptoms is key not just for relief but also to prevent more serious complications from taking hold:12,13,14

A sense of heaviness often develops toward the end of the day — If you spend long hours standing or sitting, you’ll start to notice a dull ache in your legs that eases with rest but gradually returns more often. The area will feel tight or swollen, and walking upstairs or standing still for too long makes the discomfort more noticeable.

Pain may shift from dull to throbbing or cramping — You’ll feel a throbbing sensation near the enlarged veins, sometimes accompanied by sharp or pulsing aches. The discomfort takes the form of a deep, cramping feeling that spreads through your calves or behind your knees.

You’ll also notice itching, tingling, or a burning sensation along the affected veins. These symptoms often intensify in the evening, making it harder to relax or get restful sleep.

Swelling in the lower legs becomes more common and persistent — This is because your calves and ankles start to hold onto fluid that doesn’t go away quickly. By late afternoon, your shoes will feel tight, and your socks will leave deep marks around your ankles. In some areas, the skin over the swelling will look taut or slightly shiny, and you’ll begin to see subtle changes in color around the clusters of visible veins.

Skin changes near affected veins signal advancing dysfunction — As your veins stay under pressure, the skin around them becomes increasingly vulnerable. Discoloration will begin to develop, often taking on a rusty or brown hue just above your ankle.

The skin in this area will feel thinner and more fragile. The texture will become dry or leathery, and you’ll notice more frequent itching. These changes show that the surrounding tissue is no longer getting enough oxygen or nutrients, an effect of impaired blood flow and poor venous return.

Slow healing and venous ulcers may develop in later stages — If you leave the underlying dysfunction unaddressed, even small injuries in the affected area will take longer to heal. Minor scratches will linger and turn into shallow, stubborn wounds.

Over time, you’ll develop venous ulcers, often near the ankles, that resist healing and become prone to infection. These ulcers will continue to return unless the pressure in your veins is reduced, and they will require ongoing care to prevent further skin breakdown and tissue damage.

Persistent symptoms signal the onset of chronic venous insufficiency — Chronic venous insufficiency is the term used when your symptoms become persistent and continue to worsen. At this stage, your veins will no longer be able to maintain healthy circulation. The discomfort will spread beyond individual veins and affect your entire lower leg, leading to fatigue, limited mobility, and difficulty staying on your feet for extended periods.

If these symptoms begin to appear, don’t ignore them or assume they’ll resolve on their own. The longer the underlying pressure builds, the harder it becomes to reverse the damage.

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Strategies to Address Varicose Veins

Managing varicose veins requires more than cosmetic correction — it involves addressing the underlying pressure, restoring circulation, and protecting surrounding tissue from long-term damage. The following strategies are commonly used in conventional care for varicose veins:

Compression therapy is the standard first-line approach — Medical-grade compression stockings apply graduated pressure to the lower legs, which helps support the vein walls and encourages blood to flow upward toward the heart.

This approach does not reverse the condition, but it often reduces discomfort and swelling. When compression isn’t enough, medical providers recommend procedures that close or remove dysfunctional veins to reroute blood through healthier ones.

Minimally invasive procedures are used to collapse or remove damaged veins — The most commonly used techniques include sclerotherapy, where a chemical agent is injected to scar the vein shut, and endovenous thermal ablation, which uses heat from lasers or radiofrequency to collapse the affected vessel.

In some cases, mechanochemical ablation combines mechanical disruption with a sclerosing agent to enhance effectiveness. For larger or more stubborn veins, surgical options such as ambulatory phlebectomy or vein ligation may be used to physically extract or tie off the damaged vein.

For those seeking alternatives beyond mechanical or surgical correction, several noninvasive therapies are available to help you support your vascular tone more holistically:

Dimethyl sulfoxide (DMSO) offers a broad-spectrum alternative for vascular support — DMSO is a naturally occurring substance with potent anti-inflammatory, analgesic, and circulation-enhancing effects. When applied topically, it penetrates deep into the tissues. In people with varicose veins, this often translates into reduced visibility of enlarged veins, diminished pain or itching, and lessened pressure in the lower legs.15,16

DMSO plays a significant role in healing venous ulcers and skin damage caused by poor circulation — In clinical studies and long-term case reports, it has shown an ability to promote rapid tissue repair, support granulation, reduce swelling, and prevent infection.17,18

Among diabetic patients with chronic foot ulcers, daily DMSO application helped restore tissue integrity in cases that had resisted conventional care.19 Its effectiveness appears to extend not only to wound healing but also to reducing the hyperpigmentation, thickening, and fragility often seen in longstanding venous insufficiency.20,21

Users report improvements in vein tone, skin integrity, and local circulation — As a venotropic compound, DMSO improves the tone and responsiveness of veins, helping to normalize blood return over time. It also appears to reduce capillary bleeding and post-inflammatory discoloration.22 Take a deeper look at how DMSO supports skin repair and vascular health in “How DMSO Revolutionizes Skin Care and Dermatology.”

Inclined bed therapy uses body positioning to enhance venous return — It offers a structural, systemic method for improving venous return without any invasive measures. By raising the head of the bed by 6 inches (5 degrees), your body lies at a gentle angle that uses gravity to assist the movement of blood and lymph as you sleep.

This method originated from the observation that plants circulate fluids using density and gravitational gradients, and that similar forces may support human circulation as well. In one experiment, varicose veins disappeared after four weeks of sleeping on a 6-inch incline, which is a sign that “a positive change in circulation” had been achieved.23

To explore this method in greater depth, watch the video below and read “The Surprising Benefits of Inclined Bed Therapy” for a full breakdown of how it works to support circulation.

