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More Evidence That High Iron in the Brain Promotes Alzheimer’s
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2025/08/19/brain-iron-and-alzheimers-disease.aspx
Analysis by Dr. Joseph Mercola August 19, 2025
Story at-a-glance
- New research shows excess iron in your brain triggers damage that accelerates Alzheimer’s, especially in people with Down syndrome, who develop the disease earlier and more aggressively
- Too much iron damages the outer layer of brain cells, weakens your brain’s natural protectors like glutathione, and encourages the buildup of plaques that destroy nerve cells and harm memory
- Tiny, often undetected brain bleeds are a major source of iron overload, leaking iron-rich compounds into brain tissue that fuel long-term inflammation and cellular breakdown
- Key brain enzymes meant to protect against iron damage are missing in the exact areas being attacked, leaving neurons highly vulnerable even when overall antioxidant levels appear normal
- You can reduce your risk by testing your ferritin and GGT levels, donating blood if iron is high, increasing copper and calcium from food, eliminating vegetable oils, and restoring glutathione with molecular hydrogen and sulfur-rich foods
Alzheimer’s doesn’t start with forgetfulness — it starts with damage. Long before memory loss appears, your brain begins breaking down at the cellular level. And one of the hidden drivers behind that destruction is something many people don’t think about: iron.
When iron builds up in your brain tissue and reacts with fats and proteins, it causes oxidative stress that destroys neurons from the inside out. This iron-driven process doesn’t just accompany Alzheimer’s — it could be what kicks it into gear. A study from the University of Southern California and the University of California, Irvine uncovered a key clue: people with Down syndrome who develop Alzheimer’s show far more brain iron than those with Alzheimer’s alone.1
That excess iron is tied to brain cell death, inflammation, and early buildup of harmful plaques. If your body can’t safely store and regulate iron, the damage spreads fast — especially in areas tied to memory and executive function. And once your antioxidant defenses are overwhelmed, there’s little left to stop the cascade. Understanding how and why this happens opens the door to new strategies — not just for slowing Alzheimer’s, but for preventing it before it takes hold.
Too Much Iron in Your Brain Speeds Up Alzheimer’s Damage
The study, published in Alzheimer’s & Dementia, looked at how too much iron in your brain drives Alzheimer’s disease, especially in people with both Down syndrome and Alzheimer’s.2 Researchers studied brain tissue from three groups: healthy adults, adults with Alzheimer’s, and adults with Alzheimer’s related to Down syndrome. Their goal was to understand how iron buildup harms brain cells and leads to sticky protein clumps called amyloid plaques, which are tied to Alzheimer’s.
• Iron levels were much higher in people with both Down syndrome and Alzheimer’s — Compared to healthy adults and those with Alzheimer’s alone, people who had both conditions had about twice as much iron in a key brain region responsible for memory and decision-making.
This group had much higher levels of damage from iron reacting with the fats in brain cells and breaking them down. Making matters worse, the natural defenses that protect brain cells from this type of damage were weakened or missing.
• The brain’s protective enzymes were missing where they were needed most — The study found enzymes that normally repair damage to brain cell membranes were reduced by as much as 70% in the affected areas. These enzymes are important because they help prevent brain cell death triggered by iron overload.
Another protective compound, glutathione, also wasn’t being made properly. That’s because the enzyme needed to make it was also reduced by up to 60%. Without enough glutathione, brain cells lose a major line of defense against stress and oxidation.
• Iron harmed key parts of brain cells that act like control centers — The study found that iron was attacking small areas on the cell’s surface where important proteins are handled and messages are sent. In brains affected by Alzheimer’s — especially in people with Down syndrome — these areas were badly damaged. This damage changed how certain proteins were made, increasing the toxic forms that clump together in the brain and destroy nerve cells.
Are Tiny Brain Bleeds the Source of All That Extra Iron?
One major clue came from the discovery of iron deposits in areas linked to microscopic bleeding. These “microbleeds” are tiny leaks from brain blood vessels that often go unnoticed. When blood escapes into brain tissue, it breaks down and releases iron.
Over time, this creates pockets of stored iron that cause more damage. The study found that a cleanup enzyme, which helps process iron from blood, was three times higher in the brains of people with Down syndrome and Alzheimer’s, suggesting chronic bleeding was driving iron overload.