How to Lower Your Risk of Varicose Veins

You can’t change your genetics or the natural aging process, but you do have control over how much daily stress your veins are forced to handle. Supporting healthy blood flow is one of the most effective ways to prevent varicose veins from developing or worsening. That means finding ways to reduce the pressure in your lower legs throughout the day. I recommend adopting these strategies:24

1. Move regularly — If you sit or stand for long stretches at work, make a point to change positions often. Flex your ankles, shift your weight from leg to leg, or take brief walks to keep the blood in your calves moving upward. When you’re seated, avoid crossing your legs or holding your knees tightly together for long periods, since this limits circulation and increases pressure in your lower limbs.

2. Raise your legs during the day — This helps relieve venous pressure by letting gravity assist circulation rather than working against it. Whenever possible, rest with your legs elevated above the level of your heart. This gives your veins a break and helps reduce swelling, especially after activity. Using pillows or a wedge cushion while lying down or reclining can make this a regular part of your daily routine.

3. Choose your shoes wisely — High heels reduce the ability of your calf muscles to contract fully, weakening the natural pumping action that moves blood upward. Choose shoes with lower heels and enough support to let your calves engage properly. Tight clothing around the waist, thighs, or calves also interferes with venous return, especially if worn for long hours.

4. Manage your weight — This reduces unnecessary strain on your lower body. Even a modest loss of excess weight will ease the burden on your venous system and improve overall circulation. Daily walking, swimming, or cycling keeps the blood moving and strengthens the muscle groups that support vein function. You don’t need intense workouts — what matters is consistency and rhythm, especially in the legs.

Frequently Asked Questions (FAQs) About Varicose Veins

Q: What are varicose veins and why do they develop?

A: Varicose veins are enlarged, twisted veins that usually appear in the legs. They form when the one-way valves in your veins begin to fail, allowing blood to flow backward and pool. This buildup increases pressure, stretches the vein walls, and causes the veins to bulge outward. Over time, this signals an underlying problem with circulation, not just a surface issue.

Q: What do varicose veins look and feel like?

A: You’ll usually notice them as bulging, bluish or purple veins raised above the skin’s surface. They may feel warm or tender to the touch, and symptoms like aching, swelling, or heaviness often intensify after standing or sitting for long periods. As the condition progresses, you may also experience throbbing, itching, or skin discoloration.

Q: Are varicose veins dangerous?

A: Yes, especially if left untreated. Over time, they lead to superficial vein thrombosis, deep vein thrombosis, venous ulcers, skin breakdown, and chronic swelling. These complications may begin subtly but grow more serious without early intervention.

Q: How does DMSO help with varicose veins?

A: DMSO (dimethyl sulfoxide) helps ease inflammation, improve circulation and promote healing in damaged tissue. It’s especially helpful for reducing pain, shrinking visible veins, and speeding recovery from ulcers or skin changes caused by poor circulation.

Q: How do I use inclined bed therapy for varicose veins?

A: Raise the head of your bed by 6 inches to create a gentle downward slope from head to toe. This sleeping position improves fluid drainage, reduces nighttime swelling, and supports better circulation in the legs.

It might feel counterintuitive at first, since you’d expect elevating your feet to be the goal, but tilting the entire body allows gravity to assist blood and lymphatic flow more continuously. Many people report visible improvements within weeks of consistent use.

Unlocking DMSO’s Potential — Revolutionary Combination Therapies for Pain, Infections, and More


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/07/18/dmso-combination-therapy-treatment.aspx


Analysis by A Midwestern Doctor     
July 18, 2025

dmso combination therapy treatment

Story at-a-glance

  • DMSO is an “umbrella remedy” capable of treating a wide range of challenging ailments due to its combination of therapeutic properties (e.g., reducing inflammation, improving circulation, and reviving dying cells)
  • One of DMSO’s unique properties is its ability to enter through the skin and carry anything it dissolves with it as it rapidly travels throughout the body, greatly enhancing the potency and viability of many pharmaceutical drugs
  • Because of this, numerous pharmaceutical preparations over the years have combined DMSO with a commonly used drug, and in many cases, demonstrated significant safety and efficacy of the combination to drug regulators
  • These DMSO combination therapies are able to treat challenging illnesses, such as significant musculoskeletal injuries, antibiotic resistant infections, persistent fungal and viral infections, chemotherapy resistant cancers, and chronic pain
  • Many of the most promising uses of DMSO result from combining it with another natural or conventional therapy, as in many cases, a combination can do what DMSO cannot do alone for someone. This article examines the clinical evidence for specific DMSO combination therapies

DMSO is a remarkable naturally occurring substance that (provided it’s used correctly)1 safely and rapidly improves a variety of conditions medicine struggles with — particularly chronic pain. For example, thousands of studies show DMSO treats a wide range of:

Injuries such as sprains, concussions, burns, surgical incisions, and spinal cord injuries (discussed here).

Strokes, paralysis, many neurological disorders (e.g., Down syndrome and dementia), and numerous circulatory disorders (e.g., Raynaud’s, varicose veins, or hemorrhoids), which were discussed here.

Chronic pain (e.g., from a bad disc, bursitis, arthritis, or complex regional pain syndrome), which was discussed here.

Many autoimmune, protein, and contractile disorders, such as scleroderma, amyloidosis, and interstitial cystitis (discussed here).

Head conditions, such as tinnitus, vision loss, dental problems, and sinusitis (discussed here).

Internal organ diseases such as pancreatitis, infertility, liver cirrhosis, and endometriosis (discussed here).

A wide range of skin conditions, such as burns, varicose veins, acne, hair loss, ulcers, skin cancer, and many autoimmune dermatologic diseases (discussed here).

Many challenging infections, such as shingles, herpes, chronic ear or dental infections, and osteomyelitis (discussed here).

Cancers and many complications from the illness and its treatments (discussed here).

Lung disorders such as COPD, asthma, pulmonary fibrosis, smoke injuries, and pneumonia (discussed here).

In turn, since I started this series, it has struck a chord. I have received over 2,000 reports of remarkable responses to DMSO, with many readers experiencing relief from a variety of “incurable conditions.”2 For example, this man was contemplating suicide from his disability from COPD, and after nebulizing it, immediately regained his lung function and stamina (something other readers have also reported).

This begs an obvious question — if a substance capable of doing all of that exists, why does almost no one know about it? Simply put, like many other promising unpatentable therapies, it fell victim to a pernicious campaign by the FDA, which kept it away from America despite decades of scientific research, congressional protest, and thousands of people pleading for the FDA to reconsider its actions.3

Combination DMSO Therapies

DMSO is a unique solvent that can rapidly travel throughout the body (e.g., within an hour of being applied to the skin, it can be found within the bones and teeth), and will bring whatever is dissolved with it.4 Because of this, in addition to its many curative properties, DMSO also enhances the function of many other substances, such as:

It allows drugs and nutraceuticals that would normally require injection to be given topically.

Allows them to enter regions of the body they would normally have difficulty entering, thereby making it possible to treat resistant infections and cancers.

Significantly increases the potency of the medication, allowing much lower and safer doses to be used (e.g., topical DMSO mixed with a natural anticancer agent can treat cancers and metastases below it in that region).

As such, many natural healers over the years have discovered a number of remarkable natural DMSO combinations that can be used to treat a myriad of diseases far more effectively than the natural remedy alone. Likewise, most of the interest in the medical field has been on using DMSO in combination with other patentable drugs, and numerous approved formulations exist; what many do not know is that DMSO is now widely used for that purpose.

Heparin Combinations — Revolutionizing Musculoskeletal Treatment

Heparin is one of the oldest anticoagulants, and I believe it works in part by improving zeta potential, as due to its numerous sulfate and carboxylate groups, it has the most negative charge density of any known biomolecule, making it a strong zeta potential restoring (and hence circulating improving) agent. Unfortunately, heparin cannot be absorbed orally, so it’s typically reserved for hospital settings where it can be injected, making DMSO’s ability to bypass this limitation invaluable.

Note: The one study I’m aware of that clearly compared DMSO alone to DMSO plus heparin found significant benefits from the combination in rheumatoid arthritis.5

The Dolobene Success Story — In Germany, roughly fifty years ago, researchers developed Dolobene, a gel containing 10% to 15% DMSO, 2.5% dexpanthenol (a water-soluble vitamin that breaks down into pantothenic acid, essential for cellular metabolism), and 50,000 IU of heparin. This combination promotes moisturizing, hydrating, and wound healing while reducing inflammation.

In the 1980s,6 Dolobene became one of the leading topical medications for sports injuries and arthritis. Numerous studies from that period corroborated its value for these conditions and complications of varicose veins (another condition with strong response to DMSO):

Athletic injury studies — A study of 78 patients (mostly athletes) with overstrained tendons received Dolobene for 2 to 3 weeks three times daily, with over 50% showing significant symptom improvement: 94% improvement in pain, 55% improvement in swelling, 95% improvement in redness, and 92% improvement in warmth.7

Another study gave Dolobene gel to 30 athletes with soft tissue injuries twice daily for 4 weeks. Results showed 10 excellent responses, 5 excellent to good responses, 10 good responses, and 5 moderate responses across various injury types including shoulder contusions, knee joint distortions, and ankle sprains.8

Trauma and recovery studies — A controlled study compared Dolobene gel plus ultrasound to placebo in 15 subjects with blunt-tissue trauma to the lower extremity within 24 hours. The treatment group showed faster pain relief, edema reduction, and mobility recovery compared to 15 controls.9

Vascular condition studies — A comprehensive study treated 44 patients with various vascular conditions including spontaneous and postoperative phlebitis, chronic edema, and traumatic injuries related to varicose veins. Researchers evaluated multiple parameters including leg pain, heaviness, pain intensity, and swelling, with 75% of patients showing noteworthy improvement in over half the parameters evaluated.10

Most remarkably, a study of 41 patients who had undergone varicose vein surgery or had acute thrombophlebitis received Dolobene gel for up to 31 days. Of the 34 evaluable patients, all experienced good or very good results.11

Global Expansion of Heparin-DMSO Combinations — The success of Dolobene led to numerous similar products worldwide:

European Products:

Sinedol12 and Roll-Bene13 (heparin and dexpanthenol)

Histalgan Mite14 (hydroxyethyl salicylate — HES, related to aspirin)

Sportusal Emgel and Gel15 (heparin and HES)

Venugel16 (complex combination with essential oils)

American and Russian Products:

Dendracin Neurodendraxcin17 (methyl salicylate, menthol, and capsaicin)

Капсикам18 (capsIKAM) (camphor, turpentine, benzyl nicotinate, and Nonivamide)

Clinical Applications in Bladder Treatment — In America, DMSO’s only clinically approved indication is the intravesical treatment for interstitial cystitis (painful bladder inflammation). While effective, it doesn’t work in every case. According to Stanley Jacob:19

“When IC is refractory to DMSO instillation, DMSO bladder cocktails have been tried with some success. These cocktails entail mixing DMSO with heparin, steroids [methylprednisolone], hyaluronic acid, analgesics, and other substances.”

Clinical studies support this approach.20 In one study, IC patients who didn’t respond to single agents (DMSO, silver nitrate, or chloropactin) responded to heparin-containing combinations, while another showed effectiveness in previously untreated IC patients.

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NSAID Combinations — Safer Pain Management

NSAIDs are among the most widely used medications for pain and injury, despite often having limited efficacy and significant systemic toxicity. They cause gastric bleeding, heart attacks, and kidney damage that collectively kill tens of thousands of Americans annually.