• The brain’s protein-cutting process turned more destructive under stress — Normally, certain brain proteins can be cut in ways that are either safe or harmful. In the damaged brains, the harmful cutting process became more active — not because there was more of the cutting enzyme, but because it was working faster, likely due to iron-related stress. At the same time, the safer cutting process slowed down. This shift caused the brain to make more toxic proteins instead of removing them.
• Even though the body made more antioxidants, they weren’t in the right place — The brain as a whole seemed to increase antioxidant enzyme levels in response to damage, but those enzymes weren’t where they were most needed. This mismatch meant that cells remained vulnerable to damage, even though the body was trying to defend itself. It showed that Alzheimer’s damage isn’t just about overall inflammation or oxidation — it’s about damage happening in precise, high-risk zones.
• Your genes influence how much iron builds up in your brain — In people with rare forms of Down syndrome who didn’t have an extra copy of a certain protein-making gene, there was far less brain iron, fewer harmful protein clumps, and they lived up to 20 years longer than those with the extra gene. This shows that making too much of that protein leads to more iron buildup, more brain damage, and a shorter life — helping explain why some people’s brains decline faster than others.
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How to Protect Your Brain from Iron-Driven Damage
High iron is an under-recognized health threat, and there’s a general lack of awareness in the medical community regarding the health risks associated with high iron levels. If you’re concerned about memory loss or have a family history of Alzheimer’s, it’s time to start thinking about iron — not just in your blood, but in your brain.
The study I’ve shared shows that too much brain iron doesn’t just sit there quietly. It ignites a chain reaction of oxidative stress and cell damage that accelerates cognitive decline. Your first move should be reducing the root cause: excess iron accumulation combined with poor antioxidant defenses. Here’s what I recommend to take control of the iron-oxidation cycle and give your brain the support it needs to stay sharp, focused, and protected.
1. Test your ferritin and gamma-glutamyl transpeptidase (GGT) to assess iron burden and oxidative stress — If you don’t know your ferritin level, that’s where you start. Ferritin is the storage form of iron, and the ideal range is between 60 and 75 ng/mL. High ferritin levels indicate your body is holding onto too much iron, which leaks into your brain and triggers damage.
I also recommend asking for a GGT test. GGT is a key marker of oxidative stress and helps identify if free iron is causing damage inside your body. When both ferritin and GGT are elevated, it’s a strong sign your iron is doing harm.
2. Donate blood or request phlebotomy if your iron is too high — If your body is holding onto more iron than it can safely manage, it increases your risk for heart disease, insulin resistance, and oxidative damage to your organs — including your brain. One of the most effective solutions?
Donate blood two to four times a year. This simple act pulls iron out of storage and lowers your levels gradually. If donation isn’t an option due to your health history, ask for therapeutic phlebotomy to achieve the same result.
3. Balance your copper intake to support healthy iron metabolism — Iron reduction is only one piece of the puzzle. If your copper status is low, which is common, your body can’t regulate iron properly. Copper and iron work together. When copper is deficient, iron builds up in places it doesn’t belong. Consider supplementing with 3 to 4 milligrams of copper bisglycinate daily if your intake is low.
You can also focus on copper-rich foods like bee pollen, grass fed beef liver, and acerola cherries — acerola cherry is very high in vitamin C, which contains copper-rich tyrosinase enzyme. Don’t overlook retinol either — this nutrient, found in beef liver and organ meats, helps your body absorb and use copper effectively.
4. Get calcium from food to help keep iron in check — Proper calcium intake reduces your risk of iron overload naturally. When calcium is low, your body produces more parathyroid hormone, which increases iron storage. That creates a feedback loop that worsens brain inflammation over time.
Focus on getting calcium from whole food sources like raw grass fed dairy, pasture-raised egg yolks, and powdered eggshells. Skip the synthetic calcium supplements unless medically necessary, as they don’t offer the same co-factors for absorption.
5. Remove vegetable oils and increase antioxidant-rich foods — Iron is especially dangerous when it reacts with unstable fats, like polyunsaturated fats in vegetable oils. I recommend eliminating canola, soy, corn, sunflower, safflower, and other vegetable oils from your kitchen. These oils break down in your body and feed oxidative stress.
Replace them with stable fats like grass fed butter, ghee, coconut oil, and tallow. At the same time, boost your antioxidant defenses by eating garlic, onions, and pasture-raised eggs. These foods give your body the building blocks to produce glutathione, your brain’s main defense system against iron-triggered damage.
You can also add molecular hydrogen to your daily routine. Hydrogen activates your body’s own healing system by switching on glutathione — especially important when chronic illness and oxidative stress have shut those systems down. Whether through hydrogen-rich water or tablets, this approach helps reactivate your brain’s defense systems where they’re needed most.
By actively lowering excess iron, restoring mineral balance, and strengthening your antioxidant defenses, you protect your brain from the inside out. These steps are simple, actionable, and backed by clear biological mechanisms. Start with testing, make the dietary swaps, and stay consistent — your future brain will thank you.
FAQs About Iron and Alzheimer’s Disease
Q: What does iron have to do with Alzheimer’s disease?
A: Excess iron in your brain causes oxidative damage by reacting with fats and proteins in brain cells. This process leads to neuron death and helps trigger the development of Alzheimer’s. The damage is especially severe in areas responsible for memory and decision-making.
Q: What did the new study find about brain iron and Alzheimer’s?
A: The study found that individuals with both Down syndrome and Alzheimer’s had double the brain iron compared to those with Alzheimer’s alone. The extra iron was linked to faster and more severe buildup of brain plaques, greater cell damage from stress, and weaker natural protections in the brain.
Q: Where does all this excess iron come from?
A: Tiny, undetected brain bleeds (microbleeds) appear to be a key source. When blood leaks into brain tissue, iron from hemoglobin is released and stored locally, causing long-term oxidative stress. People with Down syndrome-related Alzheimer’s had a threefold increase in the enzyme that processes blood-derived iron, suggesting chronic internal bleeding contributes to iron buildup.
Q: How can I find out if I have high iron levels?
A: Start by testing your ferritin, the storage form of iron. Ideal levels fall between 60 and 75 ng/mL. You should also request a GGT test to measure oxidative stress. High ferritin and GGT together suggest your body is not safely managing iron, which impacts brain health.
Q: What steps can I take to reduce the risk of iron-driven brain damage?
A: Donate blood regularly or ask for therapeutic phlebotomy if your ferritin is high. Balance iron with copper-rich foods or supplements, increase calcium from whole food sources, eliminate vegetable oils, and boost antioxidants like glutathione. You can also use molecular hydrogen to reactivate antioxidant enzymes and help your brain neutralize oxidative stress.
The Silent Epidemic of Excess Iron
Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2024/03/10/high-iron.aspx
The original Mercola article may not remain on the original site, but I will endeavor to keep it on this site as long as I deem it to be appropriate.
Analysis by Dr. Joseph Mercola March 10, 2024
STORY AT-A-GLANCE
- High iron is an under-recognized health threat. There’s a general lack of awareness in the medical community regarding the potential health risks associated with high iron levels
- A ferritin level above 100 typically means you’re either inflamed, have high iron, or both. A level above 200 is considered pathological. The higher your ferritin level, the shorter your lifespan. You’re also more likely to die of a heart attack and cancer
- Left untreated, high iron levels can cause liver damage and an increased susceptibility to certain diseases, including infections and cancer
- Lab tests that can help diagnose iron-related conditions such as hemochromatosis include a full iron panel, a complete blood count (CBC) test, gamma-glutamyl transferase (GGT), and a comprehensive metabolic panel to ensure you have sufficient liver enzymes. Measuring your copper and ceruloplasmin levels can also be helpful
- The easiest way to lower your iron is to donate blood on a regular basis. Natural supplements such as curcumin, silymarin and alpha-lipoic acid can also help prevent from continuing to accumulate iron from your food
In this interview, Christy Sutton, D.C., reviews the dangers of excessive iron. While most doctors look for iron deficiency, few ever pay attention to elevated iron. Sutton is the author of two books, “Genetic Testing: Defining Your Path to a Personalized Health Plan: An Integrative Approach to Optimize Health,” and “The Iron Curse, Is Your Doctor Letting High Iron Destroy Your Health?”
Iron plays an important role in health, especially for children and young adults. Without sufficient iron, you’re not going to be able to form red blood cells and certain proteins in your mitochondria that are responsible for producing energy. On the flip-side, an excess of iron can cause significant damage.