The Development of Topical NSAID-DMSO Combinations — One strategy to reduce NSAID toxicity involves topical application (like diclofenac in Voltaren gel) to minimize systemic absorption and toxicity, which numerous studies have corroborated.21,22,23,24 However, combining NSAIDs with DMSO dramatically increases absorption and effectiveness.

Pennsaid: The FDA-Approved DMSO-NSAID Combination — In the United States, the only FDA-approved topical DMSO combination is Pennsaid (45% DMSO with diclofenac).25 The approval process reveals important insights about DMSO’s effectiveness.

In a 2004 randomized controlled trial for approval, researchers found minimal systemic toxicity (the primary issue was topical skin irritation, greater in the combination group).26 Remarkably, DMSO alone (the “placebo”) improved symptoms by 28.5% on average, while DMSO plus diclofenac improved symptoms by 39.925%.

This data is particularly significant because it demonstrates DMSO’s standalone effectiveness while showing additional benefits from the combination. Given the pharmaceutical industry’s tendency to minimize placebo effects, the actual benefit from DMSO alone was likely greater than reported.

Supporting Clinical Evidence — Multiple studies corroborate these findings: A meta-analysis27 of clinician trials from 200428 and 200529 showed that DMSO alone created improvement, with greater improvement from DMSO plus diclofenac combinations.

When topical DMSO-diclofenac was compared to oral diclofenac, it proved equally effective for pain reduction but much less likely to cause systemic side effects. Another trial confirmed these findings and showed that combining topical and oral forms didn’t increase oral diclofenac toxicity.30

The FDA analysis of seven unpublished clinical studies found only 1% to 4% increases in various non-severe side effects when comparing DMSO-diclofenac to DMSO alone.31

Commercial Success and Limitations — Pennsaid was approved in 2009,32 with a new formulation approved in 2014.33 The company also developed foam-based ibuprofen DMSO formulations,34 but disappeared through corporate acquisitions.35,36,37 After patent expiration, other companies began producing generic versions.38,39

Steroid Combinations — Enhanced Anti-Inflammatory Power

Corticosteroids have significant side effects that increase with higher doses and prolonged use. However, early research revealed that DMSO dramatically increased steroid potency, potentially allowing for much lower therapeutic doses. For example:

DMSO increased steroid potency40 10 to 1,000 times in stabilizing lysozymes, and greatly enhanced steroids’ ability to reduce fibroblast proliferation.41

Investigators found that 0.025% fluocinolone in DMSO was more effective than 0.025% fluocinolone alone for various conditions, with equivalent efficacy to 0.2% fluocinolone, suggesting DMSO made the steroid ten times more potent.42

Clinical Applications in Dermatology

Most DMSO-steroid combination trials focused on dermatologic or musculoskeletal conditions:

Distribution and safety studies — Researchers found that various dyes thoroughly stained the skin’s surface layer but rarely penetrated deeper, with similar penetration patterns for hydrocortisone and other compounds.43

A 1967 study found 90% DMSO caused a fourfold increase in topical corticosteroid absorption and excretion,44 while a 1968 study of 224 patients found 70% DMSO gel with triamcinolone acetonide produced results comparable to cumbersome occlusive dressings.45

Skin condition treatments — A 1967 study demonstrated that topical DMSO with 0.025% fluocinolone effectively treated numerous conditions.46

Psoriasis treatment — A 1976 clinical trial found that DMSO combined with topical corticosteroids was very effective for steroid-resistant plaque-type psoriasis, achieving complete resolution in 3 to 4 weeks.47 The steroids synergistically counteract irritation sometimes seen with higher DMSO concentrations.

A 2009 study confirmed DMSO combined with topical corticosteroids was highly effective for resistant plaque-type psoriasis, completely clearing it in 3 to 4 weeks.48

Rheumatoid Arthritis Applications

Multiple studies demonstrated effectiveness for rheumatoid arthritis:

A 1968 study found that DMSO, combined with hydrocortisone or procaine, was more effective than DMSO alone, with improvements seen within one week in 5 out of 8 rheumatoid patients, 17 out of 20 patients with inflamed nerve roots, and 8 out of 10 with disc pain.49

A large 1979 study treated 343 arthritic patients (320 with RA) with DMSO or DMSO combinations. The DMSO-only group showed 64% significant improvement, but adding heparin, sodium salicylate, or hydrocortisone increased efficacy with quicker pain decrease and improved joint function.50

Antiviral Combinations — Forgotten Breakthrough Treatments

5-Iodo-2′-Deoxyuridine (5-IDU): A Rediscovered Antiviral — 5-IDU was a nucleotide analog with potent antiviral activity against herpes simplex virus and varicella-zoster virus, the causative agents of herpes and shingles, respectively. Unfortunately, it had difficulty penetrating the skin, limiting use primarily to eye infections.

However, early DMSO researchers realized DMSO overcame this limitation and conducted numerous clinical trials showing effective treatment for herpes and shingles,51 resulting in products like Zostrum52 (90% DMSO, 1% IDU for shingles) and Virunguent53 (1.8% DMSO, 0.2% IDU for herpes) in European and New Zealand markets during the 1980s.

Unfortunately, as decades passed, this excellent therapy was forgotten. The comprehensive research data includes:

Early clinical trials — A 1965 study of 7 patients with severe cutaneous herpes simplex infection showed significant improvement in all cases.54

A groundbreaking 1966 blinded trial of 21 patients with recurrent herpes found IDU alone ineffective, DMSO alone halved flareup duration, and DMSO-IDU reduced duration to one-third while preventing recurrences.55

Herpes simplex research — A 1990 randomized controlled trial treated 301 patients with recurrent genital herpes using 80% DMSO mixed with 15% IDU, reducing mean pain duration by 1.3 days and healing time by 1.7 days. For classic herpes lesions specifically, pain duration decreased by 2.6 days and healing time by 2.3 days.56

Shingles (Herpes Zoster) studies — Two randomized controlled trials from 1970 showed that both 5% and 40% IDU in DMSO were effective over 4 days of repeated applications, with 40% IDU being more effective in reducing shingles pain and shortening healing time.57

The patients were delighted, for the pain disappeared within a median of two days. A comprehensive 1974 trial of 118 patients found 100% DMSO with 5% IDU applied every 4 hours for 4 days significantly shortened the vesicular phase, healing time, and pain duration while improving post-herpetic neuralgia.58

Comparative effectiveness — Most remarkably, a 1992 randomized controlled trial of 171 patients with non-severe shingles (present less than 4 days) found that compared to acyclovir, 40% topical DMSO mixed with IDU was superior for vesicle drying speed, pain duration, medication requirements, new vesicle formation prevention, and post-herpetic neuralgia prevention.59

Modern Antiviral Applications — A 1983 study found DMSO effectively transported acyclovir into the skin, moderately reducing herpes lesions alone and dramatically reducing them when combined with acyclovir.60

5-Fluorouracil Combinations — Skin Cancer Treatment

5-FU is a chemotherapy drug used for various cancers and skin conditions. Actikerall,61 a 5-FU and salicylic acid combination approved in Europe and Australia for actinic keratosis, contains DMSO, though this is often not mentioned or listed as “inert.”62 5-FU with DMSO has demonstrated effectiveness for:

Skin cancer treatment — A 1967 study found DMSO significantly increased 5-FU potency, making 5% concentrations effective for locally treating keratoacanthoma, superficial basal cell carcinoma, and early-stage squamous cell carcinoma without adverse effects.63

Other skin conditions — Research showed effectiveness for seborrheic keratosis64 and common warts.65

Nail psoriasis — DMSO combined with 5-FU (in 70% ethanol) proved effective for nail psoriasis in a 20-patient series, with the best results for pitted nails, leukonychia, and oil spots, while showing marginal results for onychodystrophy and crumbly nails.66

Infection Combination Treatments — Overcoming Resistance

DMSO exhibits significant antimicrobial activity that’s dramatically enhanced when combined with antimicrobial agents. Key applications include:

Antibiotic resistance reversal — DMSO’s most remarkable property may be its ability to cause antimicrobial-resistant organisms to lose their resistance, making it possible to eliminate superbugs. This has been most conclusively demonstrated with tuberculosis — an infection whose widespread antibiotic resistance has become a global health problem.

Enhanced penetration — Potent topical medications that normally cannot penetrate the skin can do so with DMSO, allowing antimicrobial activity in previously inaccessible locations. Infections deep within the skin that typically resist elimination can be addressed when topical antimicrobials are mixed with DMSO.

Bacterial infections — DMSO’s antibiotic potentiation is well-recognized in scientific literature. For example, a 1966 study found that 5% DMSO increased bacterial antibiotic sensitivity in both sensitive and resistant strains. All four colistin-resistant Pseudomonas strains became sensitive, although the resistant E. coli didn’t become penicillin-sensitive.67

DMSO appears to enhance antibiotics targeting intracellular components (presumably by facilitating their transport into cells) while not improving those targeting cell walls, such as penicillin. A 2002 study of bacteria causing lung infections found that DMSO potentiated the effects of kanamycin, amikacin, streptomycin, and chloramphenicol, but not those of cell wall-targeting antibiotics.68

This has best been demonstrated with tuberculosis, the most deadly infection in the world, particularly due to its ever increasing antibiotic resistance. Many lab studies69 have shown DMSO directly inhibits the bacteria’s growth70 and increases its sensitivity to the antibiotics used to treat the infection by 3 to 200 times,71,72 including in bacterial extracts from tuberculosis patients.73,74

Likewise, in guinea pigs with isoniazid resistant tuberculosis, all died despite isoniazid treatment, whereas if DMSO was given prior to it, they all survived.75

As such, many studies have found that DMSO dramatically improves outcomes for tuberculosis (e.g., in patients with destructive pulmonary and endobronchial tuberculosis who received nebulized antibiotics mixed in DMSO,76 in children to heal destructive cavities from tuberculosis,77 and in children who contracted tuberculosis from contaminated vaccines).78

Fungal infections — When DMSO is combined with antifungal medications, it increases their potency79 and enhances their ability to penetrate into the skin,80 effectively treating infections in the area81,82,83,84,85,86,87,88,89,90,91,92,93 (or in the brain),94 and it frequently becomes possible to treat chronic infections that do not respond to other treatments (e.g., many have reported it treating toe nail fungus such as DMSO with ivermectin rapidly treating one infection years of other therapies had not touched).95

Note: Some commercial DMSO antifungal formulations exist.96,97,98

Viral infections — Both clinical trials and user reports show DMSO greatly helps shingles and herpes and that it effects are enhanced when it is combined with acyclovir.99 Likewise, one potent antiviral therapy, 5-IDU can’t be used to treat shingles or herpes because it cannot penetrate the skin. However, once combined with DMSO it can, and many clinical trials have shown it is a highly effective treatment for shingles,100,101,102,103,104,105,106,107,108,109,110,111 and multiple approved formulations of it exist.112,113

Conclusion

The DMSO combination story illustrates another remarkable aspect of medicine. Alone (despite a mountain of evidence to the contrary),114 DMSO (which can’t be patented) is viewed as dangerous and ineffective, however once combined with a patentable therapy, it magically becomes “safe and effective.”