A Silent Epidemic
Sutton’s interest in iron has been “lifelong” she says, as she struggled with low iron while her husband has a genetic anomaly that causes him to have elevated iron levels. So, she has personal experience with both ends of the spectrum.
“I have Crohn’s [disease], celiac, and lost part of my small intestine due to Crohn’s when I was 16,” she says. “Because of that, I have to take a bile sequestrant. Then, being menstruating female who’s had a child, low iron has been something that I have been watched very closely for and I had to take iron a lot.
Like a lot of clinicians, when I came into practice, I seemed to be more hyper-focused on people’s problems that were my own problems. I dealt with iron issues. So, I wanted to watch my patients’ iron levels closely. Then I realized, ‘Oh, not everybody is low. A lot of people actually have high iron.’
It wasn’t until I was writing my first book, ‘Genetic Testing: Defining Your Path to a Personalized Health Plan,’ that I discovered the hemochromatosis genes. I realized that my husband had a hemochromatosis gene, and I realized that that was why I kept telling him to donate blood.
His doctor would order iron labs, ferritin, CBC, and he would get elevated iron often, high ferritin. He was developing high liver enzymes and his red blood cells were getting high as well, which is a common issue with people that have too much iron …
He went to a gastroenterologist, because he was trying to figure out why his liver enzymes were high. I thought it was the high iron, but that was presented to the gastroenterologist and dismissed. So, they went down this rabbit hole of misdiagnosing him with autoimmune hepatitis.
Later we went to a hematologist where we figured out he had hereditary hemochromatosis. So, it’s not something that’s particularly difficult to treat. Removing blood, diet supplements, things like that can help.
But once I got really savvy about looking for the genes and the labs combined, I realized that this is a silent epidemic that is not really being talked about. I would tell people, ‘You have a problem with high iron,’ and then they would often go and get a second opinion.
Their second opinion would say, ‘You’re fine. Don’t worry about it,’ which is a common issue where people are getting high iron labs that should warrant more investigation and then they’re just getting dismissed.”
How to Lower Your Iron Level
I have beta thalassemia, a hemolytic anemia that results in a high turnover of red blood cells. My red blood cells only live about two months, rather than the normal three months. As a result, my iron tends to accumulate because of the rapid turnover. So, while I do not have the hemochromatosis gene, it results in similar problems. I inherited it from my father, who had a ferritin level close to 1,000 by the time he was diagnosed. Ideally, it should be below 40.
One of the supplements he tried was inositol, also referred to as hexaphosphate or IP-6, but it did nothing. I rapidly came to the conclusion that the supplements typically recommended for high iron are useless and potentially even dangerous, because they prevent you from doing what is really helpful, which is to remove iron through regular phlebotomies.
The most effective way to lower your iron is to donate blood two to four times a year. If losing 10% of your blood in one sitting is problematic for you, then you can remove blood in smaller amounts once a month on the schedule I have listed below. If you have congestive heart failure or severe COPD, you should discuss this with your doctor, but otherwise this is a fairly appropriate recommendation for most.
| Men | Postmenopausal Women | Premenopausal Women |
| 150 ml | 100 ml | 50 ml |
As it turns out, Sutton did not include IP-6 in her book, as she couldn’t find any research to back up the claims. She doesn’t dismiss all supplements, however. One of the most helpful, in her view, is curcumin.
“Clinically, I have seen curcumin’s ability to lower iron almost to a fault,” she says. “It’s annoying to me, because I can’t take curcumin for inflammation because it makes me low in iron. But for people that are high in iron or even inflamed with high iron, high ferritin, that’s a great place to start, because curcumin binds to iron.
It also has all of these other wonderful health promoting properties. It’s so good for your brain — it actually helps remove excess iron from the brain and other organs, the heart, liver, spleen.
So, unlike other iron chelators that might be used pharmaceutically, it doesn’t have all these possible negative side effects, but it works very effectively. I mean, I’ve seen it be used in hereditary hemochromatosis patients to lower iron without blood removal … Now, people that have really high iron might need 3 grams a day, which can create diarrhea. So, you have to look at other potentially limiting factors.”
She also recommends taking curcumin with an iron-rich meal, such as shellfish or red meat, to inhibit iron uptake. Other supplements that help bind iron include silymarin, (an extract from milk thistle). It too is very good for hemochromatosis patients, because it lowers iron and helps protect and repair the liver. Another thing that binds to and lowers iron is alpha-lipoic acid. It’s also great for protecting nerves and lowering blood sugar.