Fortunately, the unprecedented political climate created by the immense betrayal we witnessed throughout the COVID-19 pandemic, as well as the ascendency of MAHA and RFK Jr. to the H.H.S. Secretary position is at last making it possible to change this dysfunctional paradigm. Many are now rediscovering the Forgotten Sides of Medicine. This is an exciting time to be alive, I never imagined would happen in my lifetime, and I am incredibly grateful to be on this journey with you.

Author’s Note: This is an abridged version of a longer article about DMSO combination therapies, which provides greater detail on the points mentioned here, covers many other combinations not discussed (e.g., for tinnitus or vision loss), and offers guidance on preparing the combination therapies. That article, along with resources and protocols for obtaining and using DMSO can be read here. Additionally a companion article on how DMSO treats pain and musculoskeletal injuries can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To discover more of AMD’s work, be sure to check out “The Forgotten Side of Medicine” on Substack.

+ Sources and References

Unlocking DMSO — The Forgotten Molecule That Makes Drugs Work Better, Safer, and Faster


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/07/04/unlocking-dmso.aspx


Analysis by A Midwestern Doctor     
July 04, 2025

unlocking dmso

Story at-a-glance

  • DMSO is an “umbrella remedy” capable of treating a wide range of challenging ailments due to its combination of therapeutic properties (e.g., reducing inflammation, improving circulation, and reviving dying cells)
  • One of DMSO’s unique properties is its ability to enter through the skin and carry anything it dissolves with it as it rapidly travels throughout the body, greatly enhancing the potency and viability of many pharmaceutical drugs
  • Because of this, numerous preparations over the years have combined DMSO with a commonly used medication, and in many cases, demonstrated safety and efficacy of the combination to drug regulators
  • Some of these DMSO combination therapies are able to treat challenging illnesses, such as significant musculoskeletal injuries, antibiotic resistant infections, persistent fungal and viral infections, chemotherapy resistant cancers, and chronic pain
  • More creative DMSO combinations (which can be produced at home) have been frequently used to successfully treat many challenging conditions (e.g., tinnitus, a wide range of eye issues, cancers, and uncomfortable scars)

DMSO is a remarkable naturally occurring substance that (provided it’s used correctly1) safely and rapidly improves a variety of conditions medicine struggles with — particularly chronic pain. For example, thousands of studies show DMSO treats a wide range of:

Injuries such as sprains, concussions, burns, surgical incisions, and spinal cord injuries (discussed here).

Strokes, paralysis, many neurological disorders (e.g., Down syndrome and dementia), and numerous circulatory disorders (e.g., Raynaud’s, varicose veins, or hemorrhoids), which were discussed here.

Chronic pain (e.g., from a bad disc, bursitis, arthritis, or complex regional pain syndrome), which was discussed here.

Many autoimmune, protein, and contractile disorders, such as scleroderma, amyloidosis, and interstitial cystitis (discussed here).

Head conditions, such as tinnitus, vision loss, dental problems, and sinusitis (discussed here).

Internal organ diseases such as pancreatitis, infertility, liver cirrhosis, and endometriosis (discussed here).

A wide range of skin conditions, such as burns, varicose veins, acne, hair loss, ulcers, skin cancer, and many autoimmune dermatologic diseases (discussed here).

Many challenging infections, such as shingles, herpes, chronic ear or dental infections, and osteomyelitis (discussed here).

Cancers and many complications from the illness and its treatments (discussed here).

In turn, since I started this series, it struck a chord, and I have received over 2,000 reports of remarkable responses to DMSO, and many readers have had for a variety of “incurable conditions.”

This begs an obvious question — if a substance capable of doing all of that exists, why does almost no one know about it? Simply put, like many other promising therapies, it fell victim to a pernicious campaign by the FDA, which kept it away from America despite decades of scientific research, congressional protest, and thousands of people pleading for the FDA to reconsider its actions. Consider for example, this 60 minutes program about DMSO that aired on March 23, 1980:

Understanding DMSO’s Combination Potential

DMSO’s effectiveness in treating a wide range of illnesses stems from its unique and diverse properties, many of which appear to target the root causes of disease — such as enhancing parasympathetic activity, improving circulation, regenerating senescent cells, providing potent anti-inflammatory effects, and blocking pain conduction. Sadly, despite hundreds of studies demonstrating these promising characteristics, the FDA has refused to recognize all but one property of DMSO.

In pharmacology, DMSO is often referred to as a “vehicle” that helps other drugs get into the body. Because of this, while DMSO only has one approved (intravesical) use in the United States, a variety of drugs are on the market that use DMSO as a “vehicle” to transport them in the body.

In short, when DMSO is given alone, it is “unsafe” and “unproven” but when combined with a patentable drug, it suddenly becomes “safe and effective.” Likewise, in package inserts, DMSO is typically described as a safe and inert ingredient (despite it often being the primary “active ingredient”).

DMSO’s ability to serve as a drug delivery system is due to its being a potent solvent with a variety of unique properties.

Membrane permeability — DMSO will pass through biological membranes without damaging them, which is extremely unusual.2 This property is believed to be due to its exchange and interchange with water in biological membranes.3 In addition to not harming the skin, when tested with other substances that could enter the brain, DMSO was not observed to alter the cells lining the blood-brain barrier or the brain tissue.4

Rapid distribution — Once it contacts the skin, DMSO rapidly spreads throughout the body. Within an hour of being applied to the skin, it can be found within the bones and teeth.5 Interestingly, DMSO does not penetrate tooth enamel or nails, which may explain why certain conditions affecting these structures require different approaches.6

Solvent properties — DMSO is a highly potent solvent that can dissolve a wide range of polar and non-polar substances (and hence is sometimes used to solubilize other drug products). If a substance is dissolved within DMSO, DMSO can typically bring it into the body. While a few other substances can also serve as vehicles, DMSO is the most potent in pharmacology (e.g., DMSO is more effective than propylene glycol at delivering topical steroids into the body7).