“I don’t think silymarin lowers iron quite as much as curcumin, but it’s still a significant way to lower iron,” she says. “The best way to take these — to lower iron — is take them with iron-rich meals. If you want to take them just for medicinal properties but not to lower iron, take them away from iron-rich meals.”
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Health Risks Associated With High Iron
The health risks of high iron are manifold and include an elevated risk of skin infections and skin cancer. I suspect high iron may actually be a catalyst when it comes to skin cancer, along with high linoleic acid (LA) intake. LA is oxidized by iron, creating something called lipofuscin, which is basically iron attached to oxidized LA.
A more common term for lipofuscin is liver spots. So, liver spots are a dermal representation of oxidative damage to LA by high iron. Similarly, skin cancer is likely driven by a combination of high LA and high iron. Ancestral LA levels were below 2%. Today, the average is around 25%. If you had normal ancestral levels, you could have higher iron yet not get as much damage.
Understanding Hemochromatosis
There are several potential diagnoses related to iron, including iron deficient anemia, copper deficient anemia, iron overload and hereditary hemochromatosis, and getting to the correct diagnosis can be tricky.
“The nice thing is that you can always fall back on labs,” Sutton says. “You don’t want to just use symptoms to guide you, because if you’re using symptoms, then this person is well far down a pathological path that you could have potentially stopped years ago, if not decades before.”
Starting with hereditary hemochromatosis, this is when you have inherited one of three hemochromatosis genes, which causes increased iron absorption by decreasing hepcidin, a liver protein. If you have the hemochromatosis gene, you don’t make as much hepcidin, causing you to absorb more iron.
That can become pathological, because over time, you just keep absorbing more and more iron, until your body finally runs out of places to put it. The first place that gets overloaded is your liver. After that, your body will store the iron in other organs, such as your heart, pancreas, brain, pituitary gland, gonads, ovaries, testes and skin.
Eventually, the iron will go everywhere because the human body has evolved to hold onto as much iron as possible. The only way, really, to lose iron is through blood loss. This is why menstruating women have a lower risk for high iron and a higher risk for low iron.
“Having said that, when you start looking at the hemochromatosis genes, all bets are off, because you’ll see females that have these hemochromatosis genes that develop high iron … you will even see children with the hemochromatosis genes that develop high iron,” Sutton says.
“I discovered that in my colleague’s 5-year-old, where predatory hemochromatosis was causing her to have severe neurological problems. That was a very difficult thing to get through because the hematologist didn’t really want to deal with it.
When you look at labs, hereditary hemochromatosis can look very similar to non-hereditary hemochromatosis, which is where you have high iron but you don’t have one of those hemochromatosis genes.
So, for you, you have more of a non-hereditary secondary hemochromatosis, because you have that thalassemia issue where your red blood cells are breaking and letting all this iron out and then you develop high iron with potentially low red blood cells.
That’s common with thalassemia. Some people, they don’t have a thalassemia gene and they develop high iron without hemochromatosis gene, because they’re just eating a lot of iron-rich foods and they’re not losing iron through menstruation. This is usually men.”
How to Diagnose Hemochromatosis
When it comes to lab work, Sutton recommends starting with a full iron panel, a complete blood count (CBC) test, gamma-glutamyl transferase (GGT), and a comprehensive metabolic panel to ensure you have sufficient liver enzymes. Measuring your copper and ceruloplasmin levels can also be helpful.
“The full iron panel has the ferritin, the TIBC [total iron-binding capacity], the UIBC [unsaturated iron-binding capacity], the serum iron and the iron saturation. With hereditary hemochromatosis, you develop high ferritin with a high iron saturation. That combination is hereditary hemochromatosis. So, over 45% iron saturation and high ferritin …
With hereditary hemochromatosis, you’ll see high iron, you’ll see the TIBC go low, the UIBC go low. The serum iron often goes high, and then that ferritin will go high. You’ll often see the liver enzymes go high and it’s common to see the red blood cells, hemoglobin, hematocrit go high.
But that doesn’t always happen. These days, so many are taking testosterone. So, you have to always ask, ‘Are you on testosterone?’ Because that can cause red blood cells, hemoglobin, hematocrit to go high as well …
I always get the GGT as a part of the labs that I order. Occasionally, I will see a high GGT when the AST and ALT, which are the other two liver enzymes, are normal. More often than not, I’ll see a high ALT or high AST. Usually, if they’re not drinking alcohol and they just have high iron, you’re going to see that high ALT.”
What’s the Ideal Ferritin Level?
Sutton recommends keeping ferritin below 100. Ferritin above 100 means you’re either inflamed, have high iron, or both. Studies referenced in her book suggest that anything over 200 is pathological. The higher your ferritin level, the shorter your lifespan. You’re also more likely to die of a heart attack and cancer.
“I feel like 100 is high enough that I’m not swooping everybody in, but low enough that I’m not leaving stragglers out,” she says. “Now, if somebody has a ferritin over 100 with an iron saturation that is in the 40s or higher, then I’m highly suspicious of a hemochromatosis gene and I immediately want to get those hemochromatosis genes tested.
If they have a hemochromatosis gene, then we know why they’re high on iron and we know where this story is going — and it’s not going to be a pretty picture most likely. Then it’s time to refer to a hematologist … and talk to them about how to get iron lower …
The key is, if you don’t have a hemochromatosis gene, then you need to figure out ‘Why does this person have high iron? Do they have a thalassemia gene? Are they just eating a lot of iron?’ And then, ‘Do they have hemolysis for some unknown reason?’ That’s a non-hereditary hemochromatosis situation.
The treatment is basically the same, other than you want to use more of the supplements, go really heavy on the supplements to lower iron. If you have plenty of red blood cells and hemoglobin, then therapeutic phlebotomy is a wonderful place to start.
A lot of times people don’t because they either have a thalassemia issue where their red blood cells are getting chewed up too quickly, or they have lost so much blood so quickly because their doctors are just trying to get the iron down that they become low in hemoglobin or red blood cells. Rather than waiting for months for that to recover, you could be doing the supplements to lower the iron.”
The Link Between High Iron and Cushing’s Disease
Sutton’s husband also developed a pituitary tumor that was causing him to have high cortisol (Cushing’s disease). “Ultimately, I think the high iron created a lot of oxidative stress on his pituitary gland,” Sutton says. The only reason he was diagnosed early enough to save him was that they’d been checking his cortisol and DHEA on a regular basis.
“Periodically, they would jump up and then go back down. Then when the hemochromatosis got properly treated and the DHEA was still high, we were like, ‘Why is this happening?’ So we went to the endocrinologist and I said, ‘I’m worried my husband has Cushing’s.’ She was like, ‘He doesn’t have Cushing’s. He doesn’t look like somebody with Cushing’s. His hemoglobin A1C is normal.’
Five months later, he’s having surgery to remove the pituitary tumor. The reason I say that is because for years, he was told, ‘You just need to exercise and lose weight.’ His problem was not exercise. He had a pituitary tumor and hemochromatosis. Hemochromatosis was destroying his liver and his brain and his heart and everything else, and the pituitary tumor was causing him to have high cortisol, which made him look overweight.”
I believe progesterone may be one of the best ways to treat Cushing’s disease, as it very effectively blocks cortisol. Other natural substances that will inhibit cortisol include aspirin, DHEA, pregnenolone, emodin, vitamins A and D, gelatin or glycine, and niacinamide.1
The normal dose for progesterone is 25 to 50 milligrams. For Cushing’s, I would recommend about 300 mg. It’s virtually impossible to overdose on progesterone and there are no downsides to it. One caveat is that you need to administer it correctly to gain the optimal effects.
Avoid creams, pills and suppositories. Instead, mix pharmaceutical grade progesterone with the contents of one natural vitamin E capsule. Mix it with a paperclip or tiny spoon until all the powder is dissolved, then rub it on your gums. Vitamin E is the only natural compound that dissolves progesterone completely. For guidance on how to pick a good vitamin E supplement, see “The Four Hormones Most Adults Need More Of.”
Understanding Iron-Deficient Anemia
As explained by Sutton, iron deficient anemia is a serious issue. Children born of women with iron-deficient anemia have significantly higher risk of low IQ, ADD, ADHD and other neurological issues that often do not go away with age.