Enhanced circulation and cellular transport — Beyond simply transporting substances into the body, DMSO also greatly increases circulation. By taking the place of water (as it is small, can form hydrogen bonds, and is relatively polar) while being both fat and water soluble, it changes the permeability of the cell membrane, allowing new things to enter the cell and waste products to leave the cells.

As a result, DMSO is able to both spread what it transports throughout the body and significantly enhance the body’s innate ability to circulate what has already been absorbed (including to previously inaccessible areas).

This combination of properties enables the topical administration of drugs that would normally require injection, and in many cases, can significantly increase their potency because it penetrates deep regions of the body that pharmaceuticals typically have difficulty entering, or because it bypasses the cellular barriers that normally exclude foreign substances.

In turn, lower doses of drugs can frequently be used (reducing their toxicity) because they become more potent, and because DMSO combinations can be locally applied to bring a drug to a target region, rather than taking a standard oral dose that raises the entire body’s target concentration.

Specialized DMSO pharmaceuticals — These properties allow well established drugs to be combined with DMSO. For example, NSAIDs (which are also used to treat pain and musculoskeletal injuries) have a variety of side effects when consumed orally (e.g., fatal NSAIDs gastric bleeds killed over 16,000 Americans in 19998). However, when combined with DMSO, NSAIDs can be applied topically to the site of injury, thereby avoiding the risks of oral NSAID consumption.

One FDA-approved drug (Pennsaid) does just that, and in clinical trials, it was found to have minimal systemic toxicity. DMSO significantly enhances the efficacy of diclofenac (Pennsaid’s NSAID) while exhibiting much lower toxicity compared to oral diclofenac.9,10,11,12

Many other FDA approved pharmaceutical products utilizing DMSO further demonstrate its therapeutic versatility:

Mekinist, a targeted cancer therapy, uses DMSO to stabilize the drug and enhance its water solubility, possibly increasing tumor penetration.13

Prochymal, a stem cell product for preventing tissue rejection, uses 10% DMSO to preserve stem cells, as do many other stem cell products.14

Onyx, a liquid injected into blood vessels to seal leaks, uses DMSO to dissolve the polymer so it remains liquid until reaching problem areas. DMSO is chosen because it’s a uniquely safe substance capable of this function.15

Viadur is a non-degradable implant for prostate cancer containing Lupron dissolved in DMSO, designed to slowly release Lupron over a year.16 DMSO is essential because Lupron is otherwise difficult to dissolve, and DMSO preserves its stability while being nontoxic.

Note: Lupron is an incredibly toxic hormone eliminating drug used for prostate cancer which was adopted by urologists due to it being incredibly lucrative (which then led to it being repurposed for many other areas of medicine such as gynecology and blocking puberty in transgender children).

Critical Considerations

DMSO’s function as a vehicle and potentiator has enabled a variety of innovations for common medical therapies (e.g., pain-killers, antibiotics, and chemotherapy), which has inspired many others to experiment with these combinations. However, for anyone planning to do this, it is critical to understand the safety precautions that must accompany using DMSO in this manner.

Contamination risk — One of the major risks of DMSO is its potential to exacerbate the effects of a toxic substance already present in the skin, so it is crucial to clean the skin thoroughly before applying DMSO. The original investigator of DMSO learned this lesson the hard way when researching toxic pesticides.17

[Herschler] wanted to investigate whether certain highly toxic pesticides were soluble in DMSO. The researcher felt how soluble they were when he sprayed some of the solution onto his skin. DMSO transported the poison into the body within minutes. The poison worked: Herschler temporarily suffered from impaired consciousness and shortness of breath.

Remarkably, despite the immense potential harm, serious incidents are extremely rare, suggesting either that users are consistently careful about cleaning skin prior to DMSO applications or that the actual risk is limited to highly toxic substances.

Potentiation effects — Many agents become significantly more potent when mixed with DMSO, and in a few reports made rare side effects typically seen at higher doses manifest (something which has occasionally been reported with the more toxic antibiotics like fluoroquinolones or certain chemotherapy drugs).

With natural substances, this is generally not problematic (as their potency and toxicity are typically much less than pharmaceuticals). Still, it remains a real consideration (although I have not come across any reports of this injuring someone).

Size limitations — While DMSO can draw things inside the body, it can only do so for smaller molecules, with the size limit thought to be around 500 daltons (although there are numerous examples of larger drugs also being transported).

For this reason, DMSO tends to work well as a vehicle for individual drugs or chemicals but not larger proteins (e.g., peptides). Likewise, pathogenic organisms are far too big for DMSO to transport, so areas of application do not need to be disinfected prior to application.

Note: Below the skin, the transportation limit is much higher (e.g., evidence suggests DMSO can bring molecules larger than 70,000 Da through the blood-brain barrier, opening even wider possibilities for intravenous applications).18

Purity requirements — When making DMSO combinations, it’s essential to obtain pure ingredients, as many pharmaceutical and supplement preparations contain multiple ingredients beyond the primary active compound

Note: One of DMSO’s most promising combinations is with a common dye (hematoxylin) as this combination selectively targets tumors with no toxicity to normal tissue and has remarkable efficacy against a wide range of cancers. Unfortunately, hematoxylin is often mixed with heavy metals (to better stain tissues), illustrating the need to ensure pure substances with DMSO.

Leaching — As a solvent, DMSO can leach toxic chemicals (e.g., those added to the surfaces of plastics) and hence later bring them into the body. For this reason, it is advisable to avoid storing DMSO in plastic that is not DMSO resistant and to avoid mixing or preparing DMSO with plastic tools.

In most cases, DMSO only leaches plastic at concentrations about 20%, so if DMSO is diluted before putting it in contact with plastic many of these issues can be avoided. Likewise, many DMSO compatible materials exist for preparing DMSO combinations — all of which is discussed further here.

Note: Most implanted medical devices are not at risk of DMSO leaching them as it dilutes far below 20% by the time it reaches them and can contact their plastic components. The one exception are within dental implants, and for that reason, DMSO mouthwashes must always be sufficiently diluted.

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DMSO Drug Interactions

Given DMSO’s ability to potentiate pharmaceuticals, a critical question arises: is it safe to take alongside other drugs? The answer is nuanced:

What we know — Most pharmaceutical interactions, unfortunately, have not been studied. Fortunately (particularly since over 61% of Americans are on at least one medication19), significant reactions are rarely reported.

Generally speaking, the risk for potentiation is stronger the closer they are taken together (particularly when mixed together in an IV infusion) so it is generally advised to space DMSO and a pharmaceutical by at least two hours, and in the case of more toxic ones (e.g., fluoroquinolones and certain chemotherapies) by at least two days.

Note: DMSO can also mitigate many pharmaceutical toxicities, such as gentamicin’s kidney toxicity20 or many injuries caused by chemotherapy.

Most of the research into DMSO’s interactions was conducted during the initial trials in the 1960s, where it was discovered DMSO significantly potentiated alcohol and also potentiated barbiturates, corticosteroids, insulin, digitalis, nitroglycerin, quinidine sulfate, and chemotherapy21 (leading to lower doses sometimes being needed).

Since then, DMSO has also been observed to potentiate certain opioids (e.g., morphine patches), NSAIDs, anticonvulsants (e.g., gabapentin), and certain sedatives (e.g., trazodone). Users typically do not report potentiation of anticoagulants; however, as a serious risk might exist, it is advisable to monitor your coagulation parameters when using both concurrently.

Note: Insulin potentiation is hypothesized to result from DMSO’s protein refolding capacity restoring the functionality of insulin receptors.22

Conversely, DMSO has also been observed to reverse the effects of Botox, likely by neutralizing the toxin induced paralysis.

Therapeutic Synergies

Over the years, many remarkable pharmaceutical DMSO combinations have been developed for a wide range of medical applications. These include:

Antibiotics — Antibiotic resistance is a major problem in medicine. However, when combined with DMSO, many organisms that are chronic and debilitating or life threatening (e.g., tuberculosis) lose their resistance to antibiotics.

DMSO also makes it possible to reach infections such as those within the bones that are normally difficult to reach and otherwise require maintaining very high blood concentrations of the drugs to ensure this result. Finally, in many cases (both for cost and to protect the gut microbiome) being able to topically apply an oral or IV antibiotic can be immensely advantageous (e.g., for mastitis or Lyme disease).

Antifungals — Fungal infections are often located in areas that topical and oral antibiotics have difficulty penetrating. However, research shows combining an antifungal with topical DMSO can reach those infections and there are many reports of multiyear fungal infections quickly resolving from this combination.

Herpes and shingles — Some of the most potent antiviral medications have difficulty penetrating through a lesion to where the virus resides. However, once combined with DMSO they do, and many clinical trials have proven the efficacy of these antiviral combinations.

Corticosteroids — For issues within the body, steroids (which have significant systemic toxicity) must be injected or taken orally. When combined with DMSO, this is often no longer needed, and as DMSO potentiates steroids, much lower and far less toxic doses can be taken to address an autoimmune or musculoskeletal issue.

Chemotherapy — By potentiating chemotherapy, DMSO has been proven to cure chemotherapy resistant cancers, and in many cases does so with much lower doses being needed.

Recently, owing to the emerging popularity of using ivermectin for treating cancer (which sometimes produces spectacular results but typically fits best as a complementary therapy), physicians have begun combining ivermectin with DMSO into a paste and topically applying it over tumors. While data is limited, this appears to consistently work, and sometimes produces dramatic responses like this one James Miller MD recently shared with me:

“I had a patient with a thoracic sarcoma that was debilitatingly painful with growth through a couple of ribs and metastases to his skull base that became basically pain free after 2 days of topical DMSO-ivermectin. At his 2.5 week follow up, he was completely pain free and had returned to playing racketball.”

Note: Nothing comparable to do this can be done with conventional cancer options (and given the severity of that situation, what would be used is also fairly toxic).

Conclusion

As so many things can be combined with DMSO, the incredible things we’ve seen so far are only the tip of the iceberg, and only the most preliminary (but highly encouraging) data exists on many of them, as there is so much to research. For example, DMSO combinations have been shown to effectively treat a wide range of eye issues (e.g., eye strain, macular degeneration, glaucoma, and cataracts), traumatic injuries (e.g., whiplash) tinnitusuncomfortable scarsneuropathic pain and Lyme disease.

Likewise, DMSO combination therapies are not restricted to pharmaceuticals, and as such, over the years, the DMSO community has discovered hundreds of incredible natural DMSO combinations that revolutionize natural medicine.

Stanley Jacob, the father of DMSO who devoted his career to advancing the science of it, was driven by the recognition DMSO was not a new drug, but rather, like penicillin, a new therapeutic principle which redefined how medicine could be practiced. Fortunately, due to an extraordinary confluence of circumstances, we have now arrived in an era where it is at last (after more than a century) no longer possible to suppress natural healing methods.

People around the world are at last awakening to the Forgotten Sides of Medicine and the realization that the ways to find the cures we need is not “more research” but rather rediscovering what was already found (but not possible to profit off of). This is an incredibly exciting time and I am immensely grateful to be part of it with you.

Author’s Note: This is an abridged version of a longer article about DMSO combination therapies which goes into greater detail on the points mentioned here, many of the other combinations not covered (e.g., for tinnitus or vision loss), and provides guidance for preparing the combination therapies. That article, along with resources and protocols for obtaining and using DMSO can be read here.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.