“Many kids suffer from low iron, because they eat a lot of calcium rich foods. Calcium binds to iron, and then you get low in the iron. Maybe they’re picky eaters, they’re growing rapidly. So many kids are not being checked for their iron levels and they’re being diagnosed with ADHD when their problem is actually just low iron, because if you don’t have enough iron, you can’t make dopamine. So, low iron is a serious issue.”
People with iron-deficient anemia will typically have high TIBC and UIBC, as their bodies are trying to mobilize more iron. Serum iron and iron saturation will be low and ferritin will typically be below 30.
“Now, iron deficient anemia is more complicated in many ways because the question is, why are you low in iron?” Sutton says. “There’s so many reasons that you can be low in iron. Are you just not eating enough? Are you not absorbing it? I think the most common reasons that people develop low iron is because they have a GI bleed. They have intestinal malabsorption issues, maybe undiagnosed celiac disease.
There is a gene that can cause you to be more likely to have low iron. I have that gene and that gene actually causes you to make more hepcidin. With iron-deficient anemia you’ll also see low red blood cells sometimes, low hemoglobin and low hematocrit. MCH [mean corpuscular hemoglobin] might get low, MCV [mean corpuscular volume] might get low.”
Copper Deficiency Can Cause Both Low and High Iron
One common cause for iron-deficient anemia is a deficiency in copper. Paradoxically, lack of copper is also a common cause for iron overload. Sutton explains:
“The reason for that is because copper is necessary for two key enzymes. The first one is called hephaestin and the second one is called ceruloplasmin. Hephaestin is in the lining of the gut, the intestinal lining. Copper is necessary for iron to be absorbed in the gut lining. So, without copper, you will not absorb iron and you will develop iron deficient anemia.
Once iron has been absorbed in the gut lining by hephaestin, it passes it off to ceruloplasmin, which is the second copper-rich enzyme. Ceruloplasmin basically then allows that copper to transfer in and then move throughout the body. So, without ceruloplasmin, iron gets stuck in the tissues. It’ll get stuck in the digestive system, it’ll get stuck in the retina, it’ll get stuck in the brain, it’ll get stuck in the liver.
So, you develop iron overload in the tissues. But eventually, if you’re low in copper long enough, you might then become low in iron, and then you don’t end up with all this extra iron in the tissues. The solution is take copper to fix that problem. That’s the way you solve copper-deficient anemia.
Copper-deficient anemia looks very similar to iron-deficient anemia if you’re looking at the iron panel. You’ll have a high TIBC, high UIBC, low serum iron, low iron saturation, low ferritin. You’ll also potentially see low neutrophils and low white blood cells, because you need copper to have normal immune function as well. So, you might be more at risk for infections.
Then of course you can look at the ceruloplasmin. I don’t find ceruloplasmin to be the easiest lab to look at, because it’s an inflammatory marker … If you’re taking hormones like estrogen or birth control or you’re pregnant or you’re just inflamed or have an infection, ceruloplasmin can jump around and go high.
If you have a low or low-normal ceruloplasmin, and then you take copper and ceruloplasmin goes up, that’s a good sign that you didn’t have enough copper.”
How to Get More Iron Into Your Diet
The best way to get iron is through your diet. Shellfish and beef are iron-rich foods with highly absorbable iron. That’s key, because there are two types of iron: heme iron and non-heme iron, the latter of which is not very absorbable. Heme iron is found in animal products while non-heme iron is found in vegetables such as spinach.
“If you’re not eating iron-rich foods like red meat, then you’re more likely to get low in iron if that is something that you struggle with,” Sutton says. “If you struggle with being high in iron, maybe you don’t want to eat as many of those things or maybe you just want to remove blood and supplement accordingly, so that you continue to eat those things.
The form that I like if I’m going to go to a supplement is ferrous peptonate, which I found to be the gentlest on my gut but also get the iron levels up. I really don’t like ferrous sulfate, which is the most common given iron. I don’t think it works very well, and it tends to create a lot of stomach pain. I always have to take my iron with food and sometimes I’ll add copper or vitamin C to it. If I don’t take it with food, it’s really going to upset my stomach.”
More Information
To learn more, check out Sutton’s books, “Genetic Testing: Defining Your Path to a Personalized Health Plan: An Integrative Approach to Optimize Health,” and “The Iron Curse, Is Your Doctor Letting High Iron Destroy Your Health?”